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Impact of endometriosis on women’s health: comparative historical data show that the earlier the onset, the more severe the disease
Abstract
Looking at endometriosis from the bigger picture -- as a systemic endocrine, immunological, and gastrointestinal disease -- opens the door to broader treatments. The bigger-picture understanding of the disease also makes clear a variety of patterns of presenting symptoms, again clarifying the diagnosis. Data from over 7000 confirmed cases clearly show that delay in diagnosis (the average time to diagnosis is >9 years) is a major problem and that current treatments are far from satisfactory. In conclusion, the impact of endometriosis, a disease that already produces intense symptoms, is worsened by a current lack of understanding of the disease beyond its pelvic definition.
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“Owing to an increase in incidence of early menarche in young girls displaying endometriosis-related symptoms at an earlier age (12), the need to identify this cohort by means of a reliable diagnostic marker is imperative.”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [12]
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Mechsner, S. (2024) · Die Gynäkologie · doi:10.1007/s00129-023-05194-7
Greene, A. K. (2023) · Sustainable development goals series · doi:10.1007/978-3-031-49807-7_5
Evaluation of dietary behaviours and physical activity of Polish women with endometriosis
Adamus, A., & Oszajca, K. (2024) · Medycyna Ogólna i Nauki o Zdrowiu · doi:10.26444/monz/189910
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Ojiambo, J. (2025) · Springer eBooks · doi:10.1007/978-3-031-95508-2_3
Global variability in the clinical presentation of endometriosis: A scoping review
Kathrada, F., Eyk, A. D. V., & Chauke, L. (2025) · Women & Health · doi:10.1080/03630242.2026.2628763 · Cited by 1
Metadata
- Authors
- Ballweg, M. L.
- Corresponding author
- Ballweg, Mary Lou
- Venue
- Best Practice & Research Clinical Obstetrics & Gynaecology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 18
- Issue
- 2
- Pages
- 201-218
- ISSN
- 1521-6934 (ISSN-L)
- OpenAlex
- W2087989193
- Cited by
- 210
- References
- 12
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 10 · 2023: 16 · 2022: 15 · 2021: 15 · 2020: 11 · 2019: 13 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 14 · 2013: 10 · 2012: 6
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, age of onset, disease severity, delayed diagnosis, time to diagnosis, immunological aspects, gastrointestinal symptoms, symptom profiles, diagnosis, treatment
- MeSH terms
- Adolescent, Adult, Diagnostic Errors, Endometriosis, Female, Humans, Hypersensitivity, Middle Aged, Quality of Life, Treatment Outcome, Age of Onset
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