Dysfunctional hippocampal activity affects emotion and cognition in mood disorders

Protective and Damaging Effects of Stress Mediators

McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733

Physiology and neurobiology of stress and adaptation: central role of the brain

McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321

Antidepressant effects of ketamine in depressed patients

Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881

Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress

Tsigos, C., & Chrousos, G. P. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00429-4 · Cited by 2,822

Cognition and Depression: Current Status and Future Directions

Gotlib, I. H., & Joormann, J. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131305 · Cited by 2,420

A molecular and cellular theory of depression

Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129

The hippocampal-VTA loop: controlling the entry of information into long-term memory

Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983

The dose-dependent neuroprotective effect of norepinephrine in improving memory retrieval in an experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis

Taherian, N., Vaezi, G., Neamati, A., Hojjati, V., Ghorbani-Taherdehi, F., Sahebkar, A., & Valokola, M. G. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110907 · Cited by 5

Network dysfunction of sadness facial expression processing and morphometry in euthymic bipolar disorder

Miola, A., Trevisan, N., Salvucci, M., Minerva, M., Valeggia, S., Manara, R., & Sambataro, F. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01649-z · Cited by 5

High emotional reactivity is associated with activation of a molecularly distinct hippocampal-amygdala circuit modulated by the glucocorticoid receptor

Wei, Q., Kumar, V., Moore, S. J., Li, F. R., Murphy, G. G., Watson, S. J., & Akil, H. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100581 · Cited by 5

Setting the tone for the day: Cortisol awakening response proactively modulates fronto-limbic circuitry for emotion processing

Chen, C., Xiong, B., Tan, W., Tian, Y., Zhang, S., Wu, J., Song, P., & Qin, S. (2025) · NeuroImage · doi:10.1016/j.neuroimage.2025.121251 · Cited by 7

Metabolic effects of light deprivation in the prefrontal cortex of rats with depression-like behavior: In vivo proton magnetic resonance spectroscopy at 7T

Yoo, C., Song, K.-H., Lim, S., Woo, D., & Choe, B. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.047 · Cited by 5

Connectivity and synaptic features of hilar mossy cells and their effects on granule cell activity along the hippocampal longitudinal axis

Abdulmajeed, W. I., Wang, K., Wu, J., Ajibola, M. I., Cheng, I. H.-J., & Lien, C. (2022) · The Journal of Physiology · doi:10.1113/jp282804 · Cited by 5

Abnormal regional activity in the prefrontal‐limbic circuit at rest: Potential imaging markers and treatment predictors in drug‐naive anxiety disorders

Shan, X., Yan, H., Li, H., Liu, F., Li, P., Zhao, J., & Guo, W. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14523 · Cited by 4

The role of CA3 GABA B receptors on anxiolytic-like behaviors and avoidance memory deficit induced by D-AP5 with respect to Ca 2+ ions

Zarrabian, S., Nasehi, M., Farrahizadeh, M., & Zarrindast, M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.007 · Cited by 5

Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior

Jester, H. M., Nicol, N. I., Yang, Q., Zhang, Y., Suhocki, A., Zhou, X., Underwood, E. B., Pourhadi, H., Cheng, D., Lee, J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03408-z · Cited by 4

The interplay between gut microbiota composition and dementia

Pour, R. G. K., Zounouzi, S. K., Farshbafnadi, M., & Rezaei, N. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0113 · Cited by 3

Formyl peptide receptor 2 antagonist WRW4 ameliorates diabetes-induced cognitive decline in mice

Uno, H., Itokazu, T., & Yamashita, T. (2025) · Neuroscience Research · doi:10.1016/j.neures.2025.104932 · Cited by 3

Effects of comorbid posttraumatic stress disorder on cognitive dysfunction in Chinese male methamphetamine patients

Jiang, W. A., Tian, Y., Fan, F., Fu, F., Wei, D., Tang, S., Chen, J., Li, Y., Zhu, R., Wang, L., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110611 · Cited by 2

