Viral disruption of the blood–brain barrier

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185 · see citing works

The blood-brain barrier/neurovascular unit in health and disease

Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661 · see citing works

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917 · see citing works

Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line

Weksler, B. B., Subileau, E.-A., Perrière, N., Charneau, P., Holloway, K. E., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3458fje · Cited by 1,325 · see citing works

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry

Evans, M. J., von Hahn, T., Tscherne, D. M., Syder, A. J., Panis, M., Wölk, B., Hatziioannou, T., McKeating, J. A., Bieniasz, P. D., & Rice, C. M. (2007) · Nature · doi:10.1038/nature05654 · Cited by 1,233 · see citing works

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

Wang, T., Town, T., Alexopoulou, L., Anderson, J. F., Fikrig, E., & Flavell, R. A. (2004) · Nature Medicine · doi:10.1038/nm1140 · Cited by 1,155 · see citing works

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat

Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060 · see citing works

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

Ploß, A., Evans, M. J., Gaysinskaya, V. A., Panis, M., You, H., de Jong, Y. P., & Rice, C. M. (2009) · Nature · doi:10.1038/nature07684 · Cited by 940 · see citing works

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

Engelhardt, B., & Sorokin, L. M. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0177-0 · Cited by 792 · see citing works

The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction

Cohen, C. J., Shieh, J. T. C., Pickles, R. J., Okegawa, T., Hsieh, J., & Bergelson, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261452898 · Cited by 702 · see citing works

Junction Adhesion Molecule Is a Receptor for Reovirus

Barton, E. S., Forrest, J. C., Connolly, J. L., Chappell, J. D., Liu, Y., Schnell, F. J., Nusrat, A., Parkos, C. A., & Dermody, T. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00231-8 · Cited by 627 · see citing works

Adherens junction protein nectin-4 is the epithelial receptor for measles virus

Mühlebach, M. D., Mateo, M., Sinn, P. L., Prüfer, S., Uhlig, K. M., Léonard, V. H. J., Navaratnarajah, C. K., Frenzke, M. E., Wong, X. X., Sawatsky, B., et al. (2011) · Nature · doi:10.1038/nature10639 · Cited by 603 · see citing works

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

Candelario‐Jalil, E., Yang, Y., & Rosenberg, G. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.025 · Cited by 524 · see citing works

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

Stamatovic, S. M., Keep, R. F., & Andjelkovic, A. V. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777210 · Cited by 516 · see citing works

Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus

Noyce, R. S., Bondre, D. G., Ha, M. N., Lin, L., Sisson, G. R., Tsao, M., & Richardson, C. D. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002240 · Cited by 491 · see citing works

Subversion of the actin cytoskeleton during viral infection

Taylor, M. P., Koyuncu, O. O., & Enquist, L. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2574 · Cited by 413 · see citing works

CCL2/Monocyte Chemoattractant Protein-1 Mediates Enhanced Transmigration of Human Immunodeficiency Virus (HIV)-Infected Leukocytes across the Blood–Brain Barrier: A Potential Mechanism of HIV–CNS Invasion and NeuroAIDS

Eugenin, E. A., Osiecki, K., Lopez, L., Goldstein, H., Calderon, T. M., & Berman, J. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3863-05.2006 · Cited by 392 · see citing works

Potential role of MCP-1 in endothelial cell tight junction `opening': signaling via Rho and Rho kinase

Stamatovic, S. M., Keep, R. F., Kunkel, S. L., & Andjelkovic, A. V. (2003) · Journal of Cell Science · doi:10.1242/jcs.00755 · Cited by 381 · see citing works

Blood-Brain Barrier Tight Junction Disruption in Human Immunodeficiency Virus-1 Encephalitis

Dallasta, L. M., Pisarov, L. A., Esplen, J. E., Werley, J., Moses, A. V., Nelson, J. A., & Achim, C. L. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65511-3 · Cited by 372 · see citing works

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase and PKB signaling

Schreibelt, G., Kooij, G., Reijerkerk, A., van Doorn, R., Gringhuis, S. I., van der Pol, S., Weksler, B. B., Romero, I. A., Couraud, P., Piontek, J., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8329com · Cited by 347 · see citing works

Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood–brain barrier dysfunction

Haorah, J., Ramirez, S. H., Schall, K. A., Smith, D. L., Pandya, R., & Persidsky, Y. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04393.x · Cited by 334 · see citing works

Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood–retinal barrier

Giebel, S. J., Menicucci, G., McGuire, P. G., & Das, A. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700251 · Cited by 326 · see citing works

Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia

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Illuminating viral infections in the nervous system

McGavern, D. B., & Kang, S. S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2971 · Cited by 281 · see citing works

West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood-brain barrier

Verma, S., Lo, Y. Y., Chapagain, M. L., Lum, S., Kumar, M., Gurjav, U., Luo, H., Nakatsuka, A. S., & Nerurkar, V. R. (2009) · Virology · doi:10.1016/j.virol.2008.11.047 · Cited by 255 · see citing works

Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism

Eugenín, E. A., Clements, J. E., Zink, M. C., & Berman, J. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1460-11.2011 · Cited by 253 · see citing works

Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle

Engelhardt, B., & Coisne, C. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-4 · Cited by 247 · see citing works

Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation.

Gurney, K., Estrada, E. Y., & Rosenberg, G. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.02.006 · Cited by 243 · see citing works

Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

Feng, S., Cen, J., Huang, Y., Shen, H., Li, Y., Wang, Y., & Chen, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020599 · Cited by 236 · see citing works

Coxsackievirus Entry across Epithelial Tight Junctions Requires Occludin and the Small GTPases Rab34 and Rab5

Coyne, C. B., Shen, L., Turner, J. R., & Bergelson, J. M. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.07.003 · Cited by 232 · see citing works

Oxidative Stress and Blood–Brain Barrier Dysfunction Under Particular Consideration of Matrix Metalloproteinases

Lehner, C., Gehwolf, R., Tempfer, H., Krizbai, I. A., Hennig, B., Bauer, H., & Bauer, H. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3923 · Cited by 231 · see citing works

HIV-1 gp120 Compromises Blood–Brain Barrier Integrity and Enhance Monocyte Migration across Blood–Brain Barrier: Implication for Viral Neuropathogenesis

Kanmogne, G. D., Schall, K. A., Leibhart, J., Knipe, B., Gendelman, H. E., & Persidsky, Y. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600330 · Cited by 230 · see citing works

Breaking down the barrier: The effects of HIV-1 on the blood–brain barrier

Strazza, M., Pirrone, V., Wigdahl, B., & Nonnemacher, M. R. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.015 · Cited by 218 · see citing works

Influenza Virus–Cytokine‐Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza

Wang, S., Le, T. Q., Kurihara, N., Chida, J., Cissé, Y., Yano, M., & Kido, H. (2010) · The Journal of Infectious Diseases · doi:10.1086/656044 · Cited by 195 · see citing works

Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous system

Phares, T. W., Kean, R. B., Mikheeva, T., & Hooper, D. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7666 · Cited by 193 · see citing works

Matrix Metalloproteinase 9 Facilitates West Nile Virus Entry into the Brain

Wang, P., Dai, J., Bai, F., Kong, K., Wong, S. J., Montgomery, R. R., Madri, J. A., & Fikrig, E. (2008) · Journal of Virology · doi:10.1128/jvi.00314-08 · Cited by 186 · see citing works

A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins

Salinas, S., Schiavo, G., & Kremer, E. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2395 · Cited by 184 · see citing works

Junctional Adhesion Molecule 1 Is a Functional Receptor for Feline Calicivirus

Makino, A., Shimojima, M., Miyazawa, T., Kato, K., Tohya, Y., & Akashi, H. (2006) · Journal of Virology · doi:10.1128/jvi.80.9.4482-4490.2006 · Cited by 176 · see citing works

The specific fates of tight junction proteins in apoptotic epithelial cells

Bojarski, C., Weiske, J., Schöneberg, T., Schröder, W., Mankertz, J., Schulzke, J., Florian, P., Fromm, M., Tauber, R., & Huber, O. (2004) · Journal of Cell Science · doi:10.1242/jcs.01071 · Cited by 173 · see citing works

HIV-1 gp120 Proteins Alter Tight Junction Protein Expression and Brain Endothelial Cell Permeability: Implications for the Pathogenesis of HIV-Associated Dementia

Kanmogne, G. D., Primeaux, C., & Grammas, P. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.6.498 · Cited by 159 · see citing works

Epithelial barrier biology: good fences make good neighbours

Moens, E., & Veldhoen, M. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03506.x · Cited by 154 · see citing works

Reversal of West Nile virus-induced blood–brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor

Verma, S., Kumar, M., Gurjav, U., Lum, S., & Nerurkar, V. R. (2010) · Virology · doi:10.1016/j.virol.2009.10.036 · Cited by 151 · see citing works

Diapedesis of monocytes is associated with MMP‐ mediated occludin disappearance in brain endothelial cells

Reijerkerk, A., Kooij, G., van der Pol, S. M. A., Khazen, S., Dijkstra, C. D., & de Vries, H. E. (2006) · The FASEB Journal · doi:10.1096/fj.06-6099fje · Cited by 140 · see citing works

HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9

Xu, R., Feng, X., Xie, X., Zhang, J., Wu, D., & Xu, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.052 · Cited by 138 · see citing works

Role of oxidative damage in the pathogenesis of viral infections of the nervous system.

Vályi-Nagy, T., & Dermody, T. S. (2005) · PubMed · doi:10.14670/hh-20.957 · Cited by 132 · see citing works

Critical Role of Actin in Modulating BBB Permeability

Lai, C.-H., Kuo, K.-H., & Leo, J. M. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.03.007 · Cited by 129 · see citing works

Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV‐1‐associated dementia

Boven, L. A., Middel, J., Verhoef, J., Groot, C. J. A. D., & Nottet, H. S. L. M. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2000.00255.x · Cited by 128 · see citing works

Signaling Mechanisms of HIV-1 Tat-Induced Alterations of Claudin-5 Expression in Brain Endothelial Cells

András, I. E., Pu, H., Tian, J., Deli, M. A., Nath, A., Hennig, B., & Toborek, M. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600115 · Cited by 121 · see citing works

Acquired immunodeficiency syndrome and the blood-brain barrier

Ivey, N., MacLean, A. G., & Lackner, A. A. (2009) · Journal of NeuroVirology · doi:10.1080/13550280902769764 · Cited by 115 · see citing works

Alteration of Blood–Brain Barrier Integrity by Retroviral Infection

Afonso, P. V., Ozden, S., Cumont, M.-C., Seilhean, D., Cartier, L., Rezaie, P., Mason, S., Lambert, S., Huerre, M., Gessain, A., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000205 · Cited by 112 · see citing works

Caveolin-1 Regulates Human Immunodeficiency Virus-1 Tat-Induced Alterations of Tight Junction Protein Expression via Modulation of the Ras Signaling

Zhong, Y., Smart, E. J., Weksler, B. B., Couraud, P., Hennig, B., & Toborek, M. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0061-08.2008 · Cited by 111 · see citing works

Tight Junction Regulation by Morphine and HIV-1 Tat Modulates Blood–Brain Barrier Permeability

Mahajan, S. D., Aalinkeel, R., Sykes, D. E., Reynolds, J. L., Bindukumar, B., Fernandez, S. F., Chawda, R., Shanahan, T., & Schwartz, S. A. (2008) · Journal of Clinical Immunology · doi:10.1007/s10875-008-9208-1 · Cited by 109 · see citing works

HIV-1 gp120-Induced Injury to the Blood-Brain Barrier: Role of Metalloproteinases 2 and 9 and Relationship to Oxidative Stress

Louboutin, J., Agrawal, L., Reyes, B. A. S., Bockstaele, E. J. V., & Strayer, D. S. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181e8c96f · Cited by 108 · see citing works

Mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but not BALB/c mice

Guida, J. D., Fejér, G., Pirofski, L., Brosnan, C. F., & Horwitz, M. S. (1995) · Journal of Virology · doi:10.1128/jvi.69.12.7674-7681.1995 · Cited by 105 · see citing works

Induction of Blood Brain Barrier Tight Junction Protein Alterations by CD8 T Cells

Suidan, G. L., Mcdole, J. R., Chen, Y., Pirko, I., & Johnson, A. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003037 · Cited by 105 · see citing works

Spontaneous Intracerebral Hemorrhage during Acute and Chronic Hypertension in Mice

Wakisaka, Y., Chu, Y., Miller, J. D., Rosenberg, G. A., & Heistad, D. D. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.183 · Cited by 105 · see citing works

Lethal Silver-Haired Bat Rabies Virus Infection Can Be Prevented by Opening the Blood-Brain Barrier

Roy, A., & Hooper, D. C. (2007) · Journal of Virology · doi:10.1128/jvi.00710-07 · Cited by 102 · see citing works

Increased blood–brain barrier permeability is not a primary determinant for lethality of West Nile virus infection in rodents

