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Cited by 40Psychosomatic Disorders and Their TreatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology Studies

The Neural Bases of Interoceptive Encoding and Recall in Healthy Adults and Adults With Depression

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DeVille, Danielle C., Kerr, Kara L., Avery, Jason A., Burrows, Kaiping, Bodurka, Jerzy, Feinstein, Justin S., Khalsa, Sahib S., Paulus, Martin P. +1 more·2018·Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
DOI 10.1016/j.bpsc.2018.03.010PMC PMC6415753
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Abstract

Background Theoretical models assert that the brain's interoceptive network links external stimuli with their interoceptive consequences, thereby supporting later recall of these associations to guide the selection of healthy behaviors. If these accounts are correct, previously reported interoceptive abnormalities in major depressive disorder (MDD) should lead to altered recall of associations between external stimuli and their interoceptive (somatic) consequences. To date, the processes underlying interoceptive recall have never been experimentally investigated. Methods We designed and implemented the Interoceptive Encoding and Recall task to compare interoceptive and exteroceptive recall among subjects with MDD (n = 24) and healthy comparison subjects (n = 21). During the encoding phase, subjects learned to pair neutral visual cues (geometric shapes) with aversive interoceptive and exteroceptive stimuli. Later, while undergoing functional magnetic resonance imaging, subjects were prompted to recall the stimulus associated with each shape. Results Interoceptive recall, relative to exteroceptive recall, was associated with bilateral mid-to-posterior insula activation. Relative to the healthy control participants, participants with depression exhibited marked hypoactivation of the right dorsal mid-insula during interoceptive recall. Conclusions In healthy control subjects, simply recalling a stimulus associated with a previous interoceptive challenge activated a key region in the brain's interoceptive network. Although previous research has linked MDD with aberrant processing of interoceptive stimuli, the current study is the first to demonstrate that individuals with MDD exhibit decreased insula activity while recalling interoceptive memories. It is possible that insula hypoactivation during interoceptive recall may affect the representation of prior interoceptive experiences in ways that contribute to depressive symptomology and the relationship between depression and systemic health.

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  • Repetitive events are an important element for learning, and while there are numerous classic studies on visceral learning at the peripheral organ system level, little is known about the central mapping of learned visceral memories, especially in psychiatric disorders.

    “Repetitive events are another important element for learning, and while there are numerous classic studies on visceral learning at the peripheral organ system level (55,56), we know little about the central mapping of learned visceral memories, especially in psychiatric disorders (57).”

    From Interoception and Mental Health: A Roadmap. (2018) · cites this paper as [57]

  • DeVille et al. found decreased activity in the right dorsal mid-insula in major depressive disorder compared with controls.

    “DeVille et al. found decreased activity in the right dorsal mid-insula in MDD compared to controls [43].”

    From Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis (2026) · cites this paper as [43]

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Authors
DeVille, D. C., Kerr, K. L., Avery, J. A., Burrows, K., Bodurka, J., Feinstein, J. S., Khalsa, S. S., Paulus, M. P., & Simmons, W. K.
Affiliations
  • Laureate Institute for Brain Research (US)
  • National Institutes of Health (US)
Corresponding author
Simmons, W. Kyle
ORCID
Venue
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Publisher
Elsevier BV
Published
2018-06
Volume
3
Issue
6
Pages
546-554
ISSN
2451-9022 (ISSN-L)
DOI
10.1016/j.bpsc.2018.03.010
PMC
PMC6415753
OpenAlex
W2795187760
Cited by
40
References
7
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 1
FWCI
3.74
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry Cognitive Neuroscience and Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Institute of Mental Health (K01MH096175)
  • National Institute of General Medical Sciences (P20GM121312)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
interoception, major depressive disorder, insula, aversive stimuli
MeSH terms
Adolescent, Adult, Attention, Awareness, Brain Mapping, Cerebral Cortex, Depression, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mental Recall, Young Adult, Interoception

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