Preclinical pharmacology of amphetamine: Implications for the treatment of neuropsychiatric disorders
Abstract
The primary mechanism by which amphetamine exerts its neurobehavioral effects is through an enhancement of synaptic monoamine levels, which is mediated by interactions with monoamine transporters, storage, and metabolism. However, preclinical data are now emerging that support more widespread neurobiologic effects for amphetamine. This review describes preclinical evidence suggesting that direct interactions of amphetamine with monoamine systems, which results in increased synaptic monoamine availability, has downstream effects on nonmonoaminergic systems, including glutamate, endogenous opioid, endocannabinoid, and acetylcholine systems. Furthermore, evidence suggests that amphetamine can modulate synaptic plasticity through modulation of glutamatergic systems, intracellular signaling cascades, and neurotrophic factor activity. Functional activity of these systems is implicated in the regulation of neurobehavioral processes that include cognition, mood, motivated behavior/hedonic processes/addiction, and arousal. As such, the ability of amphetamine to influence the function of systems that mediate these processes suggests amphetamine-based agents may have utility in the treatment of psychiatric disorders in which these systems and processes are dysfunctional. Amphetamine-based agents are currently approved by the US Food and Drug Administration only for the treatment of attention-deficit/hyperactivity disorder and narcolepsy. Preclinical and clinical research for amphetamine…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Amphetamine increases synaptic levels of monoamines (dopamine, noradrenaline and serotonin) by increasing their release through a reversal of the monoamine transporters, primarily the catecholamine transporters.
“AMP increases the synaptic levels of monoamines (dopamine, noradrenaline and serotonin) by increasing their release through a reversal of the monoamine transporters, primarily the catecholamine transporters (see Fleckenstein et al., 2007; Hutson et al., 2014, for review; Kuczenski et al., 1995; Sulzer et al., 2005).”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Hutson et al., 2014
Cites
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693 · see citing works
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529 · see citing works
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347 · see citing works
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180 · see citing works
The role of acetylcholine in learning and memory
Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693 · see citing works
Role of Endogenous Cannabinoids in Synaptic Signaling
Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,567 · see citing works
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404 · see citing works
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390 · see citing works
NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337 · see citing works
The NIMH-MATRICS Consensus Statement on Negative Symptoms
Kirkpatrick, B., Fenton, W. S., Carpenter, W. T., & Marder, S. R. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj053 · Cited by 1,311 · see citing works
Identification of separable cognitive factors in schizophrenia
Nuechterlein, K. H., Barch, D. M., Gold, J. M., Goldberg, T. E., Green, M. F., & Heaton, R. K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.007 · Cited by 1,304 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197 · see citing works
Towards a glutamate hypothesis of depression
Sanacora, G., Treccani, G., & Popoli, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.036 · Cited by 1,036 · see citing works
Moghaddam, B., & Javitt, D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.181 · Cited by 1,035 · see citing works
Reward Processing by the Opioid System in the Brain
Le Merrer, J., Becker, J. A. J., Befort, K., & Kieffer, B. L. (2009) · Physiological Reviews · doi:10.1152/physrev.00005.2009 · Cited by 1,013 · see citing works
A meta-analysis of depression severity and cognitive function
McDermott, L. M., & Ebmeier, K. P. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.022 · Cited by 956 · see citing works
Neurobiology of Executive Functions: Catecholamine Influences on Prefrontal Cortical Functions
Arnsten, A. F. T., & Li, B.-M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.019 · Cited by 948 · see citing works
BDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Lu, B. (2003) · Learning & Memory · doi:10.1101/lm.54603 · Cited by 945 · see citing works
Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861 · see citing works
Dopaminergic Role in Stimulant-Induced Wakefulness
Wisor, J. P., Nishino, S., Sora, I., Uhl, G. R., Mignot, E. J.-M., & Edgar, D. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01787.2001 · Cited by 762 · see citing works
Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia
Goldman-Rakic, P. S., & Selemon, L. D. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.437 · Cited by 668 · see citing works
Neuromodulation of Brain States
Lee, S., & Dan, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.012 · Cited by 666 · see citing works
Serotoninergic regulation of emotional and behavioural control processes
Cools, R., Roberts, A. C., & Robbins, T. W. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.10.011 · Cited by 656 · see citing works
Mahan, A. L., & Ressler, K. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.007 · Cited by 616 · see citing works
What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease
Corti, O., Lesage, S., & Brice, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00022.2010 · Cited by 610 · see citing works
Dopamine: a potential substrate for synaptic plasticity and memory mechanisms
Jay, T. M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00085-6 · Cited by 576 · see citing works
How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission
Sulzer, D. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.010 · Cited by 573 · see citing works
5-HT1A receptor function in major depressive disorder
Savitz, J. B., Lucki, I., & Drevets, W. C. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.009 · Cited by 573 · see citing works
Executive functioning in adult ADHD: a meta-analytic review
MARIJE BOONSTRA, A., OOSTERLAAN, J., SERGEANT, J. A., & BUITELAAR, J. K. (2005) · Psychological Medicine · doi:10.1017/s003329170500499x · Cited by 560 · cited 1× · see citing works
“Cognitive dysfunction, including executive dysfunction, is also a core deficit of ADHD (Boonstra et al., 2005; Brown, 2008).”