Neuroanatomical Correlates of Anxiety Disorders and Their Implications in Manifestations of Cognitive and Behavioral Symptoms

Jeanne, M., Carson, F., & Toledo, F. (2023) · Psych · doi:10.3390/psych6010003 · Cited by 3

Exercise alleviates symptoms of CNS lupus

Jacob, A., Peralta, L. N., Pegues, D., Okamura, K., Chang, A., McSkimming, D. I., & Alexander, J. J. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147478 · Cited by 2

Structural brain correlates of depression and anxiety in middle-aged and older adults: A systematic reviewPreprint

Johns, S., Maharani, A., Lea‐Carnall, C., & Shryane, N. M. (2024) · medRxiv · doi:10.1101/2024.08.20.24312289 · Cited by 2

Neural Stem Cell‐Derived Astrogliogenesis: The Hidden Player of the Adult Hippocampal Cytogenic Niche

Ferreira, G. A. M., & Pinto, L. (2025) · Glia · doi:10.1002/glia.70031 · Cited by 2

Hippocampal subfield and amygdala volumes are associated with difficulties in emotion regulation of depressed patients with a history of childhood maltreatment

Gálber, M., Nagy, S. A., Orsi, G., Perlaki, G., Tényi, T., Czéh, B., & Simon, M. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1641745 · Cited by 1

Venlafaxine inhibits neuronal apoptosis in a depression rat model via ERK1/ERK2 pathway

Hou, Y., Lou, Z., Ji, Y., Ruan, L., & Gao, H. (2022) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v20i7.8 · Cited by 1

Study protocol TransTAM: Transdiagnostic research into emotional disorders and cognitive-behavioral therapy of the adaptive mind

Hermann, A., Benke, C., Blecker, C. R., de Haas, B., He, Y., Hofmann, S. G., Iffland, J. R., Jengert-Stahl, J., Kircher, T. T. J., Leinweber, K., et al. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06108-0 · Cited by 1

Maternal immune activation impairs hippocampal pyramidal neuron excitability in newborn rat offspring: Implications for neurodevelopmental disorders

Moravcikova, L., Moravcik, R., Csatlosova, K., Lacinová, Ľ., Jezova, D., & Dremencov, E. (2025) · Brain medicine : · doi:10.61373/bm025a.0029 · Cited by 2

Brain integration: From networks to the cellular–molecular level

Fuxé, K., Agnati, L. F., & Mora, F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.001 · Cited by 1

Hippocampal neurogenesis and dementia risk in age and disease

Mathews, K. J. (2019) · The Sydney eScholarship Repository (The University of Sydney) · Cited by 1

Modelling depression in animals and the potential antidepressant effect of histaminergic modulation

Magara, S. (2015) · Figshare

Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression

Fenton, E. Y. (2013) · University Library - University of Saskatchewan (University of Saskatchewan)

CYP2C19 and brain development : implications for susceptibility to anxiety in a transgenic mouse model

Persson, A. (2013) · Figshare

Chronic mania associated with left hippocampal atrophy

Chakraborty, N., & Miramontes, C. (2013) · Progress in Neurology and Psychiatry · doi:10.1002/pnp.298

Revista Brasileira de Psiquiatria

de Mello, A. R., Ribeiro, N. P. D. O., de Oliveira, A. C., Hallak, J. E. C., Hallak, C., Alexandre, J., Crippa, S. V., Nardi, A. E., & Zuardi, A. W. (2012)

Comprehensive behavioral characterization of Gpm6b null mutants as a mouse model of depression

Ritter, C. (2013) · Max Planck Institute for Plasma Physics

TITLE PAGE Genetic alterations in the aetiology of depression

Kristensen, A. F., & Lichota, J. (2013)

Efectos de la radiación X neonatal sobre el hipocampo de rata. Estrategias de neuroprotección

Caceres, L. G. (2013) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)

Adult Hippocampal Neurogenesis, Cognitive Flexibility, and Depression

Lui, E. (2016) · UWSpace (University of Waterloo)

The impact of sleep on cognition in older adults: does depression matter?

