Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline
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Longer duration of reproductive years of life and thus greater exposure to endogenous estrogen may be associated with a lower risk of age-related diseases in women. The present study examined the relationship between estimated endogenous estrogen exposure and telomere length (TL) and telomerase activity, two biomarkers of cellular aging, in a sample of postmenopausal women at risk for cognitive decline. Telomere length was measured using a quantitative PCR method and telomerase activity by TRAP (Telomere-Repeats Amplification Protocol) assay in peripheral blood mononuclear cells (PBMCs). Study subjects were 53 postmenopausal women (35 with natural and 18 with surgical menopause) receiving hormone therapy (HT) for at least one year or longer. Length of reproductive years of life, computed as the difference between age at menopause and age at menarche, was used as a proxy of duration of exposure to endogenous estrogen. Length of time on HT was the measure used for duration of exogenous estrogen exposure. We found that longer endogenous estrogen exposure was associated with greater TL (standardized β=0.06, Wald χ(2)=3.7, p=0.04) and with lower telomerase activity (standardized β=-0.09, Wald χ(2)=5.0, p=0.03). Length of reproductive years was also inversely associated with the combination of short TL and high telomerase (OR=0.78, 95% CI: 0.63, 0.97, p=0.02). Length of HT use was not associated with TL or telomerase activity in this study. The results suggest that the endogenous estrogens may be associated with deceleration of cellular aging. This is the first study to examine associations between endogenous estrogens, telomere length and telomerase activity.
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There is preliminary evidence that statins, certain hormones, and caffeine may impact LTL.
“For example, there is preliminary evidence that statins (Olivieri et al., 2012), certain hormones (Lin et al., 2011), and caffeine (Romano et al., 2013) may impact LTL.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Lin et al., 2011
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Are pregnancy and parity associated with telomere length? A systematic review
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Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts
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Lifetime Estrogen Exposure, COMT Genotype, and Cognition in Postmenopausal Women
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Fetale Programmierung von Zellalterungsprozessen
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Additional file 1 of Are pregnancy and parity associated with telomere length? A systematic review
Houminer-Klepar, N., Bord, S., Epel, E. S., & Baron‐Epel, O. (2023) · Figshare · doi:10.6084/m9.figshare.24329814
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Psychosocial Factors and Telomere Length in Peripheral Blood
Parks, C. G., & DeRoo, L. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4776-4_7
- Authors
- Lin, J., Kroenke, C. H., Epel, E., Kenna, H. A., Wolkowitz, O. M., Blackburn, E., & Rasgon, N. L.
- Affiliations
- University of California, San Francisco (US)
- Stanford Medicine (US)
- ORCID
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 1379
- Pages
- 224-231
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC3057451
- OpenAlex
- W1990822552
- Cited by
- 86
- References
- 54
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 13 · 2014: 5 · 2013: 8 · 2012: 7
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01 AG22008)
- National Center for Research Resources, National Institutes of Health (M01 RR-00070)
- Bernard and Barbro Foundation
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- endogenous estrogen exposure, telomere length, telomerase activity, cellular aging, postmenopausal women, cognitive decline, hormone therapy, surgical menopause, natural menopause, age at menopause, age at menarche
- MeSH terms
- Aged, Cognition Disorders, Estrogens, Female, Humans, Longitudinal Studies, Middle Aged, Risk Factors, Estrogen Replacement Therapy, Telomere, Postmenopause
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