BackgroundGrimm, J. W., Lü, L., Hayashi, T., Hope, B. T., Su, T., & Shaham, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00742.2003 · Cited by 551 · see citing works
Depression and Hippocampal Neurogenesis: A Road to Remission?
Eisch, A. J., & Petrik, D. (2012) · Science · doi:10.1126/science.1222941 · Cited by 516 · see citing works
Practice Parameters for the Treatment of Narcolepsy and other Hypersomnias of Central Origin
Morgenthaler, T. I., Kapur, V. K., Brown, T. M., Swick, T. J., Alessi, C., Aurora, R. N., Boehlecke, B., Chesson, A. L., Friedman, L., Maganti, R., et al. (2007) · Sleep · doi:10.1093/sleep/30.12.1705 · Cited by 488 · see citing works
Gonzalez-Burgos, G., & Lewis, D. A. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs010 · Cited by 478 · see citing works
A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
Lisman, J., Grace, A. A., & Duzel, E. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.006 · Cited by 465 · see citing works
Cognitive impairment in major depression
Marazziti, D., Consoli, G., Picchetti, M., Carlini, M., & Faravelli, L. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.08.046 · Cited by 448 · see citing works
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436 · see citing works
Potential Adverse Effects of Amphetamine Treatment on Brain and Behavior: A Review
Arcos-Burgos, M., Jain, M., Acosta, M. T., Shively, S., Stanescu, H., Wallis, D., Domené, S., Velez, J. I., Karkera, J., Balog, J. Z., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.90 · Cited by 423 · see citing works
Mechanisms of dopamine transporter regulation in normal and disease states
Vaughan, R. A., & Foster, J. D. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.07.005 · Cited by 419 · see citing works
The neurobiology and evolution of cannabinoid signalling
Elphick, M. R., & Egertová, M. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0787 · Cited by 416 · see citing works
Psychomotor retardation in depression: Biological underpinnings, measurement, and treatment
Close, J. S., McClintock, S. M., & Croarkin, P. E. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.10.019 · Cited by 401 · see citing works
The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse
Wee, S., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1825-8 · Cited by 398 · see citing works
The neurobiology of addiction: a neuroadaptational view relevant for diagnosis
Koob, G. F. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01586.x · Cited by 397 · see citing works
Horger, B. A., Iyasere, C. A., Berhow, M. T., Messer, C. J., Nestler, E. J., & Taylor, J. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04110.1999 · Cited by 375 · see citing works
The delta opioid receptor: an evolving target for the treatment of brain disorders
Pradhan, A. A. A., Befort, K., Nozaki, C., Gavériaux‐Ruff, C., & Kieffer, B. L. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.06.008 · Cited by 366 · see citing works
Major Depressive Disorder Treatment Guidelines in America and Europe
Davidson, J. R. T. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.9058se1c.04gry · Cited by 344 · see citing works
Dysregulation of Endogenous Opioid Emotion Regulation Circuitry in Major Depression in Women
Kennedy, S. E., Koeppe, R. A., Young, E. A., & Zubieta, J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1199 · Cited by 339 · see citing works
The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy
Taheri, S., Zeitzer, J. M., & Mignot, E. J.-M. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142826 · Cited by 333 · see citing works
Olive, M. F., Koenig, H. N., Nannini, M., & Hodge, C. W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-j0002.2001 · Cited by 300 · see citing works
Sun, X., Zhao, Y., & Wolf, M. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4603-04.2005 · Cited by 299 · see citing works
Datta, S., & MacLean, R. R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.02.004 · Cited by 296 · see citing works
Suen, P.-C., Wu, K. M., Levine, E. S., Mount, H. T. J., Xu, J., Lin, S.-Y., & Black, I. B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8191 · Cited by 290 · see citing works
Psychomotor stimulants and neuronal plasticity
Wolf, M. E., Sun, X., Mangiavacchi, S., & Chao, S. Z. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.006 · Cited by 288 · see citing works
Improving the Treatment of Schizophrenia: Focus on Serotonin (5-HT)1A Receptors
Millan, M. J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38982-7 · Cited by 287 · see citing works
Lü, L., Dempsey, J., Liu, S. Y., Bossert, J. M., & Shaham, Y. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5124-03.2004 · Cited by 282 · see citing works
Raehal, K. M., Schmid, C. L., Groer, C. E., & Bohn, L. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004598 · Cited by 258 · see citing works
Structural Synaptic Modifications Associated with Hippocampal LTP and Behavioral Learning
Geinisman, Y. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.952 · Cited by 256 · see citing works
Swanson, J., Baler, R. D., & Volkow, N. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.160 · Cited by 252 · see citing works
AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging
Henley, J. M., & Wilkinson, K. A. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/jhenley · Cited by 236 · see citing works
Cataplexy-Active Neurons in the Hypothalamus
John, J., Wu, M., Boehmer, L. N., & Siegel, J. M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00247-8 · Cited by 227 · see citing works
Porras, G. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00333-5 · Cited by 222 · see citing works
Mathews, D. C., Henter, I. D., & Zarate, C. A. (2012) · Drugs · doi:10.2165/11633130-000000000-00000 · Cited by 220 · see citing works
Brain serotonergic circuitries
Charnay, Y., & Léger, L. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.4/ycharnay · Cited by 211 · see citing works
The cholinergic hypothesis of cognitive aging revisited again: Cholinergic functional compensation
