Inhibition of LPS-induced inflammatory response in RAW264.7 cells by natural Chlorogenic acid isomers involved with AKR1B1 inhibition

Chronic inflammation in the etiology of disease across the life span

Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915 · see citing works

Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions

Liang, N., & Kitts, D. D. (2015) · Nutrients · doi:10.3390/nu8010016 · Cited by 824 · see citing works

Macrophage polarization and diabetic wound healing

Louiselle, A. E., Niemiec, S. M., Zgheib, C., & Liechty, K. W. (2021) · Translational research · doi:10.1016/j.trsl.2021.05.006 · Cited by 737 · see citing works

The aldo-keto reductases (AKRs): Overview

Penning, T. M. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.09.024 · Cited by 547 · see citing works

Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells

Hwang, S. J., Kim, Y., Park, Y., Lee, H., & Kim, K. (2013) · Inflammation Research · doi:10.1007/s00011-013-0674-4 · Cited by 483 · see citing works

Bioactive lipids, inflammation and chronic diseases

Leuti, A., Fazio, D., Fava, M., Piccoli, A., Oddi, S., & Maccarrone, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.028 · Cited by 368 · see citing works

Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis

Rodríguez-Morales, P., & Franklin, R. A. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.10.004 · Cited by 327 · see citing works

Inflammation, not Cholesterol, Is a Cause of Chronic Disease

Τσούπρας, Α., Lordan, R., & Zabetakis, I. (2018) · Nutrients · doi:10.3390/nu10050604 · Cited by 321 · see citing works

Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-κB and JNK/AP-1 activation

Shan, J., Fu, J., Zhao, Z., Kong, X., Huang, H., Luo, L., & Yin, Z. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.04.011 · Cited by 251 · see citing works

Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

Srivastava, S. K., Yadav, U. C. S., Reddy, A. B. M., Saxena, A., Tammali, R., Shoeb, M., Ansari, N. H., Bhatnagar, A., Petrash, M. J., Srivastava, S., et al. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.02.023 · Cited by 208 · see citing works

Physiological and Pathological Roles of Aldose Reductase

Singh, M., Kapoor, A., & Bhatnagar, A. (2021) · Metabolites · doi:10.3390/metabo11100655 · Cited by 179 · see citing works

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Almqvist, H., Axelsson, H., Jafari, R., Chen, D., Mateus, A., Haraldsson, M., Larsson, A., Molina, D. M., Artursson, P., Lundbäck, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms11040 · Cited by 165 · see citing works

Analyses of chlorogenic acids and related cinnamic acid derivatives from Nicotiana tabacumtissues with the aid of UPLC-QTOF-MS/MS based on the in-source collision-induced dissociation method

Ncube, E. N., Mhlongo, M. I., Piater, L. A., Steenkamp, P. A., Dubery, I. A., & Madala, N. E. (2014) · Chemistry Central Journal · doi:10.1186/s13065-014-0066-z · Cited by 159 · see citing works

AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program

Wu, X., Li, X., Fu, Q., Cao, Q., Chen, X., Wang, M., Yu, J. Z., Long, J., Yao, J., Liu, H., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160903 · Cited by 154 · see citing works

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells

Schwab, A., Siddiqui, A., Vazakidou, M. E., Napoli, F., Böttcher, M., Menchicchi, B., Raza, U., Saatci, Ö., Krebs, A. M., Ferrazzi, F., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2834 · Cited by 124 · see citing works

Inhibitor selectivity between aldo–keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)

Zhang, L., Zhang, H., Zhao, Y., Li, Z., Chen, S., Zhai, J. H., Chen, Y., Xie, W., Wang, Z., Li, Q., et al. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.09.031 · Cited by 117 · see citing works

Chlorogenic and caffeic acids in 64 fruits consumed in Brazil

Meinhart, A. D., Damin, F. M., Caldeirão, L., Filho, M. D. J., da Silva, L. C., Constant, L. D. S., Filho, J. T., Wagner, R. C., & Godoy, H. T. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.02.004 · Cited by 109 · see citing works

Chlorogenic acid isomer contents in 100 plants commercialized in Brazil

Meinhart, A. D., Damin, F. M., Caldeirão, L., da Silveira, T. F. F., Filho, J. T., & Godoy, H. T. (2017) · Food Research International · doi:10.1016/j.foodres.2017.06.017 · Cited by 96 · see citing works

