The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Development of a portable MIP-based electrochemical sensor for detection of SARS-CoV-2 antigen
Open accessAbstract
The current COVID-19 pandemic caused by SARS-CoV-2 coronavirus is expanding around the globe. Hence, accurate and cheap portable sensors are crucially important for the clinical diagnosis of COVID-19. Molecularly imprinted polymers (MIPs) as robust synthetic molecular recognition materials with antibody-like ability to bind and discriminate between molecules can perfectly serve in building selective elements in such sensors. Herein, we report for the first time on the development of a MIP-based electrochemical sensor for detection of SARS-CoV-2 nucleoprotein (ncovNP). A key element of the sensor is a disposable sensor chip - thin film electrode - interfaced with a MIP-endowed selectivity for ncovNP and connected with a portable potentiostat. The resulting ncovNP sensor showed a linear response to ncovNP in the lysis buffer up to 111 fM with a detection and quantification limit of 15 fM and 50 fM, respectively. Notably, the sensor was capable of signaling ncovNP presence in nasopharyngeal swab samples of COVID-19 positive patients. The presented strategy unlocks a new route for the development of rapid COVID-19 diagnostic tools.
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Cites
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Cited by
Recent advances in molecularly imprinted polymer-based electrochemical sensors
Li, Y., Luo, L., Kong, Y., Li, Y., Wang, Q., Wang, M., Li, Y., Davenport, A., & Li, B. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116018 · Cited by 308
Metadata
- Authors
- Raziq, A., Kidakova, A., Boroznjak, R., Reut, J., Öpik, A., & Syritski, V.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 178
- Pages
- 113029
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W3123452171
- Cited by
- 454
- References
- 22
- FWCI
- 27.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Raziq, A., Kidakova, A., Boroznjak, R., Reut, J., Öpik, A., & Syritski, V. (2021). Development of a portable MIP-based electrochemical sensor for detection of SARS-CoV-2 antigen. Biosensors and Bioelectronics. https://doi.org/10.1016/j.bios.2021.113029
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