Neuronal circuits for fear and anxiety
Abstract
Decades of research has identified the brain areas that are involved in fear, fear extinction, anxiety and related defensive behaviours. Newly developed genetic and viral tools, optogenetics and advanced in vivo imaging techniques have now made it possible to characterize the activity, connectivity and function of specific cell types within complex neuronal circuits. Recent findings that have been made using these tools and techniques have provided mechanistic insights into the exquisite organization of the circuitry underlying internal defensive states. This Review focuses on studies that have used circuit-based approaches to gain a more detailed, and also more comprehensive and integrated, view on how the brain governs fear and anxiety and how it orchestrates adaptive defensive behaviours.
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Flexibly shifting between freezing and active defensive modes relies on fronto-amygdala connections.
“In addition, flexibly shifting between freezing and active defensive modes is critical for adequate stress-coping and relies on fronto-amygdala connections.”
From Freeze for action: neurobiological mechanisms in animal and human freezing (2017) · cites this paper as [62]
Projections of the ventromedial prefrontal cortex and perigenual anterior cingulate cortex to the central nucleus of the amygdala facilitate rapid shifting between passive and active defence modes.
“Projections of the ventromedial prefrontal cortex (vmPFC) and the perigenual anterior cingulate cortex (ACC) in particular to the CE of the amygdala in turn facilitate rapid shifting between passive and active defence modes [41,62].”
From Freeze for action: neurobiological mechanisms in animal and human freezing (2017) · cites this paper as [62]
Humans, just like animals, recruit amygdala, periaqueductal grey and ventral forebrain structures to control the defence cascade.
“These findings provide preliminary evidence that humans, just like animals, recruit amygdala, PAG and ventral forebrain structures to control the defence cascade [62].”
From Freeze for action: neurobiological mechanisms in animal and human freezing (2017) · cites this paper as [62]
Enhanced amygdala responsivity is often associated with hyperactivity in a network that mediates anticipation of negative outcomes and hypoactivity in inhibitory systems involving ventromedial PFC.
“Enhanced amygdala responsivity is often associated with hyperactivity in a network that mediates the anticipation of negative outcomes and consists of the anterior cingulate cortex, insula, dorsolateral PFC and the medial orbitofrontal cortex, and hypoactivity in inhibitory systems, for example involving the ventromedial PFC, which is implicated in top-down inhibition of amygdala output [Fig.3;”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Tovote et al., 2015
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474 · see citing works
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · see citing works
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358 · see citing works
Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective
Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007 · see citing works
The Neuropsychology of Anxiety
Gray, J. A., & McNaughton, N. (2003) · doi:10.1093/acprof:oso/9780198522713.001.0001 · Cited by 1,933 · see citing works
Neurobiology of Pavlovian fear conditioning.
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,866 · see citing works
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · see citing works
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745 · see citing works
Functional organization of the hippocampal longitudinal axis
Strange, B. A., Witter, M. P., Lein, E. S., & Moser, E. I. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3785 · Cited by 1,738 · see citing works
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works
Optogenetic stimulation of a hippocampal engram activates fear memory recall
Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K. A., & Tonegawa, S. (2012) · Nature · doi:10.1038/nature11028 · Cited by 1,669 · see citing works
Optimizing inhibitory learning during exposure therapy
Craske, M. G., Kircanski, K., Zelikowsky, M., Mystkowski, J., Chowdhury, N., & Baker, A. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.10.003 · Cited by 1,607 · see citing works
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580 · see citing works
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498 · see citing works
Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety
Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.109 · Cited by 1,488 · see citing works
Regional dissociations within the hippocampus-memory and anxiety
Bannerman, D. M., Rawlins, J. N. P., McHugh, S. B., Deacon, R. M. J., Yee, B. K., Bast, T., Zhang, W.-N., Pothuizen, H. H. J., & Feldon, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.004 · Cited by 1,462 · see citing works
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428 · see citing works
Natural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389 · see citing works
Two types of dopamine neuron distinctly convey positive and negative motivational signals
Matsumoto, M., & Hikosaka, O. (2009) · Nature · doi:10.1038/nature08028 · Cited by 1,378 · see citing works
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365 · see citing works
Swanson, L. W., & Petrovich, G. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01265-x · Cited by 1,351 · see citing works
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310 · see citing works
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300 · see citing works
Lateral habenula as a source of negative reward signals in dopamine neurons
Matsumoto, M., & Hikosaka, O. (2007) · Nature · doi:10.1038/nature05860 · Cited by 1,292 · see citing works
Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289 · see citing works
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277 · see citing works
Cortical interneurons that specialize in disinhibitory control
Pi, H.-J., Hangya, B., Kvitsiani, D., Sanders, J. I., Huang, Z. J., & Kepecs, A. (2013) · Nature · doi:10.1038/nature12676 · Cited by 1,136 · see citing works
The neuroanatomical and neurochemical basis of conditioned fear
Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092 · see citing works
Columnar organization in the midbrain periaqueductal gray: modules for emotional expression?
