Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works

Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965 · see citing works

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904 · see citing works

Neurons containing hypocretin (orexin) project to multiple neuronal systems

Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466 · see citing works

Drug Addiction, Dysregulation of Reward, and Allostasis

Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953 · see citing works

Drug abuse: hedonic homeostatic dysregulation

Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535 · see citing works

Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors

Washton, A. M. (1986) · Journal of Studies on Alcohol · doi:10.15288/jsa.1986.47.260 · Cited by 2,531 · see citing works

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

Meunier, J., Mollereau, C., Toll, L., Suaudeau, C., Moisand, C., Alvinerie, P., Butour, J., Guillemot, J.-C., Ferrara, P., Monsarrat, B., et al. (1995) · Nature · doi:10.1038/377532a0 · Cited by 1,915 · see citing works

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

Reinscheid, R. K., Nothacker, H., Bourson, A., Ardati, A., Henningsen, R. A., Bunzow, J. R., Grandy, D. K., Langen, H., Monsma, F. J., & Civelli, O. (1995) · Science · doi:10.1126/science.270.5237.792 · Cited by 1,824 · see citing works

The reinstatement model of drug relapse: history, methodology and major findings

Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works

How does stress increase risk of drug abuse and relapse?

Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works

The Neuroscience of Natural Rewards: Relevance to Addictive Drugs

Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,465 · see citing works

A role for lateral hypothalamic orexin neurons in reward seeking

Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005) · Nature · doi:10.1038/nature04071 · Cited by 1,311 · see citing works

Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point

Ahmed, S. H., & Koob, G. F. (1998) · Science · doi:10.1126/science.282.5387.298 · Cited by 1,159 · see citing works

A Role for Brain Stress Systems in Addiction

Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056 · see citing works

Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression

Chalmers, D., Lovenberg, T. W., & Souza, E. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06340.1995 · Cited by 925 · see citing works

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M. H. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F., & Wurst, W. (1998) · Nature Genetics · doi:10.1038/520 · Cited by 919 · see citing works

Stress dysregulation of drug reward pathways, and the transition to drug dependence

Koob, & Kreek, M. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.05030503 · Cited by 868 · see citing works

Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.

Lovenberg, T. W., Liaw, C. W., Grigoriadis, D. E., Clevenger, W., Chalmers, D. T., Souza, E. B. D., & Oltersdorf, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.836 · Cited by 846 · see citing works

To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness

Willie, J. T., Chemelli, R. M., Sinton, C. M., & Yanagisawa, M. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.429 · Cited by 768 · see citing works

Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine

Borgland, S. L., Taha, S. A., Sarti, F., Fields, H. L., & Bonci, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.016 · Cited by 718 · see citing works

Stress-induced relapse to heroin and cocaine seeking in rats: a review

Shaham, Y., Erb, S. M., & Stewart, J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00024-2 · Cited by 703 · see citing works

The role of stress in drug self-administration

Piazza, P. V., & Moal, M. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01115-2 · Cited by 674 · see citing works

Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis

Pich, E., Lorang, M., Yeganeh, M., Rodriguez de Fonseca, F., Raber, J., Koob, G., & Weiss, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05439.1995 · Cited by 565 · see citing works

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., & de Lecea, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507480102 · Cited by 520 · see citing works

Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal

Rodrı́guez de Fonseca, F., Carrera, M. R. A., Navarro, M., Koob, G. F., & Weiss, F. (1997) · Science · doi:10.1126/science.276.5321.2050 · Cited by 499 · see citing works

Role of Corticotropin-Releasing Factor in Drug Addiction

Logrip, M. L., Koob, G. F., & Zorrilla, E. P. (2011) · CNS Drugs · doi:10.2165/11587790-000000000-00000 · Cited by 476 · see citing works

Relapse prevention: introduction and overview of the model

Marlatt, G. A., & George, W. H. (1984) · British Journal of Addiction · doi:10.1111/j.1360-0443.1984.tb03867.x · Cited by 476 · see citing works

Relapse Prevention: Introduction and Overview of the Model

Marlatt, G. A., & George, W. H. (1984) · British Journal of Addiction · doi:10.1111/j.1360-0443.1984.tb00274.x · Cited by 475 · see citing works

Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response

Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A. J., Sakurai, T., Kilduff, T. S., Horvath, T. L., & de Lecea, L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3459-04.2004 · Cited by 462 · see citing works

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

Edwards, C., Abusnana, S., Sunter, D., Murphy, K. G., Ghatei, M. A., & Bloom, S. R. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.160r007 · Cited by 433 · see citing works

Compulsive Drug‐Seeking Behavior and Relapse: Neuroadaptation, Stress, and Conditioning Factors

WEISS, F., CICCOCIOPPO, R., PARSONS, L. H., KATNER, S., LIU, X., ZORRILLA, E. P., VALDEZ, G. R., BEN‐SHAHAR, O., ANGELETTI, S., & RICHTER, R. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03556.x · Cited by 430 · see citing works

Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load

Schulkin, J., W. Gold, P., & S. McEwen, B. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00099-1 · Cited by 423 · see citing works

The hypocretins: Setting the arousal threshold

Sutcliffe, J. G., & de Lecea, L. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn808 · Cited by 416 · see citing works

Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat: an immunohistochemical study

Cummings, S., Elde, R., Ells, J., & Lindall, A. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-07-01355.1983 · Cited by 414 · see citing works

Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal

Rassnick, S., Heinrichs, S. C., Britton, K. T., & Koob, G. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91352-s · Cited by 407 · see citing works

Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat

Neal, C. R., Mansour, A., Reinscheid, R. K., Nothacker, H., Civelli, O., & Watson, S. J. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990419)406:4 · Cited by 399 · see citing works

The orexin system regulates alcohol-seeking in rats

Lawrence, A. J., Cowen, M. S., Yang, H., Chen, F., & Oldfield, B. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706789 · Cited by 392 · see citing works

Neurobiological evidence for hedonic allostasis associated with escalating cocaine use

Ahmed, S. H., Kenny, P. J., Koob, G. F., & Markou, A. (2002) · Nature Neuroscience · doi:10.1038/nn872 · Cited by 389 · see citing works

Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor

Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02448.x · Cited by 387 · see citing works

Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats

Funk, C. K., O'Dell, L. E., Crawford, E. F., & Koob, G. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3096-06.2006 · Cited by 381 · see citing works

The Role of Corticotropin-Releasing Factor in Drug Addiction

Sarnyai, Z., Shaham, Y., & Heinrichs, S. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01492-3 · Cited by 381 · see citing works

Stress, vulnerability and adult alcohol relapse.

Brown, S. A., Vik, P. W., Patterson, T. L., Grant, I., & Schuckit, M. A. (1995) · Journal of Studies on Alcohol · doi:10.15288/jsa.1995.56.538 · Cited by 380 · see citing works

Orphanin FQ is a functional anti-opioid peptide

Mogil, J. S., Grisel, J. E., Reinscheid, R. K., Civelli, O., Belknap, J. K., & Grandy, D. K. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00338-7 · Cited by 374 · see citing works

Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking

Wang, B., Shaham, Y., Zitzman, D., Azari, S., Wise, R. A., & You, Z.-B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0955-05.2005 · Cited by 369 · see citing works

Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.

Stewart, J. (2000) · PubMed Central · Cited by 361 · see citing works

Additive Effect of Stress and Drug Cues on Reinstatement of Ethanol Seeking: Exacerbation by History of Dependence and Role of Concurrent Activation of Corticotropin-Releasing Factor and Opioid Mechanisms

Liu, X., & Weiss, F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07856.2002 · Cited by 359 · see citing works

Cocaine but Not Natural Reward Self-Administration nor Passive Cocaine Infusion Produces Persistent LTP in the VTA

Chen, B. T., Bowers, M. S., Martín, M., Hopf, F. W., Guillory, A. M., Carelli, R. M., Chou, J., & Bonci, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.024 · Cited by 353 · see citing works

A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

Kelley, A. E., Baldo, B. A., & Pratt, W. E. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20769 · Cited by 352 · see citing works

Overlapping distributions of orexin/hypocretin‐ and dopamine‐β‐hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress

Baldo, B. A., Daniel, R. A., Berridge, C. W., & Kelley, A. E. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10783 · Cited by 346 · see citing works

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

Borgland, S. L., Chang, S., Bowers, M. S., Thompson, J. L., Vittoz, N. M., Floresco, S., Chou, J., Chen, B. T., & Bonci, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6096-08.2009 · Cited by 341 · see citing works

A selective orexin-1 receptor antagonist reduces food consumption in male and female rats

Haynes, A. C., Jackson, B., Chapman, H., Tadayyon, M., Johns, A., Porter, R. A., & Arch, J. R. S. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00199-3 · Cited by 338 · see citing works

The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy

Taheri, S., Zeitzer, J. M., & Mignot, E. J.-M. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142826 · Cited by 333 · see citing works

Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence

Sommer, W. H., Rimondini, R., Hansson, A. C., Hipskind, P. A., Gehlert, D. R., Barr, C. S., & Heilig, M. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.010 · Cited by 309 · see citing works

Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more

Darland, T., Heinricher, M. M., & Grandy, D. K. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01204-6 · Cited by 308 · see citing works

Long-lasting increase in the set point for cocaine self-administration after escalation in rats

Ahmed, S. H., & Koob, G. F. (1999) · Psychopharmacology · doi:10.1007/s002130051121 · Cited by 303 · see citing works

Corticotropin-Releasing Factor Requires CRF Binding Protein to Potentiate NMDA Receptors via CRF Receptor 2 in Dopamine Neurons

