Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity
Abstract
The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain).
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Aerucyclamide is used in pharmaceutical products as an anti-plasmodial agent isolated from the blooming of M. aeruginosa.
“Aerucyclamide is used in pharmaceutical products as an anti-plasmodial agent isolated from the blooming of M. aeruginosa [238].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [238]
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Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works
- Authors
- Peña, S., Scarone, L., Manta, E., Stewart, L., Yardley, V., Croft, S., & Serra, G.
- Affiliations
- Universidad de la República de Uruguay (UY)
- London School of Hygiene & Tropical Medicine (GB)
- Corresponding author
- Serra, Gloria
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 22
- Issue
- 15
- Pages
- 4994-4997
- ISSN
- 0960-894X (ISSN-L)
- OpenAlex
- W2074415713
- Cited by
- 31
- References
- 31
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic & Medicinal Chemistry Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agencia Nacional de Investigación e Innovación
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Keywords
- Microcystis aeruginosa, antimalarial activity, antiplasmodial activity, chloroquine resistance, heterocyclic building blocks, cyanobacterial metabolites
- MeSH terms
- Antimalarials, Drug Resistance, Microbial, Oxazoles, Peptides, Cyclic, Plasmodium falciparum, Thiazoles, Microcystis
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