Dumas, J. A., & NEWHOUSE, P. A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.022 · Cited by 209 · see citing works
D, M. F. M., Thase, M. E., & DeBattista, C. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0112 · Cited by 207 · see citing works
Robertson, S. D., Matthies, H. J. G., & Galli, A. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8053-4 · Cited by 206 · see citing works
Methylphenidate, Dextroamphetamine, and Levamfetamine
Janowsky, D. S. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770030024003 · Cited by 205 · see citing works
Qu, W., Xu, X., Yan, M., Wang, Y., Urade, Y., & Huang, Z. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4936-09.2010 · Cited by 199 · see citing works
The neuropharmacology of ADHD drugs in vivo: Insights on efficacy and safety
Heal, D. J., Cheetham, S. C., & Smith, S. L. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.08.020 · Cited by 198 · see citing works
Seixas, M., Weiss, M., & Müller, U. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111412095 · Cited by 197 · see citing works
Dopamine-Regulated MicroRNA MiR-181a Controls GluA2 Surface Expression in Hippocampal Neurons
Saba, R., Störchel, P. H., Aksoy-Aksel, A., Kepura, F., Lippi, G., Plant, T. D., & Schratt, G. M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.05896-11 · Cited by 196 · see citing works
Woolley, M. L., Pemberton, D. J., Bate, S. T., Corti, C., & Jones, D. N. C. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0974-x · Cited by 189 · see citing works
Neurotrophin-Dependent Modulation of Glutamatergic Synaptic Transmission in the Mammalian CNS
Leßmann, V. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(98)00190-6 · Cited by 189 · see citing works
DeBattista, C., Doghramji, K., Menza, M. A., Rosenthal, M. H., Fieve, R. R., & Modafinil in Depression Study Group (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0911 · Cited by 189 · see citing works
The Psychopathology and Treatment of Bipolar Disorder
Miklowitz, D. J., & Johnson, S. L. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.2.022305.095332 · Cited by 183 · see citing works
New concepts in prolactin biology
Bernichtein, S., Touraine, P. A., & Goffin, V. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0069 · Cited by 179 · see citing works
Xue, C., Ng, J. P., Li, Y., & Wolf, M. E. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67010352.x · Cited by 177 · see citing works
Ritz, M. C., & Kuhar, M. J. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24116-7 · Cited by 176 · see citing works
Amphetamine Paradoxically Augments Exocytotic Dopamine Release and Phasic Dopamine Signals
Daberkow, D. P., Brown, H. D., Bunner, K. D., Kraniotis, S. A., Doellman, M. A., Ragozzino, M. E., Garris, P. A., & Roitman, M. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2136-12.2013 · Cited by 165 · see citing works
Meredith, G. E., Callen, S. E., & Scheuer, D. A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03160-8 · Cited by 158 · see citing works
Interactions between Prolactin and Dopaminergic Neurons1
Moore, K. E. (1987) · Biology of Reproduction · doi:10.1095/biolreprod36.1.47 · Cited by 156 · see citing works
Psychostimulants for depression
Candy, B., Jones, L., Williams, R., Tookman, A., & King, M. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006722.pub2 · Cited by 156 · see citing works
Orrego, F., & Villanueva, S. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90355-j · Cited by 150 · see citing works
5-HT receptors and reward-related behaviour: A review
Hayes, D. J., & Greenshaw, A. J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.03.005 · Cited by 146 · see citing works
Relevance of Norepinephrine–Dopamine Interactions in the Treatment of Major Depressive Disorder
Mansari, M. E., Guiard, B. P., Chernoloz, O., Ghanbari, R., Katz, N., & Blier, P. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00146.x · Cited by 146 · see citing works
Do prescription stimulants increase the risk of adverse cardiovascular events?: A systematic review
Westover, A. N., & Halm, E. A. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-41 · Cited by 141 · see citing works
Patkar, A. A., Masand, P. S., Pae, C.-U., Peindl, K., Hooper-Wood, C., Mannelli, P., & Ciccone, P. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000246212.03530.fd · Cited by 140 · see citing works
Self-citationColasanti, A., Searle, G. E., Long, C. J., Hill, S. P., Reiley, R. R., Quelch, D. R., Erritzøe, D., Tziortzi, A. C., Reed, L. J., Lingford-Hughes, A. R., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.027 · Cited by 140 · see citing works
ADD/ADHD and impaired executive function in clinical practice
Brown, T. E. (2008) · Current Psychiatry Reports · doi:10.1007/s11920-008-0065-7 · Cited by 137 · see citing works
Endocannabinoid tone versus constitutive activity of cannabinoid receptors
Howlett, A. C., Reggio, P. H., Childers, S. R., Hampson, R. E., Ulloa, N. M., & Deutsch, D. G. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01364.x · Cited by 126 · see citing works
Rothman, R. B., & Baumann, M. H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1369.064 · Cited by 123 · see citing works
In vivo monoamine oxidase inhibition by d-amphetamine
Miller, H. H., Shore, P. A., & Clarke, D. E. (1980) · Biochemical Pharmacology · doi:10.1016/0006-2952(80)90429-3 · Cited by 120 · see citing works
Dopaminergic regulation of cortical acetylcholine release
Day, J. C., & Fibiger, H. C. (1992) · Synapse · doi:10.1002/syn.890120405 · Cited by 120 · see citing works
Ravindran, A. V., Kennedy, S. H., O'Donovan, M. C., Fallu, A., Camacho, F., & Binder, C. E. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0112 · Cited by 119 · cited 1× · see citing works
“However, multiple studies did not report significant improvements in depressive symptoms following augmentation with methylphenidate (Postolache et al., 1999; Patkar et al., 2006; Ravindran et al., 2008) or the wake-promoting agent modafinil (DeBattista et al.”