Ungless, M. A., Singh, V., Crowder, T. L., Yaka, R., Ron, D., & Bonci, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00461-6 · Cited by 297 · see citing works

Insular hypocretin transmission regulates nicotine reward

Hollander, J. A., Lu, Q., Cameron, M. D., Kamenecka, T. M., & Kenny, P. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808023105 · Cited by 296 · see citing works

Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state

Richardson, H. N., Lee, S. Y., O’Dell, L. E., Koob, G. F., & Rivier, C. L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06455.x · Cited by 294 · see citing works

A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats

Salmaso, N., Rodaros, D., Stewart, J., & Erb, S. (2001) · Psychopharmacology · doi:10.1007/s002130000642 · Cited by 291 · see citing works

Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats

Shalev, U., Morales, M., Hope, B. T., Yap, J. J., & Shaham, Y. (2001) · Psychopharmacology · doi:10.1007/s002130100748 · Cited by 290 · see citing works

Stress and Cocaine Addiction

Goeders, N. E. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.785 · Cited by 286 · see citing works

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats

Funk, C. K., Zorrilla, E. P., Lee, M.-J., Rice, K. C., & Koob, G. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.063 · Cited by 276 · see citing works

Blunted Stress Cortisol Response in Abstinent Alcoholic and Polysubstance-Abusing Men

Lovallo, W. R., Dickensheets, S. L., Myers, D. A., Thomas, T. L., & Nixon, S. J. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02036.x · Cited by 266 · see citing works

Brain corticotropin-releasing factor mediates ‘anxiety-like’ behavior induced by cocaine withdrawal in rats

Sarnyai, Z., Bíró, É., Gardi, J., Vecsernyés, M., Julesz, J., & Telegdy, G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00043-p · Cited by 255 · see citing works

Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress

Hansson, A. C., Cippitelli, A., Sommer, W. H., Fedeli, A., Björk, K., Soverchia, L., Terasmaa, A., Massi, M. N., Heilig, M. A., & Ciccocioppo, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604419103 · Cited by 250 · see citing works

Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats

Zorrilla, E. P., Valdez, G. R., & Weiss, F. (2001) · Psychopharmacology · doi:10.1007/s002130100773 · Cited by 246 · see citing works

Corticotropin Releasing Factor (CRF) Binding Protein: A Novel Regulator of CRF and Related Peptides

Behan, D. P., Souza, E. B. D., Lowry, P. J., Potter, E., Sawchenko, P. E., & Vale, W. W. (1995) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1995.1013 · Cited by 243 · see citing works

Alterations in the Hypothalamic-Pituitary-Adrenal Axis in Actively Drinking Alcoholics*

Wand, G. S., & Dobs, A. S. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-6-1290 · Cited by 242 · see citing works

Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake

Olive, M. F., Koenig, H. N., Nannini, M. A., & Hodge, C. W. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00748-1 · Cited by 237 · see citing works

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats

Richards, J. K., Simms, J. A., Steensland, P., Taha, S. A., Borgland, S. L., Bonci, A., & Bartlett, S. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1136-5 · Cited by 234 · see citing works

Functional antagonism of μ-, δ- and κ-opioid antinociception by orphanin FQ

Mogil, J. S., Grisel, J. E., Zhangs, G., Belknap, J. K., & Grandy, D. K. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12917-7 · Cited by 227 · see citing works

Neurobiology of relapse to alcohol in rats

Lê, A. D., & Shaham, Y. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00200-0 · Cited by 227 · see citing works

Stimuli Linked to Ethanol Availability Activate Hypothalamic CART and Orexin Neurons in a Reinstatement Model of Relapse

Dayas, C. V., McGranahan, T. M., Martin‐Fardon, R., & Weiss, F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.002 · Cited by 223 · see citing works

Lateral hypothalamic neuropeptides in reward and drug addiction

Dileone, R., Georgescu, D., & Nestler, E. J. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00408-9 · Cited by 220 · see citing works

Chronic Daily Ethanol and Withdrawal: 1. Long-Term Changes in the Hypothalamo-Pituitary-Adrenal Axis

Rasmussen, D. D., Boldt, B. M., Bryant, C. A., Mitton, D. R., Larsen, S. A., & Wilkinson, C. W. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb01988.x · Cited by 216 · see citing works

Stress-induced relapse to cocaine seeking: roles for the CRF2 receptor and CRF-binding protein in the ventral tegmental area of the rat

Wang, B., You, Z., Rice, K. C., & Wise, R. A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0782-3 · Cited by 207 · see citing works

Psychological and environmental determinants of relapse in crack cocaine smokers

Wallace, B. C. (1989) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(89)90036-6 · Cited by 198 · see citing works

Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area

Rodaros, D., Caruana, D. A., Amir, S., & Stewart, J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.043 · Cited by 194 · see citing works

Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats

Basso, A. M., Spina, M. G., Rivier, J., Vale, W., & Koob, G. F. (1999) · Psychopharmacology · doi:10.1007/s002130051028 · Cited by 190 · see citing works

Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor.

