Reconsidering anhedonia in depression: Lessons from translational neuroscience

Treadway, Michael T.; Zald, David H.

doi:10.1016/j.neubiorev.2010.06.006

Cited by 1,579Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionNeural and Behavioral Psychology Studies

Reconsidering anhedonia in depression: Lessons from translational neuroscience

Open access

Treadway, Michael T., Zald, David H.·2011·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2010.06.006PMC PMC3005986

Open this paper in CoChat — free account

Abstract

Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological mechanisms of which remain poorly understood. Despite decades of speculation regarding the role of dopamine (DA) in anhedonic symptoms, empirical evidence has remained elusive, with frequent reports of contradictory findings. In the present review, we argue that this has resulted from an underspecified definition of anhedonia, which has failed to dissociate between consummatory and motivational aspects of reward behavior. Given substantial preclinical evidence that DA is involved primarily in motivational aspects of reward, we suggest that a refined definition of anhedonia that distinguishes between deficits in pleasure and motivation is essential for the purposes of identifying its neurobiological substrates. Moreover, bridging the gap between preclinical and clinical models of anhedonia may require moving away from the conceptualization of anhedonia as a steady-state, mood-like phenomena. Consequently, we introduce the term "decisional anhedonia" to address the influence of anhedonia on reward decision-making. These proposed modifications to the theoretical definition of anhedonia have implications for research, assessment and treatment of MDD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2010.06.006

Cites

357 of 357 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Anhedonia and impaired reward circuit pathways are associated with a poorer prognosis and suboptimal treatment response.
“Anhedonia and impaired reward circuit pathways are associated with a poorer prognosis and suboptimal treatment response (Buckner et al., 2008;Uher et al., 2012;Treadway and Zald, 2011).”
From Effectiveness of Vortioxetine on Emotional Blunting in Patients with Major Depressive Disorder with inadequate response to SSRI/SNRI treatment (2021) · cites this paper as Treadway and Zald, 2011
The Introduction (page unavailable) says anhedonic symptoms predict poor treatment response and that first-line treatments may not adequately address reward-processing deficits. It also describes reward-circuit abnormalities in depression, but does not establish that those abnormalities predict poorer prognosis or treatment response. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Studies of the neurobiology of reward processing have identified separate subtypes of anhedonia: consummatory, anticipatory, motivational, and decisional.
“studies of the neurobiology of reward processing have highlighted the variety of distinct pathways involved in its different aspects resulting in the recognition of separate subtypes of anhedonia, including consummatory, anticipatory, motivational and decisional [20,21].”
From Prefrontal cortex and depression (2022) · cites this paper as [20]
The Research Highlights (section 6; page unavailable) propose motivational and consummatory anhedonia and introduce decisional anhedonia. Section 2.2 discusses anticipatory pleasure but says it is unclear whether that is the same construct as reward motivation; the paper does not establish anticipatory anhedonia as a fourth separate subtype. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Anhedonia includes deficits in anticipation, motivation, responsiveness to reward, and reward learning.
“Anhedonia is a broad construct that includes deficits in anticipation of, motivation toward, and responsiveness to reward, as well as deficits in reward learning (ability to recall and make decisions based on past rewarding experiences) (Treadway and Zald, 2011) and is estimated to be 46% heritable in studies of monozygotic twins (Bogdan and Pizzagalli, 2009).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Treadway and Zald, 2011
Hyposensitivity to reward and hypersensitivity to punishment have been a consistent finding in depression.
“hyposensitivity to reward and hypersensitivity to punishment have been a consistent finding in depression”
From Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment (2021) · cites this paper as Treadway and Zald 2011
Abnormal dopamine release in responses to reward, aversion, and cognitive demand is a plausible mechanism explaining many depression symptoms.
“Dysregulation of dopamine release in motivating responses to rewarding and aversive stimuli, as well as cognitive demand, is a plausible mechanistic cause that can explain a range of depression symptoms [24][25][26][27][28][29].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [25]