Bandler, R., & Shipley, M. T. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90047-7 · Cited by 1,051 · see citing works
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049 · see citing works
Molecular mechanisms of fear learning and memory
Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012 · see citing works
Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994 · see citing works
Engineering a memory with LTD and LTP
Nabavi, S., Fox, R., Proulx, C. D., Lin, J. Y., Tsien, R. Y., & Malinow, R. (2014) · Nature · doi:10.1038/nature13294 · Cited by 980 · see citing works
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976 · see citing works
Pitkänen, A., Pikkarainen, M., Nurminen, N., & Ylinen, A. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06738.x · Cited by 962 · see citing works
Switching on and off fear by distinct neuronal circuits
Herry, C., Ciocchi, S., Senn, V., Demmou, L., Müller, C., & Lüthi, A. (2008) · Nature · doi:10.1038/nature07166 · Cited by 950 · see citing works
Self-citationQuirk, G. J., Likhtik, E., Pelletier, J. G., & Paré, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08800.2003 · Cited by 927 · see citing works
Encoding of conditioned fear in central amygdala inhibitory circuits
Ciocchi, S., Herry, C., Grenier, F., Wolff, S. B. E., Letzkus, J. J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M. B., et al. (2010) · Nature · doi:10.1038/nature09559 · Cited by 924 · see citing works
Self-citationThe primate amygdala represents the positive and negative value of visual stimuli during learning
Paton, J. J., Belova, M. A., Morrison, S. E., & Salzman, C. D. (2006) · Nature · doi:10.1038/nature04490 · Cited by 917 · see citing works
Reduced fear expression after lesions of the ventral hippocampus
Kjelstrup, K. G., Tuvnes, F. A., Steffenach, H.-A., Murison, R., Moser, E. I., & Moser, M.-B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152112399 · Cited by 912 · see citing works
LeDoux, J. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400335111 · Cited by 891 · see citing works
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., Cho, S., Tye, K. M., Kempadoo, K. A., Zhang, F., Deisseroth, K., et al. (2011) · Nature · doi:10.1038/nature10194 · Cited by 878 · see citing works
Localization of a Stable Neural Correlate of Associative Memory
Reijmers, L. G. J. E., Perkins, B. L., Matsuo, N., & Mayford, M. R. (2007) · Science · doi:10.1126/science.1143839 · Cited by 853 · see citing works
Genetic dissection of an amygdala microcircuit that gates conditioned fear
Haubensak, W., Kunwar, P. S., Cai, H., Ciocchi, S., Wall, N. R., Ponnusamy, R., Biag, J., Dong, H.-W., Deisseroth, K., Callaway, E. M., et al. (2010) · Nature · doi:10.1038/nature09553 · Cited by 840 · see citing works
Self-citationA disinhibitory microcircuit for associative fear learning in the auditory cortex
Letzkus, J. J., Wolff, S. B. E., Meyer, E. M. M., Tovote, P., Courtin, J., Herry, C., & Lüthi, A. (2011) · Nature · doi:10.1038/nature10674 · Cited by 840 · see citing works
Self-citationMiserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824 · see citing works
Quirk, G. J., Repa, J. C., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90092-6 · Cited by 808 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
Postsynaptic receptor trafficking underlying a form of associative learning
Rumpel, S., LeDoux, J., Zador, A., & Malinow, R. (2005) · Science · doi:10.1126/science.1103944 · Cited by 775 · see citing works
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli
Lammel, S., Ion, D. I., Roeper, J., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.025 · Cited by 766 · see citing works
Amygdala Microcircuits Controlling Learned Fear
Duvarci, S., & Pare, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.042 · Cited by 751 · see citing works
Optogenetic investigation of neural circuits underlying brain disease in animal models
Tye, K. M., & Deisseroth, K. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3171 · Cited by 745 · see citing works
Adhikari, A., Topiwala, M. A., & Gordon, J. A. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.002 · Cited by 729 · see citing works
Amygdalar and Hippocampal Theta Rhythm Synchronization During Fear Memory Retrieval
Seidenbecher, T., Laxmi, T. R., Stork, O., & Pape, H.-C. (2003) · Science · doi:10.1126/science.1085818 · Cited by 728 · see citing works
Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition
Royer, S., Zemelman, B. V., Losonczy, A., Kim, J., Chance, F., Magee, J. C., & Buzsáki, G. (2012) · Nature Neuroscience · doi:10.1038/nn.3077 · Cited by 728 · see citing works
Topography of projections from amygdala to bed nuclei of the stria terminalis
Dong, H.-W., Petrovich, G. D., & Swanson, L. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00079-0 · Cited by 714 · see citing works
Distinct extended amygdala circuits for divergent motivational states
Jennings, J. H., Sparta, D. R., Stamatakis, A. M., Ung, R. L., Pleil, K. E., Kash, T. L., & Stuber, G. D. (2013) · Nature · doi:10.1038/nature12041 · Cited by 704 · see citing works
A framework for studying emotions across species
Anderson, D. J., & Adolphs, R. (2014) · Cell · doi:10.1016/j.cell.2014.03.003 · Cited by 691 · see citing works
Hippocampal synaptic plasticity, spatial memory and anxiety
Bannerman, D. M., Sprengel, R., Sanderson, D. J., McHugh, S. B., Rawlins, J. N. P., Monyer, H., & Seeburg, P. H. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3677 · Cited by 688 · see citing works
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
Falls, W., Miserendino, M., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00854.1992 · Cited by 673 · see citing works
Diverging neural pathways assemble a behavioural state from separable features in anxiety
Kim, S.-Y., Adhikari, A., Lee, S. Y., Marshel, J. H., Kim, C. K., Mallory, C. S., Lo, M., Pak, S., Mattis, J., Lim, B. K., et al. (2013) · Nature · doi:10.1038/nature12018 · Cited by 666 · see citing works
Neural circuits and mechanisms involved in Pavlovian fear conditioning: A critical review
Kim, J. J., & Jung, M. W. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.005 · Cited by 636 · see citing works
GABA Neurons of the VTA Drive Conditioned Place Aversion
Tan, K. R., Yvon, C., Turiault, M., Mirzabekov, J. J., Doehner, J., Labouèbe, G., Deisseroth, K. A., Tye, K. M., & Lüscher, C. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.015 · Cited by 635 · see citing works
Synaptic potentiation onto habenula neurons in the learned helplessness model of depression
Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C. D., Schulz, D., Henn, F., & Malinow, R. (2011) · Nature · doi:10.1038/nature09742 · Cited by 634 · see citing works
Kim, J. J., Rison, R. A., & Fanselow, M. S. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.6.1093 · Cited by 615 · see citing works
Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement
Fields, H. L., Hjelmstad, G. O., Margolis, E. B., & Nicola, S. M. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094341 · Cited by 611 · see citing works
A synaptic memory trace for cortical receptive field plasticity
Froemke, R. C., Merzenich, M. M., & Schreiner, C. E. (2007) · Nature · doi:10.1038/nature06289 · Cited by 600 · see citing works
BLA to vHPC inputs modulate anxiety-related behaviors
Felix-Ortiz, A. C., Beyeler, A., Seo, C., Leppla, C. A., Wildes, C. P., & Tye, K. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.016 · Cited by 592 · see citing works
Activity in Prelimbic Cortex Is Necessary for the Expression of Learned, But Not Innate, Fears
Corcoran, K., & Quirk, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5327-06.2007 · Cited by 580 · see citing works
Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety
Likhtik, E., Stujenske, J. M., A Topiwala, M., Harris, A. Z., & Gordon, J. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3582 · Cited by 577 · see citing works
CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala
Zhou, Y., Won, J., Karlsson, M. G., Zhou, M., Rogerson, T., Balaji, J., Neve, R. L., Poirazi, P., & Silva, A. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2405 · Cited by 577 · see citing works
Selective Erasure of a Fear Memory
Han, J., Kushner, S. A., Yiu, A. P., Hsiang, H., Buch, T., Waisman, A., Bontempi, B., Neve, R. L., Frankland, P. W., & Josselyn, S. A. (2009) · Science · doi:10.1126/science.1164139 · Cited by 570 · see citing works
Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance
Stamatakis, A. M., & Stuber, G. D. (2012) · Nature Neuroscience · doi:10.1038/nn.3145 · Cited by 564 · see citing works
Quirk, G. J., Armony, J. L., & LeDoux, J. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80375-x · Cited by 563 · see citing works
Canteras, N. S., & Swanson, L. W. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903240204 · Cited by 541 · see citing works
Wilensky, A. E., Schafe, G. E., Kristensen, M. P., & LeDoux, J. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4316-06.2006 · Cited by 533 · see citing works
Burgos-Robles, A., Vidal-Gonzalez, I., & Quirk, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0378-09.2009 · Cited by 530 · see citing works
LeDoux, J. E., Ruggiero, D. A., & Reis, D. J. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902420204 · Cited by 530 · see citing works
Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression
Courtin, J., Chaudun, F., Rozeske, R. R., Karalis, N., Gonzalez-Campo, C., Wurtz, H., Abdi, A., Baufreton, J., Bienvenu, T. C. M., & Herry, C. (2014) · Nature · doi:10.1038/nature12755 · Cited by 524 · see citing works
Long-range connectivity defines behavioral specificity of amygdala neurons
Senn, V., Wolff, S. B. E., Herry, C., Grenier, F., Ehrlich, I., Gründemann, J., Fadok, J. P., Müller, C., Letzkus, J. J., & Lüthi, A. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.006 · Cited by 522 · see citing works
Self-citationBurgos-Robles, A., Vidal-Gonzalez, I., Santini, E., & Quirk, G. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.021 · Cited by 516 · see citing works
Regulation of affect by the lateral septum: implications for neuropsychiatry
Sheehan, T. P., Chambers, R. A., & Russell, D. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.009 · Cited by 514 · see citing works
Bidirectional switch of the valence associated with a hippocampal contextual memory engram
Redondo, R. L., Kim, J., Arons, A. L., Ramirez, S., Liu, X., & Tonegawa, S. (2014) · Nature · doi:10.1038/nature13725 · Cited by 512 · see citing works
Dendritic Inhibition in the Hippocampus Supports Fear Learning
Lovett-Barron, M., Kaifosh, P., Kheirbek, M. A., Danielson, N., Zaremba, J. D., Reardon, T. R., Turi, G. F., Hen, R., Zemelman, B. V., & Losonczy, A. (2014) · Science · doi:10.1126/science.1247485 · Cited by 509 · see citing works
The paraventricular thalamus controls a central amygdala fear circuit
Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., Darvas, M., Parada, L. F., Palmiter, R. D., He, M., et al. (2015) · Nature · doi:10.1038/nature13978 · Cited by 506 · see citing works
Chemogenetic Tools to Interrogate Brain Functions
Sternson, S. M., & Roth, B. L. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014048 · Cited by 506 · see citing works
Experience-dependent modification of a central amygdala fear circuit
Li, H., Penzo, M. A., Taniguchi, H., Kopec, C. D., Huang, Z. J., & Li, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3322 · Cited by 497 · see citing works
A temporal shift in the circuits mediating retrieval of fear memory
Do-Monte, F. H., Quiñones-Laracuente, K., & Quirk, G. J. (2015) · Nature · doi:10.1038/nature14030 · Cited by 491 · see citing works
Amygdala interneuron subtypes control fear learning through disinhibition
Wolff, S. B. E., Gründemann, J., Tovote, P., Krabbe, S., Jacobson, G. A., Müller, C. R., Herry, C., Ehrlich, I., Friedrich, R. W., Letzkus, J. J., et al. (2014) · Nature · doi:10.1038/nature13258 · Cited by 489 · see citing works
Self-citationAmygdala intercalated neurons are required for expression of fear extinction
Likhtik, E., Popa, D., Apergis-Schoute, J., Fidacaro, G. A., & Paré, D. (2008) · Nature · doi:10.1038/nature07167 · Cited by 474 · see citing works
Ventromedial Prefrontal Cortex Is Critical for the Regulation of Amygdala Activity in Humans
Motzkin, J. C., Philippi, C. L., Wolf, R. C., Baskaya, M. K., & Koenigs, M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.014 · Cited by 454 · see citing works
Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs
Sotres-Bayón, F., Sierra‐Mercado, D., Pardilla‐Delgado, E., & Quirk, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.028 · Cited by 451 · see citing works
Two different lateral amygdala cell populations contribute to the initiation and storage of memory
Repa, J. C., Muller, J., Apergis, J., Desrochers, T. M., Zhou, Y., & LeDoux, J. E. (2001) · Nature Neuroscience · doi:10.1038/89512 · Cited by 440 · see citing works
Bauer, E. P., Schafe, G. E., & LeDoux, J. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05239.2002 · Cited by 438 · see citing works
Differences between trait fear and trait anxiety: Implications for psychopathology
Sylvers, P. D., Lilienfeld, S. O., & LaPrairie, J. L. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.08.004 · Cited by 431 · see citing works
Neural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429 · see citing works
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Bissière, S., Humeau, Y., & Lüthi, A. (2003) · Nature Neuroscience · doi:10.1038/nn1058 · Cited by 415 · see citing works
Self-citationRadulovic, J., Rühmann, A., Liepold, T., & Spiess, J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05016.1999 · Cited by 402 · see citing works
Hong, S., Jhou, T. C., Smith, M., Saleem, K. S., & Hikosaka, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1384-11.2011 · Cited by 390 · see citing works
The role of the amygdala in conditioned and unconditioned fear and anxiety
Davis, M. (2000) · The Amygdala · doi:10.1093/oso/9780198505013.003.0006 · Cited by 384 · see citing works
Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala
Viviani, D., Charlet, A., van den Burg, E., Robinet, C., Hurni, N., Abatis, M., Magara, F., & Stoop, R. (2011) · Science · doi:10.1126/science.1201043 · Cited by 381 · see citing works
Neurons of the lateral and basolateral amygdaloid nuclei: A golgi study in the rat
McDonald, A. J. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120307 · Cited by 371 · see citing works
GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment
Shabel, S. J., Proulx, C. D., Piriz, J., & Malinow, R. (2014) · Science · doi:10.1126/science.1250469 · Cited by 369 · see citing works
Synaptic correlates of fear extinction in the amygdala
Amano, T., Ünal, Ç. T., & Paré, D. (2010) · Nature Neuroscience · doi:10.1038/nn.2499 · Cited by 369 · see citing works
Synaptic Encoding of Fear Extinction in mPFC-amygdala Circuits
Cho, J.-H., Deisseroth, K. A., & Bolshakov, V. Y. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.025 · Cited by 367 · see citing works
An Inhibitory Interface Gates Impulse Traffic between the Input and Output Stations of the Amygdala
Royer, S., Martina, M., & Paré, D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10575.1999 · Cited by 350 · see citing works
Expectation modulates neural responses to pleasant and aversive stimuli in primate amygdala