Valdez, G. R., Roberts, A., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · PubMed · doi:10.1097/01.alc.0000033120.51856.f0 · Cited by 187 · see citing works

Effects of Orexins on the Hypothalamic‐Pituitary‐Adrenal System

Jászberényi, M., Bujdosó, E., Pataki, I., & Telegdy, G. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00572.x · Cited by 175 · see citing works

Paraventricular thalamus mediates context‐induced reinstatement (renewal) of extinguished reward seeking

Hamlin, A. S., Clemens, K. J., Choi, E. A., & McNally, G. P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06623.x · Cited by 175 · see citing works

The therapeutic potential of CRF1 antagonists for anxiety

Zorrilla, E., & Koob, G. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.7.799 · Cited by 173 · see citing works

Acquisition, Expression, and Reinstatement of Ethanol-Induced Conditioned Place Preference in Mice: Effects of Opioid Receptor-Like 1 Receptor Agonists and Naloxone

Kuzmin, A., Sandin, J., Terenius, L. Y., & Ögren, S. O. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041350 · Cited by 173 · see citing works

Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors

Overstreet, D. H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.11.010 · Cited by 169 · see citing works

Nociceptin prevents stress-induced ethanol-but not cocaine-seeking behavior in rats

Martin‐Fardon, R., Ciccocioppo, R., Massi, M., & Weiss, F. (2000) · Neuroreport · doi:10.1097/00001756-200006260-00026 · Cited by 168 · see citing works

REVIEW: Genetically selected Marchigian Sardinian alcohol‐preferring (msP) rats: an animal model to study the neurobiology of alcoholism

Ciccocioppo, R., Economidou, D., Cippitelli, A., Cucculelli, M., Ubaldi, M., Soverchia, L., Lourdusamy, A., & Massi, M. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00032.x · Cited by 168 · see citing works

Orphanin FQ/Nociceptin Modulation of Mesolimbic Dopamine Transmission Determined by Microdialysis

Murphy, N. P., & Maidment, N. T. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730179.x · Cited by 167 · see citing works

Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats

Ciccocioppo, R., Economidou, D., Fedeli, A., Angeletti, S., Weiss, F., Heilig, M. A., & Massi, M. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1645-1 · Cited by 167 · see citing works

Predictable individual differences in the initiation of cocaine self-administration by rats under extended-access conditions are dose-dependent

Mantsch, J. R., Ho, A., Schlussman, S. D., & Kreek, M. J. (2001) · Psychopharmacology · doi:10.1007/s002130100744 · Cited by 160 · see citing works

Dissociation of Psychomotor Sensitization from Compulsive Cocaine Consumption

Ahmed, S. H., & Cador, M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300834 · Cited by 158 · see citing works

Orphanin FQ/nociceptin blocks acquisition of morphine place preference

Murphy, N. P., Lee, Y., & Maidment, N. T. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01425-0 · Cited by 155 · see citing works

Categorically Distinct Acute Stressors Elicit Dissimilar Transcriptional Profiles in the Paraventricular Nucleus of the Hypothalamus

Reyes, T. M., Walker, J. R., DeCino, C., Hogenesch, J. B., & Sawchenko, P. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05607.2003 · Cited by 149 · see citing works

Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice

Haynes, A. C., Chapman, H., Taylor, C., Moore, G. B. T., Cawthorne, M. A., Tadayyon, M., Clapham, J. C., & Arch, J. R. S. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00358-5 · Cited by 142 · see citing works

The Bed Nucleus Is a Neuroanatomical Substrate for the Anorectic Effect of Corticotropin-Releasing Factor and for Its Reversal by Nociceptin/Orphanin FQ

Ciccocioppo, R., Fedeli, A., Economidou, D., Policani, F., Weiss, F., & Massi, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09445.2003 · Cited by 137 · see citing works

Effect of nociceptin/orphanin FQ on the rewarding properties of morphine

Ciccocioppo, R., Angeletti, S., Sanna, P. P., Weiss, F., & Massi, M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00590-2 · Cited by 136 · see citing works

Reinstatement of Cocaine Seeking by Hypocretin (Orexin) in the Ventral Tegmental Area: Independence from the Local Corticotropin-Releasing Factor Network

Wang, B., You, Z., & Wise, R. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.018 · Cited by 135 · see citing works

Stress-Induced Intracellular Trafficking of Corticotropin-Releasing Factor Receptors in Rat Locus Coeruleus Neurons

Reyes, B. A. S., Valentino, R. J., & Bockstaele, E. J. V. (2007) · Endocrinology · doi:10.1210/en.2007-0705 · Cited by 134 · see citing works

