Microbial Biosynthesis of Alkanes
Abstract
Toward Alkane Synthesis: Alkanes are major components of fossil fuels, and synthesis of alkanes remains a challenge in the conversion of renewable raw materials to fuels. Even though diverse organisms synthesize alkanes, synthesis pathways have remained elusive. Now Schirmer et al. (p. 559 ) describe an alkane biosynthesis pathway in cyanobacteria that converts intermediates of fatty acid metabolism to alkanes and alkenes. Heterologous expression of the biosynthetic genes resulted in production of alkanes in Escherichia coli . This pathway is likely to be a valuable tool in the production of biofuels.
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Two-step alkane biosynthesis has been reported in cyanobacteria.
“Recently, two-step alkane biosynthesis has been reported in cyanobacteria.”
From Renewable energy from Cyanobacteria: energy production optimization by metabolic pathway engineering (2011) · cites this paper as Schirmer et al. 2010
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- Authors
- Schirmer, A., Rude, M. A., Li, X., Popova, E., & del Cardayre, S. B.
- Affiliations
- LS9, Inc., 600 Gateway Boulevard, South San Francisco, CA 94080, USA.
- Corresponding author
- Schirmer, Andreas
- ORCID
- Schirmer, Andreas
- Venue
- Science
- Published
- 2010-07-30
- Volume
- 329
- Issue
- 5991
- Pages
- 559-562
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2164098890
- Cited by
- 1,040
- References
- 27
- Citations by year
- 2026: 20 · 2025: 37 · 2024: 35 · 2023: 33 · 2022: 42 · 2021: 60 · 2020: 71 · 2019: 68 · 2018: 61 · 2017: 68 · 2016: 93 · 2015: 99 · 2014: 98 · 2013: 91 · 2012: 72
- FWCI
- 32.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Environmental Science › Pollution › Microbial bioremediation and biosurfactants
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- alkane biosynthesis, cyanobacteria, fatty acid metabolism, alkenes, heterologous expression, Escherichia coli, biofuels
- MeSH terms
- Acyl Carrier Protein, Aldehyde-Lyases, Aldehydes, Cyanobacteria, Alkanes, Alkenes, Bacterial Proteins, Escherichia coli, Fatty Acids, Fatty Alcohols, Genes, Bacterial, Operon, Oxidoreductases, Protein Conformation, Recombinant Proteins, Substrate Specificity, Synechococcus, Biosynthetic Pathways
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