Cited by 31Chemical Synthesis and AnalysisOrganic Chemistry Synthesis MethodsMicrobial Natural Products and Biosynthesis

Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity

Peña, Stella, Scarone, Laura, Manta, Eduardo, Stewart, Lindsay, Yardley, Vanessa, Croft, Simon, Serra, Gloria·2012·Bioorganic & Medicinal Chemistry Letters

Abstract

The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain).

Integrity signals

Registry

Crossref · 10.1016/j.bmcl.2012.06.028

Cites

31 of 31 references verified0 citation errors · 0 not checkable

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Authors
Peña, S., Scarone, L., Manta, E., Stewart, L., Yardley, V., Croft, S., & Serra, G.
Affiliations
  • Universidad de la República de Uruguay (UY)
  • London School of Hygiene & Tropical Medicine (GB)
Corresponding author
Serra, Gloria
Venue
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier BV
Published
2012-08
Volume
22
Issue
15
Pages
4994-4997
ISSN
0960-894X (ISSN-L)
OpenAlex
W2074415713
Cited by
31
References
31
Citations by year
2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 2
FWCI
1.41
Type
journal article
Language
en
Open access
closed
Locations
  • Bioorganic & Medicinal Chemistry Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
Agencia Nacional de Investigación e Innovación
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
  • Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Keywords
Microcystis aeruginosa, antimalarial activity, antiplasmodial activity, chloroquine resistance, heterocyclic building blocks, cyanobacterial metabolites
MeSH terms
Antimalarials, Drug Resistance, Microbial, Oxazoles, Peptides, Cyclic, Plasmodium falciparum, Thiazoles, Microcystis

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