Although both DA and non-DA agents can effectively treat mood disorders, DA agents generally have superior effects on symptoms of anhedonia compared with non-DA agents.
“Particularly relevant in the present context are previous reports [290,296,297] that although both DA and non-DA agents can be used to effectively treat mood disorders, DA agents generally have superior effects on symptoms of anhedonia, specifically when compared with non-DA agents [19,298-300].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [19]
The mesolimbic DA system represents only one component of a complex integrated set of circuits, and non-DA systems also modulate reward responsivity.
“The mesolimbic DA system represents only one component of a very complex and integrated set of circuits, and although DA is clearly a crucial neurotransmitter in the reward-processing system, non-DA systems clearly also modulate reward responsibility [19,735].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [19]
Multiple non-DA compounds have shown efficacy in improving reward responses, such as agents affecting glutamate circuits involved in regulating monoamine systems.
“Additionally, multiple non-DA compounds have shown efficacy in improving reward responses, such as agents that affect glutamate circuits involved in regulating monoamine systems [19].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [19]
Many patients with schizophrenia or Parkinson's, and possibly some with major depression, are not actually anhedonic: they report normal sensory pleasure ratings of ice cream or other sensory reward in the moment, even though they attach little value to any sensory, social or other pleasant reward in life.
“However, recent studies suggest that many patients with schizophrenia or Parkinson’s, and possibly some with major depression, are not actually anhedonic after all: they report normal sensory pleasure ratings of ice cream or other sensory reward in the moment, even though they attach little value to any sensory, social or other pleasant reward in life.”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Treadway and Zald, 2011
Their deficit really reflects a selective loss of incentive motivation or 'wanting,' rather than loss of pleasure 'liking.'
“Some investigators therefore have suggested their deficit really reflects a selective loss of incentive motivation or ‘wanting,’ rather than loss of pleasure ‘liking’ (Sienkiewicz-Jarosz et al., 2005; Dowd and Barch, 2010; Treadway and Zald, 2011; Barch et al., 2014).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Treadway and Zald, 2011
Anhedonia typically does not respond to first-line pharmacotherapies.
“Anhedonia typically does not respond to first-line pharmacotherapies [5, 7, 8]”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [5]
Co-morbid traits such as depression, anxiety, or inattention/hyperactivity are often associated with ASD and affect general reward processing and intervention response.
“co-morbid traits, such as depression, anxiety, or inattention/hyperactivity, are often associated with ASD [212], and are known to affect general reward processing [213,214] and intervention response [215].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [213]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965 · see citing works
Diagnostic criteria for use in psychiatric research.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G., & Munoz, R. A. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750190059011 · Cited by 5,491 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 1× · see citing works
“Introduction With a lifetime prevalence of approximately 16% (Kessler et al., 2003), Major Depressive Disorder (MDD) is predicted to become the second leading cause of death and disability in the United States by the year 2020 (Murray and Lopez, 1997).”
Background
Précis of The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system
Gray, J. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00013066 · Cited by 4,477 · see citing works
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
A Systematic Method for Clinical Description and Classification of Personality Variants: A Proposal
Cloninger, C. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180093014 · Cited by 3,678 · see citing works
The neural basis of economic decision-making in the Ultimatum Game.
Sanfey, A. G., Rilling, J. K., Aronson, J. A., Nystrom, L. E., & Cohen, J. D. (2003) · Science · doi:10.1126/science.1082976 · Cited by 3,375 · see citing works
Stress and Depression
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979 · see citing works
Causal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,486 · cited 1× · see citing works
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript and relapse of MDD (Caspi et al., 2003; Hammen, 2005; Kendler et al., 1999; Kessler, 1997).”
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347 · see citing works
Negative Symptoms in Schizophrenia: Definition and Reliability
Andreasen, N. C. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290070020005 · Cited by 2,247 · see citing works
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
THE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111 · cited 1× · see citing works
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript and relapse of MDD (Caspi et al., 2003; Hammen, 2005; Kendler et al., 1999; Kessler, 1997).”
Background
Neurobiology of the structure of personality: Dopamine, facilitation of incentive motivation, and extraversion
Depue, R. A., & Collins, P. F. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002046 · Cited by 2,046 · see citing works
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
The Biochemical Basis of Neuropharmacology.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-4-575_2 · Cited by 1,882 · see citing works
Parsing reward
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00233-9 · Cited by 1,869 · see citing works
A scale for the assessment of hedonic tone the Snaith-Hamilton pleasure scale
Snaith, R. P., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., & Trigwell, P. (1995) · British Journal of Psychiatry · doi:10.1192/bjp.167.1.99 · Cited by 1,778 · see citing works
Behavioral Theories and the Neurophysiology of Reward
Schultz, W. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070229 · Cited by 1,637 · see citing works
Randomized trial of behavioral activation, cognitive therapy, and antidepressant medication in the acute treatment of adults with major depression.
Dimidjian, S., Hollon, S. D., Dobson, K. S., Schmaling, K. B., Kohlenberg, R. J., Addis, M. E., Gallop, R., McGlinchey, J. B., Markley, D. K., Gollan, J. K., et al. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.4.658 · Cited by 1,607 · cited 1× · see citing works
“Initially developed as a component of Cognitive Behavioral Therapy (CBT), Behavioral Activation (BA) differs primarily in its conceptualization of patient cognitions as a ruminative behavior (Dimidjian et al., 2006).”
Background
Scales for physical and social anhedonia.
Chapman, L. J., Chapman, J. P., & Raulin, M. L. (1976) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.85.4.374 · Cited by 1,557 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales.
Watson, D., Weber, K., Assenheimer, J. S., Clark, L. A., Strauss, M. E., & McCormick, R. A. (1995) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.104.1.3 · Cited by 1,423 · see citing works
Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales.
Watson, D., Weber, K., Assenheimer, J. S., Clark, L. A., Strauss, M. E., & McCormick, R. A. (1995) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.104.1.3 · Cited by 1,423 · see citing works
The control of firing pattern in nigral dopamine neurons: burst firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02877.1984 · Cited by 1,346 · see citing works
Relative reward preference in primate orbitofrontal cortex
Tremblay, L., & Schultz, W. (1999) · Nature · doi:10.1038/19525 · Cited by 1,314 · see citing works
Dissociation of reward anticipation and outcome with event-related fMRI
Knutson, B., Fong, G. W., Adams, C. M., Varner, J. L., & Hommer, D. (2001) · Neuroreport · doi:10.1097/00001756-200112040-00016 · Cited by 1,300 · see citing works
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254 · see citing works
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244 · see citing works
Scales for physical and social anhedonia.
Chapman, L. J., Chapman, J. P., & Raulin, M. L. (1976) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.85.4.374 · Cited by 1,234 · see citing works
Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232 · see citing works
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203 · see citing works
The amygdala and reward
Baxter, M. G., & Murray, E. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn875 · Cited by 1,200 · see citing works
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182 · see citing works
Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.
Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130 · see citing works
Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106 · see citing works
Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport
Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02295.1997 · Cited by 1,097 · see citing works
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076 · see citing works
Cingulate function in depression: a potential predictor of treatment response
Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., Silva, J. A., McGinnis, S., Glass, T. G., Martin, C. C., et al. (1997) · NeuroReport · doi:10.1097/00001756-199703030-00048 · Cited by 1,029 · see citing works
Anticipatory and consummatory components of the experience of pleasure: A scale development study
Gard, D. E., Gard, M. G., Kring, A. M., & John, O. P. (2006) · Journal of Research in Personality · doi:10.1016/j.jrp.2005.11.001 · Cited by 1,015 · see citing works
Action sets and decisions in the medial frontal cortex
RUSHWORTH, M., WALTON, M., KENNERLEY, S., & BANNERMAN, D. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.009 · Cited by 1,004 · see citing works
Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples.
Watson, D., Clark, L. A., Weber, K., Assenheimer, J. S., Strauss, M. E., & McCormick, R. A. (1995) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.104.1.15 · Cited by 1,002 · see citing works
Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
Salamone, J. D., Correa, M., Farrar, A., & Mingote, S. M. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0668-9 · Cited by 1,000 · see citing works
Cortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985 · see citing works
Distributed Disturbances in Brain Structure and Function in Schizophrenia
Lewis, D. A. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.1 · Cited by 971 · see citing works
Distributed Neural Representation of Expected Value
Knutson, B., Taylor, J., Kaufman, M., Peterson, R., & Glover, G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0642-05.2005 · Cited by 955 · see citing works
