Regulation of affect by the lateral septum: implications for neuropsychiatry

In the citing paper

“this area serves as a hub in the brain by integrating social, emotional, and contextual information from different brain systems and contributing to the coordination of adaptive context-specific behavioral responses (Sheehan et al., 2004; Luo et al., 2011)”

In the citing paper

“and the lateral septum plays a key role in modulating context-specific motivational states (Sheehan et al., 2004; Luo et al., 2011; Sartor and Aston-Jones, 2012).”

In the citing paper

“A possible circuit could comprise the hippocampus transmitting contextual information onto the lateral septum which, in turn, relays this information onto areas such as the lateral hypothalamus and the ventral tegmental area to modulate behavioral responses appropriate to particular environmental stimuli (Sheehan et al., 2004).”

In the citing paper

“GABA-A receptor activation presumably will result in decreased LS neuronal output while GABA-A receptor blockade will allow for increased LS output (Sheehan et al., 2004).”

In the citing paper

“Following this trend, lesions of other play-associated brain regions also impair locomotor behavior, sensory processing, etc. (Neill et al., 1974; Sheehan et al., 2004; DiBenedictis et al., 2013) making it difficult to parse out the specific impact of each region on play itself.”

In the citing paper

“Therefore, it is likely known that the effects of DA and NE in the LS are dependent on additional inputs to the LS [19].”

In the citing paper

“Early expression of maternal behavior in virgin rodents is correlated with OTR density in the NAC shell, the lateral septum (LS) and parts of the extended amygdala, all regions implicated in pair bonding and in the regulation of motivated behaviors (Champagne et al 2001; Sheehan et al 2004; Olazabal and Young 2006b; Modi and Young 2011).”

In the citing paper

“A variety of stressors induce immediate early gene (IEG) expression in subsets of LS neurons (reviewed in (Sheehan et al., 2004)).”

In the citing paper

“Thus LS output does not serve exclusively to suppress fear or anxiety in response to stressors (Sheehan et al., 2004).”

In the citing paper

“These data argue against the long standing view that LS output serves primarily to suppress fear or anxiety in response to stressors (Sheehan et al., 2004).”

In the citing paper

“The robust and dramatic ‘septal rage’ phenotype that results from certain electrolytic, physical, or chemical lesions of the septum (Spiegel et al., 1940; Brady and Nauta, 1953; Albert and Richmond, 1976) have led to a prevailing view that the output of the LS serves to dampen fear and anxiety (Sheehan et al., 2004).”

In the citing paper

“LS neurons in general are thought to send recurrent GABAergic collaterals that terminate on other neurons throughout the LS (Sheehan et al., 2004).”