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Cited by 25Acute Ischemic Stroke ManagementStroke Rehabilitation and RecoveryNeurological Disease Mechanisms and Treatments

The quantitative assessment of functional impairment and its correlation to infarct volume in rats with transient middle cerebral artery occlusion

Lim, Seong Hoon, Lee, Jung Soo, Lee, Jong In, Im, Sun, Ko, Young Jin, Kim, Hye Won·2008·Brain Research
DOI 10.1016/j.brainres.2008.07.002
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Abstract

The purpose of this study was to quantitatively assess motor activity and sensory functions and to determine their relationships to infarct severity by measuring infarct volume in rats with transient ischemic stroke. Male Sprague-Dawley rats (11 weeks old, n = 42) were randomly divided into 4 separate groups; a sham operation group, and 1-h, 2-h and 3-h middle cerebral artery occlusion (MCAO) groups. Percent weights borne on paretic hind limbs were measured consecutively for 7 days starting from the day before the induction of ischemia. Fifty percent withdrawal threshold values of forepaws and hindpaws were measured using von-Frey hairs. Infarct volumes in the three ischemic groups, which were significantly different (p < 0.01) from each other, were found to increase in size with ischemic time. The percent weight borne on paretic hind limb in the three MCAO groups were significantly lower than that in the sham group, and this functional deficit remained significant throughout the observational period (p < 0.01). A significant correlation was found between infarct volumes and percent weight borne on paretic hind limbs after ischemia (-0.7 < rho < -0.4, p < 0.05). In contrast the 50% withdrawal threshold values of paretic forepaws and hindpaws in the three ischemic groups were not significantly different from those of the sham controls. Motor test findings, which were used to assess reductions in paretic hind limb weightbearing, were shown to be correlated with infarct volume. The present study shows that this test could be used as a tool to objectively and quantitatively assess functional outcome in MCAO rats.

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  • Neurons in the IBZ may be salvageable, and their viability has been correlated to positive functional outcomes.

    “Neurons in the IBZ may be salvageable, and the viability of these cells has been correlated to positive functional outcomes [3].”

    From MicroRNA‐21 protects neurons from ischemic death (2010) · cites this paper as [3]

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Cited by

Sorted by citations

Authors
Lim, S. H., Lee, J. S., Lee, J. I., Im, S., Ko, Y. J., & Kim, H. W.
Affiliations
Catholic University of Korea (KR)
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2008-09
Volume
1230
Pages
303-309
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2008.07.002
OpenAlex
W2073647421
Cited by
25
References
1
Citations by year
2024: 1 · 2023: 2 · 2022: 3 · 2019: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 1
FWCI
1.99
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
transient middle cerebral artery occlusion, ischemic stroke, infarct size, functional disability, weight bearing, sensory function, withdrawal threshold, ischemic time, motor impairment, stroke outcome assessment
MeSH terms
Animals, Behavior, Animal, Data Interpretation, Statistical, Forelimb, Hindlimb, Functional Laterality, Male, Motor Activity, Paresis, Pressure, Psychometrics, Psychomotor Performance, Sensation, Sensory Thresholds, Weight-Bearing, Rats, Sprague-Dawley, Infarction, Middle Cerebral Artery, Rats

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