The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Aptamer–MIP hybrid receptor for highly sensitive electrochemical detection of prostate specific antigen
Open accessAbstract
This study reports the design and evaluation of a new synthetic receptor sensor based on the amalgamation of biomolecular recognition elements and molecular imprinting to overcome some of the challenges faced by conventional protein imprinting. A thiolated DNA aptamer with established affinity for prostate specific antigen (PSA) was complexed with PSA prior to being immobilised on the surface of a gold electrode. Controlled electropolymerisation of dopamine around the complex served to both entrap the complex, holding the aptamer in, or near to, it's binding conformation, and to localise the PSA binding sites at the sensor surface. Following removal of PSA, it was proposed that the molecularly imprinted polymer (MIP) cavity would act synergistically with the embedded aptamer to form a hybrid receptor (apta-MIP), displaying recognition properties superior to that of aptamer alone. Electrochemical impedance spectroscopy (EIS) was used to evaluate subsequent rebinding of PSA to the apta-MIP surface. The apta-MIP sensor showed high sensitivity with a linear response from 100pg/ml to 100ng/ml of PSA and a limit of detection of 1pg/ml, which was three-fold higher than aptamer alone sensor for PSA. Furthermore, the sensor demonstrated low cross-reactivity with a homologous protein (human Kallikrein 2) and low response to human serum albumin (HSA), suggesting possible resilience to the non-specific binding of serum proteins.
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Polydopamine—a nature-inspired polymer coating for biomedical science
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Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors
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From 3D to 2D: A Review of the Molecular Imprinting of Proteins
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Self-citationElectrochemical sensors based on molecularly imprinted polymers
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Characterization of Dopamine−Melanin Growth on Silicon Oxide
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Cited by
Wearable Chemical Sensors: Present Challenges and Future Prospects
Bandodkar, A. J., Jeerapan, I., & Wang, J. (2016) · ACS Sensors · doi:10.1021/acssensors.6b00250 · Cited by 778
Development of a portable MIP-based electrochemical sensor for detection of SARS-CoV-2 antigen
Raziq, A., Kidakova, A., Boroznjak, R., Reut, J., Öpik, A., & Syritski, V. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113029 · Cited by 454
Metadata
- Authors
- Jolly, P., Tamboli, V., Harniman, R. L., Estrela, P., Allender, C. J., & Bowen, J. L.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 75
- Pages
- 188-195
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2153088547
- Cited by
- 286
- References
- 21
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jolly, P., Tamboli, V., Harniman, R. L., Estrela, P., Allender, C. J., & Bowen, J. L. (2016). Aptamer–MIP hybrid receptor for highly sensitive electrochemical detection of prostate specific antigen. Biosensors and Bioelectronics. https://doi.org/10.1016/j.bios.2015.08.043
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