Belova, M. A., Paton, J. J., Morrison, S. E., & Salzman, C. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.004 · Cited by 349 · see citing works
Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning
Rosenkranz, J. A., & Grace, A. A. (2002) · Nature · doi:10.1038/417282a · Cited by 348 · see citing works
Cytoarchitecture of the central amygdaloid nucleus of the rat
McDonald, A. J. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902080409 · Cited by 338 · see citing works
Postsynaptic Induction and PKA-Dependent Expression of LTP in the Lateral Amygdala
Huang, Y.-Y., & Kandel, E. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80524-3 · Cited by 333 · see citing works
Walker, D. L., Miles, L. A., & Davis, M. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.06.022 · Cited by 331 · see citing works
Extinction in human fear conditioning
Hermans, D., Craske, M. G., Mineka, S., & Lovibond, P. F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.006 · Cited by 328 · see citing works
Tsvetkov, E., Carlezon, W. A., Benes, F. M., Kandel, E. R., & Bolshakov, V. Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00645-1 · Cited by 321 · see citing works
Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray
Johansen, J. P., Tarpley, J. W., LeDoux, J. E., & Blair, H. T. (2010) · Nature Neuroscience · doi:10.1038/nn.2594 · Cited by 312 · see citing works
Laurent, V., & Westbrook, R. F. (2009) · Learning & Memory · doi:10.1101/lm.1474609 · Cited by 311 · see citing works
Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit
Anthony, T. E., Dee, N., Bernard, A., Lerchner, W., Heintz, N., & Anderson, D. J. (2014) · Cell · doi:10.1016/j.cell.2013.12.040 · Cited by 310 · see citing works
Optical activation of lateral amygdala pyramidal cells instructs associative fear learning
Johansen, J. P., Hamanaka, H., Monfils, M. H., Behnia, R., Deisseroth, K., Blair, H. T., & LeDoux, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002418107 · Cited by 308 · see citing works
Placing prediction into the fear circuit
McNally, G. P., Johansen, J. P., & Blair, H. T. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.03.005 · Cited by 298 · see citing works
Kim, J. J., DeCola, J. P., Landeira-Fernández, J., & Fanselow, M. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.126 · Cited by 295 · see citing works
Sotres-Bayon, F., Bush, D. E. A., & LeDoux, J. E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301316 · Cited by 293 · see citing works
Response properties of single units in areas of rat auditory thalamus that project to the amygdala
Bordi, F., & LeDoux, J. E. (1994) · Experimental Brain Research · doi:10.1007/bf00228415 · Cited by 291 · see citing works
Context and ambiguity in the extinction of emotional learning: Implications for exposure therapy
Bouton, M. E. (1988) · Behaviour Research and Therapy · doi:10.1016/0005-7967(88)90113-1 · Cited by 287 · see citing works
Adhikari, A., Topiwala, M. A., & Gordon, J. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.027 · Cited by 285 · see citing works
Joshua, M., Adler, A., Mitelman, R., Vaadia, E., & Bergman, H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3839-08.2008 · Cited by 273 · see citing works
The Neuropsychology of Anxiety
Gray, J. A. (1984) · Lehr- und Forschungstexte Psychologie · doi:10.1007/978-3-642-69631-2_5 · Cited by 270 · see citing works
LeDoux, J. E., Farb, C. R., & Romanski, L. M. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90526-y · Cited by 261 · see citing works
Zweifel, L. S., Fadok, J. P., Argilli, E., Garelick, M. G., Jones, G. L., Dickerson, T. M. K., Allen, J. M., Mizumori, S. J. Y., Bonci, A., & Palmiter, R. D. (2011) · Nature Neuroscience · doi:10.1038/nn.2808 · Cited by 256 · see citing works
Self-citationThe hippocampus and contextual memory retrieval in Pavlovian conditioning
Maren, S., & Holt, W. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00188-6 · Cited by 256 · see citing works
Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain
Humeau, Y., Shaban, H., Bissière, S., & Lüthi, A. (2003) · Nature · doi:10.1038/nature02194 · Cited by 253 · see citing works
Self-citationThe Bed Nucleus of the Stria Terminalis Mediates Inter-individual Variations in Anxiety and Fear
Duvarci, S., Bauer, E. P., & Paré, D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2119-09.2009 · Cited by 251 · see citing works
Petrovich, G. D., & Swanson, L. W. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01361-3 · Cited by 234 · see citing works
Margolis, E. B., Mitchell, J., Ishikawa, J., Hjelmstad, G. O., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-08.2008 · Cited by 232 · see citing works
Fear-enhancing effects of septal oxytocin receptors
Guzmán, Y. F., Tronson, N. C., Jovasevic, V., Sato, K., Guedea, A. L., Mizukami, H., Nishimori, K., & Radulovic, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3465 · Cited by 215 · see citing works
Dopamine is necessary for cue-dependent fear conditioning
Fadok, J. P., Dickerson, T. M. K., & Palmiter, R. D. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1616-09.2009 · Cited by 213 · see citing works
Self-citationHobin, J. A., Ji, J.-Z., & Maren, S. (2006) · Hippocampus · doi:10.1002/hipo.20144 · Cited by 211 · see citing works
The intercalated cell masses project to the central and medial nuclei of the amygdala in cats
Paré, D., & Smith, Y. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90050-p · Cited by 209 · see citing works
Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition
Shaban, H., Humeau, Y., Herry, C., Casassus, G., Shigemoto, R., Ciocchi, S., Barbieri, S., van der Putten, H., Kaupmann, K., Bettler, B., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1732 · Cited by 208 · see citing works
Self-citationThe brainstem noradrenergic systems in stress, anxiety and depression
Itoi, K., & Sugimoto, N. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01988.x · Cited by 207 · see citing works
Extinction of auditory fear conditioning requires MAPK/ERK activation in the basolateral amygdala
Herry, C., Trifilieff, P., Micheau, J., Lüthi, A., & Mons, N. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04893.x · Cited by 203 · see citing works
Self-citationMuller, J. F., Mascagni, F., & McDonald, A. J. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20832 · Cited by 203 · see citing works
Central Amygdala Activity during Fear Conditioning
Duvarci, S., Popa, D., & Paré, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4985-10.2011 · Cited by 202 · see citing works
Tully, K., Li, Y., Tsvetkov, E., & Bolshakov, V. Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704621104 · Cited by 199 · see citing works
The Fear Circuit Revisited: Contributions of the Basal Amygdala Nuclei to Conditioned Fear
Amano, T., Duvarci, S., Popa, D., & Paré, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3410-11.2011 · Cited by 197 · see citing works
Dual role of 5-HT in defense and anxiety
Graeff, F. G., Viana, M. D. B., & Mora, P. O. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00059-0 · Cited by 195 · see citing works
Neuronal encoding of the switch from specific to generalized fear
Ghosh, S., & Chattarji, S. (2014) · Nature Neuroscience · doi:10.1038/nn.3888 · Cited by 190 · see citing works
Shabel, S. J., & Janak, P. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905580106 · Cited by 190 · see citing works
Response properties of single units in areas of rat auditory thalamus that project to the amygdala
Bordi, F., & LeDoux, J. E. (1994) · Experimental Brain Research · doi:10.1007/bf00228414 · Cited by 188 · see citing works
Hobin, J. A., Goosens, K. A., & Maren, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-23-08410.2003 · Cited by 187 · see citing works
