The DOI matches its Crossref record; 113 of the 114 references it cites were found in a registry or an index.
Surgical management of endometriosis
Abstract
The efficacy of medical and surgical treatment of endometriosis-associated infertility and pelvic pain is a source of ongoing controversy. Complete resolution of endometriosis is not yet possible and current therapy has three main objectives: (1) to reduce pain; (2) to increase the possibility of pregnancy; and (3) to delay recurrence for as long as possible. It is possible that a consensus will never be reached on the optimal treatment of minimal and mild endometriosis. In case of moderate and severe endometriosis-associated infertility, the combined approach (operative laparoscopy with a gonadotropin-releasing hormone (GnRH) agonist) should be considered as 'first-line' treatment. The mean pregnancy rate of 50% reported in the literature following surgery provides scientific proof that operative treatment should first be undertaken to give our patients the best chance of conceiving naturally. In case of rectovaginal adenomyotic nodules, surgery must be considered as first-line therapy, medical therapy being relatively in-efficacious.
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In the citing paper
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [97]
In the citing paper
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [97]
In the citing paper
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [97]
In the citing paper
“The mechanism is different from that of the GnRH agonist which, after a first phase of stimulation, desensitizes GnRH receptors, leading to full suppression of LH and FSH production and subsequently to complete suppression of E2 to levels similar to those observed after bilateral oophorectomy [95,96,97,98].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [97]
In the citing paper
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [97]
In the citing paper
“GnRH agonists are effective at treating endometriosis symptoms, but they have numerous limitations, including a delayed therapeutic impact because of the flare-up effect, excessive suppression of E2 to less than 20 pg/mL (with related unfavorable side effects), inability to titrate E2 levels, and unpredictable reversibility of treatment when injectable depot forms of GnRH agonists are used [95,96,”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [97]
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Research works printed but not linked: 4
- Donnez, 1995, L'endométriose péritonéale, le kyste endométriotique ovarien et le nodule de la lame rectovaginale sont trois pathologies différentes (éditorial), Références en Gynécologie Obstétrique, 3, 121
- Motta, 1992, Changes in the surface morphology of ovarian germinal epithelium during the reproductive life and in some pathological conditions, Submicroscopy Cytology, 99, 664
- Donnez, 1995, Rectovaginal septum endometriosis or adenomyosis: laparoscopic management in a series of 231 patients, Human Reproduction, 10, 630, 10.1093/oxfordjournals.humrep.a136001 · DOI · Paper page
- Donnez, 1997, Rectovaginal septum adenomyotic nodules: a series of 500 cases, British Journal of Obstetrics and Gynaecology, 104, 1014, 10.1111/j.1471-0528.1997.tb12059.x · DOI
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Metadata
- Authors
- Donnez, J., Pirard, C., Smets, M., Jadoul, P., & Squifflet, J.
- Affiliations
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Donnez, Jacques
- Venue
- Best Practice & Research Clinical Obstetrics & Gynaecology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 18
- Issue
- 2
- Pages
- 329-348
- ISSN
- 1521-6934 (ISSN-L)
- OpenAlex
- W2106304510
- Cited by
- 134
- References
- 114
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 11 · 2014: 3 · 2013: 7 · 2012: 9
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, surgical management, endometriosis-associated infertility, pelvic pain, laparoscopic surgery, GnRH agonist, pregnancy rate, recurrence
- MeSH terms
- Endometriosis, Female, Humans, Infertility, Female, Ovarian Diseases, Peritoneal Diseases, Laparoscopy, Retroperitoneal Space, Evidence-Based Medicine
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