Optimal decision making and the anterior cingulate cortex
Kennerley, S. W., Walton, M. E., Behrens, T. E. J., Buckley, M. J., & Rushworth, M. F. S. (2006) · Nature Neuroscience · doi:10.1038/nn1724 · Cited by 948 · see citing works
A meta-analysis of emotional reactivity in major depressive disorder
Bylsma, L. M., Morris, B. H., & Rottenberg, J. (2008) · Clinical Psychology Review · doi:10.1016/j.cpr.2007.10.001 · Cited by 933 · see citing works
Untitled work
(2001) · Medical Entomology and Zoology · Cited by 915 · see citing works
Attentional biases for negative interpersonal stimuli in clinical depression
Gotlib, I. H., Krasnoperova, E., Yue, D. N., & Joormann, J. (2004) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.113.1.121 · Cited by 911 · see citing works
A meta‐analytic study of changes in brain activation in depression
Fitzgerald, P. B., Laird, A. R., Maller, J., & Daskalakis, Z. J. (2008) · Human Brain Mapping · doi:10.1002/hbm.20426 · Cited by 903 · see citing works
Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies
Koolschijn, P. C. M. P., van Haren, N. E. M., Lensvelt‐Mulders, G. J. L. M., Hulshoff Pol, H. E., & Kahn, R. S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20801 · Cited by 902 · see citing works
Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
Volkow, N. D., Wang, G.-J., Fowler, J. S., Gatley, S. J., Logan, J., Ding, Y.-S., Hitzemann, R., & Pappas, N. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1325 · Cited by 885 · see citing works
Choice, uncertainty and value in prefrontal and cingulate cortex
Rushworth, M. F. S., & Behrens, T. E. J. (2008) · Nature Neuroscience · doi:10.1038/nn2066 · Cited by 866 · see citing works
Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies
Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861 · see citing works
Can’t shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals
Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01314-8 · Cited by 859 · see citing works
Increased Amygdala and Decreased Dorsolateral Prefrontal BOLD Responses in Unipolar Depression: Related and Independent Features
Siegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., & Thase, M. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.048 · Cited by 857 · see citing works
Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy
Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846 · see citing works
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
Zubieta, J.-K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., & Stohler, C. S. (2001) · Science · doi:10.1126/science.1060952 · Cited by 842 · see citing works
Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820 · see citing works
Anhedonia in schizophrenia: Distinctions between anticipatory and consummatory pleasure
Gard, D. E., Kring, A. M., Gard, M. G., Horan, W. P., & Green, M. F. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.03.008 · Cited by 817 · see citing works
Childhood trauma associated with smaller hippocampal volume in women with major depression
Vythilingam, M., Heim, C., Newport, J., Miller, A. H., Anderson, E., Bronen, R., Brummer, M., Staib, L., Vermetten, E., Charney, D. S., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.12.2072 · Cited by 812 · see citing works
Residual symptoms after partial remission: an important outcome in depression
Paykel, E. S., Ramana, R., Cooper, Z., Hayhurst, H., Kerr, J., & Barocka, A. (1995) · Psychological Medicine · doi:10.1017/s0033291700033146 · Cited by 791 · see citing works
Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task
Pizzagalli, D. A., Iosifescu, D., Hallett, L. A., Ratner, K. G., & Fava, M. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.001 · Cited by 780 · see citing works
Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
Zubieta, J.-K., Bueller, J. A., Jackson, L. R., Scott, D. J., Xu, Y., Koeppe, R. A., Nichols, T. E., & Stohler, C. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0439-05.2005 · Cited by 779 · see citing works
Attenuation of the Neural Response to Sad Faces in Major Depressionby Antidepressant Treatment: A Prospective, Event-Related Functional Magnetic Resonance ImagingStudy
Fu, C. H. Y., Williams, S. C. R., Cleare, A. J., Brammer, M. J., Walsh, N. D., Kim, J., Andrew, C. M., Pich, E. M., Williams, P. M., Reed, L. J., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.9.877 · Cited by 775 · see citing works
Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia
Treadway, M. T., Buckholtz, J. W., Schwartzman, A. N., Lambert, W. E., & Zald, D. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006598 · Cited by 769 · see citing works
Self-citation
Neurobiological similarities in depression and drug dependence: a self-medication hypothesis
Markou, A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00113-9 · Cited by 767 · see citing works
Diagnosis and Treatment of Depression in Late Life
Friedhoff, A. J. (1992) · JAMA · doi:10.1001/jama.1992.03490080092032 · Cited by 766 · see citing works
Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder
Cotter, D., Mackay, D., Landau, S., Kerwin, R., & Everall, I. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.545 · Cited by 766 · see citing works
Diagnosis and treatment of depression in late life. Consensus statement update
Lebowitz, B. D. (1997) · JAMA · doi:10.1001/jama.278.14.1186 · Cited by 747 · see citing works
Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples.
Watson, D., Clark, L. A., Weber, K., et al. (1995) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.104.1.15 · Cited by 745 · see citing works
Toward an objective characterization of an anhedonic phenotype: A signal-detection approach
Pizzagalli, D. A., Jahn, A. L., & O’Shea, J. P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.026 · Cited by 738 · see citing works
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
Zhou, Q.-Y., & Palmiter, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90145-0 · Cited by 731 · see citing works
Neurobehavioral Aspects of Affective Disorders
Depue, R. A., & Iacono, W. G. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.002325 · Cited by 722 · see citing works
Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria
Drevets, W. C., Gautier, C., Price, J. C., Kupfer, D. J., Kinahan, P. E., Grace, A. A., Price, J. L., & Mathis, C. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01038-6 · Cited by 706 · cited 2× · see citing works
“These data suggest that despite apparent correlations between stimulant-induced DA release and subjective euphoria (Drevets et al., 2001), this result is mediated by downstream effects on opioid function, and is unlikely to be a direct consequence of increased extracellular DA (Volkow et al., 1996).”
Background
Glucocorticoids, depression, and mood disorders: Structural remodeling in the brain
McEwen, B. S. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.008 · Cited by 687 · see citing works
The amygdala, reward and emotion
Murray, E. A. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.08.013 · Cited by 679 · see citing works
Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?
Peciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671 · see citing works
Emotion context insensitivity in major depressive disorder
Rottenberg, J., Gross, J. J., & Gotlib, I. H. (2005) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.114.4.627 · Cited by 654 · see citing works
The Neural Correlates of Anhedonia in Major Depressive Disorder
Keedwell, P. A., Andrew, C., Williams, S. C. R., Brammer, M. J., & Phillips, M. L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.019 · Cited by 650 · see citing works
Relationship between subjective effects of cocaine and dopamine transporter occupancy
Volkow, N. D., Wang, G., Fischman, M. W., Foltin, R. W., Fowler, J. S., Abumrad, N. N., Vitkun, S. A., Logan, J., Gatley, S. J., Pappas, N. R., et al. (1997) · Nature · doi:10.1038/386827a0 · Cited by 646 · see citing works
Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food
Wise, R. A., Spindler, J., de Wit, H., & Gerberg, G. J. (1978) · Science · doi:10.1126/science.566469 · Cited by 636 · see citing works
A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder
Surguladze, S., Brammer, M. J., Keedwell, P., Giampietro, V., Young, A. W., Travis, M. J., Williams, S. C. R., & Phillips, M. L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.028 · Cited by 633 · see citing works
Parallel incentive processing: an integrated view of amygdala function
Balleine, B. W., & Killcross, S. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.002 · Cited by 622 · see citing works
Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review
Vaswani, M., Linda, F. K., & Ramesh, S. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00338-x · Cited by 612 · see citing works
Altered Striatal Activation Predicting Real-World Positive Affect in Adolescent Major Depressive Disorder
Forbes, E. E., Hariri, A. R., Martin, S. L., Silk, J. S., Moyles, D. L., Fisher, P. M., Brown, S. M., Ryan, N. D., Birmaher, B., Axelson, D. A., et al. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07081336 · Cited by 582 · see citing works
Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism
Drevets, W. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00102-5 · Cited by 581 · see citing works
Is Methylphenidate Like Cocaine?: Studies on Their Pharmacokinetics and Distribution in the Human Brain
Volkow, N. D. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950180042006 · Cited by 575 · see citing works
Effort-Based Cost–Benefit Valuation and the Human Brain
Croxson, P. L., Walton, M. E., O'Reilly, J. X., Behrens, T. E. J., & Rushworth, M. F. S. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-08.2009 · Cited by 560 · see citing works
Ventral pallidum roles in reward and motivation
Smith, K. S., Tindell, A. J., Aldridge, J. W., & Berridge, K. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.038 · Cited by 548 · see citing works
Diagnosis and Treatment of Depression in Late Life
Lebowitz, B. D. (1997) · JAMA · doi:10.1001/jama.1997.03550140078045 · Cited by 528 · see citing works
Recognition Accuracy and Response Bias to Happy and Sad Facial Expressions in Patients With Major Depression.
Surguladze, S. A., Young, A. W., Senior, C., Brébion, G., Travis, M. J., & Phillips, M. L. (2004) · Neuropsychology · doi:10.1037/0894-4105.18.2.212 · Cited by 525 · see citing works
Reward Processing in Schizophrenia: A Deficit in the Representation of Value
Gold, J. M., Waltz, J. A., Prentice, K. J., Morris, S. E., & Heerey, E. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn068 · Cited by 521 · see citing works
Importance of studying the contributions of early adverse experience to neurobiological findings in depression
Heim, C., Plotsky, P. M., & Nemeroff, C. B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300397 · Cited by 514 · see citing works
Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association.
(2000) · PubMed · Cited by 509 · see citing works
Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits
Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Benning, S. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Shelby, E. S., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2510 · Cited by 497 · see citing works
Self-citation
Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release
Schott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H., Seidenbecher, C. I., Coenen, H. H., Heinze, H.-J., Zilles, K., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2058-08.2008 · Cited by 496 · see citing works
Neural Responses to Monetary Incentives in Major Depression
Knutson, B., Bhanji, J. P., Cooney, R. E., Atlas, L. Y., & Gotlib, I. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.023 · Cited by 496 · see citing works
A review of the neuropharmacology of bupropion, a dual norepinephrine and dopamine reuptake inhibitor
Stahl, S. M., Pradko, J., Haight, B. R., Modell, J. G., Rockett, C. B., & Learned-Coughlin, S. (2004) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v06n0403 · Cited by 495 · see citing works
Functional Specialization within Medial Frontal Cortex of the Anterior Cingulate for Evaluating Effort-Related Decisions
Walton, M. E., Bannerman, D. M., Alterescu, K., & Rushworth, M. F. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06475.2003 · Cited by 495 · see citing works
Use of fMRI to Predict Recovery From Unipolar Depression With Cognitive Behavior Therapy
Siegle, G. J., Carter, C. S., & Thase, M. E. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.4.735 · Cited by 495 · see citing works
Adaptive and maladaptive components of rumination? Diagnostic specificity and relation to depressive biases.
Joormann, J., Dkane, M., & Gotlib, I. (2006) · The Behavior Therapist · doi:10.1016/j.beth.2006.01.002 · Cited by 488 · see citing works
Encoding predicted outcome and acquired value in orbitofrontal cortex during cue sampling depends upon input from basolateral amygdala.
Schoenbaum, G., Setlow, B., Saddoris, M. P., & Gallagher, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00474-4 · Cited by 484 · see citing works
Translating Scientific Opportunity Into Public Health Impact: A Strategic Plan for Research on Mental Illness
Insel, T. R. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.540 · Cited by 459 · see citing works
Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine
Salamone, J. D., Correa, M., Mingote, S., & Weber, S. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.09.004 · Cited by 454 · see citing works
Neurons in the frontal lobe encode the value of multiple decision variables
Kennerley, S. W., Dahmubed, A. F., Lara, A. H., & Wallis, J. D. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21100 · Cited by 453 · see citing works
D2Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+Currents and Excitability via a Novel PLCβ1–IP3–Calcineurin-Signaling Cascade
Hernández-López, S., Tkatch, T., Perez-Garci, E., Galarraga, E., Bargas, J., Hamm, H., & Surmeier, D. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-08987.2000 · Cited by 443 · see citing works
Hedonic Hot Spots in the Brain
Peciña, S., Smith, K. S., & Berridge, K. C. (2006) · The Neuroscientist · doi:10.1177/1073858406293154 · Cited by 441 · see citing works
Interactions between decision making and performance monitoring within prefrontal cortex
Walton, M. E., Devlin, J. T., & Rushworth, M. F. S. (2004) · Nature Neuroscience · doi:10.1038/nn1339 · Cited by 440 · see citing works
Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure
Salamone, J. D., Steinpreis, R. E., McCullough, L. D., Smith, P., Grebel, D., & Mahan, K. (1991) · Psychopharmacology · doi:10.1007/bf02245659 · Cited by 436 · see citing works
Emotional experience and expression in schizophrenia and depression.
Berenbaum, H., & Oltmanns, T. F. (1992) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.101.1.37 · Cited by 431 · see citing works
Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior
Zweifel, L. S., Parker, J. G., Lobb, C. J., Rainwater, A., Wall, V. Z., Fadok, J. P., Darvas, M., Kim, M. J., Mizumori, S. J. Y., Paladini, C. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813415106 · Cited by 426 · see citing works
Appetitive Behavior
Everitt, B. J., Cardinal, R. N., Parkinson, J. A., & Robbins, T. W. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07085.x · Cited by 416 · see citing works
A neural correlate of response bias in monkey caudate nucleus
Lauwereyns, J., Watanabe, K., Coe, B. C., & Hikosaka, O. (2002) · Nature · doi:10.1038/nature00892 · Cited by 415 · see citing works
The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation
McEwen, B. S., Chattarji, S., Diamond, D. M., Jay, T. M., Reagan, L. P., Svenningsson, P., & Fuchs, E. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.80 · Cited by 406 · see citing works
The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: integration of resting EEG, fMRI, and volumetric techniques
Wacker, J., Dillon, D. G., & Pizzagalli, D. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.058 · Cited by 405 · see citing works
Coherence and Specificity of Information-Processing Biases in Depression and Social Phobia.
Gotlib, I. H., Kasch, K. L., Traill, S., Joormann, J., Arnow, B. A., & Johnson, S. L. (2004) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.113.3.386 · Cited by 396 · see citing works
The representation of economic value in the orbitofrontal cortex is invariant for changes of menu
Padoa‐Schioppa, C., & Assad, J. A. (2007) · Nature Neuroscience · doi:10.1038/nn2020 · Cited by 390 · see citing works
Appetitive behavior: impact of amygdala-dependent mechanisms of emotional learning.
Everitt, B. J., Cardinal, R. N., Parkinson, J. A., & Robbins, T. W. (2003) · PubMed · Cited by 386 · see citing works
Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression
Hastings, R. S., Parsey, R. V., Oquendo, M. A., Arango, V., & Mann, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300371 · Cited by 378 · see citing works
Choice selection and reward anticipation: an fMRI study
Ernst, M., Nelson, E. E., McClure, E. B., Monk, C. S., Munson, S., Eshel, N., Zarahn, E., Leibenluft, E., Zametkin, A., Towbin, K., et al. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.05.011 · Cited by 377 · see citing works
Regulation of Human Affective Responses by Anterior Cingulate and Limbic µ-Opioid Neurotransmission
Zubieta, J., Ketter, T. A., Bueller, J. A., Xu, Y., Kilbourn, M. R., Young, E. A., & Koeppe, R. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.11.1145 · Cited by 377 · see citing works
Abnormal temporal difference reward-learning signals in major depression
Kumar, P., Waiter, G., Ahearn, T., Milders, M., Reid, I., & Steele, J. D. (2008) · Brain · doi:10.1093/brain/awn136 · Cited by 374 · see citing works
Volumetric reduction in left subgenual prefrontal cortex in early onset depression
Botteron, K. N., Raichle, M. E., Drevets, W. C., Heath, A. C., & Todd, R. D. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01280-x · Cited by 371 · see citing works
Toward a New Understanding of Attention-Deficit Hyperactivity Disorder Pathophysiology: An Important Role for Prefrontal Cortex Dysfunction
Arnsten, A. F. T. (2009) · CNS Drugs · doi:10.2165/00023210-200923000-00005 · Cited by 371 · see citing works
The other face of depression, reduced positive affect: the role of catecholamines in causation and cure
Nutt, D., Demyttenaere, K., Janka, Z., Aarre, T., Bourin, M., Canonico, P. L., Carrasco, J. L., & Stahl, S. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106069938 · Cited by 366 · see citing works
Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment
McCabe, C., Mishor, Z., Cowen, P. J., & Harmer, C. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.001 · Cited by 365 · see citing works
The role of rat medial frontal cortex in effort-based decision making
Walton, M. E., Bannerman, D. M., & Rushworth, M. F. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10996.2002 · Cited by 364 · see citing works
Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study
Price, J., Cole, V., & Goodwin, G. M. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.051110 · Cited by 362 · see citing works
Sadness and amusement reactivity differentially predict concurrent and prospective functioning in major depressive disorder.
Rottenberg, J. A., Kasch, K. L., Gross, J. J., & Gotlib, I. H. (2002) · Emotion · doi:10.1037/1528-3542.2.2.135 · Cited by 360 · see citing works
Role of the dopaminergic system in depression
Kapur, S., & Mann, J. J. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90137-o · Cited by 350 · see citing works
Glucocorticoids have state-dependent stimulant effects on the mesencephalic dopaminergic transmission
Piazza, P. V., Rougé-Pont, F., Deroche, V, Maccari, S., Simon, H., & Le Moal, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8716 · Cited by 346 · see citing works
Emotional experience and expression in schizophrenia and depression
Berenbaum, H., & Oltmanns, T. F. (1992) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.101.1.37 · Cited by 345 · see citing works
The Yin and Yang of dopamine release: a new perspective
GOTO, Y., OTANI, S., & GRACE, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.007 · Cited by 342 · see citing works
Functional Neuroanatomical Substrates of Altered Reward Processing in Major Depressive Disorder Revealed by a Dopaminergic Probe
Tremblay, L. K., Naranjo, C. A., Graham, S. J., Herrmann, N., Mayberg, H. S., Hevenor, S., & Busto, U. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1228 · Cited by 340 · see citing works
Dysregulation of Endogenous Opioid Emotion Regulation Circuitry in Major Depression in Women
Kennedy, S. E., Koeppe, R. A., Young, E. A., & Zubieta, J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1199 · Cited by 339 · see citing works
Morphine reward in dopamine-deficient mice
Hnasko, T. S., Sotak, B. N., & Palmiter, R. D. (2005) · Nature · doi:10.1038/nature04172 · Cited by 338 · see citing works
Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: Comorbidity between depression and neurodegenerative disorders
Anisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 334 · see citing works
fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder
Smoski, M. J., Felder, J., Bizzell, J., Green, S. R., Ernst, M., Lynch, T. R., & Dichter, G. S. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.01.034 · Cited by 328 · see citing works
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration
Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91327-b · Cited by 318 · see citing works
Neural systems of positive affect: relevance to understanding child and adolescent depression?
FORBES, E. E., & DAHL, R. E. (2005) · Development and Psychopathology · doi:10.1017/s095457940505039x · Cited by 318 · see citing works
The Biochemical Basis of Neuropharmacology
Cooper, J. R., Bloom, F. E., & Roth, R. H. (2002) · doi:10.1093/oso/9780195140071.001.0001 · Cited by 310 · see citing works
The Relationship Between Aberrant Neuronal Activation in the Pregenual Anterior Cingulate, Altered Glutamatergic Metabolism, and Anhedonia in Major Depression
