Senescence and Death of Primitive Cells and Myocytes Lead to Premature Cardiac Aging and Heart Failure
Abstract
Chronological myocardial aging is viewed as the inevitable effect of time on the functional reserve of the heart. Cardiac failure in elderly patients is commonly interpreted as an idiopathic or secondary myopathy superimposed on the old heart independently from the aging process. Thus, aged diseased hearts were studied to determine whether cell regeneration was disproportionate to the accumulation of old dying cells, leading to cardiac decompensation. Endomyocardial biopsies from 19 old patients with a dilated myopathy were compared with specimens from 7 individuals of similar age and normal ventricular function. Ten patients with idiopathic dilated cardiomyopathy were also analyzed to detect differences with aged diseased hearts. Senescent cells were identified by the expression of the cell cycle inhibitor p16 INK4a and cell death by hairpin 1 and 2. Replication of primitive cells and myocytes was assessed by MCM5 labeling, myocyte mitotic index, and telomerase function. Aged diseased hearts had moderate hypertrophy and dilation, accumulation of p16 INK4a positive primitive cells and myocytes, and no structural damage. Cell death markedly increased and occurred only in cells expressing p16 INK4a that had significant telomeric shortening. Cell multiplication, mitotic index and telomerase increased but did not compensate for cell death or prevented telomeric shortening. Idiopathic dilated cardiomyopathy had severe hypertrophy and dilation, tissue injury, and minimal level of p16 INK4a labeling. In conclusion, telomere erosion, cellular senescence, and death characterize aged diseased hearts and the development of cardiac failure in humans.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Patients with genetic hypertrophic or dilated cardiomyopathy have shorter cardiomyocyte telomeres than age-matched individuals.
“Patients with genetic forms of hypertrophic or dilated cardiomyopathy, conditions that affect 1 in 500–2,500 people worldwide, have cardiomyocytes with shorter telomeres than age-matched individuals107,108.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [107]
The Abstract describes a comparison between older patients with an age-related dilated myopathy and individuals of similar age with normal ventricular function. “Length of Telomeres in Senescent Myocytes” reports significantly shorter myocyte telomeres in the diseased hearts. The paper does not establish this finding for genetic hypertrophic or dilated cardiomyopathy, and the cited passages do not support the prevalence figure. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn humans, accumulation of senescent markers has been demonstrated in skin, T lymphocytes, atherosclerotic lesions, insulin-producing β cells, kidney, endothelium, visceral fat, joint cartilage, cardiac muscle, liver, and many other tissues.
“In humans, the accumulation of senescent markers has been demonstrated in the skin, T lymphocytes, atherosclerotic lesions, insulin-producing β cells, kidney, endothelium, visceral fat, joint cartilage, cardiac muscle, liver, and many others tissues98,101–107.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [104]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244 · see citing works
Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction
Beltrami, A. P., Urbanek, K., Kajstura, J., Yan, S., Finato, N., Bussani, R., Nadal‐Ginard, B., Silvestri, F., Leri, A., Beltrami, C. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106073442303 · Cited by 1,426 · see citing works
Self-citationChimerism of the Transplanted Heart
Quaini, F., Urbanek, K., Beltrami, A. P., Finato, N., Beltrami, C. A., Nadal‐Ginard, B., Kajstura, J., Leri, A., & Anversa, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012081 · Cited by 1,264 · see citing works
Self-citationArterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises
Lakatta, E. G., & Levy, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048893.62841.f7 · Cited by 1,257 · see citing works
DNA damage activates p53 through a phosphorylation–acetylation cascade
Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., & Appella, E. (1998) · Genes & Development · doi:10.1101/gad.12.18.2831 · Cited by 1,204 · see citing works
Handbook of Physiology—The Cardiovascular System
Guyton, A. C. (1985) · Critical Care Medicine · doi:10.1097/00003246-198505000-00025 · Cited by 1,153 · see citing works
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
Vaziri, H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B., & Lansdorp, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9857 · Cited by 1,132 · see citing works
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises
Lakatta, E. G. (2003) · Circulation · doi:10.1161/01.cir.0000048894.99865.02 · Cited by 1,086 · see citing works
Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application
Kondo, M., Wagers, A. J., Manz, M. G., Prohaska, S. S., Scherer, D. C., Beilhack, G. F., Shizuru, J. A., & Weissman, I. L. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141007 · Cited by 992 · see citing works
Cardiovascular regulatory mechanisms in advanced age.