Contents of chlorogenic acids and caffeine in various coffee-related products

Jeon, J., Kim, H.-T., Jeong, I., Hong, S., Oh, M.-S., Yoon, M., Shim, J., Jeong, J. H., & El‐Aty, A. M. A. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2019.01.002 · Cited by 87 · see citing works

Phenolic Compounds and Antioxidant Activities of Potato Cultivars with White, Yellow, Red and Purple Flesh

Ru, W., Pang, Y., Gan, Y., Liu, Q., & Bao, J. (2019) · Antioxidants · doi:10.3390/antiox8100419 · Cited by 76 · see citing works

Amelioration of Oxidative Stress in Caco-2 Cells Treated with Pro-inflammatory Proteins by Chlorogenic Acid Isomers via Activation of the Nrf2–Keap1–ARE-Signaling Pathway

Liang, N., & Kitts, D. D. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03983 · Cited by 75 · see citing works

Discovery of New Selective Human Aldose Reductase Inhibitors through Virtual Screening Multiple Binding Pocket Conformations

Wang, L., Gu, Q., Zheng, X., Ye, J., Liu, Z., Li, J., Hu, X., Hagler, A. T., & Xu, J. (2013) · Journal of Chemical Information and Modeling · doi:10.1021/ci400322j · Cited by 73 · see citing works

Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo–keto reductase 1B10

Soda, M., Hu, D., Endo, S., Takemura, M., Li, J., Wada, R., Ifuku, S., Zhao, H.-T., El-Kabbani, O. A. L., Ohta, S., et al. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.12.034 · Cited by 63 · see citing works

Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus

Qi, H., Shi, Y., Wu, H., Niu, C., Sun, X., & Wang, K. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.08.002 · Cited by 60 · see citing works

Demonstrating the involvement of an active efflux mechanism in the intestinal absorption of chlorogenic acid and quinic acid using a Caco-2 bidirectional permeability assay

Mortelé, O., Jörissen, J., Spacova, I., Lebeer, S., van Nuijs, A. L. N., & Hermans, N. (2021) · Food & Function · doi:10.1039/d0fo02629h · Cited by 53 · see citing works

Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation

Curciarello, R., Canziani, K. E., Docena, G. H., & Muglia, C. I. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00647 · Cited by 48 · see citing works

Aldose reductase inhibition suppresses airway inflammation

Yadav, U. C. S., Ramana, K. V., & Srivastava, S. K. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.02.014 · Cited by 40 · see citing works

SPE-HPLC Determination of Chlorogenic and Phenolic Acids in Coffee

Yılmaz, P. K., & Kolak, U. (2017) · Journal of Chromatographic Science · doi:10.1093/chromsci/bmx025 · Cited by 38 · see citing works

Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design

Cousido-Siah, A., Ruiz, F. X., Mitschler, A., Porté, S., de Lera, Á. R., Martín, M. J., Manzanaro, S., de la Fuente, J. Á., Terwesten, F., Betz, M., et al. (2014) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s1399004713033452 · Cited by 36 · see citing works

Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity

Liang, N., & Kitts, D. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123873 · Cited by 35 · see citing works

(−)-Kusunokinin as a Potential Aldose Reductase Inhibitor: Equivalency Observed via AKR1B1 Dynamics Simulation

Tanawattanasuntorn, T., Thongpanchang, T., Rungrotmongkol, T., Hanpaibool, C., Graidist, P., & Tipmanee, V. (2020) · ACS Omega · doi:10.1021/acsomega.0c05102 · Cited by 34 · see citing works

Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells

Miláčková, I., Kapustová, K., Mučaji, P., & Hošek, J. (2017) · Phytotherapy Research · doi:10.1002/ptr.5774 · Cited by 33 · see citing works

The content of chlorogenic acids in tropical fruits

Pontes, P. V., Moreira, R. F. A., Trugo, L. C., & Maria, C. A. B. D. (2002) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.1163 · Cited by 33 · see citing works

Catalytic mechanism of the primary human prostaglandin F2α synthase, aldo‐keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H)

Nagata, N., Kusakari, Y., Fukunishi, Y., Tsuyoshi Inoue, A., & Urade, Y. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08049.x · Cited by 32 · see citing works

Pivotal role of AKR1B1 in pathogenesis of colitis associated colorectal carcinogenesis

Syamprasad, N. P., Rajdev, B., Jain, S., Panda, S. R., Puppala, E. R., Chaudhari, P., Vaidya, J. R., Gangasani, J. K., & Naidu, V. G. M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110145 · Cited by 29 · see citing works