Orexin/hypocretin is necessary for context-driven cocaine-seeking

Smith, R. J., Tahsili‐Fahadan, P., & Aston‐Jones, G. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.042 · Cited by 131 · see citing works

The Role of Corticotropin-Releasing Factor in the Median Raphe Nucleus in Relapse to Alcohol

Lê, A. D., Harding, S., Juzytsch, W., Fletcher, P. J., & Shaham, Y. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07844.2002 · Cited by 130 · see citing works

Effect of nociceptin on alcohol intake in alcohol-preferring rats

Ciccocioppo, R., Panocka, I., Polidori, C., Regoli, D. C., & Massi, M. (1999) · Psychopharmacology · doi:10.1007/s002130050828 · Cited by 130 · see citing works

SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats

Knapp, D. J., Overstreet, D. H., Moy, S. S., & Breese, G. R. (2004) · Alcohol · doi:10.1016/j.alcohol.2003.08.007 · Cited by 130 · see citing works

CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats

Specio, S. E., Wee, S., O’Dell, L. E., Boutrel, B., Zorrilla, E. P., & Koob, G. F. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0983-9 · Cited by 129 · see citing works

Making a bad thing worse: adverse effects of stress on drug addiction

Cleck, J. N., & Blendy, J. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33946 · Cited by 122 · see citing works

Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat

Economidou, D., Hansson, A. C., Weiss, F., Terasmaa, A., Sommer, W. H., Cippitelli, A., Fedeli, A., Martin-Fardon, R., Massi, M., Ciccocioppo, R., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.004 · Cited by 120 · see citing works

Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist

Breese, G. R., Knapp, D. J., & Overstreet, D. H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300282 · Cited by 115 · see citing works

Central administration of nociceptin/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice

Sakoori, K., & Murphy, N. P. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1643-3 · Cited by 112 · see citing works

Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ

Morgan, M. M., Grisel, J. E., Robbins, C. S., et al. (1997) · Neuroreport · doi:10.1097/00001756-199711100-00003 · Cited by 109 · see citing works

Ethanol Exposure Decreases Pituitary Corticotropin-Releasing Factor Binding, Adenylate Cyclase Activity, Proopiomelanocortin Biosynthesis, and Plasmaβ-Endorphin Levels in the Rat

Dave, J. R., Eiden, L. E., Karanian, J. W., & Eskay, R. L. (1986) · Endocrinology · doi:10.1210/endo-118-1-280 · Cited by 107 · see citing works

Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia

Xie, X., Wisor, J. P., Hara, J., Crowder, T. L., LeWinter, R. D., Khroyan, T. V., Yamanaka, A., Diano, S., Horváth, T. L., Sakurai, T., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35115 · Cited by 106 · see citing works

Effects of Dose and Session Duration on Cocaine Self-Administration in Rats

Wee, S., Specio, S. E., & Koob, G. F. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.113340 · Cited by 105 · see citing works

Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats

Sabino, V., Cottone, P., Koob, G. F., Steardo, L., Lee, M. J., Rice, K. C., & Zorrilla, E. P. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0546-5 · Cited by 105 · see citing works

The Corticotropin-Releasing Factor1 Receptor Antagonist R121919 Attenuates the Behavioral and Endocrine Responses to Stress

Gutman, D. A., Owens, M. J., Skelton, K. H., Thrivikraman, K. V., & Nemeroff, C. B. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.042788 · Cited by 99 · see citing works

Stressor- and corticotropin releasing factor-induced reinstatement and active stress-related behavioral responses are augmented following long-access cocaine self-administration by rats

Mantsch, J. R., Baker, D. L., Francis, D. M., Katz, E. S., Hoks, M. A., & Serge, J. P. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0950-5 · Cited by 98 · see citing works

An examination of the cocaine relapse process

McKay, J. R., Rutherford, M. J., Alterman, A. I., Cacciola, J. S., & Kaplan, M. R. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01098-j · Cited by 96 · see citing works

Regulatory Mechanisms Underlying Corticotropin-Releasing Factor Gene Expression in the Hypothalam

Kageyama, K., & Suda, T. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-075 · Cited by 95 · see citing works

The paraventricular nucleus of the thalamus as an interface between the orexin and CART peptides and the shell of the nucleus accumbens

Parsons, M. P., Li, S., & Kirouac, G. J. (2006) · Synapse · doi:10.1002/syn.20264 · Cited by 93 · see citing works

Antidepressant-like effect of ethanol revealed in the forced swimming test in Sardinian alcohol-preferring rats

Ciccocioppo, R., Panocka, I., Froldi, R., et al. (1999) · Psychopharmacology · doi:10.1007/s002130050988 · Cited by 91 · see citing works

Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and nucleus caudate in rats

Giannuario, A. D., & Pieretti, S. (2000) · Peptides · doi:10.1016/s0196-9781(00)00250-3 · Cited by 90 · see citing works

