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Nano-bio-chips for high performance multiplexed protein detection: Determinations of cancer biomarkers in serum and saliva using quantum dot bioconjugate labels
Open accessAbstract
The integration of semiconductor nanoparticle quantum dots (QDs) into a modular, microfluidic biosensor for the multiplexed quantitation of three important cancer markers, carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), and Her-2/Neu (C-erbB-2) was achieved. The functionality of the integrated sample processing, analyte capture and detection modalities was demonstrated using both serum and whole saliva specimens. Here, nano-bio-chips that employed a fluorescence transduction signal with QD-labeled detecting antibody were used in combination with antigen capture by a microporous agarose bead array supported within a microfluidics ensemble so as to complete the sandwich-type immunoassay. The utilization of QD probes in this miniaturized biosensor format resulted in signal amplification 30 times relative to that of standard molecular fluorophores as well as affording a reduction in observed limits of detection by nearly 2 orders of magnitude (0.02 ng/mL CEA; 0.11 pM CEA) relative to enzyme-linked immunosorbent assay (ELISA). Assay validation studies indicate that measurements by the nano-bio-chip system correlate to standard methods at R2 = 0.94 and R2 = 0.95 for saliva and serum, respectively. This integrated nano-bio-chip assay system, in tandem with next-generation fluorophores, promises to be a sensitive, multiplexed tool for important diagnostic and prognostic applications.
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Bhasin, S., Zhang, A., Coviello, A., Jasuja, R., Ulloor, J., Singh, R., Vesper, H., & Vasan, R. S. (2008) · Steroids · doi:10.1016/j.steroids.2008.07.003 · Cited by 79
Cited by
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Jokerst, J. V., Cole, A. J., Van de Sompel, D., & Gambhir, S. S. (2012) · ACS Nano · doi:10.1021/nn304347g · Cited by 397
Self-citationApplication of semiconductor quantum dots in bioimaging and biosensing
Martynenko, I. V., Litvin, A. P., Purcell-Milton, F., Baranov, A. V., Fedorov, A. V., & Gun'ko, Y. K. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb01425b · Cited by 382
Cancer detection using nanoparticle-based sensors
Perfézou, M., Turner, A., & Merkoçi, A. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15134g · Cited by 364
Application of Nanotechnology in Cancer Diagnosis and Therapy - A Mini-Review
Jin, C., Wang, K., Oppong-Gyebi, A., & Hu, J. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.49801 · Cited by 353
Metadata
- Authors
- Jokerst, J. V., Raamanathan, A., Christodoulides, N., Floriano, P. N., Pollard, A. A., Simmons, G. W., Wong, J., Gage, C., Furmaga, W. B., Redding, S. W., & McDevitt, J. T.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 24
- Issue
- 12
- Pages
- 3622-3629
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2119624780
- Cited by
- 253
- References
- 1
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Jokerst, J. V., Raamanathan, A., Christodoulides, N., Floriano, P. N., Pollard, A. A., Simmons, G. W., Wong, J., Gage, C., Furmaga, W. B., Redding, S. W., & McDevitt, J. T. (2009). Nano-bio-chips for high performance multiplexed protein detection: Determinations of cancer biomarkers in serum and saliva using quantum dot bioconjugate labels. Biosensors and Bioelectronics. https://doi.org/10.1016/j.bios.2009.05.026
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