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Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder

Miller, Christine L., Llenos, Ida C., Dulay, Jeannette R., Weis, Serge·2006·Brain Research
DOI 10.1016/j.brainres.2005.12.056
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Research works printed but not linked: 65

  1. Badawy, 1976, The regulation of rat liver tryptophan pyrrolase activity by reduced nicotinamide-adenine dinucleotide (phosphate), Biochem. J., 156, 381, 10.1042/bj1560381 · DOI
  2. Bara, 2000, Kynurenic acid metabolism in the brain of HIV-1 infected patients, J. Neural Transm., 107, 1127, 10.1007/s007020070026 · DOI
  3. Bloxam, 1974, Error in determination of tryptophan by the method of Denkla and Dewey. A revised procedure, Anal. Biochem., 60, 621, 10.1016/0003-2697(74)90275-9 · DOI · Paper page
  4. Cho-chung, 1967, Feedback control of rat liver tryptophan pyrrolase, J. Biol. Chem., 242, 1192, 10.1016/S0021-9258(18)96163-6 · DOI
  5. Cho-chung, 1968, Regulatory effects of nicotinamide on tryptophan pyrrolase synthesis in rat liver in vivo, Eur. J. Biochem., 3, 401, 10.1111/j.1432-1033.1967.tb19543.x · doi:10.1111/j.1432-1033.1967.tb19543.x
  6. Erhardt, 2001, Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons, Naunyn-Schmiedebergs Arch. Pharmacol., 363, 21, 10.1007/s002100000325 · doi:10.1007/s002100000325
  7. Erhardt, 2003, Kynurenic acid and schizophrenia, Adv. Exp. Med. Biol., 527, 155, 10.1007/978-1-4615-0135-0_18 · DOI
  8. Foster, 1984, Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid, Neurosci. Lett., 48, 273, 10.1016/0304-3940(84)90050-8 · DOI · Paper page
  9. Freedman, 2003, The genetics of sensory gating deficits in schizophrenia, Curr. Psychiatry Rep., 5, 155, 10.1007/s11920-003-0032-2 · DOI · Paper page
  10. Guidetti, 1999, 3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum, Eur. J. Neurosci., 11, 3857, 10.1046/j.1460-9568.1999.00806.x · DOI · Paper page
  11. Guidetti, 2000, Early kynurenergic impairment in Huntington's disease and in a transgenic animal model, Neurosci. Lett., 283, 233, 10.1016/S0304-3940(00)00956-3 · DOI
  12. Guillemin, 2001, Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection, J. Neurochem., 78, 842, 10.1046/j.1471-4159.2001.00498.x · DOI · Paper page
  13. Hayaishi, 1976, Properties and function of indoleamine 2,3-dioxygenase, J. Biochem., 79, 13, 10.1093/oxfordjournals.jbchem.a131115 · DOI
  14. Heyes, 1991, Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease, Neurosci. Lett., 122, 265, 10.1016/0304-3940(91)90874-S · DOI
  15. Heyes, 1998, Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques, FASEB J., 12, 881, 10.1096/fasebj.12.10.881 · DOI
  16. Hilmas, 2001, The brain metabolite kynurenic acid inhibits α7 nicotinic receptor activity and increases non-α7 nicotinic receptor expression: physiopathological implications, J. Neurosci., 21, 7463, 10.1523/JNEUROSCI.21-19-07463.2001 · DOI · Paper page
  17. Hitsman, 2005, Effects of acute tryptophan depletion on negative symptoms: a smoking topography in nicotine-dependent schizophrenics and nonpsychiatric controls, Neuropsychopharmacology, 30, 640, 10.1038/sj.npp.1300651 · DOI
  18. Holmes, 1988, Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography, Anal. Biochem., 172, 518, 10.1016/0003-2697(88)90478-2 · DOI
  19. Horrobin, 1980, Niacin flushing, prostaglandin E and evening primrose oil: a possible objective test for monitoring therapy in schizophrenia, Orthomol. Psychiatry, 9, 33
  20. Ivarsson, 1998, Evaluation of the effects of DNase treatment on signal specificity in RT-PCR and in situ RT-PCR, BioTechniques, 25, 630, 10.2144/98254st04 · doi:10.2144/98254st04
  21. Johnston, 1997, Multivariate analysis of RNA levels from postmortem human brains as measured by three different methods of RT-PCR. Stanley Neuropathology Consortium, J. Neurosci. Methods, 77, 83, 10.1016/S0165-0270(97)00115-5 · DOI
