The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Role of interleukin-1β during pain and inflammation
Open accessAbstract
The cytokine cascade in pain and inflammatory processes is a tremendously complex system, involving glial, immune, and neuronal cell interactions. IL-1β is a pro-inflammatory cytokine that has been implicated in pain, inflammation and autoimmune conditions. This review will focus on studies that shed light on the critical role of IL-1β in various pain states, including the role of the intracellular complex, the inflammasome, which regulates IL-1β production. Evidence will be presented demonstrating the importance of IL-1β in both the induction of pain and in the maintenance of pain in chronic states, such as after nerve injury. Additionally, the involvement of IL-1β as a key mediator in the interaction between glia and neurons in pain states will be discussed. Taken together, the evidence presented in the current review showing the importance of IL-1β in animal and human pain states, suggests that blockade of IL-1β be considered as a therapeutic opportunity.
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Cites
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Neuronal plasticity: Increasing the gain in pain
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Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M. M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C. L., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08692.2003 · Cited by 893
NMDA receptor subunits: function and pharmacology
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A pilot study of IL-1 inhibition by anakinra in acute gout
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Cited by
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630
Dhimolea, E. (2010) · mAbs · doi:10.4161/mabs.2.1.10328 · Cited by 270
Proinflammatory Pathways: The Modulation by Flavonoids
Ribeiro, D., Freitas, M., Lima, J. L. F. C., & Fernandes, E. (2015) · Medicinal Research Reviews · doi:10.1002/med.21347 · Cited by 147
Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms
Lu, H.-J., & Gao, Y.-J. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-00961-3 · Cited by 118
Yoon, W. J., Moon, J. Y., Song, G., Lee, Y. K., Han, M. S., Lee, J. S., Ihm, B. S., Lee, W. J., Lee, N. H., & Hyun, C. G. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.02.014 · Cited by 114
Metadata
- Authors
- Ren, K., & Torres, R.
- Venue
- Brain Research Reviews
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 60
- Issue
- 1
- Pages
- 57-64
- ISSN
- 0165-0173 (ISSN-L)
- OpenAlex
- W2015157276
- Cited by
- 717
- References
- 8
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
