Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering
Abstract
The advent of various systems metabolic engineering tools and strategies has enabled more sophisticated engineering of microorganisms for the production of industrially useful fuels and chemicals. Advances in systems metabolic engineering have been made in overproducing natural chemicals and producing novel non-natural chemicals. In this paper, we review the tools and strategies of systems metabolic engineering employed for the development of microorganisms for the production of various industrially useful chemicals belonging to fuels, building block chemicals, and specialty chemicals, in particular focusing on those reported in the last three years. It was aimed at providing the current landscape of systems metabolic engineering and suggesting directions to address future challenges towards successfully establishing processes for the bio-based production of fuels and chemicals from renewable resources.
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E. coli and yeast have successfully been reprogrammed to convert sugars at commercially relevant rates and concentrations to new products like farnesene, isobutanol, 1,3-propanediol, and 1,4-butanediol.
“These have successfully been reprogrammed to convert sugars at commercially relevant rates and concentrations to new products like farnesene, isobutanol, 1,3-propanediol (1,3-PDO), and 1,4-butanediol (1,4-BDO) (Lan and Liao, 2013; Cho et al., 2014; George et al., 2015; Burk and Van Dien, 2016).”
From Gas Fermentation—A Flexible Platform for Commercial Scale Production of Low-Carbon-Fuels and Chemicals from Waste and Renewable Feedstocks (2016) · cites this paper as Cho et al., 2014
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Flagged first, then by citations
Cited by
Sorted by citations
Liew, F., Martin, M. E., Tappel, R. C., Heijstra, B. D., Mihalcea, C., & Köpke, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00694 · Cited by 485 · see citing works
- Authors
- Cho, C., Choi, S. Y., Luo, Z. W., & Lee, S. Y.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Lee, Sang Yup
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 33
- Issue
- 7
- Pages
- 1455-1466
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W2026027064
- Cited by
- 98
- References
- 130
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 9 · 2020: 16 · 2019: 13 · 2018: 16 · 2017: 12 · 2016: 16 · 2015: 5
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Funders
- National Research Foundation (NRF) of Korea (NRF-2012M1A2A2026556)
- Advanced Biomass R&D Center of Korea (NRF-2010-0029799)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Biochemical and biochemical processes
- Keywords
- systems metabolic engineering, microbial fuel production, microbial chemical production, biofuels, platform chemicals, specialty chemicals, renewable resources, microbial cell factories
- MeSH terms
- Industrial Microbiology, Systems Biology, Metabolic Engineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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