Lakatta, E. G. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.2.413 · Cited by 789 · see citing works
Expression and function of c-kit in hemopoietic progenitor cells.
Ogawa, M., Matsuzaki, Y., Nishikawa, S., Hayashi, S., Kunisada, T., Sudo, T., Kina, T., Nakauchi, H., & Nishikawa, S. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.1.63 · Cited by 744 · see citing works
Hara, E., Smith, R., Parry, D., Tahara, H., Stone, S., & Peters, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.859 · Cited by 733 · see citing works
Uninterrupted MCM2-7 function required for DNA replication fork progression.
Labib, K., Tercero, J. A., & Diffley, J. (2000) · Science · doi:10.1126/science.288.5471.1643 · Cited by 689 · see citing works
Structural basis of end-stage failure in ischemic cardiomyopathy in humans.
Beltrami, C. A., Finato, N., Rocco, M., Feruglio, G. A., Puricelli, C., Cigola, E., Quaini, F., Sonnenblick, E. H., Olivetti, G., & Anversa, P. (1994) · Circulation · doi:10.1161/01.cir.89.1.151 · Cited by 595 · see citing works
Self-citationMyocyte proliferation in end-stage cardiac failure in humans
Kajstura, J., Leri, A., Finato, N., Loreto, C. D., Beltrami, C. A., & Anversa, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8801 · Cited by 567 · see citing works
Self-citationMyocyte Death, Growth, and Regeneration in Cardiac Hypertrophy and Failure
Nadal‐Ginard, B., Kajstura, J., Leri, A., & Anversa, P. (2003) · Circulation Research · doi:10.1161/01.res.0000053618.86362.df · Cited by 501 · see citing works
Self-citationIntense myocyte formation from cardiac stem cells in human cardiac hypertrophy
Urbanek, K., Quaini, F., Tasca, G., Torella, D., Castaldo, C., Nadal‐Ginard, B., Leri, A., Kajstura, J., Quaini, E. L., & Anversa, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1832855100 · Cited by 488 · see citing works
Self-citationDifferent telomere damage signaling pathways in human and mouse cells
Smogorzewska, A., & de Lange, T. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf433 · Cited by 482 · see citing works
Age and the Cardiovascular System
Epstein, F. H., & Wei, J. Y. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212103272408 · Cited by 475 · see citing works
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1
Itahana, K., Zou, Y., Itahana, Y., Martinez, J.-L., Beausejour, C., Jacobs, J. J. L., van Lohuizen, M., Band, V., Campisi, J., & Dimri, G. P. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.389-401.2003 · Cited by 438 · see citing works
Myocyte Death in the Failing Human Heart Is Gender Dependent
Guerra, S., Leri, A., Wang, X., Finato, N., Loreto, C. D., Beltrami, C. A., Kajstura, J., & Anversa, P. (1999) · Circulation Research · doi:10.1161/01.res.85.9.856 · Cited by 416 · see citing works
Self-citationLeri, A., Franco, S., Zacheo, A., Barlucchi, L., Chimenti, S., Limana, F., Nadal‐Ginard, B., Kajstura, J., Anversa, P., & Blasco, M. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg013 · Cited by 313 · see citing works
Self-citationCoordinated regulation of life and death by RB
Chau, B. N., & Wang, J. Y. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc993 · Cited by 292 · see citing works
The cellular basis of dilated cardiomyopathy in humans
Beltrami, C. A., Finato, N., ROCCO, M., Feruglio, G. A., Puricelli, C., Cigola, E., Eh, S., Olivetti, G., & Anversa, P. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(08)80028-4 · Cited by 267 · see citing works
Self-citationFrom cells to organisms: can we learn about aging from cells in culture?
