Demonstrating the involvement of an active efflux mechanism in the intestinal absorption of chlorogenic acid and quinic acid using a Caco-2 bidirectional permeability assay
Abstract
The intestinal absorption of chlorogenic acid and quinic acid was investigated using an in vitro bidirectional Caco-2 permeability assay and LC-MS/MS.
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Cites
Chlorogenic Acids from Green Coffee Extract Are Highly Bioavailable in Humans
Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S. (2008) · The Journal of Nutrition · doi:10.3945/jn.108.095554 · Cited by 578 · see citing works
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Yuan, Q., Liu, C., Zhang, Z., Chen, F., Xiao, Q., Zhang, L., Pan, X., He, F., & Xiao, M. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1613048 · Cited by 27 · see citing works
Han, X., Wu, X., Liu, F., Chen, H., & Hou, H. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117942 · Cited by 21 · see citing works
- Authors
- Mortelé, O., Jörissen, J., Spacova, I., Lebeer, S., van Nuijs, A. L. N., & Hermans, N.
- Affiliations
- University of Antwerp (BE)
- Toxicological Centre
- Corresponding author
- Mortelé, Olivier
- Hermans, Nina
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 12
- Issue
- 1
- Pages
- 417-425
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W3112673736
- Cited by
- 53
- References
- 1
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 7 · 2023: 8 · 2022: 11 · 2021: 2
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- chlorogenic acid, quinic acid, intestinal absorption, Caco-2 cells, bioavailability, coffee polyphenols, dietary supplements, pharmacokinetics
- MeSH terms
- Chlorogenic Acid, Humans, Intestinal Absorption, Quinic Acid, Caco-2 Cells, In Vitro Techniques
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