Morrey, J. D., Olsen, A. L., Siddharthan, V., Motter, N. E., Wang, H., Taro, B., Chen, D., Ruffner, D. E., & Hall, J. O. (2008) · Journal of General Virology · doi:10.1099/vir.0.83345-0 · Cited by 94 · see citing works

Evidence of blood-brain barrier alteration and activation in HIV-1 gp120 transgenic mice

Toneatto, S., Finco, O., van der Putten, H., Abrignani, S., & Annunziata, P. (1999) · AIDS · doi:10.1097/00002030-199912030-00005 · Cited by 91 · see citing works

Pathogenic Old World Hantaviruses Infect Renal Glomerular and Tubular Cells and Induce Disassembling of Cell-to-Cell Contacts

Krautkrämer, E., Grouls, S., Stein, N., Reiser, J., & Zeier, M. (2011) · Journal of Virology · doi:10.1128/jvi.00568-11 · Cited by 88 · see citing works

Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: Implications for HIV-1–associated neurocognitive disorder

Gandhi, N. H., Saiyed, Z. M., Napuri, J., Samikkannu, T., Reddy, P. V. B., Agudelo, M., Khatavkar, P., Saxena, S. K., & Nair, M. (2010) · Journal of NeuroVirology · doi:10.3109/13550284.2010.499891 · Cited by 88 · see citing works

A Peroxynitrite-Dependent Pathway Is Responsible for Blood-Brain Barrier Permeability Changes during a Central Nervous System Inflammatory Response: TNF-α Is Neither Necessary nor Sufficient

Phares, T. W., Fabis, M. J., Brimer, C. M., Kean, R. B., & Hooper, D. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7334 · Cited by 87 · see citing works

Hepatitis C Virus Infection Reduces Hepatocellular Polarity in a Vascular Endothelial Growth Factor–Dependent Manner

Mee, C., Farquhar, M. J., Harris, H. J., Hu, K., Ramma, W., Ahmed, A., Maurel, P., Bicknell, R., Balfe, P., & McKeating, J. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.047 · Cited by 86 · see citing works

Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability

Chuang, Y., Lei, H.-Y., Liu, H., Lin, Y.-S., Fu, T.-F., & Yeh, T. (2011) · Cytokine · doi:10.1016/j.cyto.2011.01.013 · Cited by 83 · see citing works

Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-κB dependent pathway in human astrocytes

Ju, S. M., Song, H. Y., Lee, J. A., Lee, S. J., Choi, S. Y., & Park, J. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.2.011 · Cited by 82 · see citing works

Innate immunity and brain inflammation: the key role of complement

Francis, K. L., van Beek, J., Canova, C., Neal, J. W., & Gasque, P. (2003) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399403006252 · Cited by 80 · see citing works

Human immunodeficiency virus type 1 gp120–mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells

Nakamuta, S., Endô, H., Higashi, Y., Kousaka, A., Yamada, H., Yano, M., & Kido, H. (2008) · Journal of NeuroVirology · doi:10.1080/13550280801993630 · Cited by 73 · see citing works

TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress

Hicks, K., O'Neil, R. G., Dubinsky, W. S., & Brown, R. C. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00458.2009 · Cited by 70 · see citing works

HIV-1 Tat-Mediated Effects on Focal Adhesion Assembly and Permeability in Brain Microvascular Endothelial Cells

Avraham, H. K., Jiang, S., Lee, T.-H., Prakash, O., & Avraham, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.6228 · Cited by 70 · see citing works

Mouse Adenovirus Type 1-Induced Breakdown of the Blood-Brain Barrier

Gralinski, L. E., Ashley, S. L., Dixon, S. D., & Spindler, K. R. (2009) · Journal of Virology · doi:10.1128/jvi.00954-09 · Cited by 70 · see citing works

Herpes-simplex virus encephalitis is characterized by an early MMP-9 increase and collagen type IV degradation

Sellner, J., Simon, F., Meyding‐Lamadé, U., & Leib, S. L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.093 · Cited by 68 · see citing works

Distribution of Mouse Adenovirus Type 1 in Intraperitoneally and Intranasally Infected Adult Outbred Mice

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Intercellular Junctional Proteins as Receptors and Barriers to Virus Infection and Spread

Bergelson, J. M. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.009 · Cited by 67 · see citing works

