Cited by 98Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversionBiochemical and biochemical processes

Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering

Cho, Changhee, Choi, So Young, Luo, Zi Wei, Lee, Sang Yup·2015·Biotechnology Advances

Abstract

The advent of various systems metabolic engineering tools and strategies has enabled more sophisticated engineering of microorganisms for the production of industrially useful fuels and chemicals. Advances in systems metabolic engineering have been made in overproducing natural chemicals and producing novel non-natural chemicals. In this paper, we review the tools and strategies of systems metabolic engineering employed for the development of microorganisms for the production of various industrially useful chemicals belonging to fuels, building block chemicals, and specialty chemicals, in particular focusing on those reported in the last three years. It was aimed at providing the current landscape of systems metabolic engineering and suggesting directions to address future challenges towards successfully establishing processes for the bio-based production of fuels and chemicals from renewable resources.

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Crossref · 10.1016/j.biotechadv.2014.11.006

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130 of 130 references verified0 citation errors · 0 not checkable

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  • E. coli and yeast have successfully been reprogrammed to convert sugars at commercially relevant rates and concentrations to new products like farnesene, isobutanol, 1,3-propanediol, and 1,4-butanediol.

    “These have successfully been reprogrammed to convert sugars at commercially relevant rates and concentrations to new products like farnesene, isobutanol, 1,3-propanediol (1,3-PDO), and 1,4-butanediol (1,4-BDO) (Lan and Liao, 2013; Cho et al., 2014; George et al., 2015; Burk and Van Dien, 2016).”

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Authors
Cho, C., Choi, S. Y., Luo, Z. W., & Lee, S. Y.
Affiliations
Korea Advanced Institute of Science and Technology (KR)
Corresponding author
Lee, Sang Yup
Venue
Biotechnology Advances
Publisher
Elsevier BV
Published
2015-11
Volume
33
Issue
7
Pages
1455-1466
ISSN
0734-9750 (ISSN-L)
OpenAlex
W2026027064
Cited by
98
References
130
Citations by year
2026: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 9 · 2020: 16 · 2019: 13 · 2018: 16 · 2017: 12 · 2016: 16 · 2015: 5
FWCI
1.04
Type
journal article
Language
en
Open access
closed
Locations
  • Biotechnology Advances (publishedVersion)
  • PubMed (publishedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Funders
  • National Research Foundation (NRF) of Korea (NRF-2012M1A2A2026556)
  • Advanced Biomass R&D Center of Korea (NRF-2010-0029799)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Biochemical and biochemical processes
Keywords
systems metabolic engineering, microbial fuel production, microbial chemical production, biofuels, platform chemicals, specialty chemicals, renewable resources, microbial cell factories
MeSH terms
Industrial Microbiology, Systems Biology, Metabolic Engineering

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