CoChat
Sign Up
Cited by 129Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsIon Transport and Channel Regulation

Critical Role of Actin in Modulating BBB Permeability

Lai, Char-Huei, Kuo, Kuo-Hsing, Leo, Joyce M.·2005·Brain Research Reviews
DOI 10.1016/j.brainresrev.2005.03.007
Open this paper in CoChat — free account

Abstract

A major obstacle in the treatment of degenerative manifestations and debilitating diseases in the central nervous system (CNS) lies in the impediment of drug delivery into these tissues. The impediment is due to a membrane barrier referred to as the blood-brain barrier (BBB). It is known that the BBB is a unique membranous structure in brain capillaries that tightly segregates the brain from systemic blood circulation. It is imperative to have a thorough understanding of the molecular components and their integrated function of this barrier to develop effective therapeutics for CNS disorders and diseases. Although there are other cell and biochemical properties that underlie this barrier function, it is well established that the barrier is mainly made up of the physical elements of tight junction (TJ) complex. The major constituents of TJ, such as occludin, claudins, zonula occludens (ZOs) and junctional adhesion molecule (JAM) have been subjects of intensive studies and reviews. However, after examining currently proposed models, we have come to believe that a cytoskeletal component-actin may play a critical role in interacting TJ molecular constituents and modulating functional TJ complex. In this review, we will discuss the correlation of temporal and spatial distribution and remodeling of actin filaments with altering integrity of TJ complexes in various systems and present a hypothesis to depict its potential role in modulating BBB permeability.

Integrity signals

Registry

Crossref · 10.1016/j.brainresrev.2005.03.007

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Actin filaments are a fundamental component of the cytoskeleton and play an important role in maintaining structural and functional integrity of endothelial tight junctions at the blood-brain barrier.

    “Actin filaments are a fundamental component of the cytoskeleton and play an important role in maintaining the structural and functional integrity of endothelial tight junctions at the BBB (Lai et al., 2005).”

    From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Lai et al., 2005

Cites

Flagged first, then by citations

1 of the 75 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Lai, C.-H., Kuo, K.-H., & Leo, J. M.
Affiliations
University of British Columbia (CA)
Corresponding author
Lai, Char-Huei
ORCID
Kuo, Kuo-Hsing
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
2005-12
Volume
50
Issue
1
Pages
7-13
ISSN
0165-0173 (ISSN-L)
DOI
10.1016/j.brainresrev.2005.03.007
OpenAlex
W2057041797
Cited by
129
References
75
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 8 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 9 · 2012: 9
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
actin, blood-brain barrier permeability, tight junctions, actin cytoskeleton, occludin, claudins, zonula occludens, junctional adhesion molecules, tight junction remodeling, brain drug delivery, barrier integrity
MeSH terms
Actins, Animals, Blood-Brain Barrier, Capillary Permeability, Cytoskeleton, Models, Biological, Tight Junctions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review