Interaction between noradrenaline and corticotrophin-releasing factor in the reinstatement of cocaine seeking in the rat

Brown, Z. J., Tribe, E., D’souza, N. A., & Erb, S. M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1376-4 · Cited by 90 · see citing works

Agonist‐induced internalization of corticotropin‐releasing factor receptors in noradrenergic neurons of the rat locus coeruleus

Reyes, B. A. S., Fox, K. M., Valentino, R. J., & Bockstaele, E. J. V. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04820.x · Cited by 90 · see citing works

Protracted Withdrawal from Alcohol and Drugs of Abuse Impairs Long-Term Potentiation of Intrinsic Excitability in the Juxtacapsular Bed Nucleus of the Stria Terminalis

Francesconi, W. G., Berton, F., Repunte‐Canonigo, V., Hagihara, K., Thurbon, D., Lekić, D., Specio, S. E., Greenwell, T. N., Chen, S. A., Rice, K. C., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5129-08.2009 · Cited by 90 · see citing works

PRECLINICAL STUDY: Region‐specific down‐regulation of Crhr1 gene expression in alcohol‐preferring msP rats following ad lib access to alcohol

Hansson, A. C., Cippitelli, A., Sommer, W. H., Ciccocioppo, R., & Heilig, M. A. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00050.x · Cited by 88 · see citing works

Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala

Roberto, M., & Siggins, G. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601899103 · Cited by 87 · see citing works

Chronic Cocaine Enhances Corticotropin-Releasing Factor-Dependent Potentiation of Excitatory Transmission in Ventral Tegmental Area Dopamine Neurons

Hahn, J., Hopf, F. W., & Bonci, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4773-08.2009 · Cited by 85 · see citing works

Altered Amygdalar CRF Release and Increased Anxiety-Like Behavior in Sardinian Alcohol-Preferring Rats: A Microdialysis and Behavioral Study

Richter, R. M., Zorrilla, E. P., Basso, A. M., Koob, G. F., & Weiss, F. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb01979.x · Cited by 82 · see citing works

Cocaine withdrawal enhances long‐term potentiation induced by corticotropin‐releasing factor at central amygdala glutamatergic synapses via CRF1, NMDA receptors and PKA

Pollandt, S., Liu, J., Orozco-Cabal, L. F., Grigoriadis, D. E., Vale, W., Gallagher, J. P., & Shinnick‐Gallagher, P. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05049.x · Cited by 82 · see citing works

Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference

Kotlinska, J. H., Wichmann, J., Łęgowska, A., Rolka, K., & Silberring, J. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200205000-00006 · Cited by 78 · see citing works

The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats

Ciccocioppo, R., Economidou, D., Fedeli, A., & Massi, M. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00112-4 · Cited by 74 · see citing works

Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis

Rodi, D., Zucchini, S., Simonato, M., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0985-7 · Cited by 70 · see citing works

Neurobiology of Stress and Cocaine Addiction: Studies on Corticotropin-Releasing Factor in Rats, Monkeys, and Humansa

Sarnyai, Z. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09011.x · Cited by 70 · see citing works

Dopamine‐dependent responses to cocaine depend on corticotropin‐releasing factor receptor subtypes

Lü, L., Liu, Z., Huang, M., & Zhang, Z. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01635.x · Cited by 70 · see citing works

Nociceptin/orphanin FQ inhibits stress- and CRF-induced anorexia in rats

Ciccocioppo, R., Martin‐Fardon, R., Weiss, F., & Massi, M. (2001) · Neuroreport · doi:10.1097/00001756-200105080-00019 · Cited by 69 · see citing works

Long-Term Potentiation (LTP) in the Central Amygdala (CeA) Is Enhanced After Prolonged Withdrawal From Chronic Cocaine and Requires CRF1Receptors

Fu, Y., Pollandt, S., Liu, J., Krishnan, B., Genzer, K. M., Orozco-Cabal, L. F., Gallagher, J. P., & Shinnick‐Gallagher, P. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00349.2006 · Cited by 68 · see citing works

The disease called addiction: emerging evidence in a 200-year debate

Meyer, R. E. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90345-1 · Cited by 67 · see citing works

Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system

Bonci, A., & Borgland, S. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.024 · Cited by 64 · see citing works

Nociceptin inhibits acquisition of amphetamine-induced place preference and sensitization to stereotypy in rats

Kotlinska, J. H., Rafalski, P., Biała, G., Dyląg, T., Rolka, K., & Silberring, J. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02081-8 · Cited by 62 · see citing works

Prolonged Exposure to Intermittent Alcohol Vapors Blunts Hypothalamic Responsiveness to Immune and Non-Immune Signals

Lee, S., Schmidt, D., Tilders, F. J. H., Cole, M., Smith, A., & RIVIER, C. L. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04560.x · Cited by 62 · see citing works