Penzo, M. A., Robert, V., & Li, B. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4166-13.2014 · Cited by 187 · see citing works
Mascagni, F., McDonald, A. J., & Coleman, J. R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90016-9 · Cited by 186 · see citing works
Walker, P., & Carrive, P. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00744-3 · Cited by 173 · see citing works
McDonald, A. J. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90186-7 · Cited by 170 · see citing works
Bienvenu, T., Busti, D., Magill, P. J., Ferraguti, F., & Capogna, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.022 · Cited by 168 · see citing works
Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses
Trouche, S., Sasaki, J. M., Tu, T., & Reijmers, L. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.047 · Cited by 166 · see citing works
Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety
Birn, R. M., Shackman, A. J., Oler, J. A., Williams, L. E., McFarlin, D. R., Rogers, G. M., Shelton, S. E., Alexander, A. L., Pine, D. S., Slattery, M. J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.46 · Cited by 159 · see citing works
McDonald, A. J., & Mascagni, F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00380-3 · Cited by 157 · see citing works
Postsynaptic targets of somatostatin‐containing interneurons in the rat basolateral amygdala
Muller, J. F., Mascagni, F., & McDonald, A. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21185 · Cited by 153 · see citing works
Reduced amygdalar and hippocampal size in adults with generalized social phobia
Irle, E., Ruhleder, M., Lange, C., Seidler-Brandler, U., Salzer, S., Dechent, P., Weniger, G., Leibing, E., & Leichsenring, F. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090041 · Cited by 148 · see citing works
Rainnie, D. G., Mania, I., Mascagni, F., & McDonald, A. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21049 · Cited by 145 · see citing works
Blanchard, R. J. (2008) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(07)x0001-8 · Cited by 142 · see citing works
The medial geniculate, not the amygdala, as the root of auditory fear conditioning
Weinberger, N. M. (2010) · Hearing Research · doi:10.1016/j.heares.2010.03.093 · Cited by 142 · see citing works
Memory recall and modifications by activating neurons with elevated CREB
Kim, J., Kwon, J.-T., Kim, H.-S., Josselyn, S. A., & Han, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3592 · Cited by 136 · see citing works
Chapter 2.4 Defensive behaviors, fear, and anxiety
Blanchard, D. C., & Blanchard, R. J. (2008) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(07)00005-7 · Cited by 133 · see citing works
Electrical Synapses Control Hippocampal Contributions to Fear Learning and Memory
Bissière, S., Zelikowsky, M., Ponnusamy, R., Jacobs, N. S., Blair, H. T., & Fanselow, M. S. (2011) · Science · doi:10.1126/science.1193785 · Cited by 129 · see citing works
Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala.Preprint
Maren, S., & Hobin, J. A. (2007) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.477007 · Cited by 128 · see citing works
Cellular and behavioral interactions of gabapentin with alcohol dependence
Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., & Koob, G. F. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0575-08.2008 · Cited by 126 · see citing works
Heldt, S. A., & Ressler, K. J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05970.x · Cited by 125 · see citing works
Mao, S.-C., Hsiao, Y., & Gean, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0365-06.2006 · Cited by 112 · see citing works
Linke, R., Braune, G., & Schwegler, H. (2000) · Experimental Brain Research · doi:10.1007/s002210000475 · Cited by 106 · see citing works
Lang, E. J., & Paré, D. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.1.341 · Cited by 100 · see citing works
Muller, J. F., Mascagni, F., & McDonald, A. J. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21486 · Cited by 93 · see citing works
The conditions that promote fear learning: Prediction error and Pavlovian fear conditioning
Li, S. S. Y., & McNally, G. P. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.05.002 · Cited by 89 · see citing works
Increased Amygdalar and Hippocampal Volumes in Young Adults with Social Anxiety
Machado‐de‐Sousa, J. P., Osório, F. D. L., Jackowski, A. P., Bressan, R. A., Chagas, M. H. N., Alves, N. T., DePaula, A. L. D., Crippa, J. A., & Hallak, J. E. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088523 · Cited by 85 · see citing works
Altered GABA transmission in a mouse model of increased trait anxiety
Tasan, R. O., Bukovac, A., Peterschmitt, Y., Sartori, S. B., Landgraf, R., Singewald, N., & Sperk, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.051 · Cited by 82 · see citing works
de Lima, A. D., Merten, M. D. P., & Voigt, T. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970602)382:2 · Cited by 80 · see citing works
Dopaminergic innervation of interneurons in the rat basolateral amygdala
Pinard, C. R., Muller, J. F., Mascagni, F., & McDonald, A. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.043 · Cited by 75 · see citing works
Sparta, D. R., Smithuis, J., Stamatakis, A. M., Jennings, J. H., Kantak, P. A., Ung, R. L., & Stuber, G. D. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00129 · Cited by 75 · see citing works
Functional Circuits and Anatomical Distribution of Response Properties in the Primate Amygdala
Zhang, W., Schneider, D. M., Belova, M. A., Morrison, S. E., Paton, J. J., & Salzman, C. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2970-12.2013 · Cited by 74 · see citing works
Oka, T., Tsumori, T., Yokota, S., & Yasui, Y. (2008) · Neuroscience Research · doi:10.1016/j.neures.2008.10.004 · Cited by 73 · see citing works
Druhan, J. P., Rajabi, H., & Stewart, J. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199610)24:2 · Cited by 69 · see citing works
Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression
Li, Y., Dong, X., Li, S., & Kirouac, G. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00094 · Cited by 69 · see citing works
Lin, H., Mao, S.-C., & Gean, P. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.003 · Cited by 66 · see citing works
Coactivation of thalamic and cortical pathways induces input timing–dependent plasticity in amygdala
Cho, J.-H., Bayazitov, I. T., Meloni, E. G., Myers, K. M., Carlezon, W. A., Zakharenko, S. S., & Bolshakov, V. Y. (2011) · Nature Neuroscience · doi:10.1038/nn.2993 · Cited by 57 · see citing works
Kim, D., Paré, D., & Nair, S. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2430-13.2013 · Cited by 56 · see citing works
Tools for Resolving Functional Activity and Connectivity within Intact Neural Circuits
Jennings, J. H., & Stuber, G. D. (2014) · Current Biology · doi:10.1016/j.cub.2013.11.042 · Cited by 54 · see citing works
Long-Term Neural Correlates of Reversible Fear Learning in the Lateral Amygdala
An, B., Hong, I., & Choi, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3017-12.2012 · Cited by 54 · see citing works
A Specific Class of Interneuron Mediates Inhibitory Plasticity in the Lateral Amygdala
Polepalli, J. S., Sullivan, R., Yanagawa, Y., & Sah, P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3252-10.2010 · Cited by 53 · see citing works
The amygdala in brain function : basic and clinical approaches
Shinnick‐Gallagher, P. (2003) · Cited by 50 · see citing works
Muller, J. F., Mascagni, F., & McDonald, A. J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22550 · Cited by 49 · see citing works