BackgroundStability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine
Mao, L., Wang, W., Chu, X., Zhang, G.-C., Liu, X., Yang, Y., Haines, M. M., Papasian, C. J., Fibuch, E. E., Buch, S. J., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2300 · Cited by 113 · see citing works
Brain Dopamine Receptors: A Primer on Their Current Status, Basic and Clinical
Baldessarini, R. J., & Tarazi, F. I. (1996) · Harvard Review of Psychiatry · doi:10.3109/10673229609017200 · Cited by 112 · see citing works
Self-citationChoe, E. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00341-x · Cited by 109 · see citing works
Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders
Jun, H., Hussaini, S. M. Q., Rigby, M. J., & Jang, M. (2012) · Neural Plasticity · doi:10.1155/2012/854285 · Cited by 108 · see citing works
Lindenmayer, J., Nasrallah, H., Pucci, M., James, S., & Citrome, L. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.03.019 · Cited by 108 · see citing works
Naltrexone Attenuates the Subjective Effects of Amphetamine in Patients with Amphetamine Dependence
Jayaram‐Lindström, N., Konstenius, M., Eksborg, S., Beck, O., Hammarberg, A., & Franck, J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301572 · Cited by 107 · see citing works
Faraone, S. V. (2009) · PubMed Central · Cited by 107 · see citing works
Cognitive enhancers for the treatment of ADHD
Bidwell, L. C., McClernon, F. J., & Kollins, S. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.05.002 · Cited by 101 · see citing works
Chen, R., Furman, C. A., Zhang, M., Kim, M. N., Gereau, R. W., Leitges, M., & Gnegy, M. E. (2009) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.147959 · Cited by 99 · see citing works
Dextro-amphetamine Diminishes Negative Symptoms in Schizophrenia
KAMMEN, D. P. V., & BORONOW, J. J. (1988) · International Clinical Psychopharmacology · doi:10.1097/00004850-198804000-00002 · Cited by 99 · see citing works
Stereoselectivity and isoenzyme selectivity of monoamine oxidase inhibitors
Robinson, J. B. (1985) · Biochemical Pharmacology · doi:10.1016/0006-2952(85)90201-1 · Cited by 96 · see citing works
Woodbury, C. J., Ritter, A. M., & Koerber, H. R. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000131)417:1 · Cited by 89 · see citing works
The Role of 5-HT3 Receptors in Drug Abuse and as a Target for Pharmacotherapy
Engleman, E., Rodd, Z. A., Bell, R. L., & Murphy, J. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708786927886 · Cited by 88 · see citing works
Effects of Naltrexone on the Subjective Response to Amphetamine in Healthy Volunteers
Jayaram‐Lindström, N., Wennberg, P., Hurd, Y. L., & Franck, J. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000144893.29987.e5 · Cited by 88 · see citing works
Recent Advances in Imaging of Dopaminergic Neurons for Evaluation of Neuropsychiatric Disorders
Shen, L., Liao, M.-H., & Tseng, Y.-C. (2012) · BioMed Research International · doi:10.1155/2012/259349 · Cited by 86 · see citing works
Giorgetti, M., Hotsenpiller, G., Ward, P., Teppen, T. L., & Wolf, M. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06362.2001 · Cited by 86 · see citing works
Dopaminergic Regulation of Septohippocampal Cholinergic Neurons
Day, J. C., & Fibiger, H. C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062086.x · Cited by 82 · see citing works
Valvassori, S. S., Elias, G., de Souza, B., Petronilho, F., Dal-Pizzol, F., Kapczinski, F., Trzesniak, C., Tumas, V., Dursun, S., Nisihara Chagas, M. H., et al. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881109106925 · Cited by 80 · see citing works
Nicotinic Mechanisms in the Treatment of Psychotic Disorders: A Focus on the α7 Nicotinic Receptor
D, A. O. M., & Freedman, R. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25758-2_8 · Cited by 80 · see citing works
Effects of cocaine and amphetamine on acetylcholine release in the hippocampus and caudate nucleus
Impérato, A., Obinu, M. C., & Gessa, G. L. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90869-j · Cited by 80 · see citing works
Cognition in older adults with bipolar disorder versus major depressive disorder
Gildengers, A. G., Butters, M. A., Chisholm, D., Anderson, S., Begley, A. E., Holm, M. B., Rogers, J. C., Reynolds, C. F., & Mulsant, B. H. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.00995.x · Cited by 77 · see citing works
Shen, F., Meredith, G. E., & Napier, T. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2898-06.2006 · Cited by 75 · see citing works
Cumming, P., Wong, D. F., Gillings, N., Hilton, J., Scheffel, U., & Gjedde, A. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200205000-00011 · Cited by 71 · see citing works
Huang, Y.-C., Wang, S., Chiou, L., & Gean, P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10311.2003 · Cited by 70 · see citing works
Effects of cannabinoids on the anxiety-like response in mice.
