The efficacy of medical and surgical treatment of endometriosis-associated infertility: arguments in favour of a medico-surgical aproach
Abstract
This review discusses the efficacy of a combined, medical (GnRH agonist) and surgical, therapy in endometriosis-associated infertility. Because of the limited information currently available on the activity of lesions in minimal and mild endometriosis, any absolute statement is inappropriate at this time, although some arguments exist in favour of treating endometriosis at laparoscopy. In moderate and severe endometriosis, this review provides arguments in favour of a medico-surgical approach and discusses the possibility of combining medical and surgical therapy.
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Hormonal treatment impedes conception, excluding this approach in women wishing to conceive.
“However, hormonal treatment also impedes conception, excluding this approach in women wishing to conceive [1,4].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [1]
Endometriosis is a common chronic inflammatory disease causing pain and infertility.
“endometriosis, a common chronic inflammatory disease causing pain and infertility [1,2,3]”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [1]
Post-operative recurrence of endometriosis is common because persistent foci not detected at surgery may progress under the influence of circulating estrogens.
“post-operative recurrence is common, because persistent foci not detected at the time of surgery may progress under the influence of circulating estrogens [1,2,3,5,6].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [1]
Cites
Nisolle, M., & Donnez, J. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00191-x · Cited by 1,279 · see citing works
Laparoscopic Surgery in Infertile Women with Minimal or Mild Endometriosis
Marcoux, S., Maheux, R., & Bérubé, S. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707243370401 · Cited by 948 · see citing works
Donnez, J., Nisolle, M., Gillet, N., Smets, M., Bassil, S., & Casanas-Roux, F. (1996) · Human Reproduction · doi:10.1093/humrep/11.3.641 · Cited by 360 · cited 1× · see citing works
“In a third study (Donnez et al., 1996), 814 women who presented with ovarian endometriomas received combined treatment with GnRH agonist and laparoscopic surgery.”
BackgroundSelf-citationRelationship between endometriotic foci and nerves in rectovaginal endometriotic nodules
Anaf, V. (2000) · Human Reproduction · doi:10.1093/humrep/15.8.1744 · Cited by 333 · see citing works
Optimal use of infertility diagnostic tests and treatments
The ESHRE Capri Workshop Group (2000) · Human Reproduction · doi:10.1093/humrep/15.3.723 · Cited by 279 · see citing works
A quantitative overview of controlled trials in endometriosis-associated infertility
Hughes, E. G., Fedorkow, D. M., & Collins, J. A. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55911-1 · Cited by 259 · see citing works
Gonadotropin-releasing hormone analogues for the treatment of endometriosis: long-term follow-up
Waller, K. G., & Shaw, R. W. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55791-4 · Cited by 249 · see citing works
Adamson, G. D., & Pasta, D. J. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(94)90392-1 · Cited by 212 · see citing works
Recto vaginal septum adenomyotic nodules: a series of 500 cases
Donnez, J., Nisolle, M., Gillerot, S., Smets, M., Bassil, S., & Casanas‐Roux, F. (1997) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb12059.x · Cited by 150 · see citing works
Self-citationNisolle, M., Casanas-Roux, F., & Donnez, J. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00341-5 · Cited by 148 · see citing works
Self-citationOvarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage
Donnez, J., Nisolle, M., Gillerot, S., Anaf, V., Clerckxbraun, F., & Casanas‐Roux, F. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56816-2 · Cited by 145 · see citing works
Self-citationUse of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis
Hornstein, M. D., Hemmings, R., Yuzpe, A. A., & Heinrichs, W. L. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00360-9 · Cited by 145 · see citing works
Recurrent endometriosis: Incidence, management, and prognosis
Wheeler, J. M., & Malinak, L. R. (1983) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(83)90744-5 · Cited by 130 · see citing works
Telimaa, S., & Kauppila, A. (1987) · Gynecological Endocrinology · doi:10.3109/09513598709082709 · Cited by 127 · see citing works
Pagidas, K., Falcone, T., Hemmings, R., & Miron, P. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58215-6 · Cited by 121 · see citing works
Histologic study of ovarian endometriosis after hormonal therapy
Nisolle-Pochet, M., Casanas-Roux, F., & Donnez, J. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59766-0 · Cited by 111 · see citing works
Self-citationDepot leuprolide versus danazol in treatment of women with symptomatic endometriosis
Wheeler, J. M., Knittle, J. D., & Miller, J. D. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)91718-9 · Cited by 106 · see citing works
CO2 laser laparoscopy in infertile women with endometriosis and women with adnexal adhesions
Donnez, J. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59404-7 · Cited by 86 · see citing works
Self-citationLaser laparoscopic surgery in the treatment of ovarian endometriomas