A Mini-Review of Flavone Isomers Apigenin and Genistein in Prostate Cancer Treatment

Ji, X., Liu, K., Li, Q., Shen, Q., Han, F., Ye, Q., & Zheng, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.851589 · Cited by 28 · see citing works

Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase

Shi, W., Xu, G., Gao, Y., Zhao, J., Liu, T., Zhao, J. W., Yang, H., Wei, Z., Li, H., Xu, A., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04380-4 · Cited by 26 · see citing works

Identifying the molecular basis of Jinhong tablets against chronic superficial gastritis via chemical profile identification and symptom-guided network pharmacology analysis

Shi, D., Liu, L., Li, H., Pan, D., Yao, X., Xiao, W. L., Yao, X., & Yu, Y. (2021) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2021.01.005 · Cited by 23 · see citing works

Immune and Non-Immune Inflammatory Cells Involved in Autoimmune Fibrosis: New Discoveries

Sisto, M., & Lisi, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12113801 · Cited by 22 · see citing works

Chlorogenic acid acts upon Leishmania donovani arresting cell cycle and modulating cytokines and nitric oxide in vitro

Majumder, N., Ganguly, S., Ghosh, A. K., Kundu, S., Banerjee, A., & Saha, S. (2020) · Parasite Immunology · doi:10.1111/pim.12719 · Cited by 21 · see citing works

Epalrestat suppresses inflammatory response in lipopolysaccharide-stimulated RAW264.7 cells

Sato, K., Tatsunami, R., & Wakame, K. (2021) · Allergologia et Immunopathologia · doi:10.15586/aei.v49i5.102 · Cited by 21 · see citing works

Biorelevant physicochemical profiling of (E)- and (Z)-resveratrol determined from isomeric mixtures

Orgován, G., Gonda, I., & Noszál, B. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.09.019 · Cited by 20 · see citing works

Simultaneous separation and determination of five chlorogenic acid isomers in Honeysuckle by capillary electrophoresis using self‐synthesized ionic liquid [N‐methylimidazole‐β‐cyclodextrin] [bromide] as separation selector

Xie, W., Yu, Y., Hou, M., Zhang, Y., Yu, H., Zhang, H., Zhang, G., Jing, H., & Chen, A. (2022) · Journal of Separation Science · doi:10.1002/jssc.202200352 · Cited by 18 · see citing works

Linarin ameliorates ischemia-reperfusion injury by the inhibition of endoplasmic reticulum stress targeting AKR1B1

Zhang, Y., Gao, S., Xia, S., Yang, H., Bao, X., Zhang, Q. C., & Xu, Y. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110868 · Cited by 15 · see citing works

Attacking the devil: the thalidomide story

Coombes, R. (2016) · BMJ · doi:10.1136/bmj.i353 · Cited by 14 · see citing works

Tautomerism and bioactivities of curcumenol, a common sesquiterpenoid widely existing in edible plants

Zhang, L.-S., Shen, S.-N., Gao, Y.-L., Shi, S., Zhou, C., Mo, J., Xu, Y., Lin, L., & Gan, L. (2019) · Food & Function · doi:10.1039/c8fo02549e · Cited by 12 · see citing works

Avertin affects murine colitis by regulating neutrophils and macrophages

Wang, D., Chen, L., Fu, Y., Kang, Q., Wang, X., Ma, X., Li, X., & Sheng, J. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106153 · Cited by 11 · see citing works

Effects of Piperazine Derivative on Paclitaxel Pharmacokinetics

Lee, J., Chae, S. W., Oh, A., Yoo, J. H., Choo, H. P., Rhie, S. J., & Lee, H. J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11010023 · Cited by 9 · see citing works

Design and synthesis of novel quinazolin‐4(1H)‐one derivatives as potent and selective inhibitors targeting AKR1B1

Han, Z., Li, J., Xu, Z., Su, Y. C., Wang, Y., Zhuo, L., Du, J., Zhu, C., & Hao, X. (2023) · Archiv der Pharmazie · doi:10.1002/ardp.202200577 · Cited by 8 · see citing works

Artichoke leaf extract, as AKR1B1 inhibitor, decreases sorbitol level in the rat eye lenses under high glucose conditionsex vivo

Šušaníková, I., Balleková, J., Štefek, M., Hošek, J., & Mučaji, P. (2018) · Phytotherapy Research · doi:10.1002/ptr.6174 · Cited by 8 · see citing works

Decoding selectivity: computational insights into AKR1B1 and AKR1B10 inhibition

Liu, M., Qin, X., Li, J., Jiang, Y., Jiang, J., Guo, J., Xu, H., Wang, Y., Bi, H., & Wang, Z. (2024) · Physical Chemistry Chemical Physics · doi:10.1039/d3cp05985e · Cited by 7 · see citing works

Blocking SIRPα could restore macrophage appetite and mitigate pneumonia

Bordon, Y. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0339-9 · Cited by 4 · see citing works

Expression of Aldo-keto-reductase 1B1 (AKR1B1) in tubulocytic carcinoma of kidney.

