The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.
Alterations in regional homogeneity of resting-state brain activity in autism spectrum disorders
Abstract
Measures assessing resting-state brain activity with blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) can reveal cognitive disorders at an early stage. Analysis of regional homogeneity (ReHo) measures the local synchronization of spontaneous fMRI signals and has been successfully utilized in detecting alterations in subjects with attention-deficit hyperactivity disorder (ADHD), depression, schizophrenia, Parkinson's disease and Alzheimer's dementia. Resting-state brain activity was investigated in 28 adolescents with autism spectrum disorders (ASD) and 27 typically developing controls being imaged with BOLD fMRI and analyzed with the ReHo method. The hypothesis was that ReHo of resting-state brain activity would be different between ASD subjects and controls in brain areas previously shown to display functional alterations in stimulus or task based fMRI studies. Compared with the controls, the subjects with ASD had significantly decreased ReHo in right superior temporal sulcus region, right inferior and middle frontal gyri, bilateral cerebellar crus I, right insula and right postcentral gyrus. Significantly increased ReHo was discovered in right thalamus, left inferior frontal and anterior subcallosal gyrus and bilateral cerebellar lobule VIII. We conclude that subjects with ASD have right dominant ReHo alterations of resting-state brain activity, i.e., areas known to exhibit abnormal stimulus or task related functionality. Our results demonstrate that there is potential in utilizing the ReHo method in fMRI analyses of ASD.
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“Studies of FC in ASD have found evidence of reduced long-range FC in various cortical circuits (14-24).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [17]
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Di Martino, A., Yan, C.-G., Li, Q., Denio, E., Castellanos, F. X., Alaerts, K., Anderson, J. S., Assaf, M., Bookheimer, S. Y., Dapretto, M., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.78 · Cited by 2,780
REST: A Toolkit for Resting-State Functional Magnetic Resonance Imaging Data Processing
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Self-citationAdvances and pitfalls in the analysis and interpretation of resting-state FMRI data
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Resting-state functional connectivity in autism spectrum disorders: a review
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Metadata
- Authors
- Paakki, J.-J., Rahko, J., Long, X., Moilanen, I., Tervonen, O., Nikkinen, J., Starck, T., Remes, J., Hurtig, T., Haapsamo, H., Jussila, K., Kuusikko-Gauffin, S., Mattila, M.-L., Zang, Y., & Kiviniemi, V.
- Affiliations
- Oulu University Hospital (FI)
- Beijing Normal University (CN)
- Corresponding author
- Paakki, Jyri-Johan
- ORCID
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 1321
- Pages
- 169-179
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2071904348
- Cited by
- 286
- References
- 69
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 11 · 2023: 12 · 2022: 17 · 2021: 22 · 2020: 16 · 2019: 18 · 2018: 20 · 2017: 15 · 2016: 16 · 2015: 27 · 2014: 19 · 2013: 31 · 2012: 18
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- autism spectrum disorder, regional homogeneity, resting-state brain activity, adolescents, superior temporal sulcus, frontal cortex, cerebellum, thalamus, insula, hemispheric lateralization
- MeSH terms
- Adolescent, Brain, Brain Mapping, Child, Child Development Disorders, Pervasive, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Rest
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