Memantine improves memory impairment and depressive-like behavior induced by amphetamine withdrawal in rats
Abstract
Amphetamine (AMPH) induces deficits in cognition, and depressive-like behavior following withdrawal. The aim of the present study was to investigate whether pre-treatment with memantine (5mg/kg, i.p.), a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, attenuates memory impairment induced by withdrawal from a 1 day binge regimen of AMPH (2mg/kg, four times every 2h, i.p.), in the novel object recognition test in rats. Herein, the influence of scopolamine (0.1mg/kg), an antagonist of the muscarinic cholinergic receptors, and the impact of MK-801 (0.1mg/kg), an antagonist of the NMDA receptors, on the memantine effect, were ascertained. Furthermore, the impact of memantine (5; 10; 20mg/kg, i.p.) was measured on depression-like effects of abstinence, 14 days after the last AMPH treatment (2mg/kg×1×14 days), in the forced swim test. In this test, the efficacy of memantine was compared to that of tricyclic antidepressant imipramine (10; 20; 30mg/kg, i.p.). Our study indicated that withdrawal from a binge regimen of AMPH impaired recognition memory. This effect was attenuated by administration of memantine at both 72h and 7 days of withdrawal. Moreover, prior administration of scopolamine, but not MK-801, decreased the memantine-induced recognition memory improvement. In addition, memantine reversed the AMPH-induced depressive-like behavior in the forced swim test in rats. The antidepressant-like effects of memantine were stronger than those of imipramine. Our study…
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Chronic administration and withdrawal of amphetamine and morphine have been shown to cause severe spatial recognition memory and executive impairment in rodents and humans.
“Chronic administration and withdrawal of amphetamine and morphine have been shown to cause severe spatial recognition memory and executive impairment in rodents and humans (49–51).”
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- Authors
- Marszalek-Grabska, M., Gibula-Bruzda, E., Jenda, M., Gawel, K., & Kotlinska, J. H.
- Affiliations
- Medical University of Lublin (PL)
- Corresponding author
- Kotlinska, J.H.
- ORCID
- Kotlinska, J.H.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 1642
- Pages
- 389-396
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2338117572
- Cited by
- 22
- References
- 7
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2022: 2 · 2021: 1 · 2019: 4 · 2017: 2 · 2016: 3
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Statutory Funds of the Medical University of Lublin (DS 22/15)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- memantine, amphetamine withdrawal, memory impairment, depression-like behavior, NMDA receptor antagonists, recognition memory, scopolamine, MK-801, imipramine, antidepressant-like effects, cognitive impairment
- MeSH terms
- Amphetamine, Central Nervous System Stimulants, Animals, Antidepressive Agents, Depression, Disease Models, Animal, Dose-Response Relationship, Drug, Imipramine, Male, Memantine, Memory Disorders, Scopolamine, Substance Withdrawal Syndrome, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Rats, Wistar, Excitatory Amino Acid Antagonists, Nootropic Agents, Muscarinic Antagonists, Amphetamine-Related Disorders, Recognition, Psychology
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