Hashimoto, Y., Tanaka, T. D., Imai, A., Hatakeyama, S., Yoneyama, T., Koie, T., & Οhyama, C. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.2_suppl.507 · Cited by 2 · see citing works

N-substituted phthalimide–carboxylic acid hybrids as dual-targeted aldose reductase inhibitors: Synthesis, mechanistic insights, and cancer-relevant profiling

Zognjani, B., Nixha, A. R., Duran, H. E., Arslan, M., Yıldıztekin, G., Ece, A., & Türkeş, C. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108788 · Cited by 76 · see citing works

Recent Advances in Biosynthesis and Bioactivity of Plant Caffeoylquinic Acids

Chen, H., Pan, B., Zhang, S., Li, X., Zhang, Y., Gao, K., Chen, D., Wang, L., Jiang, T., Luo, C. S., et al. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47110942 · Cited by 21 · see citing works

Food–medicine homology nanostructures: self-assembly, sustained release, and extended anti-inflammatory effects of Eucommia ulmoides nanoparticles

Yu, Z., Lu, T., Luo, S., Meng, X., He, F., Peng, Z., Yu, J., Gu, Y., Dong, X., Zhang, P., et al. (2026) · npj Science of Food · doi:10.1038/s41538-026-00726-6 · Cited by 7 · see citing works

Preparation, characterization, and protective effects of Gardenia fructus carbon dots against oxidative damage induced by LPS in IPEC-J2 cells

Chen, B.-L., Zang, X., Mo, J.-R., Zhang, R., Wang, H., Wang, Q.-X., & Li, J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1423760 · Cited by 6 · see citing works

Immunomodulatory activity of single chitooligosaccharides in LPS-induced RAW264.7 cells and endotoxemia mice

Zhu, S., Li, A., Yang, H., Li, Y., Wang, W., Li, J., Li, K., Xing, R., Li, P., & Li, K. (2025) · Carbohydrate Research · doi:10.1016/j.carres.2025.109523 · Cited by 6 · see citing works

Main characteristic metabolites with xanthine oxidase inhibitory activities from Yunnan Coffea arabica husks

Wang, H., Wan, L., Wang, Y., Li, Y., Zhao, W., & Liang, W. (2026) · Food Chemistry X · doi:10.1016/j.fochx.2026.103637 · Cited by 3 · see citing works

Molecular insights into α-Lactalbumin–Chlorogenic acid interaction: Peptide design and anti-inflammatory mechanisms

Zheng, S., Han, C., Zhang, T., Zeng, X., Bao, W., Pan, D., Tu, M., & Wu, Z. F. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117365 · Cited by 2 · see citing works

Uncovering key anti-inflammatory constituents and mechanism of Wuwei Xiaodu Decoction by a combined strategy of phytochemistry, AIDD, network pharmacology, and in vitro and in vivo assay

Li, B., Zhou, Z., Zhang, Y., Zhu, J. P., Liu, Q., Ma, J., Gong, Z., Xu, Z., Shen, J., Zhu, W., et al. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-05072-w · Cited by 2 · see citing works

Rosmarinic Acid Targets AKR1B1 to Ameliorate Atherosclerosis via Vascular Endothelial Cell Energy Metabolism Regulation

Sun, T., Luo, Q., Liu, T., Lv, X., Lin, L., Liao, D., Tuo, Q., & Chen, W. (2026) · Biomolecules · doi:10.3390/biom16030403 · Cited by 2 · see citing works

Phenolic compounds from spontaneously fermented coffee beans alleviate cellular stress and modulate inflammatory signaling in lipopolysaccharide-treated RAW264.7 macrophages

Wu, H., Caldow, M. K., Chan, A. S. M., Liu, Z., Lynch, G. S., & Suleria, H. A. R. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108601 · Cited by 1 · see citing works