Campisi, J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00230-8 · Cited by 263 · see citing works
Lessons from human progeroid syndromes
Martin, G. M., & Oshima, J. (2000) · Nature · doi:10.1038/35041705 · Cited by 261 · see citing works
The aging of lympho-hematopoietic stem cells
Geiger, H., & Van Zant, G. (2002) · Nature Immunology · doi:10.1038/ni0402-329 · Cited by 233 · see citing works
INK4a‐deficient human diploid fibroblasts are resistant to RAS‐induced senescence
Brookes, S., Rowe, J., Ruas, M., Llanos, S., Clark, P. A., Lomax, M., James, M. C., Vatcheva, R., Bates, S., Vousden, K. H., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf289 · Cited by 220 · see citing works
Expression of mouse telomerase catalytic subunit in embryos and adult tissues
Martı́n-Rivera, L., Herrera, E., Albar, J. P., & Blasco, M. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10471 · Cited by 218 · see citing works
Madine, M. A., Swietlik, M., Pelizon, C., et al. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4218 · Cited by 126 · see citing works
Telomere Shortening Is an in Vivo Marker of Myocyte Replication and Aging
Kajstura, J., Pertoldi, B., Leri, A., Beltrami, C.-A., Deptała, A., Darżynkiewicz, Z., & Anversa, P. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64949-8 · Cited by 122 · see citing works
Self-citationA matter of life and death: cardiac myocyte apoptosis and regeneration
Nadal‐Ginard, B., Kajstura, J., Anversa, P., & Leri, A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18611 · Cited by 105 · see citing works
Self-citationLeri, A., Barlucchi, L., Limana, F., Deptała, A., Darżynkiewicz, Z., Hintze, T. H., Kajstura, J., Nadal‐Ginard, B., & Anversa, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151013298 · Cited by 95 · see citing works
Self-citationA matter of life and death: cardiac myocyte apoptosis and regeneration
Nadal‐Ginard, B., Kajstura, J., Anversa, P., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318611 · Cited by 91 · see citing works
Self-citationChimenti, C., Calabrese, F., Thiene, G., Pieroni, M., Maseri, A., & Frustaci, A. (2001) · Circulation · doi:10.1161/01.cir.104.2.168 · Cited by 87 · see citing works
Self-citationTakahashi, Y., Kuro‐o, M., & Ishikawa, F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.210382097 · Cited by 83 · see citing works
Allsopp, R., & Weissman, I. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205314 · Cited by 71 · see citing works
Epigenetic stratification: the role of individual change in the biological aging process
Jazwinski, S. M., Kim, S., Lai, C., et al. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00029-1 · Cited by 61 · see citing works
Cellular Basis of Physiological and Pathological Myocardial Growth
Anversa, P., & Olivetti, G. (2002) · Comprehensive physiology · doi:10.1002/cphy.cp020102 · Cited by 52 · see citing works
Self-citationCellular mechanisms of ventricular failure: myocyte kinetics and geometry with age
Capasso, J. M., FitzPatrick, D. R., & Anversa, P. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.262.6.h1770 · Cited by 48 · see citing works
Self-citationPrimitive Cells and Tissue Regeneration
Anversa, P., Kajstura, J., Nadal‐Ginard, B., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000066879.66293.87 · Cited by 43 · see citing works
Self-citationNakazawa, Y., Kamijo, T., Koike, K., & Noda, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300510200 · Cited by 38 · see citing works
Werner's syndrome T lymphocytes display a normal in vitro life-span
James, S. E., Faragher, R., Burke, J. F., Shall, S., & Mayne, L. V. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00205-0 · Cited by 31 · see citing works
Multilineage development from adult bone marrow cells
Dorshkind, K. A. (2002) · Nature Immunology · doi:10.1038/ni0402-311 · Cited by 29 · see citing works
Premature aging in Werner's syndrome spares the central nervous system
Postiglione, A., Soricelli, A., Covelli, E. M., Iazzetta, N., Ruocco, A., Milan, G., Santoro, L., Alfano, B., & Brunetti, A. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00033-4 · Cited by 29 · see citing works
Dabelsteen, S., Troelsen, J. T., & Olsen, J. (2003) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504003108748401 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [7]7. Hara E, Smith R, Parry D, Tahara H, Stone S, Peters G. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol. 1996;16:859 -867.
