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The α1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration

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Management of the Alcohol withdrawal Syndrome

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‘Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration

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Effects of Neuropeptide Y on Sucrose and Ethanol Intake and on Anxiety‐Like Behavior in High Alcohol Drinking (HAD) and Low Alcohol Drinking (LAD) Rats

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Neurocircuitry of Addiction

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The neuro-symphony of stress

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Drug addiction: updating actions to habits to compulsions ten years on

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Reward Processing by the Opioid System in the Brain

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Amygdala inhibitory circuits and the control of fear memory

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Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making

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From the ventral to the dorsal striatum: devolving views of their roles in drug addiction

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Diverging neural pathways assemble a behavioural state from separable features in anxiety

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Understanding the broad influence of sex hormones and sex differences in the brain

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The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors

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Factors modulating neural reactivity to drug cues in addiction: a survey of human neuroimaging studies

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Addiction as a stress surfeit disorder

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ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses

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Neurobiology of opioid addiction: Opponent process, hyperkatifeia, and negative reinforcement

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Stress-induced reinstatement of drug seeking: 20 years of progress

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Dynorphin, stress, and depression

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The dark side of emotion: the addiction perspective

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Nicotine addiction and nicotinic receptors: lessons from genetically modified mice

Changeux, J.-P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2849 · Cited by 453 · see citing works

Addiction is a Reward Deficit and Stress Surfeit Disorder

Koob, G. F. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00072 · Cited by 397 · see citing works

Brain stress systems in the amygdala and addiction

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Reward, addiction, withdrawal to nicotine

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Effects of Adrenal Sensitivity, Stress- and Cue-Induced Craving, and Anxiety on Subsequent Alcohol Relapse and Treatment Outcomes

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Stress and multiple memory systems: from ‘thinking’ to ‘doing’

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Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence

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Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

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Gabapentin Treatment for Alcohol Dependence: A Randomized Clinical Trial

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Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories – indications for novel treatments of addiction

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Addiction and Stress: An Allostatic View

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Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking

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The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction

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Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state

Richardson, H. N., Lee, S. Y., O’Dell, L. E., Koob, G. F., & Rivier, C. L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06455.x · Cited by 294 · see citing works

Mindfulness-based treatment of addiction: current state of the field and envisioning the next wave of research

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Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models

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A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development

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Neighborhood matters: divergent patterns of stress-induced plasticity across the brain

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The role of glucagon‐like peptide 1 (GLP‐1) in addictive disorders

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Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction

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Food addiction and associations with mental health symptoms: A systematic review with meta-analysis

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“White Box” Epidemiology and the Social Neuroscience of Health Behaviors: The Environmental Affordances Model

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Improving translation of animal models of addiction and relapse by reverse translation

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Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain

Shurman, J., Koob, G. F., & Gutstein, H. B. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.00881.x · Cited by 215 · see citing works

kappa-Opioid receptor signaling and brain reward function

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Retraining the addicted brain: A review of hypothesized neurobiological mechanisms of mindfulness-based relapse prevention.

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NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

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CRF system recruitment mediates dark side of compulsive eating

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Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems

George, O., Le Moal, M., & Koob, G. F. (2012) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2011.11.004 · Cited by 184 · see citing works

A meta-analysis of longitudinal associations between substance use and interpersonal attachment security

Fairbairn, C. E., Briley, D. A., Kang, D., Fraley, R. C., Hankin, B. L., & Ariss, T. (2018) · Psychological Bulletin · doi:10.1037/bul0000141 · Cited by 182 · see citing works

Operant alcohol self-administration in dependent rats: Focus on the vapor model

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Recent advances in the genetic epidemiology and molecular genetics of substance use disorders

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Polymodal activation of the endocannabinoid system in the extended amygdala

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Addiction as a coping response: hyperkatifeia, deaths of despair, and COVID-19

Koob, G. F., Powell, P., & White, A. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20091375 · Cited by 166 · see citing works

Impaired Emotional-Like Behavior and Serotonergic Function During Protracted Abstinence from Chronic Morphine

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Development of pharmacotherapies for drug addiction: a Rosetta stone approach

Koob, G. F., Kenneth Lloyd, G., & Mason, B. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2828 · Cited by 154 · see citing works

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats

de Guglielmo, G., Kallupi, M., Pomrenze, M. B., Crawford, E., Simpson, S., Schweitzer, P., Koob, G. F., Messing, R. O., & George, O. (2019) · Nature Communications · doi:10.1038/s41467-019-09183-0 · Cited by 127 · see citing works

Mindfulness-based treatments for co-occurring depression and substance use disorders: what can we learn from the brain?

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The association between negative affect and prescription opioid misuse in patients with chronic pain: the mediating role of opioid craving

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Annual research review: on the developmental neuropsychology of substance use disorders

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The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice

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Neurofunctional domains derived from deep behavioral phenotyping in alcohol use disorder

Kwako, L. E., Schwandt, M. L., Ramchandani, V. A., Diazgranados, N., Koob, G. F., Volkow, N. D., Blanco, C., & Goldman, D. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.18030357 · Cited by 138 · see citing works

Agency and the Calibration of Motivated Behavior

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Activation of the hypothalamic–pituitary–adrenal axis by addictive drugs: different pathways, common outcome

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Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake

Schlosburg, J. E., Whitfield, T. W., Park, P. E., Crawford, E. F., George, O., Vendruscolo, L. F., & Koob, G. F. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1979-13.2013 · Cited by 119 · see citing works

Existing and future drugs for the treatment of the dark side of addiction

Koob, G. F., & Mason, B. J. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103143 · Cited by 121 · see citing works

The Role of the Central Amygdala in Alcohol Dependence

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Craving in response to stress induction in a human laboratory paradigm predicts treatment outcome in alcohol-dependent individuals

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Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin

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Hedonic homeostatic dysregulation as a driver of drug-seeking behavior

Koob, G. F. (2008) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2009.04.002 · Cited by 114 · see citing works

Extended Heroin Access Increases Heroin Choices Over a Potent Nondrug Alternative

Lenoir, M., Cantin, L., Vanhille, N., Serre, F., & Ahmed, S. H. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.17 · Cited by 114 · see citing works

Changes in Cerebral CB₁Receptor Availability after Acute and Chronic Alcohol Abuse and Monitored Abstinence

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Central amygdala circuits mediate hyperalgesia in alcohol-dependent rats

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The neurobiology of appetite: hunger as addiction.

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Mindfulness meditation in the treatment of substance use disorders and preventing future relapse: neurocognitive mechanisms and clinical implications

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Gabapentin for the treatment of alcohol use disorder

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Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats

Gilpin, N. W., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1967-8 · Cited by 99 · see citing works

Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking

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Endocannabinoid-mediated synaptic plasticity and addiction-related behavior

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Gabapentin enacarbil extended-release for alcohol use disorder: a randomized, double-blind, placebo-controlled, multisite trial assessing efficacy and safety

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Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats

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