Mellor, A. (2014) · UWA Profiles and Research Repository (University of Western Australia)

Are adult neurogenesis and glucocorticoid signaling missing links between stress and depression?

Jukić, M. M., & Pešić, V. (2016) · Arhiv za farmaciju · doi:10.5937/arhfarm1605207j

Early-life exposure to fluoxetine and/or exercise on bio-behavioural markers of depression in early adulthood in stress sensitive rats

Schoeman, J. C. (2015) · Boloka Institutional Repository (North-west University)

アルコール性脳障害とうつ病に対する(イメージング・エピジェネティクス・末梢由来マー カーを用いた)トランスレーショナルリサーチの展望─病態解明と診断の観点から─

鵜飼, 渉. (2014) · 日本生物学的精神医学会誌 = Japanese journal of biological psychiatry · doi:10.11249/jsbpjjpp.25.1_24

Pathophysiological changes of neurofunctional interaction between the dopaminergic reward system and the hippocampus in schizophrenia and bipolar disorder

Wolter, S. (2018) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7020

THE ASSOCIATIONS AMONG HISTORY OF PSYCHOSIS, NEUROPSYCHOLOGICAL PERFORMANCE, AND FUNCTIONING IN REMITTED LATER-LIFE MAJOR DEPRESSION

Bingham, K. S., DAWSON, D. R., Mulsant, B. H., Banerjee, S., & Flint, A. J. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.01.022

Hippocampal Celsr3 Inactivation Impairs Hippocampal Efferent Pathways and Synapse Formation

Zhang, J., & Duan, J. (2021) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.4775991

Study Protocol TransTAM: Transdiagnostic Research into Emotional Disorders and Cognitive-Behavioral Therapy of the Adaptive MindPreprint

Hermann, A., Benke, C., Blecker, C. R., de Haas, B., He, Y., Hofmann, S. G., Iffland, J. R., Jengert-Stahl, J., Kircher, T. T. J., Leinweber, K., et al. (2024) · doi:10.31219/osf.io/zwrp8

MMoGCN: a multi-gate mixture of graph convolutional network model for EEG emotion and mood disorder recognition

Zhang, D., Guo, Y., Kong, X., Ouyang, Y., Li, Z., & Zeng, H. (2026) · Journal of Neural Engineering · doi:10.1088/1741-2552/ae37dc

Diversité Génétique des Molécules de Réponse Immunitaire Innée dans les Troubles Bipolaires

Oliveira, J. (2015) · theses.fr (ABES) · doi:10.70675/b5f62909z8b9az49b8zb797zc725c6e8f7ef

Moral emotion processing in euthymic bipolar disorder: insights from network analysis

Lussignoli, M., Cattarinussi, G., Miola, A., Trevisan, N., Valeggia, S., Manara, R., & Sambataro, F. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02344-5

Topography-specific white matter hyperintensities, hippocampal atrophy, and gait slowing as independent and interrelated correlates of late-life depression

Kim, J., Yang, H. J., 박수연, Kim, B. S., & Park, J. H. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122651

Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications

Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408

The role of hippocampus in the pathophysiology of bipolar disorder

Frey, B. N., Andreazza, A. C., Nery, F. G., Martins, M. R., Quevedo, J., Soares, J. C., & Kapczinski, F. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282df3cde · Cited by 162

Synaptic Plasticity in the Pathophysiology and Treatment of Bipolar Disorder

Du, J., Machado‐Vieira, R., & Khairova, R. A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_65 · Cited by 17

Neural circuitry and neuroplasticity in mood disorders: Insights for novel therapeutic targets

Carlson, P. J., Singh, J. B., Zarate, C. A., Drevets, W. C., & Manji, H. K. (2006) · NeuroRx · doi:10.1016/j.nurx.2005.12.009 · Cited by 157

The role of the hippocampus in the pathophysiology of major depression

Campbell, S., & MacQUEEN, G. M. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0441 · Cited by 891