- [13]13. Leri A, Franco S, Zacheo A, Barlucchi L, Chimenti S, Limana F, Nadal- Ginard B, Kajstura J, Anversa P, Blasco MA. Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure. EMBO J. 2003;22:131-139.
Cited by
Sorted by citations
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
The intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585 · see citing works
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works
Mitochondria are required for pro-ageing features of the senescent phenotype
Correia‐Melo, C., Marques, F. D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201592862 · Cited by 796 · see citing works
Telomere dysfunction in ageing and age-related diseases
Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754 · see citing works
Astrocyte Senescence as a Component of Alzheimer’s Disease
Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045069 · Cited by 586 · see citing works
Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
Dai, D.-F., Chen, T., Johnson, S. C., Szeto, H., & Rabinovitch, P. S. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4179 · Cited by 334 · see citing works
Rota, M., LeCapitaine, N., Hosoda, T., Boni, A., De Angelis, A., Padin-Iruegas, M. E., Esposito, G., Vitale, S., Urbanek, K., Casarsa, C., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000231289.63468.08 · Cited by 330 · see citing works
Self-citationAged-senescent cells contribute to impaired heart regeneration
Lewis‐McDougall, F. C., Ruchaya, P. J., Domenjo‐Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., et al. (2019) · Aging Cell · doi:10.1111/acel.12931 · Cited by 317 · see citing works
Self-citationMyocyte Turnover in the Aging Human Heart
Kajstura, J., Gurusamy, N., Ogórek, B., Goichberg, P., Clavo-Rondon, C., Hosoda, T., D'Amario, D., Bardelli, S., Beltrami, A. P., Cesselli, D., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.231498 · Cited by 287 · see citing works
Self-citationRetractedCellular senescence in vivo: Its relevance in ageing and cardiovascular disease
Erusalimsky, J. D., & Kurz, D. J. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.010 · Cited by 252 · see citing works
Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion
Zhai, P., Sciarretta, S., Galeotti, J., Volpe, M., & Sadoshima, J. (2011) · Circulation Research · doi:10.1161/circresaha.111.249532 · Cited by 218 · see citing works
Gevaert, A. B., Shakeri, H., Leloup, A. J., Van Hove, C. E., De Meyer, G. R. Y., Vrints, C. J., Lemmens, K., & Van Craenenbroeck, E. M. (2017) · Circulation: Heart Failure · doi:10.1161/circheartfailure.116.003806 · Cited by 211 · see citing works
Senescent cells: a therapeutic target for cardiovascular disease
Childs, B. G., Li, H., & van Deursen, J. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95146 · Cited by 192 · see citing works
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Song, P., An, J., & Zou, M.-H. (2020) · Cells · doi:10.3390/cells9030671 · Cited by 198 · see citing works
Assessing cell and organ senescence biomarkers
de Jesus, B. B., & Blasco, M. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.247866 · Cited by 187 · see citing works
Mitochondria: Are they causal players in cellular senescence?