Japanese encephalitis virus induces matrix metalloproteinase‐9 in rat brain astrocytes via NF‐κB signalling dependent on MAPKs and reactive oxygen species

Tung, W., Tsai, H., Lee, I., Hsieh, H., Chen, W., Chen, Y., & Yang, C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00982.x · Cited by 66 · see citing works

Multiple Roles of Metalloproteinases in Neurological Disorders

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Circulating gp120 alters the blood–brain barrier permeability in HIV-1 gp120 transgenic mice

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The blood-brain barrier in the cerebrum is the initial site for the Japanese encephalitis virus entering the central nervous system

Liu, T.-H., Liang, L.-C., Wang, C.-C., Liu, H.-C., & Chen, W. (2008) · Journal of NeuroVirology · doi:10.1080/13550280802339643 · Cited by 56 · see citing works

Transcellular transport of West Nile virus-like particles across human endothelial cells depends on residues 156 and 159 of envelope protein

Hasebe, R., Suzuki, T., Makino, Y., Igarashi, M., Yamanouchi, S., Maeda, A., Horiuchi, M., Sawa, H., & Kimura, T. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-165 · Cited by 54 · see citing works

HIV Immune Evasion

Wonderlich, E. R., Leonard, J. A., & Collins, K. L. (2011) · Advances in virus research · doi:10.1016/b978-0-12-385987-7.00005-1 · Cited by 49 · see citing works

Susceptibility and signs associated with mouse adenovirus type 1 infection of adult outbred Swiss mice

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Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium

Prato, M., D’Alessandro, S., den Steen, P. E. V., Opdenakker, G., Arese, P., Taramelli, D., & Basilico, N. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01620.x · Cited by 48 · see citing works

Microbial Induction of Vascular Pathology in the CNS

Kang, S. S., & McGavern, D. B. (2010) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-010-9208-9 · Cited by 44 · see citing works

Metabolic Acidosis Induced by Plasmodium Falciparum Intraerythrocytic Stages Alters Blood—Brain Barrier Integrity

Zougbédé, S., Miller, F., Ravassard, P., Rebollo, A., Cicéron, L., Couraud, P., Mazier, D., & Sabater, A. M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.121 · Cited by 44 · see citing works

Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes

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Role of Dendritic Cells in Viral Brain Infections

Constant, O., Maarifi, G., Blanchet, F. P., Van de Perre, P., Simonin, Y., & Salinas, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.862053 · Cited by 35 · see citing works

Neuro-Axonal Damage and Alteration of Blood–Brain Barrier Integrity in COVID-19 Patients

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Innate Immune Signaling and Role of Glial Cells in Herpes Simplex Virus- and Rabies Virus-Induced Encephalitis

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Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries

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N-Butylphthalide Alleviates Blood–Brain Barrier Impairment in Rats Exposed to Carbon Monoxide

Bi, M., Zhang, M., Guo, D., Bi, W., Liu, B., Zou, Y., & Li, Q. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00394 · Cited by 34 · see citing works

Extremely Low Organ Toxicity and Strong Antitumor Activity of miR-34-Regulated Oncolytic Coxsackievirus B3

Jia, Y., Miyamoto, S., Soda, Y., Takishima, Y., Sagara, M., Liao, J., Hirose, L., Hijikata, Y., Miura, Y., Hara, K., et al. (2019) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2019.01.003 · Cited by 33 · see citing works

Cerebrospinal fluid metabolites in tryptophan‐kynurenine and nitric oxide pathways: biomarkers for acute neuroinflammation

Yan, J., Kuzhiumparambil, U., Bandodkar, A., Bandodkar, S., Dale, R. C., & Fu, S. (2020) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14774 · Cited by 32 · see citing works

Brain Microvascular Endothelial Cell-Derived HMGB1 Facilitates Monocyte Adhesion and Transmigration to Promote JEV Neuroinvasion

Zou, S.-S., Zou, Q., Xiong, W., Cui, N.-Y., Wang, K., Liu, H., Lou, W., Higazy, D., Zhang, Y., & Cui, M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.701820 · Cited by 32 · see citing works

Understanding the link between neurotropic viruses, BBB permeability, and MS pathogenesis

Rani, A., Ergün, S., Karnati, S., & Jha, H. C. (2024) · Journal of NeuroVirology · doi:10.1007/s13365-023-01190-8 · Cited by 35 · see citing works

Transcriptomic Analysis of Human Brain -Microvascular Endothelial Cell Driven Changes in -Vascular Pericytes