Anti-cytokine storm activity of fraxin and quercetin, alone and in combination, and their possible molecular mechanisms via TLR4 and PPAR-γ signaling pathways in lipopolysaccharide-induced RAW 264.7 cell line

Shaker, N. S., Sahib, H. B., Hussein, Z. A., & Tahseen, N. J. (2023) · F1000Research · doi:10.12688/f1000research.133145.1

Preventive Effect of Upland Pigmented Potatoes Against LPS‐Induced Inflammation in THP‐1 Macrophages

Toccaceli, M., Marinelli, A., Ballabio, F., Bassolino, L., Scalzo, R. L., Parisi, B., Pacifico, D., Nicoletti, F., Camilloni, C., Mandolino, G., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70073

Anti-inflammatory potential of Aronia melanocarpa leaf phenolic extract via NF-κB pathway suppression in LPS-stimulated RAW264.7 macrophages

Owczarek, K., Caban, M., Niewinna, K., Sosnowska, D., Kajszczak, D., & Lewandowska, U. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11666-5

Anti-inflammatory activity and antioxidant capacity of Clerodendrum japonicum (Thunb.) sweet extract in LPS-stimulated macrophages

Noh, J., Park, K.-H., Pitisopa, F., Sirikolo, M. Q., Kim, J. J., Suh, S., & Seo, J. B. (2026) · Genes & Genomics · doi:10.1007/s13258-026-01769-5

Stevia extract alleviated spleen inflammatory injury in LPS-stressed mice by inhibiting the TLR4/MYD88/NF-κB signaling pathway

Wu, Q., Jing, J., Chen, X., Yin, S., Jia, G., Chen, X., Feng, B., Che, L., & Zhao, H. Y. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110873

Metabolically guided reconstruction of a urolithin mixture from dietary ellagic acid alleviates experimental colitis

Xie, Z., Dai, X., You, J., Yao, Z., Xiao, M., Huang, S., Liu, Q. H., & Ruan, Z. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109245

Chemical Composition and Anti‐Inflammatory Activity of Selaginella tamariscina

Kuai, H., Wu, X., Feng, Y., Lai, J., Xu, W., Wang, R., & Wang, H. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.71422

Aldose Reductase Inhibitor, Epalrestat, Suppresses Colorectal Cancer Cell Proliferation Through Complement-Dependent Cytotoxicity

Peng, D., Yi, Z., Chen, Y., Xu, Y., Zhang, N., Zheng, L., & He, Z. (2026) · International Journal of Toxicology · doi:10.1177/10915818261465349

An LPS-Immobilized Affinity Screening Platform Identifies Lipopolysaccharide Binding Phytochemicals from Taraxacum mongolicum

Zhang, D., Li, R., Wang, R., Tang, Y., Luosang, L., Zhao, X., Li, Q., Zhao, X., & Liang, Y. (2026) · Biology · doi:10.3390/biology15151264

Carboxyl Amidation of Chlorogenic Acid Improves Anti-Inflammatory Activity and Biosafety via Potent AKR1B1 Inhibition in LPS-Induced Macrophages

Yang, F., Guang, C., Chen, H., & Hou, H. (2026) · Molecules · doi:10.3390/molecules31183247

Modulation of Osteogenesis by Conditioned Media of Differently Activated Macrophages: A Comparative In Vitro Study

Najman, S. J., Živković, J., & Stojanović, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209185

Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-κB and JNK/AP-1 activation

Shan, J., Fu, J., Zhao, Z., Kong, X., Huang, H., Luo, L., & Yin, Z. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.04.011 · Cited by 251 · see citing works

Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity

Liang, N., & Kitts, D. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123873 · Cited by 35 · see citing works

Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells

Hwang, S. J., Kim, Y., Park, Y., Lee, H., & Kim, K. (2013) · Inflammation Research · doi:10.1007/s00011-013-0674-4 · Cited by 483 · see citing works

Chlorogenic Acid Alleviates LPS-Induced Inflammation and Oxidative Stress by Modulating CD36/AMPK/PGC-1α in RAW264.7 Macrophages

Gu, T., Zhang, Z., Liu, J., Chen, L., Tian, Y., Xu, W., Zeng, T., Wu, W., & Lu, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713516 · Cited by 82 · see citing works

Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages

Zhao, X., Yu, L., Zhang, S.-D., Kou, P., Ni, H.-Y., Qin, X., Zhao, C.-J., Wang, W., Efferth, T., & Fu, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106436 · Cited by 95 · see citing works