The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.
Dysfunctional hippocampal activity affects emotion and cognition in mood disorders
Abstract
Mood disorders, such as major depressive disorder (MDD), bipolar disorder and generalized anxiety disorder usually comprise mood related as well as cognitive symptoms and the interaction between these symptoms is still not clear. Most antidepressant drugs have a positive effect on mood but do not treat the cognitive dysfunctions or even aggravate the symptoms. In this review we will evaluate the association between mood and cognition in the context of mood disorders. In the first section we will summarize the brain circuits at the intersection between cognition and emotion, highlighting the role of the hippocampus. In the second section, we will survey the contribution of the glutamate and GABA systems in the pathophysiology of mood disorders, making an effort to understand the link between emotions and cognition and how novel therapeutic approaches deal with them. In the third section we will explore the monoamine involvement in the emotion/cognition duality in the context of mood disorders. Finally we will underline the role of synaptic plasticity and neurogenesis in depression. We consider that a broader knowledge about the integrative mechanisms involved in specific aspects of mood disorders is crucial in the development of more powerful and effective antidepressant drugs. This article is part of a Special Issue entitled: Brain Integration.
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“The common occurrence of cognitive impairment in individuals with MDD may be related to the shared neurobiologic systems and processes that can modulate cognitive function and mood.”
From Cognitive Effects of Pharmacotherapy for Major Depressive Disorder: A Systematic Review (2014) · cites this paper as [60]
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Self-citationGut microbial molecules in behavioural and neurodegenerative conditions
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Metadata
- Authors
- Femenía, T., Gómez-Galán, M., Lindskog, M., & Magara, S.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Lindskog, Maria
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 1476
- Pages
- 58-70
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2059580803
- Cited by
- 143
- References
- 175
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 15 · 2015: 15 · 2014: 14 · 2013: 19 · 2012: 5
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- mood disorders, hippocampus, emotion-cognition interaction, major depressive disorder, bipolar disorder, generalized anxiety disorder, glutamatergic system, GABA system, monoamines, synaptic plasticity, neurogenesis, antidepressants, cognitive impairment
- MeSH terms
- Animals, Antidepressive Agents, Behavioral Symptoms, Cognition Disorders, gamma-Aminobutyric Acid, Hippocampus, Humans, Synapses, Prefrontal Cortex, Glutamic Acid, Mood Disorders
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