Cited by 31Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchAttention Deficit Hyperactivity Disorder

Preclinical pharmacology of amphetamine: Implications for the treatment of neuropsychiatric disorders

Hutson, Peter H., Tarazi, Frank I., Madhoo, Manisha, Slawecki, Craig, Patkar, Ashwin A.·2014·Pharmacology & Therapeutics

Abstract

The primary mechanism by which amphetamine exerts its neurobehavioral effects is through an enhancement of synaptic monoamine levels, which is mediated by interactions with monoamine transporters, storage, and metabolism. However, preclinical data are now emerging that support more widespread neurobiologic effects for amphetamine. This review describes preclinical evidence suggesting that direct interactions of amphetamine with monoamine systems, which results in increased synaptic monoamine availability, has downstream effects on nonmonoaminergic systems, including glutamate, endogenous opioid, endocannabinoid, and acetylcholine systems. Furthermore, evidence suggests that amphetamine can modulate synaptic plasticity through modulation of glutamatergic systems, intracellular signaling cascades, and neurotrophic factor activity. Functional activity of these systems is implicated in the regulation of neurobehavioral processes that include cognition, mood, motivated behavior/hedonic processes/addiction, and arousal. As such, the ability of amphetamine to influence the function of systems that mediate these processes suggests amphetamine-based agents may have utility in the treatment of psychiatric disorders in which these systems and processes are dysfunctional. Amphetamine-based agents are currently approved by the US Food and Drug Administration only for the treatment of attention-deficit/hyperactivity disorder and narcolepsy. Preclinical and clinical research for amphetamine…

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Crossref · 10.1016/j.pharmthera.2014.03.005

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Authors
Hutson, P. H., Tarazi, F. I., Madhoo, M., Slawecki, C., & Patkar, A. A.
Affiliations
  • Takeda (United States) (US)
  • Harvard University (US)
  • Duke University (US)
Corresponding author
Hutson, Peter H.
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2014-09
Volume
143
Issue
3
Pages
253-264
ISSN
0163-7258 (ISSN-L)
OpenAlex
W2030742716
Cited by
31
References
188
Citations by year
2026: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 1
FWCI
0.42
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Shire Development LLC
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords
amphetamine, monoamine transporters, glutamatergic system, endocannabinoid system, endogenous opioid system, acetylcholine, synaptic plasticity, neurotrophic factors, intracellular signaling, addiction, mood regulation, cognition, arousal, neuropsychiatric disorders, psychopharmacological treatment, attention deficit hyperactivity disorder, narcolepsy
MeSH terms
Amphetamine, Animals, Mental Disorders, Biogenic Amines, Humans, Synaptic Transmission, Glutamic Acid, Opioid Peptides, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2

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