Endogenous Nociceptin (Orphanin FQ) Suppresses Basal Hedonic State and Acute Reward Responses to Methamphetamine and Ethanol, but Facilitates Chronic Responses

Sakoori, K., & Murphy, N. P. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301459 · Cited by 60 · see citing works

Distinct Conformations of the Corticotropin Releasing Factor Type 1 Receptor Adopted following Agonist and Antagonist Binding Are Differentially Regulated

Perry, S. J., Junger, S., Kohout, T. A., Hoare, S. R. J., Struthers, R. S., Grigoriadis, D. E., & Maki, R. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412914200 · Cited by 60 · see citing works

Central injections of CRF reinstate cocaine seeking in rats after postinjection delays of up to 3 h: an influence of time and environmental context

Erb, S. M., Petrovic, A., Yi, D., & Kayyali, H. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0392-5 · Cited by 58 · see citing works

Effects of Cocaine Self-Administration on Plasma Corticosterone and Prolactin in Rats

Mantsch, J. R., Schlussman, S. D., Ho, A., & Kreek, M. J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39062-7 · Cited by 58 · see citing works

Daily cocaine self-administration under long-access conditions augments restraint-induced increases in plasma corticosterone and impairs glucocorticoid receptor-mediated negative feedback in rats

Mantsch, J. R., Cullinan, W. E., Tang, L. C., Baker, D. L., Katz, E. S., Hoks, M. A., & Ziegler, D. R. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.080 · Cited by 54 · see citing works

Effect of novel nociceptin/orphanin FQ–NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats

Economidou, D., Fedeli, A., Martin‐Fardon, R., Weiss, F., Massi, M. N., & Ciccocioppo, R. (2006) · Peptides · doi:10.1016/j.peptides.2006.09.007 · Cited by 52 · see citing works

Orphanin FQ/nociceptin blocks methamphetamine place preference in rats

Zhao, R., Woo, R., Jeong, M.-S., Shin, B., Kim, D.-G., & Kim, K.-W. (2003) · Neuroreport · doi:10.1097/00001756-200312190-00019 · Cited by 51 · see citing works

Critical role of endogenous corticotropin-releasing factor (CRF) in the mediation of the behavioral action of cocaine in rats

Sarnyai, Z., Hőhn, J., Szabó, G., et al. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90151-e · Cited by 48 · see citing works

A neuropeptide‐centric view of psychostimulant addiction

Boutrel, B. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.133 · Cited by 46 · see citing works

Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats

Lutfy, K., Khaliq, I., Carroll, I. F., et al. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1192-1 · Cited by 46 · see citing works

Prior, repeated exposure to cocaine potentiates locomotor responsivity to central injections of corticotropin-releasing factor (CRF) in rats

Erb, S. M., Funk, D. R., & Lê, A. D. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1556-1 · Cited by 45 · see citing works

HUMAN GENETIC STUDY: Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence

Xuei, X., Wetherill, L. F., Almasy, L. A., Bierut, L. J., Tischfield, J. A., Schuckit, M. A., Nürnberger, J. I., Foroud, T., & Edenberg, H. J. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00082.x · Cited by 44 · see citing works

Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats

Przegaliński, E., Filip, M., Frankowska, M., Zaniewska, M., & Papla, I. (2005) · Neuropeptides · doi:10.1016/j.npep.2005.07.002 · Cited by 43 · see citing works

Revisiting Intragastric Ethanol Intubation as a Dependence Induction Method for Studies of Ethanol Reward and Motivation in Rats

Braconi, S., Sidhpura, N., Aujla, H., et al. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01119.x · Cited by 42 · see citing works

GENETIC STUDY: Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence

Huang, J., Young, B. M., Pletcher, M. T., et al. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00089.x · Cited by 35 · see citing works

The Corticotropin-Releasing Factor-Hypocretin Connection: Implications in Stress Response and Addiction

Pañeda, C., Winsky‐Sommerer, R., Boutrel, B., et al. (2005) · Drug News & Perspectives · doi:10.1358/dnp.2005.18.4.908659 · Cited by 34 · see citing works

Effect of blockade of corticotropin-releasing factor receptors in the median raphe nucleus on stress-induced c-fos mRNA in the rat brain

Funk, D. R., Li, Z., Shaham, Y., & Lê, A. D. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.003 · Cited by 33 · see citing works

Increased Perioculomotor Urocortin 1 Immunoreactivity in Genetically Selected Alcohol Preferring Rats

Chamine, I., Spangler, E., Cannella, N., Sabino, V., Cottone, P., Ciccocioppo, R., Zorrilla, E. P., & Ryabinin, A. E. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01033.x · Cited by 31 · see citing works

Enhanced nicotine sensitivity in nociceptin/orphanin FQ receptor knockout mice

Sakoori, K., & Murphy, N. P. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.01.016 · Cited by 27 · see citing works