Sutton, C. J. G., Ewen, S. P., Jacobs, S. A., & Whitelaw, N. L. (1997) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(05)80222-1 · Cited by 86 · see citing works
Rana, N., Thomas, S. M., Rotman, C., & Dmowski, W. P. (1996) · PubMed · Cited by 65 · see citing works
Audebert, A. J. M., Descamps, P., Marret, H., Ory‐Lavollée, L., Bailleul, F., & Hamamah, S. (1998) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(98)00028-1 · Cited by 59 · see citing works
Administration of nasal Buserelin as compared with subcutaneous Buserelin implant for endometriosis
Donnez, J., Nisolle-Pochet, M., Casanas‐Roux, F., Sandow, J., & Clerckxbraun, F. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60783-5 · Cited by 57 · see citing works
Self-citationCombined (hormonal and microsurgical) therapy in infertile women with endometriosis
Donnez, J., Lemaire-Rubbers, M., Karaman, Y., Nisolle-Pochet, M., & Casanas-Roux, F. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59349-2 · Cited by 54 · see citing works
Self-citationFollow-up of laparoscopic treatment of stage III–IV endometriosis
Busacca, M., Bianchi, S., Agnoli, B., Candiani, M., Calia, C., Marinis, S. D., & Vignali, M. (1999) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(99)80041-3 · Cited by 46 · see citing works
A cost-effective approach to the management of endometriosis
Winkel, C. A. (2000) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-200008000-00009 · Cited by 37 · see citing works
Laparoscopic treatment of symptomatic endometriosis
Pouly, J.-L., Drolet, J., Canis, M. J., Boughazine, S., Mage, G., Bruhat, M. A., & Wattiez, A. (1996) · Human Reproduction · doi:10.1093/humrep/11.suppl_3.67 · Cited by 27 · see citing works
Chang, F.-H., Chou, H., Soong, Y., Chang, M.-Y., Lee, C., & Lai, Y.-M. (1997) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(97)80013-8 · Cited by 26 · see citing works
Donnez, J., Nisolle-Pochet, M., & Casanas‐Roux, F. (1991) · PubMed · Cited by 24 · see citing works
Self-citationUPDATE ON THE MEDICAL TREATMENT OF ENDOMETRIOSIS
Minjarez, D. A., & Schlaff, W. D. (2000) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70161-3 · Cited by 23 · see citing works
Soong, Y., Chang, F.-H., Chou, H., Chang, M.-Y., Lee, C., Lai, Y.-M., & Chang, S. (1997) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(97)80014-x · Cited by 16 · see citing works
Endometriosis. The case for early, aggressive treatment.
Johnson, K. M. (1998) · PubMed · Cited by 9 · see citing works
[What is the value of combined surgical-hormonal therapy of endometriosis management?].
Schindler, A. E., Bühler, K. F., Lübben, G., et al. (1998) · PubMed · Cited by 5 · see citing works
(1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91435-8 · Cited by 2 · see citing works
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Potential involvement of iron in the pathogenesis of peritoneal endometriosis
Defrere, S., Lousse, J. C., Gonzalez-Ramos, R., Colette, S., Donnez, J., & Van Langendonckt, A. (2008) · Molecular Human Reproduction · doi:10.1093/molehr/gan033 · Cited by 204 · see citing works
Self-citationInvolvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis
González-Ramos, R., Van Langendonckt, A., Defrère, S., Lousse, J.-C., Colette, S., Devoto, L., & Donnez, J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.01.013 · Cited by 179 · see citing works
Self-citationDonnez, J., & Dolmans, M.-M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051085 · Cited by 182 · see citing works
Self-citationPeritoneal endometriosis is an inflammatory disease
Donnez, J. (2012) · Frontiers in Bioscience · doi:10.2741/e358 · Cited by 127 · see citing works
Self-citationDonnez, J., Taylor, H. S., Taylor, R. N., Akin, M. D., Tatarchuk, T. F., Wilk, K., Gotteland, J.-P., Lecomte, V., & Bestel, E. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.02.114 · Cited by 124 · see citing works
Self-citationLessey, B. A., Gordts, S., Donnez, O., Somigliana, E., Chapron, C., Garcia-Velasco, J. A., & Donnez, J. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.10.003 · Cited by 48 · see citing works
Self-citationEndometriosis and Fertility Preservation
BARNETT, R., BANKS, N., & DECHERNEY, A. H. (2017) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000311 · Cited by 31 · see citing works
Lousse, J.-C., Defrère, S., Ramos, R. G., Van Langendonckt, A., Colette, S., & Donnez, J. (2009) · Journal of Endometriosis · doi:10.1177/228402650900100104 · Cited by 10 · see citing works
Self-citation
- Authors
- Donnez, J.
- Affiliations
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Donnez, J.
- ORCID
- Donnez, J.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-01-01
- Volume
- 8
- Issue
- 1
- Pages
- 89-94
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2168993609
- Cited by
- 65
- References
- 33
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 6 · 2012: 3
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- ORBi (University of Liège) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis-associated infertility, GnRH agonist therapy, laparoscopic surgery, combined medical and surgical treatment, treatment efficacy
- MeSH terms
- Endometriosis, Female, Humans, Infertility, Female, Gonadotropin-Releasing Hormone, Palliative Care, Severity of Illness Index, Gynecologic Surgical Procedures, Evidence-Based Medicine
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