Cited by 180Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

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Prefrontal cortex and drug abuse vulnerability: Translation to prevention and treatment interventions

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Perry, Jennifer L., Joseph, Jane E., Jiang, Yang, Zimmerman, Rick S., Kelly, Thomas H., Darna, Mahesh, Huettl, Peter, Dwoskin, Linda P., Bardo, Michael T.·2011·Brain Research Reviews

DOI 10.1016/j.brainresrev.2010.09.001PMC PMC3005953

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Abstract

Vulnerability to drug abuse is related to both reward seeking and impulsivity, two constructs thought to have a biological basis in the prefrontal cortex (PFC). This review addresses similarities and differences in neuroanatomy, neurochemistry and behavior associated with PFC function in rodents and humans. Emphasis is placed on monoamine and amino acid neurotransmitter systems located in anatomically distinct subregions: medial prefrontal cortex (mPFC); lateral prefrontal cortex (lPFC); anterior cingulate cortex (ACC); and orbitofrontal cortex (OFC). While there are complex interconnections and overlapping functions among these regions, each is thought to be involved in various functions related to health-related risk behaviors and drug abuse vulnerability. Among the various functions implicated, evidence suggests that mPFC is involved in reward processing, attention and drug reinstatement; lPFC is involved in decision-making, behavioral inhibition and attentional gating; ACC is involved in attention, emotional processing and self-monitoring; and OFC is involved in behavioral inhibition, signaling of expected outcomes and reward/punishment sensitivity. Individual differences (e.g., age and sex) influence functioning of these regions, which, in turn, impacts drug abuse vulnerability. Implications for the development of drug abuse prevention and treatment strategies aimed at engaging PFC inhibitory processes that may reduce risk-related behaviors are discussed, including the design of effective public service announcements, cognitive exercises, physical activity, direct current stimulation, feedback control training and pharmacotherapies. A major challenge in drug abuse prevention and treatment rests with improving intervention strategies aimed at strengthening PFC inhibitory systems among at-risk individuals.

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Abbasi, M., Seddighfar, M., Karimian-Sani-Varjovi, H., & Haghparast, A. (2026) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2026.108209

Authors: Perry, J. L., Joseph, J. E., Jiang, Y., Zimmerman, R. S., Kelly, T. H., Darna, M., Huettl, P., Dwoskin, L. P., & Bardo, M. T.
Affiliations: University of Kentucky (US)
Corresponding author: Bardo, Michael T.
ORCID: Joseph, Jane E.
Jiang, Yang
Zimmerman, Rick S.
Kelly, Thomas H.
Bardo, Michael T.
Venue: Brain Research Reviews
Publisher: Elsevier BV
Published: 2011-01-01
Volume: 65
Issue: 2
Pages: 124-149
ISSN: 0165-0173 (ISSN-L)
DOI: 10.1016/j.brainresrev.2010.09.001
PMC: PMC3005953
OpenAlex: W1969360450
Cited by: 180
References: 366
Citations by year: 2026: 8 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 25 · 2014: 18 · 2013: 16 · 2012: 14
FWCI: 7.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA012964, T32DA007304, P50DA005312, P50 DA05312, R21DA024401)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: prefrontal cortex, drug abuse vulnerability, reward processing, impulsivity, medial prefrontal cortex, lateral prefrontal cortex, anterior cingulate cortex, orbitofrontal cortex, monoamines, amino acid neurotransmitters, behavioral inhibition, decision-making, individual differences, age and sex differences, substance use prevention, addiction treatment, transcranial direct current stimulation, cognitive exercises, physical activity, pharmacotherapy, public service announcements
MeSH terms: Animals, Exploratory Behavior, Humans, Impulsive Behavior, Motivation, Reward, Risk Factors, Prefrontal Cortex, Substance-Related Disorders, Genetic Predisposition to Disease, Risk Reduction Behavior, Rats, Executive Function

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Prefrontal cortex and drug abuse vulnerability: Translation to prevention and treatment interventions

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