Cocaine pre-exposure enhances CRF-induced expression of c-fos mRNA in the central nucleus of the amygdala: An effect that parallels the effects of cocaine pre-exposure on CRF-induced locomotor activity

Erb, S. M., Funk, D. R., & Lê, A. D. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.04.013 · Cited by 27 · see citing works

Nociceptin/orphanin FQ tissue concentration in the rat brain. Effects of repeated ethanol administration at various post-treatment intervals

Lindholm, S., Ploj, K., Franck, J., & Nylander, I. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00270-6 · Cited by 22 · see citing works

CLINICAL AND IMAGING STUDY: Glucocorticoid negative feedback in methadone‐maintained former heroin addicts with ongoing cocaine dependence: dose–response to dexamethasone suppression

Aouizerate, B., Ho, A., Schluger, J. H., Perret, G., Borg, L., Moal, M. L., Piazza, P. V., & Kreek, M. J. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00006.x · Cited by 21 · see citing works

A role for corticotropin-releasing factor in the long-term expression of behavioral sensitization to cocaine

Erb, S. M., & Brown, Z. J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.024 · Cited by 20 · see citing works

Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study

Rosin, Å., Kitchen, I., & Georgieva, J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02674-x · Cited by 20 · see citing works

Effects of CP-154,526 on responding during extinction from cocaine self-administration in rats

Gurkovskaya, O. V., & Goeders, N. E. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01465-0 · Cited by 16 · see citing works

Alterations in the level of OFQ/N-IR in rat brain regions by cocaine

Lutfy, K., Lam, H. A., & Narayanan, S. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.010 · Cited by 12 · see citing works

The roles of urocortins 1, 2, and 3 in the brain

Zorrilla, E. P., & Koob, G. F. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80013-6 · Cited by 11 · see citing works

Differences in uniquantal amplitude between sites reduce uniquantal variance when few release sites are active

Frerking, M., & Wilson, M. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19990615)32:4 · Cited by 2 · see citing works

The dark side of emotion: the addiction perspective

Koob, G. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.044 · Cited by 433 · see citing works

Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works

Addiction and Stress: An Allostatic View

Koob, G. F., & Schulkin, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.008 · Cited by 315 · see citing works

The dark side of food addiction

Parylak, S. L., Koob, G. F., & Zorrilla, E. P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.063 · Cited by 257 · see citing works

Multiple roles for orexin/hypocretin in addiction

Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59489-1.00007-0 · Cited by 215 · see citing works

Influence of stress associated with chronic alcohol exposure on drinking

Becker, H. C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.028 · Cited by 191 · see citing works

Existing and future drugs for the treatment of the dark side of addiction

Koob, G. F., & Mason, B. J. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103143 · Cited by 121 · see citing works

Activation of Brain NOP Receptors Attenuates Acute and Protracted Alcohol Withdrawal Symptoms in the Rat: N/OFQ REDUCES ALCOHOL WITHDRAWAL SYMPTOMS IN RATS

Economidou, D., Cippitelli, A., Stopponi, S., Braconi, S., Clementi, S., Ubaldi, M., Martin-Fardon, R., Weiss, F., Massi, M., & Ciccocioppo, R. (2011) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01392.x · Cited by 71 · see citing works

Blockade of orexin receptors in the infralimbic cortex prevents stress‐induced reinstatement of alcohol‐seeking behaviour in alcohol‐dependent rats

Flores‐Ramirez, F. J., Varodayan, F. P., Patel, R. R., Illenberger, J. M., Di Ottavio, F., Roberto, M., & Martin‐Fardon, R. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16015 · Cited by 19 · see citing works

UFP-112 a Potent and Long-Lasting Agonist Selective for the Nociceptin/Orphanin FQ Receptor

Calò, G., Rizzi, A., Cifani, C., et al. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00107.x · Cited by 42 · see citing works

Cellular Mechanisms of Nociceptin/Orphanin FQ (N/OFQ) Peptide (NOP) Receptor Regulation and Heterologous Regulation by N/OFQ

Donica, C. L., Awwad, H. O., Thakker, D. R., et al. (2013) · Molecular Pharmacology · doi:10.1124/mol.112.084632 · Cited by 54 · see citing works

Investigating Nociceptin/Orphanin Fq (N/OFQ) Function via Nop Receptor in Cannabis Users

Mizrahi, R., & Lalang, N. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.229

Designing bifunctional NOP receptor–mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.

Zaveri, N. T., Jiang, F., Olsen, C. M., et al. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.03.101 · Cited by 38 · see citing works

Further studies on the pharmacological features of the nociceptin/orphanin FQ receptor ligand ZP120

Fischetti, C., Rizzi, A., Gavioli, E. C., et al. (2008) · Peptides · doi:10.1016/j.peptides.2008.10.001 · Cited by 14 · see citing works