Cited by 40Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationPrenatal Substance Exposure Effects

Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS α7 nicotinic acetylcholine receptors

Slotkin, Theodore A., Cousins, Mandy M., Seidler, Frederic J.·2004·Brain Research

Abstract

Alpha 7 Nicotinic acetylcholine receptors (nAChRs) play a role in axonogenesis, synaptogenesis and synaptic plasticity, and are therefore targets for developmental neurotoxicants. We administered nicotine to adolescent rats and evaluated the effects on alpha 7 nAChRs in the striatum, brainstem and cerebellum. During the period of nicotine administration (30-47.5 days of age), nicotine elicited alpha 7 nAChR upregulation with a regional hierarchy of striatum>brainstem>cerebellum. Values returned to normal or became slightly subnormal almost immediately after the cessation of treatment (50 days of age) with no further changes through 75 days of age. The temporal and regional patterns of the effects on alpha 7 nAChRs were distinct from those reported earlier for the alpha 4 beta 2 subtype, and neither adult nor fetal/neonatal administration upregulates the alpha 7 subtype in the striatum. Targeting of the striatum is thus unique to nicotine exposure during adolescence and parallels earlier work showing regionally selective effects of this treatment on synaptic signaling. We obtained preliminary evidence for nicotine-induced oxidative stress as a potential contributory mechanism. The present findings reinforce the concept of biologically distinct effects of nicotine in the adolescent brain and provide evidence for a mechanistic involvement of alpha 7 nAChRs in its unique effects during this developmental period.

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Crossref · 10.1016/j.brainres.2004.10.009

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Authors
Slotkin, T. A., Cousins, M. M., & Seidler, F. J.
Affiliations
Duke University (US)
Corresponding author
Slotkin, Theodore A.
Venue
Brain Research
Publisher
Elsevier BV
Published
2004-12
Volume
1030
Issue
1
Pages
159-163
ISSN
0006-8993 (ISSN-L)
OpenAlex
W1988177534
Cited by
40
References
38
Citations by year
2026: 2 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
nicotine, alpha7 nicotinic acetylcholine receptor, adolescent brain development, striatum, brainstem, cerebellum, developmental neurotoxicity, oxidative stress, synaptic plasticity, receptor desensitization
MeSH terms
Age Factors, Animals, Brain, Brain Stem, Cerebellum, Corpus Striatum, Nicotine, Receptors, Nicotinic, Sexual Maturation, Up-Regulation, Rats, Sprague-Dawley, Nicotinic Agonists, Rats, alpha7 Nicotinic Acetylcholine Receptor

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