Rutkowska, M., Jamontt, J., & Gliniak, H. (2006) · PubMed · Cited by 66 · see citing works
Carlson, P. J., Merlock, M., & Suppes, T. M. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00132.x · Cited by 63 · see citing works
Adler, L. A., Dirks, B., Deas, P. F., Raychaudhuri, A., Dauphin, M. R., Lasser, R. A., & Weisler, R. H. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m08144 · Cited by 62 · cited 1× · see citing works
“, 2011), with evidence that they demonstrate short-term efficacy versus placebo and long-term effectiveness for the core symptoms of ADHD (Hodgkins et al., 2012; Adler et al., 2013).”
BackgroundSantosh, P. J., Sattar, S., & Canagaratnam, M. (2011) · CNS Drugs · doi:10.2165/11593070-000000000-00000 · Cited by 62 · see citing works
Lu, W., & Wolf, M. E. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00136-8 · Cited by 61 · see citing works
Olsson, S. K., Andersson, A., Linderholm, K. R., Holtze, M., Nilsson-Todd, L. K., Schwieler, L., Olsson, E., Larsson, K., Engberg, G., & Erhardt, S. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009383 · Cited by 58 · see citing works
Chronic amphetamine treatment reduces NGF and BDNF in the rat brain
Angelucci, F., Gruber, S. H. M., Khoury, A. E., Tonali, P. A., & Mathé, A. A. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.03.002 · Cited by 57 · see citing works
Dipace, C., Sung, U., Binda, F., Blakely, R., & Galli, A. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026690 · Cited by 56 · see citing works
Nelson, C. L., Milovanovic, M., Wetter, J. B., Ford, K. A., & Wolf, M. E. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05911.x · Cited by 54 · see citing works
Amphetamine releases dopamine from synaptic vesicles by dual mechanisms
Floor, E., & Meng, L. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)12963-3 · Cited by 54 · see citing works
Dunlop, B., Crits-Christoph, P., Evans, D., Hirschowitz, J., Solvason, H., Rickels, K., Garlow, S. J., Gallop, R., & Ninan, P. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31815abefb · Cited by 52 · see citing works
Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse
Enman, N. M., & Unterwald, E. M. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.027 · Cited by 51 · see citing works
Amphetamine response and relapse risk after depot neuroleptic discontinuation
ANGRIST, B. M., Peselow, E. D., Rubinstein, M. E., Wolkin, A., & Rotrosen, J. (1985) · Psychopharmacology · doi:10.1007/bf00428187 · Cited by 49 · see citing works
Miele, M., Mura, M. A., Enrico, P., Esposito, G., Serra, P. A., Migheli, R., Zangani, D., MIELE, E., & Desole, M. S. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703066 · Cited by 48 · see citing works
Regulation of the Human Norepinephrine Transporter by Cocaine and Amphetamine
Zhu, M., Shamburger, S., Li, J., & Ordway, G. A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38993-1 · Cited by 48 · see citing works
Karoum, T., Chrapusta, S. J., Brinjak, R., Hitri, A., & Wyatt, R. J. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb17152.x · Cited by 48 · see citing works
The use of serotonergic drugs to treat obesity – is there any hope?
