Structure-Activity Relationship of Clovamide and its Related Compounds for the Inhibition of Amyloid β Aggregation

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431 · see citing works

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291 · see citing works

Amyloid deposition as the central event in the aetiology of Alzheimer’s disease

Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538 · see citing works

A possible role for π‐stacking in the self‐assembly of amyloid fibrils

Gazit, E. (2002) · The FASEB Journal · doi:10.1096/fj.01-0442hyp · Cited by 1,128 · see citing works

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

Hamley, I. W. (2012) · Chemical Reviews · doi:10.1021/cr3000994 · Cited by 881 · see citing works

Amyloid β-Protein Assembly and Alzheimer Disease

Roychaudhuri, R., Yang, M., Hoshi, M. M., & Teplow, D. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800036200 · Cited by 617 · see citing works

Structure–activity Relationships of Amyloid Beta‐aggregation Inhibitors Based on Curcumin: Influence of Linker Length and Flexibility

Reinke, A. A., & Gestwicki, J. E. (2007) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2007.00557.x · Cited by 330 · see citing works

[20] Kinetic analysis of amyloid fibril formation

Naiki, H., & Gejyo, F. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)09022-9 · Cited by 287 · see citing works

Covalent modification of proteins by green tea polyphenol (–)-epigallocatechin-3-gallate through autoxidation

Ishii, T., Mori, T., Tanaka, T., Mizuno, D., Yamaji, R., Kumazawa, S., Nakayama, T., & Akagawa, M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.07.023 · Cited by 242 · see citing works

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

Sato, M., Murakami, K., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K., Masuda, Y., Takegoshi, K., & Irie, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.464222 · Cited by 232 · see citing works

Antioxidative Polyphenols Isolated from Theobroma cacao

Sanbongi, C., Osakabe, N., Natsume, M., Takizawa, T., Gomi, S., & Osawa, T. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf970575o · Cited by 222 · see citing works

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.

Murakami, K., Irie, K., Morimoto, A., Ohigashi, H., Shindo, M., Nagao, M., Shimizu, T., & Shirasawa, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301874200 · Cited by 190 · see citing works

Roasting impact on the contents of clovamide (N-caffeoyl-L-DOPA) and the antioxidant activity of cocoa beans (Theobroma cacao L.)

Arlorio, M., Locatelli, M., Travaglia, F., Coïsson, J. D., Grosso, E. D., Minassi, A., Appendino, G., & Martelli, A. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.07.009 · Cited by 131 · see citing works

Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein

Miyamae, Y., Kurisu, M., Murakami, K., Han, J., Isoda, H., Irie, K., & Shigemori, H. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.08.001 · Cited by 86 · see citing works

Drugs: A tangled web of targets

Gravitz, L. (2011) · Nature · doi:10.1038/475s9a · Cited by 81 · see citing works

Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside

Kurisu, M., Miyamae, Y., Murakami, K., Han, J., Isoda, H., Irie, K., & Shigemori, H. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.130101 · Cited by 68 · see citing works

Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor

Endo, H., Nikaido, Y., Nakadate, M., Ise, S., & Konno, H. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.10.076 · Cited by 48 · see citing works

Clovamides; l -Dopa Conjugated withtrans- andcis-Caffeic Acids in Red Clover (Trifolium pratense)

Yoshihara, T., Yoshikawa, H., Sakamura, S., & Sakuma, T. (1974) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1974.10861294 · Cited by 33 · see citing works

3,4,5-tri-O-caffeoylquinic acid inhibits amyloid β-mediated cellular toxicity on SH-SY5Y cells through the upregulation of PGAM1 and G3PDH

Miyamae, Y., Han, J., Sasaki, K., Terakawa, M., Isoda, H., & Shigemori, H. (2011) · Cytotechnology · doi:10.1007/s10616-011-9341-1 · Cited by 32 · see citing works

クロバミド,赤クローバ中のtrans-およびcis-カフェイン酸と結合したL-トーパ

Yoshihara, T., Yoshikawa, H., Sakamura, S., & Sakuma, T. (1974) · Cited by 16 · see citing works

Inhibitory Activity of Hispidin Derivatives Isolated from Inonotus obliquus on Amyloid β Aggregation

Shigemori, H., Aihara, Y., Kawaguchi, A., Hanaki, M., Murakami, K., & Irie, K. (2017) · Heterocycles · doi:10.3987/com-17-13733 · Cited by 8 · see citing works

Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

Magaña, A. A., Kamimura, N., Soumyanath, A., Stevens, J. F., & Maier, C. S. (2021) · The Plant Journal · doi:10.1111/tpj.15390 · Cited by 283 · see citing works

Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms

Pagano, K., Tomaselli, S., Molinari, H., & Ragona, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.619667 · Cited by 137 · see citing works

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works

Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties

Murakami, K., & Irie, K. (2019) · Molecules · doi:10.3390/molecules24112125 · Cited by 31 · see citing works

Inhibitory activities of kukoamines A and B from Lycii Cortex on amyloid aggregation related to Alzheimer’s disease and type 2 diabetes

Jiang, G., Takase, M., Aihara, Y., & Shigemori, H. (2019) · Journal of Natural Medicines · doi:10.1007/s11418-019-01337-0 · Cited by 31 · see citing works

Quinic and caffeic acids derivatives: Affecting antioxidant capacities and phenolics contents of certain therapeutic and specialty crops employing water and ethanolic extracts

Islam, S., Adam, Z., & Akanda, J. H. (2024) · Food Chemistry Advances · doi:10.1016/j.focha.2024.100693 · Cited by 25 · see citing works

Clovamide, a Hydroxycinnamic Acid Amide, Is a Resistance Factor Against Phytophthora spp. in Theobroma cacao

Knollenberg, B. J., Li, G., Lambert, J. D., Maximova, S. N., & Guiltinan, M. J. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.617520 · Cited by 24 · see citing works

Phytochemical Analysis of Polyphenols in Leaf Extract from Vernonia amygdalina Delile Plant Growing in Uganda

Nowak, J., Kiss, A. K., Wambebe, C. O., Katuura, E., & Kuźma, Ł. (2022) · Applied Sciences · doi:10.3390/app12020912 · Cited by 20 · see citing works

Theobromacacao Criollo var. Beans: Biological Properties and Chemical Profile

Lavorgna, M., Pacifico, S., Nugnes, R., Russo, C., Orlo, E., Piccolella, S., & Isidori, M. (2021) · Foods · doi:10.3390/foods10030571 · Cited by 18 · see citing works

Effects of clovamide and its related compounds on the aggregations of amyloid polypeptides

Nomoto, D., Tsunoda, T., & Shigemori, H. (2021) · Journal of Natural Medicines · doi:10.1007/s11418-020-01467-w · Cited by 17 · see citing works

Evaluation of Amyloid Polypeptide Aggregation Inhibition and Disaggregation Activity of A-Type Procyanidins

Tanaka, T., Betkekar, V. V., Ohmori, K., Suzuki, K., & Shigemori, H. (2021) · Pharmaceuticals · doi:10.3390/ph14111118 · Cited by 16 · see citing works

LC-MS based validation and DFT investigation on the antioxidant properties of clovamide: •OH and •OOH scavenging and Cu(II) chelation mechanisms

Madala, N. E., & Kabanda, M. M. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.130349 · Cited by 12 · see citing works

Production of clovamide and its analogues inSaccharomyces cerevisiaeandLactococcus lactis

Bouchez, P., Benites, V. T., Baidoo, E. E. K., Mortimer, J. C., Sullivan, M. L., Scheller, H. V., & Eudes, A. (2019) · Letters in Applied Microbiology · doi:10.1111/lam.13190 · Cited by 11 · see citing works

Red Clover HDT, a BAHD Hydroxycinnamoyl-Coenzyme A:L-3,4-Dihydroxyphenylalanine (L-DOPA) Hydroxycinnamoyl Transferase That Synthesizes Clovamide and Other N-Hydroxycinnamoyl-Aromatic Amino Acid Amides

Sullivan, M. L., & Knollenberg, B. J. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.727461 · Cited by 11 · see citing works

Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation

Shinoda, S., Tozawa, Y., Kurimoto, S., Shigemori, H., & Sekiguchi, M. (2023) · Journal of Natural Medicines · doi:10.1007/s11418-023-01693-y · Cited by 9 · see citing works

Effects of Cooking Methods on Caffeoylquinic Acids and Radical Scavenging Activity of Sweet Potato

Kido, M., Yoshimoto, M., Sakao, K., Wada, K., & Hou, D. (2024) · Foods · doi:10.3390/foods13071101 · Cited by 8 · see citing works

Clovamide and Its Derivatives—Bioactive Components of Theobroma cacao and Other Plants in the Context of Human Health

Kołodziejczyk-Czepas, J. (2024) · Foods · doi:10.3390/foods13071118 · Cited by 7 · see citing works

Tyrosine and proline conjugated trolox, hydroxy-cinnnamic acid and diclofenac hybrids as strong hypolipidemic and anti-inflammatory agents.