  22. Jurczuk, 2003, Iron body status of rats chronically exposed to cadmium and ethanol, Alcohol Alcohol., 38, 202, 10.1093/alcalc/agg057 · DOI
  23. Korpi, 1986, Neurotransmitter amino acids in post-mortem brains of chronic schizophrenic patients, Psychiatry Res., 22, 291, 10.1016/0165-1781(87)90108-9 · doi:10.1016/0165-1781(87)90108-9
  24. Leonard, 1993, Biological stability of mRNA isolated from human postmortem brain collections, Biol. Psychiatry, 33, 456, 10.1016/0006-3223(93)90174-C · DOI
  25. Leonard, 1996, Nicotinic receptor function in schizophrenia, Schizophr. Bull., 22, 431, 10.1093/schbul/22.3.431 · DOI · Paper page
  26. Littlejohn, 2000, Expression and purification of recombinant human indoleamine 2,3-dioxygenase, Protein Expr. Purif., 19, 22, 10.1006/prep.2000.1214 · DOI
  27. Luntz-Leybman, 1992, Cholinergic gating of response to auditory stimuli in rat hippocampus, Brain Res., 587, 130, 10.1016/0006-8993(92)91437-J · DOI · Paper page
  28. Magni, 1999, Enzymology of NAD+ synthesis, Adv. Enzymol. Relat. Areas Mol. Biol., 73, 135
  29. McCoy, 2002, The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis, J. Clin. Invest., 110, 651, 10.1172/JCI0215528 · DOI · Paper page
  30. Miller, 2003, Methods to optimize the generation of cDNA from postmortem human brain tissue, Brain Res. Protoc., 10, 156, 10.1016/S1385-299X(02)00214-3 · DOI
  31. Miller, 1992, Phencyclidine and auditory sensory gating in the hippocampus of the rat, Neuropharmacology, 31, 1041, 10.1016/0028-3908(92)90106-Y · DOI
  32. Miller, 2004, Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia, Neurobiol. Dis., 15, 618, 10.1016/j.nbd.2003.12.015 · DOI · Paper page
  33. Miller, 2004, Evaluating RNA status for RT-PCR in extracts of postmortem human brain tissue, BioTechniques, 36, 628, 10.2144/04364ST03 · DOI
  34. Morgan, 1992, Effects of acute carbamazepine administration on haem metabolism in rat liver, Biochem. Pharmacol., 43, 1473, 10.1016/0006-2952(92)90204-V · doi:10.1016/0006-2952(92)90204-v
  35. Moroni, 1999, Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites, Eur. J. Pharmacol., 375, 87, 10.1016/S0014-2999(99)00196-X · DOI · Paper page
  36. Morrow, 1989, Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid, Prostaglandins, 38, 263, 10.1016/0090-6980(89)90088-9 · DOI · Paper page
  37. Obrenovitch, 2003, Accumulation of quinolinic acid with neuroinflammation: does it mean excitotoxicity?, Adv. Exp. Med. Biol., 527, 147, 10.1007/978-1-4615-0135-0_17 · DOI
  38. Ogg, 1999, The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration, Magn. Reson. Imaging, 17, 1141, 10.1016/S0730-725X(99)00017-X · DOI · Paper page
  39. Pfefferkorn, 1986, Characterization of an indolemanine 2,3-dioxygenase induced by gamma-interferon in cultured human fibroblasts, J. Interf. Res., 6, 267, 10.1089/jir.1986.6.267 · DOI · Paper page
  40. Pfuhl, 2005, Simultaneous determination of niacin, niacinamide and nicotinuric acid in human plasma, J. Pharm. Biomed. Anal., 36, 1045, 10.1016/j.jpba.2004.08.033 · doi:10.1016/j.jpba.2004.08.033
  41. Preece, 2003, Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance, Brain Res. Mol. Brain Res., 118, 60, 10.1016/S0169-328X(03)00337-1 · DOI · Paper page
  42. Ravikumar, 2000, Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders, Neurol. India, 48, 231
  43. Ren, 1996, Expression of rat liver tryptophan 2,3-dioxygenase in Escherischia coli: structural and functional characterization of the purified enzyme, Arch. Biochem. Biophys., 333, 96, 10.1006/abbi.1996.0368 · DOI
  44. Rice, 2000, Ascorbate regulation and its neuroprotective role in the brain, Trends Neurosci., 23, 209, 10.1016/S0166-2236(99)01543-X · DOI · Paper page
  45. Rosario, 2003, Identification of oxidation products and free radicals of tryptophan by mass spectrometry, J. Am. Soc. Mass Spectrom., 14, 406, 10.1016/S1044-0305(03)00127-2 · DOI
  46. Rybakowski, 1991, Niacin test in schizophrenia and affective illness, Biol. Psychiatry, 29, 834, 10.1016/0006-3223(91)90202-W · DOI