Bello, N. T., & Liang, N.-C. (2011) · Drug Design Development and Therapy · doi:10.2147/dddt.s11859 · Cited by 47 · see citing works
Amphetamine‐induced locomotion and gene expression are altered in BDNF heterozygous mice
Saylor, A. J., & McGinty, J. F. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00430.x · Cited by 47 · see citing works
Lasser, R. A., Dirks, B., Nasrallah, H. A., Kirsch, C., Gao, J., Pucci, M. L., Knesevich, M. A., & Lindenmayer, J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.111 · Cited by 46 · see citing works
Pharmacotherapy of Pediatric Attention-Deficit/Hyperactivity Disorder
Vaughan, B., & Kratochvil, C. J. (2012) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2012.07.005 · Cited by 46 · see citing works
Levy, D. L., Smith, M. J., Robinson, D. G., Jody, D. N., Lerner, G., Alvir, J. M., Geisler, S., Szymanski, S., Gonzalez, A., Mayerhoff, D. I., et al. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90192-g · Cited by 45 · see citing works
The Pharmacology and Clinical Outcomes of Amphetamines to Treat ADHD
Hodgkins, P., Shaw, M., McCarthy, S., & Sallee, F. R. (2012) · CNS Drugs · doi:10.2165/11599630-000000000-00000 · Cited by 45 · see citing works
Flores, C., & Stewart, J. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00115-9 · Cited by 44 · see citing works
Ahn, K.-C., Bernier, B. E., Harnett, M. T., & Morikawa, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4453-09.2010 · Cited by 44 · see citing works
The Nicotinic Acetylcholine Receptor as a Target for Antidepressant Drug Development
Philip, N. S., Carpenter, L. L., Tyrka, A. R., & Price, L. H. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/104105 · Cited by 43 · see citing works
Individual differences in amphetamine sensitization, behavior and central monoamines
Scholl, J. L., Feng, N., Watt, M. J., Renner, K. J., & Forster, G. L. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.12.001 · Cited by 43 · see citing works
Rahman, S., & Bardo, M. T. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.052 · Cited by 42 · see citing works
Pehrson, A. L., & Moghaddam, B. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1914-8 · Cited by 42 · see citing works
Metabolic, toxicological, and safety considerations for drugs used to treat ADHD
Duong, S., Chung, K., & Wigal, S. B. (2012) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2012.671295 · Cited by 42 · see citing works
Biała, G., Kruk, M., & Budzyńska, B. (2009) · PubMed · Cited by 41 · see citing works
Recent Advances in the Treatment of Narcolepsy
Hirai, N., & Nishino, S. (2011) · Current Treatment Options in Neurology · doi:10.1007/s11940-011-0137-6 · Cited by 38 · see citing works
Rademacher, D. J., Rosenkranz, J. A., Morshedi, M. M., Sullivan, E. M., & Meredith, G. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6165-09.2010 · Cited by 38 · see citing works
van den Buuse, M., Ruimschotel, E., Martin, S., Risbrough, V. B., & Halberstadt, A. L. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.001 · Cited by 37 · see citing works
Mao, L., Conquet, F., & Wang, J. Q. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00284-6 · Cited by 36 · see citing works
Amphetamine-stimulated cortical acetylcholine release: role of the basal forebrain
Arnold, H. M., Fadel, J., Sarter, M. F., & Bruno, J. P. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03328-x · Cited by 36 · see citing works
Häggkvist, J., Lindholm, S., & Franck, J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.021 · Cited by 35 · see citing works
Xu, T., Ma, Q., Spealman, R. D., & Yao, W. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07073.x · Cited by 33 · see citing works
Dextroamphetamine treatment of mania.
Garvey, M. J., Hwang, S., Teubner-Rhodes, D., Zander, J., & Rhem, C. (1987) · PubMed · Cited by 33 · see citing works
McIntyre, R. S., Alsuwaidan, M. T., Soczynska, J. K., Szpindel, I., Bilkey, T. S., Almagor, D., Woldeyohannes, H. O., Powell, A. M., Cha, D. S., Gallaugher, L. A., et al. (2013) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2325 · Cited by 31 · see citing works
The Dopaminergic Projection System, Basal Forebrain Macrosystems, and Conditioned Stimuli
Zahm, D. S., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900016138 · Cited by 31 · see citing works
Keys, A. S., & Mark, G. P. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00018-9 · Cited by 31 · see citing works
Kleijn, J., Wiskerke, J., Cremers, T. I. F. H., Schoffelmeer, A. N. M., Westerink, B. H. C., & Pattij, T. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.03.002 · Cited by 29 · see citing works
Nonstriatal Dopamine D1 Receptors Regulate Striatal Acetylcholine Release In Vivo
Acquas, E., Wilson, C., & Fibiger, H. C. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36622-4 · Cited by 29 · see citing works
Zhou, J., Mo, Z., & Zhou, S. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.05.007 · Cited by 28 · see citing works
Pehek, E. A., & Bi, Y. (1997) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(97)00040-7 · Cited by 27 · see citing works
Behavioral response to methylphenidate and treatment outcome in first episode schizophrenia.
Jody, D. N., Lieberman, J. A., Geisler, S., Szymanski, S., & Alvir, J. M. (1990) · PubMed · Cited by 27 · see citing works
Morshedi, M. M., Rademacher, D. J., & Meredith, G. E. (2008) · Synapse · doi:10.1002/syn.20591 · Cited by 26 · see citing works
Early augmentation of sertraline with methylphenidate
Postolache, T. T., Rosenthal, R. N., Hellerstein, D. J., Aromin, R., Kelton, G. M., Muran, J. C., & Londono, J. H. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0210c · Cited by 26 · cited 1× · see citing works
“However, multiple studies did not report significant improvements in depressive symptoms following augmentation with methylphenidate (Postolache et al., 1999; Patkar et al., 2006; Ravindran et al., 2008) or the wake-promoting agent modafinil (DeBattista et al.”
