The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Effects of aging on articular cartilage homeostasis
Open accessAbstract
This review is focused on aging-related changes in cells and extracellular matrix of the articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage, proteolysis, advanced glycation and calcification. The cellular changes include reduced cell density, cellular senescence with abnormal secretory profiles, and impaired cellular defense mechanisms and anabolic responses. The extracellular and cellular changes compound each other, leading to biomechanical dysfunction and tissue destruction. The consequences of aging-related changes for joint homeostasis and risk for osteoarthritis are discussed.
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Cites
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ARTHRITIS AND ALLIED CONDITIONS
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Cited by
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The role of metabolism in the pathogenesis of osteoarthritis
Mobasheri, A., Rayman, M. P., Gualillo, O., Sellam, J., van der Kraan, P., & Fearon, U. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.50 · Cited by 742
Aging and osteoarthritis: Central role of the extracellular matrix
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Metadata
- Authors
- Lotz, M., & Loeser, R. F.
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 51
- Issue
- 2
- Pages
- 241-248
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- OpenAlex
- W2000982813
- Cited by
- 398
- References
- 121
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