Kurmann, L., Okoniewski, M. J., & Dubey, R. K. (2021) · Cells · doi:10.3390/cells10071784 · Cited by 30 · see citing works

Interferon-λ Attenuates Rabies Virus Infection by Inducing Interferon-Stimulated Genes and Alleviating Neurological Inflammation

Li, Y., Zhao, L., Luo, Z., Zhang, Y., Lv, L., Zhao, J., Sui, B., Huang, F., Cui, M., Fu, Z. F., et al. (2020) · Viruses · doi:10.3390/v12040405 · Cited by 30 · see citing works

Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected hcMEC/D3 Cells on the Blood–Brain Barrier System

Fikatas, A., Dehairs, J., Noppen, S., Doijen, J., Vanderhoydonc, F., Meyen, E., Swinnen, J. V., Pannecouque, C. C., & Schols, D. (2021) · Viruses · doi:10.3390/v13122363 · Cited by 30 · see citing works

Enhancement of blood–brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice

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Targeting Non-coding RNA for Glioblastoma Therapy: The Challenge of Overcomes the Blood-Brain Barrier

Sharma, R. K., Calderon, C., & Vivas‐Mejía, P. E. (2021) · Frontiers in Medical Technology · doi:10.3389/fmedt.2021.678593 · Cited by 28 · see citing works

Differential permissivity of human cerebrovascular endothelial cells to enterovirus infection and specificities of serotype EV-A71 in crossing an in vitro model of the human blood–brain barrier

Volle, R., Weksler, B. B., Romero, I. A., Couraud, P., Archimbaud, C., Henquell, C., Pereira, B., Peigue‐Lafeuille, H., Bailly, J., & Mirand, A. (2015) · Journal of General Virology · doi:10.1099/vir.0.000103 · Cited by 29 · see citing works

Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis

Alonso, A., Eisele, P., Ebert, A., Griebe, M., Engelhardt, B., Szabo, K., Hennerici, M. G., & Gass, A. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000164 · Cited by 29 · see citing works

Inflammasome activation in mouse inner ear in response to MCMV induced hearing loss

Shi, X., Dong, Y., Li, Y., Zhao, Z., Li, H., Qiu, S., Li, Y., Guo, W., & Qiao, Y. (2015) · Journal of Otology · doi:10.1016/j.joto.2015.12.001 · Cited by 29 · see citing works

The influence of physiological and pathological perturbations on blood-brain barrier function

Zhao, N., Chung, T. D., Guo, Z., Jamieson, J. J., Liang, L. R., Linville, R. M., Pessell, A. F., Wang, L., & Searson, P. C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1289894 · Cited by 30 · see citing works

Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1

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Differential induction of CCL5 by pathogenic and non-pathogenic strains of West Nile virus in brain endothelial cells and astrocytes

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Cytomegalovirus Initiates Infection Selectively from High-Level β1 Integrin–Expressing Cells in the Brain

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Genome-Wide Mouse Mutagenesis Reveals CD45-Mediated T Cell Function as Critical in Protective Immunity to HSV-1

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Large-Scale Quantitative Comparison of Plasma Transmembrane Proteins between Two Human Blood–Brain Barrier Model Cell Lines, hCMEC/D3 and HBMEC/ciβ

Masuda, T., Hoshiyama, T., Uemura, T., Hirayama‐Kurogi, M., Ogata, S., Furukawa, A., Couraud, P., Furihata, T., Ito, S., & Ohtsuki, S. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00114 · Cited by 29 · see citing works

Hepatitis E Virus Quasispecies in Cerebrospinal Fluid with Neurological Manifestations

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Blood-Brain Barrier Tight Junction Disruption in Human Immunodeficiency Virus-1 Encephalitis

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Disruption of the blood brain barrier is vital property of neurotropic viral infection of the central nervous system

Al‐Obaidi, M. M. J., Bahadoran, A., Wang, S., Manikam, R., Raju, C. S., & Sekaran, S. D. (2018) · Acta Virologica · doi:10.4149/av_2018_102 · Cited by 134 · see citing works

HIV and viral protein effects on the blood brain barrier

McRae, M. (2016) · Tissue Barriers · doi:10.1080/21688370.2016.1143543 · Cited by 71 · see citing works

Mechanisms of the Blood–Brain Barrier Disruption in HIV-1 Infection

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The blood brain barrier in HIV infection

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