BackgroundHäggkvist, J., Lindholm, S., & Franck, J. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00150.x · Cited by 25 · see citing works
Tzavara, E. T., Degroot, A., Wade, M. R., Davis, R. J., & Nomikos, G. G. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.11.003 · Cited by 25 · see citing works
Mattson, B. J., Crombag, H. S., Mitchell, T. B., SIMMONS, D., KREUTER, J., MORALES, M., & Hope, B. T. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.07.024 · Cited by 24 · see citing works
Different Black Box Warning Labeling for Same-Class Drugs
Panagiotou, O. A., Contopoulos‐Ioannidis, D. G., Papanikolaou, P. N., Ntzani, E., & Ioannidis, J. P. A. (2011) · Journal of General Internal Medicine · doi:10.1007/s11606-011-1633-9 · Cited by 23 · see citing works
Parelkar, N. K., & Wang, J. Q. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.01.015 · Cited by 23 · see citing works
Bosse, K. E., Jutkiewicz, E. M., Gnegy, M. E., & Traynor, J. R. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.017 · Cited by 22 · see citing works
Benneyworth, M. A., & Coyle, J. T. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.108 · Cited by 22 · see citing works
Lsamp–/– mice display lower sensitivity to amphetamine and have elevated 5-HT turnover
Innos, J., Leidmaa, E., Philips, M., Sütt, S., O’Leary, A., Harro, J., Kõks, S., & Vasar, E. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.077 · Cited by 21 · see citing works
Acute Amphetamine Exposure Selectively Desensitizes κ-Opioid Receptors in the Nucleus Accumbens
Xia, Y., Li, H., Whistler, J. L., & Hjelmstad, G. O. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301463 · Cited by 21 · see citing works
Behavioral Neurobiology of Bipolar Disorder and its Treatment
Manji, H. K., & Zarate, C. A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-15757-8 · Cited by 20 · see citing works
Ito, T., Suzuki, T., Wellman, S. E., & Ho, I. K. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199602)22:2 · Cited by 18 · see citing works
Gramage, E., Olmo, N. D., Fole, A., Martín, Y. B., & Herradón, G. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00362.x · Cited by 17 · see citing works
Shaffer, C., Guo, M.-L., Fibuch, E. E., Mao, L.-M., & Wang, J. Q. (2010) · Brain Research · doi:10.1016/j.brainres.2010.02.062 · Cited by 17 · see citing works
Doremus‐Fitzwater, T. L., & SPEAR, L. P. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.005 · Cited by 16 · see citing works
McGinty, J. F., Bache, A. J., Coleman, N. T., & Sun, W. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00060 · Cited by 16 · see citing works
Hetzel, A., Meredith, G. E., Rademacher, D. J., & Rosenkranz, J. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.015 · Cited by 12 · see citing works
The Role of the Aminergic Systems in the Pathophysiology of Bipolar Disorder
Walderhaug, E., Varga, M., Pedro, M. S., Hu, J., & Neumeister, A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_72 · Cited by 12 · see citing works
Fukushiro, D. F., Josino, F. S., Saito, L. P., Costa, J. M., Zanlorenci, L. H. F., Berro, L. F., Fernandes‐Santos, L., Morgado, F., Mári-Kawamoto, E., & Frussa‐Filho, R. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.12.026 · Cited by 12 · see citing works
Restoration of amphetamine-induced locomotor sensitization in dopamine D1 receptor-deficient mice
El-Ghundi, M., Fan, T., Karasinska, J. M., Yeung, J. M., Zhou, M., O’Dowd, B. F., & George, S. R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1690-5 · Cited by 11 · see citing works
Brunk, I., Sanchis‐Segura, C., Blex, C., Perreau‐Lenz, S., Bilbao, A., Spanagel, R., & Ahnert‐Hilger, G. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06921.x · Cited by 5 · see citing works
Managò, F., Lopez, S., Oliverio, A., Amalric, M., Mele, A., & Leonibus, E. D. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2925-4 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kinetics, mechanism, and inhibition of monoamine oxidase
Ramsay, R. R., & Albreht, A. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1861-9 · Cited by 108 · see citing works
Clinical management of negative symptoms of schizophrenia: An update
Tsapakis, E.-M., Dimopoulou, T., & Tarazi, F. I. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.008 · Cited by 72 · see citing works
Self-citationBinge-eating disorder: Clinical and therapeutic advances
Hutson, P. H., Balodis, I. M., & Potenza, M. N. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.08.002 · Cited by 59 · see citing works
Self-citationRippberger, H., van Gaalen, M. M., Schwarting, R. K. W., & Wöhr, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1302150525124408 · Cited by 42 · see citing works
Engelhardt, K.-A., Fuchs, E., Schwarting, R. K. W., & Wöhr, M. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.01.003 · Cited by 40 · see citing works
Silveira, M. M., Malcolm, E., Shoaib, M., & Winstanley, C. A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.029 · Cited by 31 · see citing works