  47. Saareks, 1999, Nicotinic acid and pyridoxine modulate arachidonic acid metabolism in vitro and ex vivo in man, Pharmacol. Toxicol., 84, 274, 10.1111/j.1600-0773.1999.tb01494.x · doi:10.1111/j.1600-0773.1999.tb01494.x
  48. Scherer, 1972, Influence of niacinamide administration on brain 5-HT and a possible mode of action, Life Sci., 11, 189, 10.1016/0024-3205(72)90260-3 · doi:10.1016/0024-3205(72)90260-3
  49. Schutz, 1972, Purification and properties of rat liver tryptophan oxygenase, J. Biol. Chem., 247, 5327, 10.1016/S0021-9258(20)81108-9 · DOI
  50. Schwarcz, 2001, Increased cortical kynurenate content in schizophrenia, Biol. Psychiatry, 50, 521, 10.1016/S0006-3223(01)01078-2 · DOI · Paper page
  51. Shepard, 2003, Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat, Neuropsychopharmacology, 28, 1454, 10.1038/sj.npp.1300188 · DOI
  52. Smesny, 2005, Impaired niacin sensitivity in acute first-episode but not in multi-episode schizophrenia, Prostaglandins, Leukot. Essent. Fat. Acids, 72, 393, 10.1016/j.plefa.2005.02.007 · DOI
  53. Smith, 1997, Relapse of depression after rapid depletion of tryptophan, Lancet, 349, 915, 10.1016/S0140-6736(96)07044-4 · DOI · Paper page
  54. Smythe, 2003, ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue, Adv. Exp. Med. Biol., 527, 705, 10.1007/978-1-4615-0135-0_83 · DOI
  55. Stadtman, 1991, Fenton chemistry. Amino acid oxidation, J. Biol. Chem., 266, 17201, 10.1016/S0021-9258(19)47359-6 · DOI · Paper page
  56. Stevens, 1998, Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice, Psychopharmacology (Berlin), 136, 320, 10.1007/s002130050573 · DOI · Paper page
  57. Stone, 1993, Neuropharmacology of quinolinic and kynurenic acids, Pharmacol. Rev., 45, 309
  58. Swanson, 2003, A role for noradrenergic transmission in the actions of phencyclidine and the antipsychotic and antistress effects of mGlu2/3 receptor agonists, Ann. N. Y. Acad. Sci., 1003, 309, 10.1196/annals.1300.019 · DOI
  59. Torrey, 2000, The Stanley Foundation brain collection and Neuropathology Consortium, Schizophr. Res., 44, 151, 10.1016/S0920-9964(99)00192-9 · DOI · Paper page
  60. Uchida, 1992, Characteristics of substrates and inhibitors in binding to rat liver l-tryptophan 2,3-dioxygenase: a Fourier transform infrared and kinetic study, Biochim. Biophys. Acta, 1121, 153, 10.1016/0167-4838(92)90348-H · DOI
  61. Waldo, 1999, Co-distribution of sensory gating and impaired niacin flush response in the parents of schizophrenics, Schizophr. Res., 40, 49, 10.1016/S0920-9964(99)00031-6 · DOI
  62. Ward, 1998, Niacin skin flush in schizophrenia: a preliminary report, Schizophr. Res., 29, 269, 10.1016/S0920-9964(97)00100-X · DOI
  63. Weis, 1993, Astroglial changes in the cerebral cortex of AIDS brains. A morphometric and immunohistochemical investigation, Neuropathol. Appl. Neurobiol., 19, 329, 10.1111/j.1365-2990.1993.tb00448.x · DOI
  64. Weiss, 2001, Selenium regulation of transcript abundance and translational efficiency of glutathione peroxidase-1 and -4 in rat liver, Biochem. J., 357, 851B, 10.1042/bj3570851 · doi:10.1042/bj3570851
  65. Young, 1985, Tryptophan depletion causes rapid lowering of mood in normal males, Psychopharmacology, 87, 173, 10.1007/BF00431803 · DOI · Paper page

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Metadata

Authors
Miller, C. L., Llenos, I. C., Dulay, J. R., & Weis, S.
Venue
Brain Research
Publisher
Elsevier BV
Published
2006-02
Volume
1073-1074
Pages
25-37
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2005.12.056
OpenAlex
W2050792638
Cited by
242
References
6
FWCI
2.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. https://app.cochat.ai/papers/10.1016/j.brainres.2005.12.056
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Miller, C. L., Llenos, I. C., Dulay, J. R., & Weis, S. (2006). Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Research. https://doi.org/10.1016/j.brainres.2005.12.056

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