Cited by 129Global Health and SurgeryHealth and Medical Research ImpactsHealth Policy Implementation Science

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Barriers to clinical research in Africa: a quantitative and qualitative survey of clinical researchers in 27 African countries

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Conradie, A., Duys, R., Forget, P., Biccard, B.M.·2018·British Journal of Anaesthesia

DOI 10.1016/j.bja.2018.06.013

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Abstract

Background There is a need for high quality research to improve perioperative patient care in Africa. The aim of this study was to understand the particular barriers to clinical research in this environment.Methods We conducted an electronic survey of African Surgical Outcomes Study (ASOS) investigators, including 29 quantitative Likert scale questions and eight qualitative questions with subsequent thematic analysis. Protocol compliant and non-compliant countries were compared according to WHO statistics for research and development, health workforce data, and world internet statistics.Results Responses were received from 134/418 of invited researchers in 24/25 (96%) of participating countries, and three non-participating countries. Barriers included lack of a dedicated research team (47.7%), reliable internet access (32.6%), staff skilled in research (31.8%), and team commitment (23.8%). Protocol compliant countries had significantly more physicians per 1000 population (4 vs 0.9, P<0.01), internet penetration (38% vs 28%, P=0.01) and published clinical trials (1461 vs 208, P<0.01) compared with non-compliant countries. Facilitators of research included establishing a research culture (86.9%), simple data collection tools (80%), and ASOS team interaction (77.9%). Most participants are interested in future research (93.8%). Qualitative data reiterated human resource, financial resource, and regulatory barriers. However, the desire to contribute to an African collaboration producing relevant data to improve patient outcomes was expressed strongly by ASOS investigators.Conclusions Barriers to successful participation in ASOS related to resource limitations and not motivation of the clinician investigators. Practical solutions to individual barriers may increase the success of multi-centre perioperative research in Africa.

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Authors: Conradie, A., Duys, R., Forget, P., & Biccard, B. M.
Affiliations: University of Cape Town (ZA)
Vrije Universiteit Brussel (BE)
Corresponding author: Conradie, A.
ORCID: Duys, R.
Forget, P.
Biccard, B.M.
Venue: British Journal of Anaesthesia
Publisher: Elsevier BV
Published: 2018-10
Volume: 121
Issue: 4
Pages: 813-821
ISSN: 0007-0912 (ISSN-L)
DOI: 10.1016/j.bja.2018.06.013
OpenAlex: W2884038031
Cited by: 129
References: 23
Citations by year: 2026: 16 · 2025: 16 · 2024: 18 · 2023: 26 · 2022: 21 · 2021: 17 · 2020: 10 · 2019: 3 · 2018: 1
FWCI: 7.38
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: British Journal of Anaesthesia (publishedVersion)
PubMed (publishedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Surgery
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
Keywords: barriers to clinical research, research capacity, research workforce, internet access, research funding, research regulation, research culture, Africa
MeSH terms: Africa, Clinical Trials as Topic, Culture, Humans, Surveys and Questionnaires, Research, Research Personnel, Outcome Assessment, Health Care, Guideline Adherence, Internet, Qualitative Research, Quality Improvement

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Barriers to clinical research in Africa: a quantitative and qualitative survey of clinical researchers in 27 African countries

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