Walter, M., Henning, A., Grimm, S., Schulte, R. F., Beck, J., Dydak, U., Schnepf, B., Boeker, H., Boesiger, P., & Northoff, G. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.39 · Cited by 306 · see citing works
Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making
Floresco, S. B., Onge, J. R. S., Ghods-Sharifi, S., & Winstanley, C. A. (2008) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.8.4.375 · Cited by 305 · see citing works
Weighing up the benefits of work: Behavioral and neural analyses of effort-related decision making
Walton, M. E., Kennerley, S. W., Bannerman, D. M., Phillips, P. E. M., & Rushworth, M. F. S. (2006) · Neural Networks · doi:10.1016/j.neunet.2006.03.005 · Cited by 305 · see citing works
Remission Rates Following Antidepressant Therapy With Bupropion or Selective Serotonin Reuptake Inhibitors: A Meta-Analysis of Original Data From 7 Randomized Controlled Trials
Thase, M. E., Haight, B. R., Richard, N., Rockett, C. B., Mitton, M., Modell, J. G., VanMeter, S., Harriett, A. E., & Wang, Y. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0803 · Cited by 304 · see citing works
Reduced Brain Norepinephrine and Dopamine Release in Treatment-Refractory Depressive Illness: Evidence in Support of the Catecholamine Hypothesis of Mood Disorders
Lambert, G., Johansson, M., Ågren, H., & Friberg, P. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.787 · Cited by 303 · see citing works
Neurobiological and clinical effects of the antidepressant tianeptine
Kasper, S., & McEwen, B. S. (2008) · CNS Drugs · doi:10.2165/00023210-200822010-00002 · Cited by 302 · see citing works
Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort
Denk, F., Walton, M. E., Jennings, K. A., Sharp, T., Rushworth, M. F. S., & Bannerman, D. M. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2059-4 · Cited by 294 · see citing works
The role of dopamine in the mechanism of action of antidepressant drugs
D’Aquila, P. S., Collu, M., Gessa, G. L., & Serra, G. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00566-5 · Cited by 290 · see citing works
Food Acceptance and Genetic Variation in Taste
Duffy, V. B., & Bartoshuk, L. M. (2000) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(00)00191-7 · Cited by 287 · see citing works
Reward without dopamine
Cannon, C. M., & Palmiter, R. D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10827.2003 · Cited by 280 · see citing works
The effects of psychotherapy on neural responses to rewards in major depression
Dichter, G. S., Felder, J. N., Petty, C., Bizzell, J., Ernst, M., & Smoski, M. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.021 · Cited by 278 · see citing works
Dopamine and depression: A review of recent evidence. I. Empirical studies
Willner, P. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90005-x · Cited by 273 · see citing works
Endophenotypes: Bridging Genomic Complexity and Disorder Heterogeneity
Insel, T. R., & Cuthbert, B. N. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.008 · Cited by 273 · see citing works
Anhedonia in schizophrenia and major depression: state or trait
Pelizza, L., & Ferrari, A. (2009) · Annals of General Psychiatry · doi:10.1186/1744-859x-8-22 · Cited by 271 · see citing works
Lower dopamine transporter binding potential in striatum during depression
Meyer, J. H., Krüger, S., Wilson, A. A., Christensen, B. K., Goulding, V. S., Schaffer, A., Minifie, C., Houle, S., Hussey, D., & Kennedy, S. H. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00052 · Cited by 269 · see citing works
Nucleus accumbens dopamine depletions make rats more sensitive to high ratio requirements but do not impair primary food reinforcement
Aberman, J. E., & Salamone, J. D. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00004-4 · Cited by 263 · see citing works
Blunted response to feedback information in depressive illness
Steele, J. D., Kumar, P., & Ebmeier, K. P. (2007) · Brain · doi:10.1093/brain/awm150 · Cited by 261 · see citing works
Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent
Dwoskin, L. P., Rauhut, A. S., King‐Pospisil, K. A., & Bardo, M. T. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00178.x · Cited by 259 · see citing works
Determinants of poor 1-year outcome of DSM-III-R major depression in the general population: results of the Netherlands mental health survey and incidence study (NEMESIS)
Spijker, J., Bijl, R. V., De Graaf, R., & Nolen, W. A. (2001) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2001.103002122.x · Cited by 254 · see citing works
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors
Cryan, J. F., O’Leary, O. F., Jin, S., Friedland, J. C., Ouyang, M., Hirsch, B. R., Page, M. E., Dalvi, A., THOMAS, S. A., & Lucki, I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401080101 · Cited by 252 · see citing works
Common and Distinct Amygdala-Function Perturbations in Depressed vs Anxious Adolescents
Beesdo, K., Lau, J. Y. F., Guyer, A. E., McClure-Tone, E. B., Monk, C. S., Nelson, E. E., Fromm, S. J., Goldwin, M. A., Wittchen, H.-U., Leibenluft, E., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.545 · Cited by 250 · see citing works
Neural representation of reward in recovered depressed patients
McCabe, C., Cowen, P. J., & Harmer, C. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1573-9 · Cited by 248 · see citing works
Delay discounting in schizophrenia
Heerey, E. A., Robinson, B. M., McMahon, R. P., & Gold, J. M. (2007) · Cognitive Neuropsychiatry · doi:10.1080/13546800601005900 · Cited by 248 · see citing works
Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density
Chana, G., Landau, S., Beasley, C. L., Everall, I., & Cotter, D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00114-8 · Cited by 245 · see citing works
A placebo-controlled comparison of the antidepressant efficacy and effects on sexual functioning of sustained-release bupropion and sertraline
Croft, H. A., Settle, E. C., Houser, T. L., Batey, S. R., Donahue, R. M. J., & Ascher, J. A. (1999) · Clinical Therapeutics · doi:10.1016/s0149-2918(00)88317-4 · Cited by 243 · see citing works
The biochemical basis of neuropharmacology, 8th ed.
Cooper, J. R., Bloom, F. E., & Roth, R. H. (2003) · Cited by 243 · see citing works
Calculating utility: preclinical evidence for cost–benefit analysis by mesolimbic dopamine
Phillips, P. E. M., Walton, M. E., & Jhou, T. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0626-6 · Cited by 237 · see citing works
Nucleus accumbens dopamine depletions alter relative response allocation in a T-maze cost/benefit task
Cousins, M. S., Atherton, A., Turner, L., & Salamone, J. D. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00151-4 · Cited by 236 · see citing works
Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine
Gan, J. O., Walton, M. E., & Phillips, P. E. M. (2009) · Nature Neuroscience · doi:10.1038/nn.2460 · Cited by 235 · see citing works
A meta-analytic study of changes in brain activation in depression
Fitzgerald, P. B., Maller, J. J., Hoy, K. E., Oxley, T. J., Daskalakis, Z. J., & Laird, A. R. (2006) · Acta Neuropsychiatrica · doi:10.1017/s0924270800031173 · Cited by 233 · see citing works
Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity
Smith, I. D., & Grace, A. A. (1992) · Synapse · doi:10.1002/syn.890120406 · Cited by 232 · see citing works
Taste and smell perception in depression.
Amsterdam, J., Settle, R., Doty, R. L., Abelman, E., & Winokur, A. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90108-9 · Cited by 231 · see citing works
Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta
Futami, T., Takakusaki, K., & Kitai, S. T. (1995) · Neuroscience Research · doi:10.1016/0168-0102(94)00869-h · Cited by 230 · see citing works
Diminished response to pleasant stimuli by depressed women
Sloan, D. M., Strauss, M. E., & Wisner, K. L. (2001) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.110.3.488 · Cited by 229 · see citing works
The lateral nucleus of the amygdala mediates expression of the amphetamine-produced conditioned place preference
Hiroi, N., & White, N. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-07-02107.1991 · Cited by 228 · see citing works
Prefrontostriatal Circuitry Regulates Effort-Related Decision Making
Hauber, W., & Sommer, S. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn241 · Cited by 224 · see citing works
Neural Encoding in Ventral Striatum during Olfactory Discrimination Learning
Setlow, B., Schoenbaum, G. M., & Gallagher, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00264-2 · Cited by 220 · see citing works
A Double Dissociation of Ventromedial Prefrontal Cortical Responses to Sad and Happy Stimuli in Depressed and Healthy Individuals
Keedwell, P. A., Andrew, C., Williams, S. C. R., Brammer, M. J., & Phillips, M. L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.035 · Cited by 218 · see citing works
Sensitivity to reward and punishment and the prefrontal cortex in major depression
Must, A., Szabó, Z., Bódi, N., Szász, A., Janka, Z., & Kéri, S. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.12.005 · Cited by 218 · see citing works
How Humans Integrate the Prospects of Pain and Reward during Choice
Talmi, D., Dayan, P., Kiebel, S. J., Frith, C., & Dolan, R. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2026-09.2009 · Cited by 217 · see citing works
Reward fails to alter response bias in depression.
Henriques, J. B., Glowacki, J. M., & Davidson, R. J. (1994) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.103.3.460 · Cited by 215 · see citing works
Affective startle modulation in clinical depression: Preliminary findings
Allen, N. B., Trinder, J., & Brennan, C. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00025-6 · Cited by 214 · see citing works
Measuring hedonic capacity in depression: A psychometric analysis of three anhedonia scales
Leventhal, A. M., Chasson, G. S., Tapia, E., Miller, E. K., & Pettit, J. W. (2006) · Journal of Clinical Psychology · doi:10.1002/jclp.20327 · Cited by 213 · see citing works
Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression
Duman, R. S. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/rsduman · Cited by 210 · see citing works
Neural Response to Catecholamine Depletion in Unmedicated Subjects With Major Depressive Disorder in Remission and Healthy Subjects
Hasler, G., Fromm, S., Carlson, P. J., Luckenbaugh, D. A., Waldeck, T., Geraci, M., Roiser, J. P., Neumeister, A., Meyers, N., Charney, D. S., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.521 · Cited by 209 · see citing works
Decision-making and risk aversion among depressive adults
Smoski, M. J., Lynch, T. R., Rosenthal, M. Z., Cheavens, J. S., Chapman, A. L., & Krishnan, R. R. (2008) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2008.01.004 · Cited by 198 · see citing works
Decreased presynaptic dopamine function in the left caudate of depressed patients with affective flattening and psychomotor retardation
Martinot, M.-L. P., Bragulat, V., Artiges, E., Dollé, F., Hinnen, F., Jouvent, R., & Martinot, J.-L. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.2.314 · Cited by 194 · see citing works