Correia-Melo, C., & Passos, J. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.017 · Cited by 160 · see citing works
Westhoff, J. H., Hilgers, K. F., Steinbach, M. P., Hartner, A., Klanke, B., Amann, K., & Melk, A. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.099432 · Cited by 152 · see citing works
Ink4a/Arf links senescence and aging
Sharpless, N. E. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.025 · Cited by 142 · see citing works
Chen, J., Huang, X., Halicka, D., Brodsky, S., Avram, A., Eskander, J., Bloomgarden, N. A., Darzynkiewicz, Z., & Goligorsky, M. S. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00364.2005 · Cited by 142 · see citing works
The Aging Cardiomyocyte: A Mini-Review
Bernhard, D., & Laufer, G. (2008) · Gerontology · doi:10.1159/000113503 · Cited by 110 · see citing works
Wong, L. S. M., Oeseburg, H., de Boer, R. A., van Gilst, W. H., van Veldhuisen, D. J., & van der Harst, P. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn337 · Cited by 88 · see citing works
Lin, J., Kroenke, C. H., Epel, E., Kenna, H. A., Wolkowitz, O. M., Blackburn, E., & Rasgon, N. L. (2011) · Brain Research · doi:10.1016/j.brainres.2010.10.033 · Cited by 86 · see citing works
Sanborn, M. A., Wang, X., Gao, S., Dai, Y., & Rehman, J. (2025) · Nature Communications · doi:10.1038/s41467-025-57047-7 · Cited by 82 · see citing works
“Senescent cells contribute to cardiovascular pathology 6,41 , but their role in disease has never been spatiotemporally characterized.”
Therapeutic Potential of Senolytics in Cardiovascular Disease
Dookun, E., Passos, J. F., Arthur, H. M., & Richardson, G. D. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07075-w · Cited by 69 · see citing works
Pallante, B. A., Duignan, I., Okin, D., Chin, A., Bressan, M. C., Mikawa, T., & Edelberg, J. M. (2007) · Circulation Research · doi:10.1161/01.res.0000253487.02398.85 · Cited by 62 · see citing works
Nalapareddy, K., Jiang, H., Gutierrez, L. M. G., & Rudolph, K. L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.09.002 · Cited by 50 · see citing works
Telomeres and telomerase in risk assessment of cardiovascular diseases
Boniewska-Bernacka, E., Pańczyszyn, A., & Klinger, M. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112361 · Cited by 31 · see citing works
Morin, D., Long, R., Panel, M., Laure, L., Taranu, A., Gueguen, C., Pons, S., Leoni, V., Caccia, C., Vatner, S. F., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.04.035 · Cited by 24 · see citing works
- Authors
- Chimenti, C., Kajstura, J., Torella, D., Urbanek, K., Heleniak, H., Colussi, C., Di Meglio, F., Nadal-Ginard, B., Frustaci, A., Leri, A., Maseri, A., & Anversa, P.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- From the Cardiovascular Research Institute (C. Chimenti, J.K., D.T., K.U., H.H., C. Colussi, F.D.M., B.N.-G., A.F., A.L., P.A.), Department of Medicine, New York Medical College, Valhalla, NY; Department of Cardiology (A.F.), Sacred Heart University, Rome, Italy; and Department of Cardiology (A.M.), San Raffaele Hospital, Milan, Italy.
- Venue
- Circulation Research
- Published
- 2003-10-03
- Volume
- 93
- Issue
- 7
- Pages
- 604-613
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2096391100
- Cited by
- 386
- References
- 46
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 14 · 2023: 10 · 2022: 10 · 2021: 13 · 2020: 18 · 2019: 7 · 2018: 13 · 2017: 27 · 2016: 9 · 2015: 18 · 2014: 19 · 2013: 30 · 2012: 25
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG-15756, R01AG017042, AG-023071, R01AG015756, P01AG023071, AG17042)
- National Heart, Lung, and Blood Institute (HL65573, HL65577, R01HL066923, HL 38132, HL-66923, R01HL065573, R01HL065577, R01HL038132)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- cellular senescence, cardiomyocyte death, heart failure, dilated cardiomyopathy, p16INK4a, telomere shortening, telomerase, myocyte proliferation, MCM5, endomyocardial biopsy, cardiac hypertrophy, cell cycle inhibitors
- MeSH terms
- Aged, Aged, 80 and over, Biopsy, Cardiomyopathy, Dilated, DNA-Binding Proteins, Female, Heart Failure, Humans, Male, Mitotic Index, Myocardium, Cellular Senescence, Cell Death, Microscopy, Confocal, Cell Cycle Proteins, Telomerase, Cyclin-Dependent Kinase Inhibitor p16, Schizosaccharomyces pombe Proteins, Myocytes, Cardiac
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
