Cited by 255Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeuroscience and Neuropharmacology Research

Nicotine addiction: the possible role of functional upregulation

Buisson, Bruno, Bertrand, Daniel·2002·Trends in Pharmacological Sciences

Abstract

Upregulation of binding to nicotinic acetylcholine receptors (nAChRs) is observed in the brains of both smokers and animals chronically exposed to nicotine, although whether this in vivo change is accompanied by an increase in receptor function is unknown. In vitro recordings indicate that alpha4beta2- and alpha7-subtypes of nAChRs, which are the most abundant subtypes in the brain, are functionally upregulated following prolonged exposure to nicotine. The possible consequences of functional upregulation for nicotine addiction are discussed. Moreover, we propose a new paradigm that describes the unusual behavior of these neuronal nAChRs and helps to explain the effects of nicotine in the CNS and the diffuse effects of ACh.

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Crossref · 10.1016/s0165-6147(00)01979-9

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Authors
Buisson, B., & Bertrand, D.
Affiliations
University of Geneva (CH)
Corresponding author
Buisson, Bruno
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2002-03
Volume
23
Issue
3
Pages
130-136
ISSN
0165-6147 (ISSN-L)
OpenAlex
W2042529247
Cited by
254
References
55
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 10 · 2013: 8 · 2012: 7
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
nicotine dependence, nicotinic acetylcholine receptors, receptor up-regulation, alpha4beta2 nAChR, alpha7 nAChR, chronic nicotine exposure, receptor function, cholinergic system
MeSH terms
Animals, Binding Sites, Brain, Cells, Cultured, Humans, Neurons, Nicotine, Receptors, Nicotinic, Tobacco Use Disorder, Up-Regulation, Smoking Cessation

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