Higgins, G. A., Silenieks, L. B., MacMillan, C., Thevarkunnel, S., Parachikova, A. I., Mombereau, C., Lindgren, H. S., & Bastlund, J. F. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00427 · Cited by 25 · see citing works
Diester, C. M., Santos, E. J., Moerke, M. J., & Negus, S. S. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000464 · Cited by 23 · see citing works
Marszalek-Grabska, M., Gibula-Bruzda, E., Jenda, M., Gawel, K., & Kotlinska, J. H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.026 · Cited by 22 · see citing works
Tendilla‐Beltrán, H., Arroyo‐García, L. E., Díaz, A., Camacho‐Abrego, I., de la Cruz, F., Moreno, A. R., & Flores, G. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.05.004 · Cited by 20 · see citing works
Silveira, M. M., Murch, W. S., Clark, L., & Winstanley, C. A. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000203 · Cited by 21 · see citing works
Mapping trait-like socio-affective phenotypes in rats through 50-kHz ultrasonic vocalizations
Engelhardt, K.-A., Schwarting, R. K. W., & Wöhr, M. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4746-y · Cited by 18 · see citing works
Chiang, F.-K., Cheng, R., & Liao, R. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.01.002 · Cited by 15 · see citing works
Ito, T., Yoshida, M., Aida, T., Kushima, I., Hiramatsu, Y., Ono, M., Yoshimi, A., Tanaka, K., Ozaki, N., & Noda, Y. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15790 · Cited by 13 · see citing works
Bardgett, M. E., Crane, C., Thompson, E. C. B., Cox, B., & Downnen, T. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.044 · Cited by 13 · see citing works
Dias, V. T., Rosa, H. Z., D’avila, L. F., Vey, L. T., Barcelos, R. C. S., & Bürger, M. E. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.007 · Cited by 13 · see citing works
Kassim, F. M. (2023) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.2856 · Cited by 11 · see citing works
“AMP is a prototype psychostimulant (Berman et al., 2009; Fleckenstein et al., 2007; Hutson et al., 2014), used for the treatment of attention deficit hyperactivity disorder (ADHD) (Castells et al., 2018; Easton et al., 2007), narcolepsy (Turner, 2019), and obesity (Harris et al., 1947).”
BackgroundSungur, A. Ö., Redecker, T. M., Andres, E., Dürichen, W., Schwarting, R. K. W., del Rey, A., & Wöhr, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00419 · Cited by 8 · see citing works
Pharmacological Strategies to Improve Mental Performance
Cutsem, J. V., & Pattyn, N. (2024) · Routledge eBooks · doi:10.4324/9781003378969-8 · Cited by 4 · see citing works
The Effects of Drug Treatments for ADHD in Measures of Cognitive Performance
Higgins, G. A., & Silenieks, L. B. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_341 · Cited by 4 · see citing works
Dexamphetamine influences funneling illusion based on psychometric score
Kassim, F. M., Lim, J. H. M., Albrecht, M. A., & Martin-Iverson, M. T. (2023) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2862 · Cited by 4 · see citing works
Dexamphetamine widens temporal and spatial binding windows in healthy participants
Kassim, F. M., Krakonja, S., Keay, E. A., Iyyalol, R., Rodger, J., Albrecht, M. A., & Martin-Iverson, M. T. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.220149 · Cited by 2 · see citing works
Polysubstance Use and Overdose Visualized via Maps: Amphetamines and Cocaine
Raffa, R. B., Pergolizzi, J. V., & Cukier, H. (2022) · Pharmacology & Pharmacy · doi:10.4236/pp.2022.135011
van Gaalen, M. M., Schlumbohm, C., Folgering, J. H. A., Adhikari, S., Bhattacharya, C. S., Steinbach, D., & Stratford, R. E. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254508
Chapter 45. Psychostimulants and Wakefulness-Promoting Agents
DeBattista, C. (2024) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375523.as45
Frye, M. A., Sánchez-Ruiz, J. A., Ali, D. N., Núñez, N. A., Lindstrom, K., Pazdernik, V. K., Mori, N. N., Singh, B., Barboza, A. B. C., Georgiev, G., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122257
- Authors
- Hutson, P. H., Tarazi, F. I., Madhoo, M., Slawecki, C., & Patkar, A. A.
- Affiliations
- Takeda (United States) (US)
- Harvard University (US)
- Duke University (US)
- Corresponding author
- Hutson, Peter H.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 143
- Issue
- 3
- Pages
- 253-264
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2030742716
- Cited by
- 31
- References
- 188
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 1
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shire Development LLC
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- amphetamine, monoamine transporters, glutamatergic system, endocannabinoid system, endogenous opioid system, acetylcholine, synaptic plasticity, neurotrophic factors, intracellular signaling, addiction, mood regulation, cognition, arousal, neuropsychiatric disorders, psychopharmacological treatment, attention deficit hyperactivity disorder, narcolepsy
- MeSH terms
- Amphetamine, Animals, Mental Disorders, Biogenic Amines, Humans, Synaptic Transmission, Glutamic Acid, Opioid Peptides, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review