Szinyei, C., Narayanan, R. T., & Pape, H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05349.x · Cited by 42 · see citing works
The Amygdala in Brain Function: Basic and Clinical Approaches
Huhman, K. L. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00913-5 · Cited by 35 · see citing works
Livneh, U., & Paz, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-12.2012 · Cited by 34 · see citing works
Tang, J., Wagner, S., Schachner, M., Dityatev, A. E., & Wotjak, C. T. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02758.x · Cited by 29 · see citing works
Chapter 2.5 Unconditioned models of fear and anxiety
Litvin, Y., Pentkowski, N. S., Pobbe, R. L. H., Blanchard, D. C., & Blanchard, R. J. (2008) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(07)00006-9 · Cited by 13 · see citing works
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Emotional expressions reconsidered: Challenges to inferring emotion from human facial movements
Barrett, L. F., Adolphs, R., Marsella, S., Martinez, A. M., & Pollak, S. D. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619832930 · Cited by 1,748 · see citing works
The theory of constructed emotion: an active inference account of interoception and categorization
Barrett, L. F. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw154 · Cited by 1,426 · see citing works
“Optogenetic research and some lesion research in rodents (Furlong et al., 2010; Gross and Canteras, 2012; Herry and Johansen, 2014; Sharpe and Killcross, 2015; Tovote et al., 2015; McGaugh, 2016)”
Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework
LeDoux, J. E., & Pine, D. S. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16030353 · Cited by 1,035 · see citing works
The theory of constructed emotion: an active inference account of interoception and categorization
Barrett, L. F. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx060 · Cited by 950 · see citing works
“…et al., 2015) Neural reuse: Mapping one neural assembly to many emotion categories Optogenetic research and some lesion research in rodents (Tovote et al., 2015) Predictive coding explains aversive (‘fear’) learning Optogenetic research and some lesion research in rodents (Furlong et al.,…”
Lonsdorf, T. B., Menz, M. M., Andreatta, M., Fullana, M. A., Golkar, A., Haaker, J., Heitland, I., Hermann, A., Kuhn, M., Kruse, O., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.026 · Cited by 837 · see citing works
Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain
Bliss, T., Collingridge, G. L., Kaang, B., & Zhuo, M. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.68 · Cited by 781 · see citing works
Resolving the neural circuits of anxiety
Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766 · see citing works
Midbrain circuits for defensive behaviour
Tovote, P., Esposito, M. S., Botta, P., Chaudun, F., Fadok, J. P., Marković, M., Wolff, S. B. E., Ramakrishnan, C., Fenno, L. E., Deisseroth, K. A., et al. (2016) · Nature · doi:10.1038/nature17996 · Cited by 739 · see citing works
Self-citationTemporal evolution of cortical ensembles promoting remote memory retrieval
DeNardo, L. A., Liu, C. D., Allen, W. E., Adams, E. L., Friedmann, D., Dadgar‐Kiani, E., Fu, L., Guenthner, C. J., Lee, J. H., Tessier‐Lavigne, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0318-7 · Cited by 615 · see citing works
Freeze for action: neurobiological mechanisms in animal and human freezing
Roelofs, K. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0206 · Cited by 616 · see citing works
A Network Model of the Emotional Brain
Pessoa, L. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.03.002 · Cited by 526 · see citing works
The endocannabinoid system in guarding against fear, anxiety and stress
Lutz, B., Marsicano, G., Maldonado, R., & Hillard, C. J. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4036 · Cited by 506 · see citing works
A competitive inhibitory circuit for selection of active and passive fear responses
Fadok, J. P., Krabbe, S., Marković, M., Courtin, J., Xu, C., Massi, L., Botta, P., Bylund, K., Müller, C. R., Kovacevic, A., et al. (2017) · Nature · doi:10.1038/nature21047 · Cited by 475 · see citing works
Self-citationBrain circuit dysfunction in post-traumatic stress disorder: from mouse to man
Fenster, R. J., Lebois, L. A. M., Ressler, K. J., & Suh, J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0039-7 · Cited by 456 · see citing works
Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453 · see citing works
Antagonistic negative and positive neurons of the basolateral amygdala
Kim, J., Pignatelli, M., Xu, S., Itohara, S., & Tonegawa, S. (2016) · Nature Neuroscience · doi:10.1038/nn.4414 · Cited by 450 · see citing works
The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm
Palmiter, R. D. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.03.007 · Cited by 433 · see citing works
The microbiota regulate neuronal function and fear extinction learning
Chu, C., Murdock, M. H., Jing, D., Won, T. H., Chung, H., Kressel, A. M., Tsaava, T., Addorisio, M. E., Putzel, G. G., Zhou, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1644-y · Cited by 421 · see citing works
The role of serotonin 5-HT2A receptors in memory and cognition
Zhang, G., & Stackman, R. W. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00225 · Cited by 386 · see citing works
The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm
LeDoux, J. E., Moscarello, J., Sears, R., & Campese, V (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.166 · Cited by 348 · see citing works
A connectome of a learning and memory center in the adult Drosophila brain
Takemura, S.-Y., Aso, Y., Hige, T., Wong, A., Lu, Z., Xu, C. S., Rivlin, P. K., Hess, H., Zhao, T., Parag, T., et al. (2017) · eLife · doi:10.7554/elife.26975 · Cited by 367 · see citing works
Preservation of a remote fear memory requires new myelin formation
Pan, S., Mayoral, S. R., Choi, H. S., Chan, J. R., & Kheirbek, M. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0582-1 · Cited by 366 · see citing works
Luczynski, P., Whelan, S. O., O'SULLIVAN, C. T. D., Clarke, G. A., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13291 · Cited by 345 · see citing works
Neural Mechanisms Underlying Anxiety–Chronic Pain Interactions
Zhuo, M. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.01.006 · Cited by 341 · see citing works
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324 · see citing works
Septic-Associated Encephalopathy: a Comprehensive Review
Mazeraud, A., Righy, C., Bouchereau, E., Benghanem, S., Bozza, F. A., & Sharshar, T. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00862-1 · Cited by 344 · see citing works
Facial expressions of emotion states and their neuronal correlates in mice
Dolensek, N., Gehrlach, D. A., Klein, A. S., & Gogolla, N. (2020) · Science · doi:10.1126/science.aaz9468 · Cited by 327 · see citing works
Inhibition in the amygdala anxiety circuitry
Babaev, O., Chatain, C. P., & Krueger‐Burg, D. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0063-8 · Cited by 312 · see citing works
Distinct hippocampal engrams control extinction and relapse of fear memory
Lacagnina, A. F., Brockway, E. T., Crovetti, C. R., Shue, F., McCarty, M. J., Sattler, K. P., Lim, S. C., Santos, S. L., Denny, C. A., & Drew, M. R. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0361-z · Cited by 311 · see citing works
Hippocampal-Prefrontal Interactions in Cognition, Behavior and Psychiatric Disease
Sigurdsson, T., & Duvarci, S. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00190 · Cited by 309 · see citing works
Fear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants
Fullana, M. A., Albajes-Eizagirre, A., Soriano-Mas, C., Vervliet, B., Cardoner, N., Benet, O., Radua, J., & Harrison, B. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.002 · Cited by 308 · see citing works
Encoding of danger by parabrachial CGRP neurons
Campos, C., Bowen, A. J., Roman, C. W., & Palmiter, R. D. (2018) · Nature · doi:10.1038/nature25511 · Cited by 307 · see citing works
High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
Mahn, M., Gibor, L., Patil, P., Malina, K. C.-K., Oring, S., Printz, Y., Levy, R., Lampl, I., & Yizhar, O. (2018) · Nature Communications · doi:10.1038/s41467-018-06511-8 · Cited by 279 · see citing works
Rethinking avoidance: Toward a balanced approach to avoidance in treating anxiety disorders
Hofmann, S. G., & Hay, A. C. (2018) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2018.03.004 · Cited by 315 · see citing works
A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)
Peng, J., Fan, M., An, C., Ni, F., Huang, W., & Luo, J. (2022) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13710 · Cited by 291 · see citing works
Encoding of contextual fear memory in hippocampal–amygdala circuit
Kim, W. B., & Cho, J.-H. (2020) · Nature Communications · doi:10.1038/s41467-020-15121-2 · Cited by 289 · see citing works
Distinct Hippocampal Pathways Mediate Dissociable Roles of Context in Memory Retrieval
Xu, C., Krabbe, S., Gründemann, J., Botta, P., Fadok, J. P., Osakada, F., Saur, D., Grewe, B. F., Schnitzer, M. J., Callaway, E. M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.051 · Cited by 277 · see citing works
Self-citationSpace, Time, and Fear: Survival Computations along Defensive Circuits
Mobbs, D., Headley, D. B., Ding, W., & Dayan, P. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.12.016 · Cited by 269 · see citing works
Bocchio, M., Nabavi, S., & Capogna, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.022 · Cited by 259 · see citing works
Contributions of the central extended amygdala to fear and anxiety
Shackman, A. J., & Fox, A. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0982-16.2016 · Cited by 269 · see citing works
Amygdala Inhibitory Circuits Regulate Associative Fear Conditioning
Krabbe, S., Gründemann, J., & Lüthi, A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.006 · Cited by 255 · see citing works
Self-citationNew perspectives on central amygdala function
Fadok, J. P., Marković, M., Tovote, P., & Lüthi, A. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.009 · Cited by 255 · see citing works
Self-citationDivergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice
Shang, C., Chen, Z., Liu, A., Li, Y., Zhang, J., Qu, B., Yan, F., Zhang, Y., Liu, W., Liu, Z., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03580-7 · Cited by 250 · see citing works
Sartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236 · see citing works
The emergence and influence of internal states
Flavell, S. W., Gogolla, N., Lovett-Barron, M., & Zelikowsky, M. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.030 · Cited by 233 · see citing works
Dispositional negativity: An integrative psychological and neurobiological perspective
Shackman, A., Tromp, D., Stockbridge, M., Kaplan, C. M., Tillman, R., & Fox, A. (2016) · Psychological bulletin · doi:10.1037/bul0000073 · Cited by 218 · see citing works
Roy, D. S., Park, Y.-G., Kim, M. E., Zhang, Y., Ogawa, S. K., DiNapoli, N., Gu, X., Cho, J. H., Choi, H., Kamentsky, L. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29384-4 · Cited by 233 · see citing works
Emotional Mirror Neurons in the Rat’s Anterior Cingulate Cortex
Carrillo, M., Han, Y., Migliorati, F., Liu, M., Gazzola, V., & Keysers, C. (2019) · Current Biology · doi:10.1016/j.cub.2019.03.024 · Cited by 229 · see citing works
Fear extinction requires infralimbic cortex projections to the basolateral amygdala
Bloodgood, D. W., Sugam, J. A., Holmes, A., & Kash, T. L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0106-x · Cited by 229 · see citing works
Adult Hippocampal Neurogenesis, Fear Generalization, and Stress
Besnard, A., & Sahay, A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.167 · Cited by 226 · see citing works
Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice
Lee, C., Hsu, L., Wu, I.-L., Wang, Y., Chen, W.-C., Liu, Y., Yang, L.-T., Tan, C.-L., Luo, Y.-H., Wang, C.-C., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128431 · Cited by 226 · see citing works
An emerging circuit pharmacology of GABAA receptors
Engin, E., Benham, R. S., & Rudolph, U. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.04.003 · Cited by 225 · see citing works
Bienkowski, M. S., Bowman, I., Song, M. Y., Gou, L., Ard, T., Cotter, K., Zhu, M., Benavidez, N. L., Yamashita, S., Abu-Jaber, J., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0241-y · Cited by 224 · see citing works
de la Fuente Revenga, M., Zhu, B., Guevara, C. A., Naler, L. B., Saunders, J. M., Zhou, Z., Toneatti, R., Sierra, S., Wolstenholme, J. T., Beardsley, P. M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109836 · Cited by 224 · see citing works
Lisieski, M. J., Eagle, A. L., Conti, A. C., Liberzon, I., & Perrine, S. A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00196 · Cited by 224 · see citing works
Xu, J., Van Dam, N. T., Feng, C., Luo, Y., Ai, H., Gu, R., & Xu, P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.005 · Cited by 212 · see citing works
Functional heterogeneity in the bed nucleus of the stria terminalis
Gungor, N. Z., & Pare, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0856-16.2016 · Cited by 214 · see citing works
Ko, J. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00041 · Cited by 212 · see citing works
A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses
Zhou, Z., Liu, X., Chen, S., Zhang, Z., Liu, Y., Montardy, Q., Tang, Y., Wei, P., Liu, N., Li, L., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.027 · Cited by 211 · see citing works
Serotonin, Amygdala and Fear: Assembling the Puzzle
Bocchio, M., McHugh, S. B., Bannerman, D. M., Sharp, T., & Capogna, M. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00024 · Cited by 207 · see citing works
Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala
Kim, W. B., & Cho, J.-H. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.004 · Cited by 206 · see citing works
Modeling Trait Anxiety: From Computational Processes to Personality
Raymond, J. G., Steele, J. D., & Seriès, P. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00001 · Cited by 203 · see citing works
Synapse-specific representation of the identity of overlapping memory engrams
Abdou, K., Shehata, M., Choko, K., Nishizono, H., Matsuo, M., Muramatsu, S., & Inokuchi, K. (2018) · Science · doi:10.1126/science.aat3810 · Cited by 188 · see citing works
A Central Amygdala CRF Circuit Facilitates Learning about Weak Threats
Sanford, C. A., Soden, M. E., Baird, M. A., Miller, S. M., Schulkin, J. A., Palmiter, R. D., Clark, M., & Zweifel, L. S. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.034 · Cited by 199 · see citing works
The microbiome regulates amygdala-dependent fear recall
Hoban, A. E., Stilling, R. M., Moloney, G., Shanahan, F., Dinan, T. G., Clarke, G., & Cryan, J. F. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.100 · Cited by 197 · see citing works
Fox, A. S., & Shackman, A. J. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.11.056 · Cited by 194 · see citing works
Regulating anxiety with extrasynaptic inhibition
Botta, P., Demmou, L., Kasugai, Y., Markovic, M., Xu, C., Fadok, J. P., Lu, T., Poe, M. M., Xu, L., Cook, J. M., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4102 · Cited by 192 · see citing works
“In contrast to fear circuits, the neuronal circuitry mediating sustained anxiety is poorly understood 6 .”
