Cited by 389Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

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Brain stress systems in the amygdala and addiction

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Koob, George F.·2009·Brain Research

DOI 10.1016/j.brainres.2009.03.038PMC PMC2774745

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Abstract

Dysregulation of the brain emotional systems that mediate arousal and stress is a key component of the pathophysiology of drug addiction. Drug addiction is a chronically relapsing disorder characterized by a compulsion to seek and take drugs and the development of dependence and manifestation of a negative emotional state when the drug is removed. Activation of brain stress systems is hypothesized to be a key element of the negative emotional state produced by dependence that drives drug-seeking through negative reinforcement mechanisms. The focus of the present review is on the role of two key brain arousal/stress systems in the development of dependence. Emphasis is placed on the neuropharmacological actions of corticotropin-releasing factor (CRF) and norepinephrine in extrahypothalamic systems in the extended amygdala, including the central nucleus of the amygdala, bed nucleus of the stria terminalis, and a transition area in the shell of the nucleus accumbens. Compelling evidence argues that these brain stress systems, a heretofore largely neglected component of dependence and addiction, play a key role in engaging the transition to dependence and maintaining dependence once it is initiated. Understanding the role of the brain stress and anti-stress systems in addiction not only provides insight into the neurobiology of the "dark side" of addiction but also provides insight into the organization and function of basic brain emotional circuitry that guides motivated behavior.

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Authors: Koob, G. F.
Affiliations: Scripps Research Institute (US)
Corresponding author: Koob, George F.
ORCID: Koob, George F.
Venue: Brain Research
Publisher: Elsevier BV
Published: 2009-10
Volume: 1293
Pages: 61-75
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2009.03.038
PMC: PMC2774745
OpenAlex: W2010555262
Cited by: 388
References: 112
Citations by year: 2026: 11 · 2025: 10 · 2024: 22 · 2023: 17 · 2022: 20 · 2021: 24 · 2020: 31 · 2019: 33 · 2018: 34 · 2017: 20 · 2016: 25 · 2015: 28 · 2014: 24 · 2013: 24 · 2012: 20
FWCI: 1.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA008459, AA-06420, AA-08459, P50AA006420, R37AA008459, P60AA006420)
National Institute on Drug Abuse (DA04043, DA04398, R01DA004398, R01DA004043)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: drug addiction, extended amygdala, corticotropin-releasing factor, norepinephrine, central amygdala, bed nucleus of the stria terminalis, nucleus accumbens shell, negative reinforcement, emotional arousal, relapse, motivated behavior
MeSH terms: Amygdala, Animals, Compulsive Behavior, Corticotropin-Releasing Hormone, Humans, Hypothalamo-Hypophyseal System, Motivation, Norepinephrine, Pituitary-Adrenal System, Stress, Psychological, Substance Withdrawal Syndrome, Substance-Related Disorders

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Brain stress systems in the amygdala and addiction

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