Theodosis‐Nobelos, P., & Rekka, E. A. (2025) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2025.130194 · Cited by 6 · see citing works

Amyloid Polypeptide Disaggregation Activity of Passion Fruit Seed-Derived Polyphenol Compounds

Sampei, T., Wu, Y., & Shigemori, H. (2022) · Natural Product Communications · doi:10.1177/1934578x221092710 · Cited by 3 · see citing works

Synthesis and evaluation of l-dopa and L-Tyr derivatives as amyloid-beta aggregation inhibitors

Xu, F., Okada, M., Makabe, K., & Konno, H. (2023) · Phytochemistry Letters · doi:10.1016/j.phytol.2023.08.014 · Cited by 3 · see citing works

Synthesis and evaluation of catecholamine derivatives as amyloid-beta aggregation inhibitors

Xu, F., Takiguchi, Y., Makabe, K., & Konno, H. (2024) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2024.129788 · Cited by 3 · see citing works

Clovamide protects cardiac progenitor cells from H2O2-induced oxidative stress

Antonini, S., Colangelo, D., Oltolina, F., Diena, M., Arlorio, M., & Prat, M. (2018) · Journal of Applied Biotechnology & Bioengineering · doi:10.15406/jabb.2018.05.00138 · Cited by 3 · see citing works

Inhibition of Amyloid β Aggregation by p-Terphenyl Derivatives Isolated from Boletopsis leucomelas

Shigemori, H., Kobori, A., & Hosaka, K. (2022) · Heterocycles · doi:10.3987/com-22-14628 · Cited by 3 · see citing works

Effect of Meroterpenoids from Sargassum macrocarpum on the Inhibition of Amyloid Polypeptide Aggregation

Tozawa, Y., Shinoda, S., Sekiguchi, M., Miyamae, Y., & Shigemori, H. (2024) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00610 · Cited by 2 · see citing works

Pelliolatifolias A‐D, Four Undescribed Compounds from Pellionia latifolia Boerl. and Their Nitric Oxide Production Inhibitory Activity

Hà, T. T. T., Cúc, N. T., Tài, B. H., Trung, K. H., Khanh, T. D., & Kiệm, P. V. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202300731 · Cited by 1 · see citing works

Design, synthesis, and biological evaluation of clovamide analogues as anti-colitis agents modulating NF-κB/STAT3/iNOS signaling

Elnur, M. M. K., Yadav, K., Ghimire, K., Chaudhary, P., Choi, D., Kim, J.-A., & Jeong, B. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110097

Effects of clovamide and its related compounds on the aggregations of amyloid polypeptides

Nomoto, D., Tsunoda, T., & Shigemori, H. (2021) · Journal of Natural Medicines · doi:10.1007/s11418-020-01467-w · Cited by 17 · see citing works

Synthesis and evaluation of l-dopa and L-Tyr derivatives as amyloid-beta aggregation inhibitors

Xu, F., Okada, M., Makabe, K., & Konno, H. (2023) · Phytochemistry Letters · doi:10.1016/j.phytol.2023.08.014 · Cited by 3 · see citing works

Synthesis and evaluation of catecholamine derivatives as amyloid-beta aggregation inhibitors

Xu, F., Takiguchi, Y., Makabe, K., & Konno, H. (2024) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2024.129788 · Cited by 3 · see citing works

Inhibitory Activity of Hispidin Derivatives Isolated from Inonotus obliquus on Amyloid β Aggregation

Shigemori, H., Aihara, Y., Kawaguchi, A., Hanaki, M., Murakami, K., & Irie, K. (2017) · Heterocycles · doi:10.3987/com-17-13733 · Cited by 8 · see citing works

Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside

Kurisu, M., Miyamae, Y., Murakami, K., Han, J., Isoda, H., Irie, K., & Shigemori, H. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.130101 · Cited by 68 · see citing works