Behavioral and molecular effects of prenatal continuous light exposure in the adult rat
Abstract
Disruption of the maternal environment during pregnancy leads to behavioral changes and diseases in the adult offspring. To explore the influence of prenatal continuous light exposure (PCLE) on the adult offspring, we exposed pregnant Wistar rats to constant light during late gestation. Adult PCLE offspring showed an anxiety-like behavior and impairment of short-term memory in different tests. Measurements in the whole brain homogenates from newborn and adult offspring indicated decreased melatonin and serotonin levels and increased reactive oxygen species level in PCLE offspring. Further, we determined melatonin-, serotonin-, oxidative stress-, apoptosis-, and circadian system-related genes expression in different brain areas of adult offspring. The serotonin reuptaker Slc6a4 displayed a decreased expression in the prefrontal cortex of PCLE group. The circadian rhythm-related gene Rora was upregulated in the amygdala of PCLE offspring. Our results point to adverse behavioral effects of PCLE on adult offspring, involving serotonin and melatonin signaling dysregulation, increased chronic oxidative stress, and altered gene expression.
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Alterations in the rhythms of circadian gene expression are associated with impaired spatial memory in these offspring, and these memory deficits can be prevented by regularly scheduled supplementation of melatonin to the mother.
“Alterations in the rhythms of circadian gene expression are also associated with impaired spatial memory in these offspring46,47, and these memory deficits can be prevented by regularly scheduled supplementation of melatonin to the mother46.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [47]
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Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
- Authors
- Voiculescu, S. E., Le Duc, D., Roșca, A. E., Zeca, V., Chiţimuș, D. M., Arsene, A. L., Drăgoi, C. M., Nicolae, A. C., Zăgrean, L., Schöneberg, T., & Zăgrean, A.-M.
- Affiliations
- Carol Davila University of Medicine and Pharmacy (RO)
- Leipzig University (DE)
- Corresponding author
- Zăgrean, Ana-Maria
- ORCID
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 1650
- Pages
- 51-59
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2511293994
- Cited by
- 56
- References
- 65
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 8 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 12 · 2018: 5 · 2017: 4 · 2016: 1
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Molecular Biochemistry Institute of the Medical Faculty
- EXCEL-FIN (POSDRU/107/1.5/S/82839)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- anxiety-like behavior, short-term memory impairment, melatonin, serotonin, oxidative stress, reactive oxygen species, apoptosis, circadian rhythm genes, RORA, serotonin transporter, prefrontal cortex, amygdala, gene expression, offspring behavior
- MeSH terms
- Animals, Animals, Newborn, Anxiety, Behavior, Animal, Brain, Circadian Rhythm, Female, Light, Male, Melatonin, Memory, Short-Term, Pregnancy, Prenatal Exposure Delayed Effects, Serotonin, Rats, Wistar, Oxidative Stress, Maze Learning, Serotonin Plasma Membrane Transport Proteins, Rats, Nuclear Receptor Subfamily 1, Group F, Member 1
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