Naturally-occurring beta-lactamase inhibitors with antibacterial activity
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Clavulanic acid was first purified as a β-lactamase inhibitor from S. clavuligerus ATCC 27064, isolated from South American soil in 1971.
“Clavulanic acid was first purified as a novel β-lactamase inhibitor from S. clavuligerus ATCC 27064, which was isolated from South American soil in 1971 (Higgens and Kastner, 1971; Brown et al., 1976).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Brown et al., 1976
The main text (page unavailable) identifies clavulanic acid as a β-lactamase inhibitor produced by Streptomyces clavuligerus ATCC 27064 and says it was isolated as a sodium salt. It does not say that the strain came from South American soil or was isolated in 1971; those details cannot be verified from this paper. (LLM, conf=0.88)
Experimental — accuracy not yet measuredClavulanic acid as a β-lactamase inhibitor was initially isolated from S. clavuligerus ATCC 27064 using the traditional fermentation system.
“Clavulanic acid as a β-lactamase inhibitor was initially isolated from S. clavuligerus ATCC 27064 using the traditional fermentation system (Higgens and Kastner, 1971; Brown et al., 1976).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Brown et al., 1976
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Cites
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Research works printed but not linked: 2
- HOWARTH, T. T.; A. G. BROWN & T. J. KING: Clavulanic acid, a novel (3-lactam antibiotic isolated from Streptomyces clavuligerus. J.C.S. Chem. Comm. 1976 in press
- MIYAMURA, S. & H. OCHIAI: Inhibitors of 9- lactamases from Gram-negative bacilli. Proc. 8th Internat. Congr. Chemotherapy, Athens. pp. 218~223, 1973
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“Clavulanic acid was first purified as a novel β-lactamase inhibitor from S. clavuligerus ATCC 27064, which was isolated from South American soil in 1971 (Higgens and Kastner, 1971; Brown et al., 1976).”
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- Authors
- BROWN, A. G., BUTTERWORTH, D., COLE, M., HANSCOMB, G., HOOD, J. D., READING, C., & ROLINSON, G. N.
- ORCID
- BROWN, A. G.
- Venue
- The Journal of Antibiotics
- Published
- 1976
- Volume
- 29
- Issue
- 6
- Pages
- 668-669
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2000168862
- Cited by
- 399
- References
- 2
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 13 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 7
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Antibiotics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis of β-Lactam Compounds
- Keywords
- beta-lactamase inhibitors, natural products, antibacterial activity, beta-lactam antibiotics, enzyme inhibition
- MeSH terms
- Amidohydrolases, Anti-Bacterial Agents, Bacteria, Enterobacteriaceae, Streptomyces, beta-Lactams, beta-Lactamase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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