Flagged first, then by citations

Sorted by citations

Toward the future of psychiatric diagnosis: the seven pillars of RDoC
Cuthbert, B. N., & Insel, T. R. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-126 · Cited by 3,053 · see citing works
Pleasure Systems in the Brain
Berridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730 · see citing works
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473 · see citing works
The mysterious motivational functions of mesolimbic dopamine
Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418 · see citing works
The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology: Forum - The Research Domain Criteria Project
Cuthbert, B. N. (2014) · World Psychiatry · doi:10.1002/wps.20087 · Cited by 1,377 · see citing works
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
Pizzagalli, D. A. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185606 · Cited by 1,155 · see citing works
Depression and obesity: evidence of shared biological mechanisms
Milaneschi, Y., Simmons, W. K., van Rossum, E. F. C., & Penninx, B. W. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0017-5 · Cited by 1,073 · see citing works
Network analysis of depression and anxiety symptom relationships in a psychiatric sample
Beard, C., Millner, A. J., Forgeard, M. J. C., Fried, E. I., Hsu, K. J., Treadway, M. T., Leonard, C. V., Kertz, S. J., & Björgvinsson, T. (2016) · Psychological Medicine · doi:10.1017/s0033291716002300 · Cited by 929 · see citing works
Self-citation
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788 · see citing works
Dopamine system dysregulation in major depressive disorders
Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754 · see citing works
Reward processing dysfunction in major depression, bipolar disorder and schizophrenia
Whitton, A. E., Treadway, M. T., & Pizzagalli, D. A. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000122 · Cited by 740 · see citing works
Self-citation
Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia
Treadway, M. T., Bossaller, N. A., Shelton, R. C., & Zald, D. H. (2012) · Journal of Abnormal Psychology · doi:10.1037/a0028813 · Cited by 733 · see citing works
Self-citation
From prediction error to incentive salience: mesolimbic computation of reward motivation.
Berridge, K. C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.07990.x · Cited by 700 · see citing works
Precision psychiatry: a neural circuit taxonomy for depression and anxiety
Williams, L. M. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00579-9 · Cited by 641 · see citing works
The NIMH research domain criteria initiative: Background, issues, and pragmatics
Kozak, M. J., & Cuthbert, B. N. (2016) · Psychophysiology · doi:10.1111/psyp.12518 · Cited by 655 · see citing works
Neuroscience of apathy and anhedonia: a transdiagnostic approach
Husain, M., & Roiser, J. P. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0029-9 · Cited by 642 · see citing works
Prefrontal cortex and depression
Pizzagalli, D. A., & Roberts, A. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01101-7 · Cited by 644 · see citing works
The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities
Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631 · see citing works
Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
Felger, J. C., Li, Z., Haroon, E., Woolwine, B. J., Jung, M. Y., Hu, X., & Miller, A. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.168 · Cited by 620 · see citing works
Assessing anhedonia in depression: potentials and pitfalls
Rizvi, S. J., Pizzagalli, D. A., Sproule, B. A., & Kennedy, S. H. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.004 · Cited by 571 · see citing works
Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies
Keren, H., O’Callaghan, G., Vidal-Ribas, P., Buzzell, G. A., Brotman, M. A., Leibenluft, E., Pan, P. M., Meffert, L., Kaiser, A., Wolke, S., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17101124 · Cited by 521 · see citing works
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis
Huys, Q. J., Pizzagalli, D. A., Bogdan, R., & Dayan, P. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-12 · Cited by 480 · see citing works
Disentangling pleasure from incentive salience and learning signals in brain reward circuitry
Smith, K. S., Berridge, K. C., & Aldridge, J. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101920108 · Cited by 464 · see citing works
Neurons in the frontal lobe encode the value of multiple decision variables
Kennerley, S. W., Dahmubed, A. F., Lara, A. H., & Wallis, J. D. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21100 · Cited by 453 · see citing works
Inflammation Effects on Motivation and Motor Activity: Role of Dopamine
Felger, J. C., & Treadway, M. T. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.143 · Cited by 453 · see citing works
Self-citation
Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression
McMakin, D. L., Olino, T. M., Porta, G., Dietz, L. J., Emslie, G., Clarke, G., Wagner, K. D., Asarnow, J. R., Ryan, N. D., Birmaher, B., et al. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.01.011 · Cited by 448 · see citing works
Reduced Reward Learning Predicts Outcome in Major Depressive Disorder
Vrieze, E., Pizzagalli, D. A., Demyttenaere, K., Hompes, T., Sienaert, P. A., de Boer, P., Schmidt, M. E., & Claes, S. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.014 · Cited by 443 · see citing works
Great Expectations: Using Whole-Brain Computational Connectomics for Understanding Neuropsychiatric Disorders
Deco, G., & Kringelbach, M. L. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.034 · Cited by 402 · see citing works
Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting”
Castro, D. C., & Berridge, K. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4458-13.2014 · Cited by 395 · see citing works
Positive emotion regulation in emotional disorders: A theoretical review
Carl, J. R., Soskin, D. P., Kerns, C., & Barlow, D. H. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.01.003 · Cited by 391 · see citing works
Dopaminergic mechanisms of individual differences in human effort-based decision-making
Treadway, M. T., Buckholtz, J. W., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Kessler, R. M., & Zald, D. H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6459-11.2012 · Cited by 385 · see citing works
Treatment for Anhedonia: A Neuroscience Driven Approach: 2015 ADAA Scientific Research Symposium: Treatment for Anhedonia
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., & Dour, H. J. (2016) · Depression and Anxiety · doi:10.1002/da.22490 · Cited by 387 · see citing works
The anatomy of apathy: a neurocognitive framework for amotivated behaviour
Le Heron, C., Apps., M. A. J., & Husain, M. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.07.003 · Cited by 380 · see citing works
Anticipatory pleasure predicts motivation for reward in major depression.
Sherdell, L., Waugh, C. E., & Gotlib, I. H. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0024945 · Cited by 369 · see citing works
The comorbidity of insomnia, chronic pain, and depression: Dopamine as a putative mechanism
Finan, P. H., & Smith, M. T. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.03.003 · Cited by 367 · see citing works
Beyond the FRN: Broadening the time-course of EEG and ERP components implicated in reward processing
Glazer, J. E., Kelley, N. J., Pornpattananangkul, N., Mittal, V. A., & Nusslock, R. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.02.002 · Cited by 362 · see citing works
Research review: altered reward function in adolescent depression: what, when and how?
Forbes, E. E., & Dahl, R. E. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02477.x · Cited by 350 · see citing works
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Salamone, J. D., Yohn, S. E., López-Cruz, L., San Miguel, N., & Correa, M. (2016) · Brain · doi:10.1093/brain/aww050 · Cited by 350 · see citing works
Motivation and cognitive control in depression
Grahek, I., Shenhav, A., Musslick, S., Krebs, R. M., & Koster, E. H. W. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.011 · Cited by 360 · see citing works
Childhood Trauma Exposure Disrupts the Automatic Regulation of Emotional Processing
Marusak, H. A., Martin, K. R., Etkin, A., & Thomason, M. E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.311 · Cited by 343 · see citing works
Dysfunctional reward processing in depression
Admon, R., & Pizzagalli, D. A. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2014.12.011 · Cited by 343 · see citing works
Anhedonia and Reward-Circuit Connectivity Distinguish Nonresponders from Responders to Dorsomedial Prefrontal Repetitive Transcranial Magnetic Stimulation in Major Depression
Downar, J. H., Geraci, J., Salomons, T. V., Dunlop, K., Wheeler, S. M., McAndrews, M. P., Bakker, N., Blumberger, D. M., Daskalakis, Z. J., Kennedy, S. H., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.026 · Cited by 338 · see citing works
The Brain’s Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample
Stringaris, A., Vidal-Ribas Belil, P., Artiges, E., Lemaitre, H., Gollier-Briant, F., Wolke, S., Vulser, H., Miranda, R., Penttilä, J., Struve, M., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101298 · Cited by 322 · see citing works
Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective
Nusslock, R., & Alloy, L. B. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.001 · Cited by 322 · see citing works
Neuroscience and approach/avoidance personality traits: A two stage (valuation–motivation) approach
Corr, P. J., & McNaughton, N. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.09.013 · Cited by 315 · see citing works
Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum
Kotov, R., Jonas, K. G., Carpenter, W. T., Dretsch, M. N., Eaton, N. R., Forbes, M. K., Forbush, K. T., Hobbs, K. A., Reininghaus, U., Slade, T. N., et al. (2020) · World Psychiatry · doi:10.1002/wps.20730 · Cited by 310 · see citing works
Self-citation
The neuroscience of positive emotions and affect: Implications for cultivating happiness and wellbeing
Alexander, R., Aragón, O. R., Bookwala, J., Cherbuin, N., Gatt, J. M., Kahrilas, I. J., Kästner, N., Lawrence, A. B., Lowe, L. J., Morrison, R., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.002 · Cited by 329 · see citing works
Measurement invariance of the patient health questionnaire‐9 (PHQ‐9) depression screener in U.S. adults across sex, race/ethnicity, and education level: NHANES 2005–2016
Patel, J. S., Oh, Y., Rand, K. L., Wu, W., Cyders, M. A., Kroenke, K., & Stewart, J. C. (2019) · Depression and Anxiety · doi:10.1002/da.22940 · Cited by 306 · see citing works
Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Defining biotypes for depression and anxiety based on large-scale circuit dysfunction: a theoretical review of the evidence and future directions for clinical translation
