Clavulanic acid: a review
Abstract
Natural antibiotics are almost universal secondary metabolites, not essential for the growth of the producing organisms generally produced at low growth rates or after growth has ceased. Clavulanic acid (CA), a naturally occurring powerful inhibitor of bacterial beta-lactamases is a major beta-lactam antibiotic produced by organism Streptomyces clavuligerus and is active against a wide spectrum of Gram-positive and Gram-negative bacteria. The review discusses the biosynthetic pathway, fermentative production, downstream processing and applications of CA.
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Clavulanic acid prevents degradation of the β-lactam ring, thereby preventing resistance of pathogens to β-lactam antibiotics.
“Clavulanic acid prevents drug resistance by pathogens against these β-lactam antibiotics by preventing the degradation of the β-lactam ring, thus ensuring eradication of these harmful microorganisms from the host.”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Saudagar et al., 2008
Cites
Naturally-occurring beta-lactamase inhibitors with antibacterial activity
BROWN, A. G., BUTTERWORTH, D., COLE, M., HANSCOMB, G., HOOD, J. D., READING, C., & ROLINSON, G. N. (1976) · The Journal of Antibiotics · doi:10.7164/antibiotics.29.668 · Cited by 399 · see citing works
Saudagar, P. S., & Singhal, R. S. (2007) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-007-9030-x · Cited by 26 · see citing works
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Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
- Authors
- Saudagar, P. S., Survase, S. A., & Singhal, R. S.
- Affiliations
- Institute of Chemical Technology (IN)
- Corresponding author
- Singhal, Rekha S.
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 26
- Issue
- 4
- Pages
- 335-351
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W2011886013
- Cited by
- 128
- References
- 2
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 9 · 2023: 6 · 2022: 14 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 8 · 2012: 5
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis of β-Lactam Compounds
- Keywords
- clavulanic acid, beta-lactamase inhibitors, Streptomyces clavuligerus, secondary metabolites, biosynthetic pathway, fermentation production, downstream processing, antibiotic applications, Gram-positive and Gram-negative bacteria
- MeSH terms
- Animals, Communicable Diseases, Fermentation, Humans, Clavulanic Acid
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