Regional homogeneity of fMRI time series in autism spectrum disorders
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Functional magnetic resonance imaging (fMRI) and functional connectivity MRI (fcMRI) studies of autism spectrum disorders (ASD) have suggested atypical patterns of activation and long-distance connectivity for diverse tasks and networks in ASD. We explored the regional homogeneity (ReHo) approach in ASD, which is analogous to conventional fcMRI, but focuses on local connectivity. FMRI data of 26 children with ASD and 29 typically developing (TD) children were acquired during continuous task performance (visual search). Effects of motion and task were removed and Kendall's coefficient of concordance (KCC) was computed, based on the correlation of the blood oxygen level dependent (BOLD) time series for each voxel and its six nearest neighbors. ReHo was lower in the ASD than the TD group in superior parietal and anterior prefrontal regions. Inverse effects of greater ReHo in the ASD group were detected in lateral and medial temporal regions, predominantly in the right hemisphere. Our findings suggest that ReHo is a sensitive measure for detecting cortical abnormalities in autism. However, impact of methodological factors (such as spatial resolution) on ReHo require further investigation.
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Morphometric studies of individuals with ASD have revealed reduced grey and white matter in the pons and brainstem more broadly.
“Evidence from neuropathology (96) and electrophysiology (97) also implicate the brainstem in ASD; morphometric studies of individuals with ASD have revealed reduced grey and white matter in the pons, and brainstem more broadly (90;e.g., 98).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [90]
ASD-related abnormalities in temporal gyri gray matter have been noted.
“ASD-related abnormalities in temporal gyri gray matter have also been noted (90).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [90]
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- Authors
- Shukla, D. K., Keehn, B., & Müller, R. A.
- Affiliations
- San Diego State University (US)
- Corresponding author
- Müller, Ralph Axel
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 476
- Issue
- 1
- Pages
- 46-51
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC2879288
- OpenAlex
- W2053352217
- Cited by
- 109
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 10 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 12
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH081023)
- National Institute on Deafness and Other Communication Disorders (R01DC006155, T32DC007361)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- autism spectrum disorder, regional homogeneity, BOLD time series, superior parietal cortex, anterior prefrontal cortex, temporal lobe, cortical abnormalities, children, visual search task, Kendall's coefficient of concordance
- MeSH terms
- Adolescent, Brain, Child, Child Development Disorders, Pervasive, Female, Humans, Magnetic Resonance Imaging, Male, Oxygen, Case-Control Studies
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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