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Cited by 163

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

A ratiometric fluorescent probe based on a coumarin–hemicyanine scaffold for sensitive and selective detection of endogenous peroxynitrite

Open access
Zhou, Xin, Kwon, Younghee, Kim, Gyoungmi, Ryu, Ji-Hwan, Yoon, Juyoung·2015·Biosensors and Bioelectronics

Abstract

In the study described herein, the red emitting probe CHCN, which possesses a linked coumarin-hemicyanine scaffold, was developed for detection of peroxynitrite (ONOO(-)) under physiological conditions. The studies show that CHCN displays a dual ratiometric and colorimetric response to ONOO(-) that is caused by an oxidation process. A possible mechanism of this oxidation process was proposed and confirmed by ESI-MS spectra for the first time. CHCN shown highly selective and sensitive towards ONOO(-) with a low limit of detection LOD (49.7 nM). Moreover, CHCN has appreciable cell permeability and, as a result, it is applicable to ratiometric detection of exogenous and endogenous ONOO(-) in living cells during phagocytic immune response. We anticipate that, owing to their ideal properties, probes of this type will find great use in explorations of the role played by ONOO(-) in biology.

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Metadata

Authors
Zhou, X., Kwon, Y., Kim, G., Ryu, J.-H., & Yoon, J.
Venue
Biosensors and Bioelectronics
Publisher
Elsevier BV
Published
2015-02
Volume
64
Pages
285-291
ISSN
0956-5663 (ISSN-L)
OpenAlex
W2084326249
Cited by
163
References
3
FWCI
6.67
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: A ratiometric fluorescent probe based on a coumarin–hemicyanine scaffold for sensitive and selective detection of endogenous peroxynitrite. https://app.cochat.ai/papers/10.1016/j.bios.2014.08.089
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Zhou, X., Kwon, Y., Kim, G., Ryu, J.-H., & Yoon, J. (2015). A ratiometric fluorescent probe based on a coumarin–hemicyanine scaffold for sensitive and selective detection of endogenous peroxynitrite. Biosensors and Bioelectronics. https://doi.org/10.1016/j.bios.2014.08.089

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