Self-citationInhibitory Control of Prefrontal Cortex by the Claustrum
Jackson, J., Karnani, M., Zemelman, B. V., Burdakov, D., & Lee, A. K. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.031 · Cited by 192 · see citing works
Li, X., Matsuura, T., Xue, M., Chen, Q., Liu, R., Lu, J.-S., Shi, W., Fan, K., Zhou, Z., Miao, Z., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109411 · Cited by 191 · see citing works
The Neurobiology of Fear Generalization
Asok, A., Kandel, E. R., & Rayman, J. B. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00329 · Cited by 187 · see citing works
The neural circuits of innate fear: detection, integration, action, and memorization
Silva, B. A., Gross, C. T., & Gräff, J. (2016) · Learning & Memory · doi:10.1101/lm.042812.116 · Cited by 186 · see citing works
Historical pitfalls and new directions in the neuroscience of emotion
Barrett, L. F., & Satpute, A. B. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.045 · Cited by 180 · see citing works
Myelin: A gatekeeper of activity-dependent circuit plasticity?
Bonetto, G., Belin, D., & Káradóttir, R. T. (2021) · Science · doi:10.1126/science.aba6905 · Cited by 186 · see citing works
Pediatric Irritability: A Systems Neuroscience Approach
Leibenluft, E. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.02.002 · Cited by 179 · see citing works
Salinas-Hernández, X. I., Vogel, P., Betz, S., Kalisch, R., Sigurdsson, T., & Duvarci, S. (2018) · eLife · doi:10.7554/elife.38818 · Cited by 181 · see citing works
Fear balance is maintained by bodily feedback to the insular cortex in mice
Klein, A. S., Dolensek, N., Weiand, C., & Gogolla, N. (2021) · Science · doi:10.1126/science.abj8817 · Cited by 176 · see citing works
Monday, H. R., Younts, T. J., & Castillo, P. E. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-062155 · Cited by 175 · see citing works
Williams, Z. J., He, J. L., Cascio, C. J., & Woynaroski, T. G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.030 · Cited by 175 · see citing works
The roots of empathy: Through the lens of rodent models
Meyza, K. Z., Bartal, I. B.-A., Monfils, M., Panksepp, J. B., & Knapska, E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.028 · Cited by 167 · see citing works
Effects of early life stress on amygdala and striatal development
Fareri, D. S., & Tottenham, N. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.04.005 · Cited by 166 · see citing works
Adaptive disinhibitory gating by VIP interneurons permits associative learning
Krabbe, S., Paradiso, E., d‘Aquin, S., Bitterman, Y., Courtin, J., Xu, C., Yonehara, K., Marković, M., Müller, C. R., Eichlisberger, T., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0508-y · Cited by 161 · see citing works
Self-citationNeuroimaging of Anxiety in Parkinson's Disease: A Systematic Review
Carey, G., Görmezoğlu, M., de Jong, J. J. A., Hofman, P. A. M., Backes, W. H., Dujardin, K., & Leentjens, A. F. G. (2020) · Movement Disorders · doi:10.1002/mds.28404 · Cited by 166 · see citing works
Zhang, J.-E., Tan, L., Ren, Y., Liang, J., Lin, R., Feng, Q., Zhou, J., Hu, F., Ren, J., Wei, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.026 · Cited by 162 · see citing works
Panksepp, J., Lane, R. D., Solms, M., & Smith, R. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.010 · Cited by 167 · see citing works
Anxiety and Brain Mitochondria: A Bidirectional Crosstalk
Filiou, M. D., & Sandi, C. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.07.002 · Cited by 164 · see citing works
The translational neural circuitry of anxiety
Robinson, O. J., Pike, A. C., Cornwell, B., & Grillon, C. (2019) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321400 · Cited by 158 · see citing works
Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior
Zhang, G., Shen, L., Tao, C., Jung, A.-H., Peng, B., Li, Z., Zhang, L. I., & Tao, H. W. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00784-3 · Cited by 158 · see citing works
Enhanced and unified anatomical labeling for a common mouse brain atlas
Chon, U., Vanselow, D. J., Cheng, K. C., & Kim, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-13057-w · Cited by 156 · see citing works
A Central Extended Amygdala Circuit That Modulates Anxiety
Ahrens, S., Wu, M. V., Furlan, A., Hwang, G., Paik, R., Li, H., Penzo, M. A., Tollkühn, J., & Li, B. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0705-18.2018 · Cited by 151 · see citing works
Algorithms for survival: a comparative perspective on emotions
Bach, D. R., & Dayan, P. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.35 · Cited by 144 · see citing works
Li, L., Feng, X., Zhou, Z., Zhang, H., Shi, Q., Lei, Z., Shen, P., Yang, Q., Zhao, B., Chen, S., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.005 · Cited by 151 · see citing works
Hsp90 and FKBP51: complex regulators of psychiatric diseases
Criado‐Marrero, M., Rein, T., Binder, E. B., Porter, J. T., Koren, J., & Blair, L. J. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0532 · Cited by 145 · see citing works
A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System
Hasan, M. T., Althammer, F., Gouveia, M. D. S., Goyon, S., Eliava, M., Lefèvre, A., Kerspern, D., Schimmer, J., Raftogianni, A., Wahis, J., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.029 · Cited by 141 · see citing works
Hippocampus: Molecular, Cellular, and Circuit Features in Anxiety
Shi, H., Wang, S., Wang, X., Zhang, R.-X., & Zhu, L. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01020-1 · Cited by 144 · see citing works
Cavanagh, J. F., Bismark, A. W., Frank, M. J., & Allen, J. J. B. (2018) · Computational Psychiatry · doi:10.1162/cpsy_a_00024 · Cited by 143 · see citing works
Lee, J. L. C., Bertoglio, L. J., Guimarães, F. S., & Stevenson, C. W. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13724 · Cited by 140 · see citing works
The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Adams, T. G., Kelmendi, B., Brake, C. A., Gruner, P., Badour, C. L., & Pittenger, C. (2018) · Chronic Stress · doi:10.1177/2470547018758043 · Cited by 141 · see citing works
Fear, anxiety, and their disorders from the perspective of psychophysiology
Hamm, A. O. (2019) · Psychophysiology · doi:10.1111/psyp.13474 · Cited by 148 · see citing works
A comparative fMRI meta-analysis of altruistic and strategic decisions to give
Cutler, J., & Campbell-Meiklejohn, D. K. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.09.009 · Cited by 142 · see citing works
- Authors
- Tovote, P., Fadok, J. P., & Lüthi, A.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Lüthi, Andreas
- Venue
- Nature Reviews Neuroscience
- Published
- 2015-05-20
- Volume
- 16
- Issue
- 6
- Pages
- 317-331
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1547865271
- Semantic Scholar
- c2361b90aa8185adfda7e7329fc00f24a5a64602
- Cited by
- 1,786
- References
- 195
- Citations by year
- 2026: 141 · 2025: 174 · 2024: 188 · 2023: 184 · 2022: 186 · 2021: 176 · 2020: 173 · 2019: 154 · 2018: 163 · 2017: 123 · 2016: 103 · 2015: 21
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-06-10)
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Brain Research Foundation
- Novartis Foundation
- National Alliance for Research on Schizophrenia and Depression
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fear, anxiety, neural circuits, fear extinction, defensive behavior, neuronal connectivity, optogenetics, in vivo imaging, genetic instruments
- MeSH terms
- Animals, Anxiety, Brain, Fear, Humans, Neural Pathways
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