Cited by 143Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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Dysfunctional hippocampal activity affects emotion and cognition in mood disorders

Femenía, Teresa, Gómez-Galán, Marta, Lindskog, Maria, Magara, Salvatore·2012·Brain Research

DOI 10.1016/j.brainres.2012.03.053

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Abstract

Mood disorders, such as major depressive disorder (MDD), bipolar disorder and generalized anxiety disorder usually comprise mood related as well as cognitive symptoms and the interaction between these symptoms is still not clear. Most antidepressant drugs have a positive effect on mood but do not treat the cognitive dysfunctions or even aggravate the symptoms. In this review we will evaluate the association between mood and cognition in the context of mood disorders. In the first section we will summarize the brain circuits at the intersection between cognition and emotion, highlighting the role of the hippocampus. In the second section, we will survey the contribution of the glutamate and GABA systems in the pathophysiology of mood disorders, making an effort to understand the link between emotions and cognition and how novel therapeutic approaches deal with them. In the third section we will explore the monoamine involvement in the emotion/cognition duality in the context of mood disorders. Finally we will underline the role of synaptic plasticity and neurogenesis in depression. We consider that a broader knowledge about the integrative mechanisms involved in specific aspects of mood disorders is crucial in the development of more powerful and effective antidepressant drugs. This article is part of a Special Issue entitled: Brain Integration.

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Authors: Femenía, T., Gómez-Galán, M., Lindskog, M., & Magara, S.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Lindskog, Maria
ORCID: Femenía, Teresa
Lindskog, Maria
Venue: Brain Research
Publisher: Elsevier BV
Published: 2012-10
Volume: 1476
Pages: 58-70
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2012.03.053
OpenAlex: W2059580803
Cited by: 143
References: 175
Citations by year: 2026: 3 · 2025: 10 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 15 · 2015: 15 · 2014: 14 · 2013: 19 · 2012: 5
FWCI: 1.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Vetenskapsrådet
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: mood disorders, hippocampus, emotion-cognition interaction, major depressive disorder, bipolar disorder, generalized anxiety disorder, glutamatergic system, GABA system, monoamines, synaptic plasticity, neurogenesis, antidepressants, cognitive impairment
MeSH terms: Animals, Antidepressive Agents, Behavioral Symptoms, Cognition Disorders, gamma-Aminobutyric Acid, Hippocampus, Humans, Synapses, Prefrontal Cortex, Glutamic Acid, Mood Disorders

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Dysfunctional hippocampal activity affects emotion and cognition in mood disorders

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