Williams, L. M. (2016) · Depression and Anxiety · doi:10.1002/da.22556 · Cited by 290 · see citing works
Emotion and decision-making: affect-driven belief systems in anxiety and depression
Paulus, M. P., & Yu, A. J. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.07.009 · Cited by 287 · see citing works
Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients
Yang, X.-H., Huang, J., Zhu, C.-Y., Wang, Y.-F., Cheung, E. F. C., Chan, R. C. K., & Xie, G.-R. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.08.056 · Cited by 288 · see citing works
Evolving Concepts of Emotion and Motivation
Berridge, K. C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01647 · Cited by 273 · see citing works
Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression
Lally, N., Nugent, A. C., Luckenbaugh, D. A., Ameli, R., Roiser, J. P., & Zarate, C. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.105 · Cited by 271 · see citing works
Anhedonia is associated with suicidal ideation independently of depression: A meta-analysis
Ducasse, D., Loas, G., Dassa, D., Gramaglia, C. M., Zeppegno, P., Guillaume, S., Olié, É., & Courtet, P. (2017) · Depression and Anxiety · doi:10.1002/da.22709 · Cited by 270 · see citing works
Development and validation of the Dimensional Anhedonia Rating Scale (DARS) in a community sample and individuals with major depression
Rizvi, S. J., Quilty, L. C., Sproule, B. A., Cyriac, A., Michael Bagby, R., & Kennedy, S. H. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.062 · Cited by 274 · see citing works
Flexible Emotion Regulation: How Situational Demands and Individual Differences Influence the Effectiveness of Regulatory Strategies
Kobylińska, D., & Kusev, P. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00072 · Cited by 289 · see citing works
Amping Up Effort: Effects ofd-Amphetamine on Human Effort-Based Decision-Making
Wardle, M. C., Treadway, M. T., Mayo, L. M., Zald, D. H., & de Wit, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4387-11.2011 · Cited by 258 · see citing works
Self-citation
Mechanisms of Memory Disruption in Depression
Dillon, D. G., & Pizzagalli, D. A. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2017.12.006 · Cited by 254 · see citing works
Reward functioning in PTSD: a systematic review exploring the mechanisms underlying anhedonia
Nawijn, L., van Zuiden, M., Frijling, J. L., Koch, S. B. J., Veltman, D. J., & Olff, M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.019 · Cited by 250 · see citing works
Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression
Satterthwaite, T. D., Kable, J. W., Vandekar, L., Katchmar, N., Bassett, D. S., Baldassano, C. F., Ruparel, K., Elliott, M. A., Sheline, Y. I., Gur, R. C., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.75 · Cited by 249 · see citing works
Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit
Ng, T. H., Alloy, L. B., & Smith, D. V. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0644-x · Cited by 244 · see citing works
An investigation of the relationship between positive affect regulation and depression
Werner-Seidler, A., Banks, R., Dunn, B. D., & Moulds, M. L. (2013) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.11.001 · Cited by 241 · see citing works
Is low positive emotionality a specific risk factor for depression? A meta-analysis of longitudinal studies.
Khazanov, G. K., & Ruscio, A. M. (2016) · Psychological Bulletin · doi:10.1037/bul0000059 · Cited by 240 · see citing works
Reinforcement learning in depression: a review of computational research
Chen, C., Takahashi, T., Nakagawa, S., Inoue, T., & Kusumi, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.005 · Cited by 233 · see citing works
Anhedonia and Substance Dependence: Clinical Correlates and Treatment Options
Hatzigiakoumis, D. S., Martinotti, G., Giannantonio, M. D., & Janiri, L. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00010 · Cited by 238 · see citing works
Why not try harder? Computational approach to motivation deficits in neuro-psychiatric diseases
Pessiglione, M., Vinckier, F., Bouret, S., Jean Daunizeau, A., & Bouc, R. L. (2017) · Brain · doi:10.1093/brain/awx278 · Cited by 230 · see citing works
The Behavioral Activation System and Mania
Johnson, S. L., Edge, M. D., Holmes, M. K., & Carver, C. S. (2012) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032511-143148 · Cited by 230 · see citing works
Building a neuroscience of pleasure and well-being
Berridge, K. C., & Kringelbach, M. L. (2011) · Psychology of Well-Being: Theory, Research and Practice · doi:10.1186/2211-1522-1-3 · Cited by 229 · see citing works
Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain
Thomsen, K. R., Whybrow, P. C., & Kringelbach, M. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00049 · Cited by 235 · see citing works
Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 226 · see citing works
PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression
Guo, N., Wang, X., Xu, M., Bai, J., Yu, H., & Zhang, L. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107300 · Cited by 232 · see citing works
Positive Imagery-Based Cognitive Bias Modification as a Web-Based Treatment Tool for Depressed Adults
Blackwell, S. E., Browning, M. D., Mathews, A., Pictet, A., Welch, J., Davies, J., Watson, P., Geddes, J. R., & Holmes, E. A. (2015) · Clinical Psychological Science · doi:10.1177/2167702614560746 · Cited by 225 · see citing works
Reward-Processing Behavior in Depressed Participants Relative to Healthy Volunteers
Halahakoon, D. C., Kieslich, K., O’Driscoll, C., Nair, A., Lewis, G., & Roiser, J. P. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.2139 · Cited by 222 · see citing works
On what motivates us: a detailed review of intrinsic v. extrinsic motivation
Morris, L. S., Grehl, M. M., Rutter, S., Mehta, M., & Westwater, M. L. (2022) · Psychological Medicine · doi:10.1017/s0033291722001611 · Cited by 226 · see citing works
Neural correlates of change in major depressive disorder anhedonia following open-label ketamine
Lally, N., Nugent, A. C., Luckenbaugh, D. A., Niciu, M. J., Roiser, J. P., & Zarate, C. A. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114568041 · Cited by 224 · see citing works
Parsing Anhedonia
Treadway, M. T., & Zald, D. H. (2013) · Current Directions in Psychological Science · doi:10.1177/0963721412474460 · Cited by 224 · see citing works
Self-citation
Depression: a decision-theoretic analysis
Huys, Q. J. M., Daw, N. D., & Dayan, P. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033928 · Cited by 221 · see citing works
Inflammation and the dimensions of depression: A review
Majd, M., Saunders, E. F. H., & Engeland, C. G. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100800 · Cited by 222 · see citing works
A Transdiagnostic Review of Negative Symptom Phenomenology and Etiology
Strauss, G. P., & Cohen, A. S. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx066 · Cited by 222 · see citing works
Anhedonia in substance use disorders: a systematic review of its nature, course and clinical correlates
Garfield, J. B. B., Lubman, D. I., & Yücel, M. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413508455 · Cited by 213 · see citing works
Bipolar depression: the clinical characteristics and unmet needs of a complex disorder
McIntyre, R. S., & Calabrese, J. R. (2019) · Current Medical Research and Opinion · doi:10.1080/03007995.2019.1636017 · Cited by 211 · see citing works
Neuroscience of Behavioral and Pharmacological Treatments for Addictions
Potenza, M. N., Sofuoglu, M., Carroll, K. M., & Rounsaville, B. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.009 · Cited by 214 · see citing works
PERIL AND PLEASURE: AN RDOC-INSPIRED EXAMINATION OF THREAT RESPONSES AND REWARD PROCESSING IN ANXIETY AND DEPRESSION: Neighborhood Characteristics and Mental Health
Dillon, D. G., Rosso, I. M., Pechtel, P., Killgore, W. D. S., Rauch, S. L., & Pizzagalli, D. A. (2014) · Depression and Anxiety · doi:10.1002/da.22202 · Cited by 209 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression
Borsini, A., Wallis, A. S. J., Zunszain, P., Pariante, C. M., & Kempton, M. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00804-6 · Cited by 207 · see citing works
Mesolimbic Dopamine and the Regulation of Motivated Behavior
Salamone, J. D., Pardo, M., Yohn, S. E., López-Cruz, L., SanMiguel, N., & Correa, M. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_383 · Cited by 204 · see citing works
A resilience framework for promoting stable remission from depression
Waugh, C. E., & Koster, E. H. W. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.05.004 · Cited by 202 · see citing works
Anterior Cingulate Cortexγ-Aminobutyric Acid in Depressed Adolescents: Relationship to Anhedonia
Gabbay, V. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.131 · Cited by 201 · see citing works
Toward a Better Understanding of the Mechanisms and Pathophysiology of Anhedonia: Are We Ready for Translation?
Pizzagalli, D. A. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20220423 · Cited by 204 · see citing works
Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications
Kohls, G., Chevallier, C., Troiani, V., & Schultz, R. T. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-10 · Cited by 197 · see citing works
Amotivation in Schizophrenia: Integrated Assessment With Behavioral, Clinical, and Imaging Measures
Wolf, D. H., Satterthwaite, T. D., Kantrowitz, J. J., Katchmar, N., Vandekar, L., Elliott, M. A., & Ruparel, K. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu026 · Cited by 200 · see citing works
Musical pleasure and reward: mechanisms and dysfunction
Zatorre, R. J. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12677 · Cited by 194 · see citing works
Blunted reward responsiveness in remitted depression
Pechtel, P., Dutra, S. J., Goetz, E. L., & Pizzagalli, D. A. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.08.011 · Cited by 192 · see citing works
The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels
Chen, C., Nakagawa, S., An, Y., Ito, K., Kitaichi, Y., & Kusumi, I. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.001 · Cited by 191 · see citing works
Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play
Savitz, J. B., Rauch, S. L., & Drevets, W. C. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.25 · Cited by 189 · see citing works
Hidden consequences of olfactory dysfunction: a patient report series
Keller, A., & Malaspina, D. (2013) · BMC Ear, Nose and Throat Disorders · doi:10.1186/1472-6815-13-8 · Cited by 177 · see citing works
Anhedonia in depression: biological mechanisms and computational models
Cooper, J. A., Arulpragasam, A. R., & Treadway, M. T. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.024 · Cited by 188 · see citing works
Self-citation
Error-related brain activity in the age of RDoC: A review of the literature
Weinberg, A., Dieterich, R., & Riesel, A. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.02.029 · Cited by 179 · see citing works

Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence
Wang, S., Leri, F., & Rizvi, S. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110289 · Cited by 164 · see citing works
Translational Models of Dopaminergic Mechanisms for Motivational Deficits in Anhedonic Patients
Treadway, M. T., & Zald, D. H. (2014) · Springer eBooks · doi:10.1007/978-94-017-8591-4_7 · Cited by 2 · see citing works
Self-citation
From Neural Circuits to Behavior: Examining the Central Role of Anhedonia in Major Depression
Ghanayem, L. K., Kumar, P., & Rizvi, S. J. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-6872-7_8
Anhedonia as a Crucial Factor of Depression: Assessment, Neurobiological Underpinnings and Treatment
Chow, T. K., Kennedy, S. H., & Rizvi, S. J. (2017) · Springer eBooks · doi:10.1007/978-981-10-6577-4_7 · Cited by 3 · see citing works
Anhedonia in Depression:Definition and Neuralbiological Mechanism
Xin-hu, Y. (2013) · Zhongguo linchuang xinlixue zazhi

Authors: Treadway, M. T., & Zald, D. H.
Affiliations: Vanderbilt University (US)
Corresponding author: Treadway, Michael T.
ORCID: Treadway, Michael T.
Zald, David H.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2011-01
Volume: 35
Issue: 3
Pages: 537-555
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2010.06.006
PMC: PMC3005986
OpenAlex: W2049882268
Cited by: 1,579
References: 357
Citations by year: 2026: 154 · 2025: 141 · 2024: 107 · 2023: 120 · 2022: 93 · 2021: 109 · 2020: 158 · 2019: 107 · 2018: 118 · 2017: 95 · 2016: 93 · 2015: 92 · 2014: 74 · 2013: 51 · 2012: 48
FWCI: 3.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (F31MH087015)
National Institute on Drug Abuse (R01DA019670)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: anhedonia, major depressive disorder, dopamine, reward motivation, translational neuroscience
MeSH terms: Animals, Depression, Dopamine, Humans, Motivation, Neurosciences, Reward, Translational Research, Biomedical

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reconsidering anhedonia in depression: Lessons from translational neuroscience

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks