Interleukin-6, a mental cytokine

Spooren, Anneleen, Kolmus, Krzysztof, Laureys, Guy, Clinckers, Ralph, De Keyser, Jacques, Haegeman, Guy, Gerlo, Sarah·2011·Brain Research Reviews

DOI 10.1016/j.brainresrev.2011.01.002

Cites (325)

Items 201–325 of 325

CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis1Part of this work was presented in abstract form at the Twenty-Seventh Annual Meeting of the Society for Neuroscience, October 25–30, 1997, New Orleans, LA, USA.1
Frank Padberg, Wolfgang Walter Feneberg, Stephan Schmidt, Markus Schwarz, Dirk A. Körschenhausen, B. D. Greenberg, Tom Nolde, Norbert Müller, H Trapmann, N. König et al. · 1999 · Journal of Neuroimmunology
Increased interleukin-6 mRNA expression in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis.
V. Navikas, D. Matusevicius, M. Söderström, S. Fredrikson, P. Kivisäkk, Å. Ljungdahl, B. Hojeberg, H. Link · 1996 · Journal of Neuroimmunology
Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus
Reto A. Gadient, U. Otten · 1993 · Neuroscience Letters
Modulation of Hypothalamic–Pituitary–Adrenal Function by Transgenic Expression of Interleukin-6 in the CNS of Mice
Jacob Raber, Ross D. O’Shea, Floyd E. Bloom, Iain Leslie Campbell · 1997 · Journal of Neuroscience
Interleukin-6 Upregulates Neuronal Adenosine A1 Receptors: Implications for Neuromodulation and Neuroprotection
Knut P. H. Biber, António Pinto‐Duarte, Maria C. Wittendorp, Amalia M. Dolga, C C Fernandes, Jacobien von Frijtag Drabbe Künzel, Jan N. Keijser, R de Vries, Adriaan P. IJzerman, Joaquim Alexandre Ribeiro et al. · 2007 · Neuropsychopharmacology
Role of IL-6 in Spinal Cord Injury in a Mouse Model
Masaya Nakamura, Seiji Okada, Yoshiaki Toyama · 2005 · Clinical Reviews in Allergy & Immunology
Astrocyte‐targeted expression of interleukin‐6 protects the central nervous system during neuroglial degeneration induced by 6‐aminonicotinamide
M. Penkowa, J. Camats, H. Hadberg, A. Quintana, S. Rojas, M. Giralt, A. Molinero, I. Campbell, J. Hidalgo · 2003 · Journal of Neuroscience Research
Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice.
P. C. Baier, U. May, J. Scheller, S. Rose-John, T. Schiffelholz · 2009 · Behavioural Brain Research
Interaction of polymorphisms in the genes encoding interleukin‐6 and estrogen receptor beta on the susceptibility to Parkinson's disease
Anna Schröder Håkansson, Lars Westberg, Staffan Nilsson, Silvia Buervenich, Andrea Carmine Belin, Björn Holmberg, Olof Sydow, Lars Olson, Bo Johnels, Elias Eriksson et al. · 2005 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
Suppression of interleukin-6 by minocycline in a rat model of neuropathic pain
Taraneh Moini Zanjani, Masoumeh Sabetkasaei, Nariman Mosaffa, Homa Shardi Manaheji, Farzaneh Labibi, Babak Farokhi · 2006 · European Journal of Pharmacology
Interleukin-6 Protects Anterior Horn Neurons from Lethal Virus-Induced Injury
K. Pavelko, C. Howe, K. Drescher, J. Gamez, Aaron J. Johnson, T. Wei, R. Ransohoff, Moses Rodriguez · 2003 · Journal of Neuroscience
Soluble Interleukin-6 (IL-6) Receptor/IL-6 Fusion Protein Enhances in Vitro Differentiation of Purified Rat Oligodendroglial Lineage Cells
Alessandra Valerio · 2002 · Molecular and Cellular Neuroscience
Interleukin-6 and leukemia inhibitory factor promote the survival of acetylcholinesterase-positive neurons in culture from embryonic rat spinal cord
Yoichi Kushima, Hiroshi Hatanaka · 1992 · Neuroscience Letters
Interleukin-6, β-amyloid peptide and NMDA interactions in rat cortical neurons
Zhihua Qiu, Donna L. Gruol · 2003 · Journal of Neuroimmunology
Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons
Orellana, Daniel I., Quintanilla, Rodrigo A., Gonzalez-Billault, Christian, Maccioni, Ricardo B. · 2005 · Neurotoxicity Research
IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6.
A. Armario, J. Hernández, H. Bluethmann, J. Hidalgo · 1998 · Journal of Neuroimmunology
Abnormal Iron Deposition Associated With Lipid Peroxidation in Transgenic Mice Expressing Interleukin-6 in the Brain
Pierre Castelnau, Robert S. Garrett, Wulf Palinski, Joseph Lee Witztum, Iain Leslie Campbell, Henry C. Powell · 1998 · Journal of Neuropathology & Experimental Neurology
IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier
Ralf Andreas Linker, Fred Lühder, Karl‐Josef Kallen, De-Hyung Lee, Britta Engelhardt, Stefan Rose‐John, Ralf Gold · 2008 · Journal of Neuroimmunology
Interleukine-6 serum levels correlate with response to antidepressant sleep deprivation and sleep phase advance
Francesco Benedetti, Adelio Lucca, Frăncesca Brambilla, Cristina Colombo, Enrico Smeraldi · 2002 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
IL-6-type cytokines enhance epidermal growth factor-stimulated astrocyte proliferation
Steven W. Levison, Fengjun Jiang, Olivia K. Stoltzfus, Melissa H. Ducceschi · 2000 · Glia
Genetics of interleukin 6: implications for Alzheimer's disease
Andreas Papassotiropoulos · 2001 · Neurobiology of Aging
Oligodendrocyte-specific gene expression in mouse brain: Use of a myelin-forming cell type-specific promoter in an adeno-associated virus
Hong Chen, Douglas M. McCarty, Andrew T. Bruce, Kunihiko Suzuki, Kinuko Suzuki · 1999 · Journal of Neuroscience Research
Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice
Giovambattista De Sarro, Emilio Russo, Guido Ferreri, Giuseppe Bruzzese, Maria Antonietta Flocco, Eugenio Donato Di Paola, Angela De Sarro · 2004 · Pharmacology Biochemistry and Behavior
The –74 G/C polymorphism of the interleukin-6 gene promoter is associated with Alzheimerʼs disease in an Italian population
Roberto Pola, Andrea Flex, Eleonora Gaetani, Antonio Dal Lago, Laura Gerardino, Paolo Pola, Roberto Bernabei · 2002 · Neuroreport
Neuroprotective effect of various cytokines on developing spinal motoneurons following axotomy
Ken Ikeda, Yasuo Iwasaki, Toshiya Shiojima · 1996 · Journal of the Neurological Sciences
Synergistic Induction of Neurite Outgrowth by Nerve Growth Factor or Epidermal Growth Factor and Interleukin-6 in PC12 Cells
Yvonne Y. Wu, Ralph A. Bradshaw · 1996 · Journal of Biological Chemistry
Brain-IL-1 beta triggers astrogliosis through induction of IL-6: inhibition by propranolol and IL-10.
Christian Woiciechowsky, Britta Schöning, Gisela Stoltenburg, Florian Stockhammer, Hans‐Dieter Volk · 2004 · PubMed
Ciliary neurotrophic factor and interleukin‐6 differentially activate microglia
J. Kyle Krady, Hsiao‐Wen Lin, Christina M. Liberto, Anirban Basu, Sergey G. Kremlev, Steven W. Levison · 2008 · Journal of Neuroscience Research
Interleukin-6 and cAMP Induce Stromal Cell-derived Factor-1 Chemotaxis in Astroglia by Up-regulating CXCR4 Cell Surface Expression
Veysel Ödemis, Barbara Moepps, Peter Gierschik, Jürgen Engele · 2002 · Journal of Biological Chemistry
Compromised reactive microgliosis in MPTP-lesioned IL-6 KO mice
Hernan Cardenas, Laurel M. Bolin · 2003 · Brain Research
Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish
Owen A. Ross, C.M. O'Neill, Irene Maeve Rea, Timothy Lynch, David Yunus Gosal, Andrew Wallace, Martin D. Curran, Derek Middleton, J. Mark Gibson · 2004 · Human Immunology
Feeding, exploratory, anxiety- and depression-related behaviors are not altered in interleukin-6-deficient male mice.
A. Świergiel, A. Dunn · 2006 · Behavioural Brain Research
Role of Very-late Antigen-4 (VLA-4) in Myelin Basic Protein-primed T Cell Contact-induced Expression of Proinflammatory Cytokines in Microglial Cells
Subhajit Dasgupta, Malabendu Jana, Xiaojuan Liu, Kalipada Pahan · 2003 · Journal of Biological Chemistry
Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat
Juan Hidalgo, Sergi Florit, Mercedes Giralt, Beatriz Ferrer, Charlotte Keller, Henriette Pilegaard · 2009 · Brain Behavior and Immunity
Interleukin‐6 promotes sprouting and functional recovery in lesioned organotypic hippocampal slice cultures
David Hakkoum, Luc Stoppini, Dominique Müller · 2006 · Journal of Neurochemistry
The IL-6/sIL-6R Fusion Protein Hyper-IL-6 Promotes Neurite Outgrowth and Neuron Survival in Cultured Enteric Neurons
Karl‐Herbert Schäfer, P. Mestres, Pia März · 1999 · Journal of Interferon & Cytokine Research
Astrocytic Alterations in Interleukin-6/Soluble Interleukin-6 Receptor α Double-Transgenic Mice
Anna Brunello, Jakob Weissenberger, Андреас Каппелер · 2000 · American Journal Of Pathology
Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity
Noëlle Callizot, Emile Andriambeloson, Jonathan D. Glass, Michel Revel, Pamela Ferro, Rocco Cirillo, Pierre‐Alain Vitte, Michel Dréano · 2008 · Cancer Chemotherapy and Pharmacology
IL-6 and CCL2 levels in CSF are associated with the clinical course of MS: Implications for their possible immunopathogenic roles
Clas Malmeström, Bengt A. Andersson, Sara Haghighi, Jan Lycke · 2006 · Journal of Neuroimmunology
Is IL-6 both a cytokine and a neurotrophic factor?
John A. Wagner · 1996 · The Journal of Experimental Medicine
Increased Pro-Inflammatory Response by Dendritic Cells from Patients with Alzheimer's Disease
Antonio Ciaramella, Federica Bizzoni, Francesca Salani, Diego Vanni, Gianfranco Spalletta, Nunzia Sanarico, Silvia Vendetti, Carlo Caltagirone, Paola Bossù · 2010 · Journal of Alzheimer s Disease
Granulocyte macrophage colony stimulating factor stimulates in vitro proliferation of astrocytes derived from simian mature brains
Gilles J. Guillemin, François Dominique Boussin, Roger Le Grand, Juliana Croitoru‐Lamoury, Hervé Coffigny, Dominique Dormont · 1996 · Glia
Coadministration of interleukin-6 (IL-6) and soluble IL-6 receptor delays progression of wobbler mouse motor neuron disease
Ken Ikeda, Kinoshita Masao, Nozomu Tagaya · 1996 · Brain Research
Increased post-traumatic survival of neurons in IL-6-knockout mice on a background of EAE susceptibility
Jasmin Fisher, Tal Mizrahi, Hadas Schori · 2001 · Journal of Neuroimmunology
Activation of the Stat3 Signaling Pathway Is Required for Differentiation by Interleukin-6 in PC12-E2 Cells
Yvonne Y. Wu, Ralph A. Bradshaw · 2000 · Journal of Biological Chemistry
Effect of a carboxy-terminal fragment of the alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells
Young-Hae Chong · 1997 · Life Sciences
Interleukin‐6 induces proliferation in adult spinal cord‐derived neural progenitors via the JAK2/STAT3 pathway with EGF‐induced MAPK phosphorylation
M. Kang, Sung Keun Kang · 2008 · Cell Proliferation
Brain response to traumatic brain injury in wild‐type and interleukin‐6 knockout mice: a microarray analysis
Christian Bjørn Poulsen, Milena Penkowa, Rehannah Borup, Finn Cilius Nielsen, Mario Cáceres, Albert Quintana, Amalia Molinero, Javier Carrasco, Mercedes Giralt, Juan Hidalgo · 2004 · Journal of Neurochemistry
Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity
Yu-Ping Peng, Yihua Qiu, Jianhua Lu, Jianjun Wang · 2004 · Neuroscience Letters
CEREBROSPINAL FLUID AND SERUM PROTEIN LEVELS OF TUMOUR NECROSIS FACTOR-ALPHA (TNF-α), INTERLEUKIN-6 (IL-6) AND SOLUBLE INTERLEUKIN-6 RECEPTOR (sIL-6R gp80) IN MULTIPLE SCLEROSIS PATIENTS
Anton Vladić, Gordana Horvat, Stjepan Vukadin · 2002 · Cytokine
Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK
Xiaoqin Wang, Yu-Ping Peng, Jianhua Lu, Beibei Cao, Yihua Qiu · 2008 · Neuroscience Letters
Cytokines Are a Therapeutic Target for the Prevention of Inflammation-Induced Cancers
Stefan Rose‐John, Heidi Schooltink · 2007 · Springer eBooks
Interleukin‐6 is required for the early induction of glial fibrillary acidic protein in Schwann cells during Wallerian degeneration
Hyun Kyoung Lee, In Ae Seo, Duk Joon Suh, Jeong‐In Hong, Young Hyun Yoo, Hwan Tae Park · 2008 · Journal of Neurochemistry
Neuroprotective effect of interleukin‐6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome
Jean‐Charles Bensadoun, Luís Pereira de Almeida, Michel Dréano, Patrick Aebischer, Nicole Déglon · 2001 · European Journal of Neuroscience
Chronic Interleukin-6 Exposure Alters Electrophysiological Properties and Calcium Signaling in Developing Cerebellar Purkinje Neurons in Culture
Thomas E. Nelson, C. L. Ur, Donna L. Gruol · 2002 · Journal of Neurophysiology
Interleukin‐6 attenuates the development of experimental diabetes‐related neuropathy
Emile Andriambeloson, Caroline Baillet, Pierre‐Alain Vitte, Gianni Garotta, Michel Dréano, Noëlle Callizot · 2006 · Neuropathology
IL-6 up-regulates CNTF mRNA expression and enhances neurite regeneration
Takashi Shuto, Hidenori Horie, Naoshi Hikawa · 2001 · Neuroreport
Increased expression of the β4 and α5 integrin subunits in cerebral blood vessels of transgenic mice chronically producing the pro-inflammatory cytokines IL-6 or IFN-α in the central nervous system
Richard Milner, Iain Leslie Campbell · 2006 · Molecular and Cellular Neuroscience
Interleukin-6 Gene Polymorphism Is Related to Bone Mineral Density During and After Puberty in Healthy White Males: A Cross-Sectional and Longitudinal Study
Mattias Lorentzon, Ronny Lorentzon, Peter Nordström · 2000 · Journal of Bone and Mineral Research
Role of interleukin-6 in lipopolysaccharide-induced brain injury and behavioral dysfunction in neonatal rats
Yi Pang, L.-W. Fan, B. Zheng, Zhengwei Cai, P.G. Rhodes · 2006 · Neuroscience
Meningeal cells can communicate with astrocytes by calcium signaling
Bernice Grafstein, Shujun Liu, Maria Luisa Cotrina, Steven A. Goldman, Maiken Nedergaard · 2000 · Annals of Neurology
Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levels
Akira Nakajima, Kiyofumi Yamada, Libo Zou, Yijin Yan, Makoto Mizuno, Toshitaka Nabeshima · 2002 · Free Radical Biology and Medicine
Altered physiology of purkinje neurons in cerebellar slices from transgenic mice with chronic central nervous system expression of interleukin-6
T.E. Nelson, Iain Leslie Campbell, D.L. Gruol · 1999 · Neuroscience
Chronic interleukin‐6 exposure alters metabotropic glutamate receptor‐activated calcium signalling in cerebellar Purkinje neurons
Thomas E. Nelson, Jeffrey G. Netzeband, Donna L. Gruol · 2004 · European Journal of Neuroscience
Overexpression of interleukin-6 in the central nervous system of transgenic mice increases central but not systemic proinflammatory cytokine production
Elena Di Santo, Tonino Alonzi, Elena Fattori, Valeria Poli, Gennaro Ciliberto, Marina Sironi, Paola Gnocchi, Paola Ricciardi‐Castagnoli, Pietro Ghezzi · 1996 · Brain Research
Context‐dependent IL‐6 potentiation of interferon‐ gamma‐induced IL‐12 secretion and CD40 expression in murine microglia
Hsiao-Wen Lin, S. Levison · 2009 · Journal of Neurochemistry
Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation
Xuezhong Li, Long-mei Bai, Yaping Yang, Wei-feng Luo, Weidong Hu, Juping Chen, Chengjie Mao, Chun-Feng Liu · 2009 · Neuroscience Research
Janus faces of microglia in multiple sclerosis
Patricia Sanders, Jacques De Keyser · 2007 · Brain Research Reviews
Cytokines promote the survival of mouse cranial sensory neurones at different developmental stages
Antony R. Horton, Perry Francis Bartlett, Diane Pennica, Alun Milward Davies · 1998 · European Journal of Neuroscience
Metallothionein‐I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte‐targeted interleukin‐6 expression
Milena Penkowa, Jordi Camats, Mercedes Giralt, Amalia Molinero, Joaquim Hernández, Javier Carrasco, Iain Leslie Campbell, Juan Hidalgo · 2003 · Glia
Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore
Hiroyuki Umegaki, Kiyofumi Yamada, Michitaka Naito · 1996 · Biochemical Pharmacology
Effect of astrocyte‐targeted production of IL‐6 on traumatic brain injury and its impact on the cortical transcriptome
A. Quintana, A. Molinero, R. Borup, F. Nielsen, I. Campbell, M. Penkowa, J. Hidalgo · 2008 · Developmental Neurobiology
Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage
Yasuya Inomata, Akira Hirata, Naoko Yonemura · 2003 · Biochemical and Biophysical Research Communications
Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture
Janet Holliday, Katherine Parson, Jennifer Curry, Soo Yeun Lee, Donna L. Gruol · 1995 · Brain Research
Neuronal IκB Kinase β Protects Mice from Autoimmune Encephalomyelitis by Mediating Neuroprotective and Immunosuppressive Effects in the Central Nervous System
Mary Emmanouil, Era Taoufik, Vivian Tseveleki, Sotirios‐Spyridon M. Vamvakas, Theodore V. Tselios, Michael Karin, Hans Lassmann, Lesley Probert · 2009 · The Journal of Immunology
Interleukin 1α and interleukin 6 protect human neuronal SH-SY5Y cells from oxidative damage
Christopher J. Bissonnette, Andis Klegeris, Patrick L. McGeer, Edith G. McGeer · 2004 · Neuroscience Letters
Expression of interleukin 6 in the rat striatum following stereotaxic injection of quinolinic acid
Johannes Schiefer, Rudolf Töpper, Werner Schmidt, F. Block, Peter Claus Heinrich, J. Noth, Michael Schwarz · 1998 · Journal of Neuroimmunology
Interleukin-1β and interleukin-6 gene polymorphisms as risk factors for AD: A prospective study
Giovanni Ravaglia, F PAOLA, F. Maioli, Mabel Martelli, Fausta Montesi, Luciana Bastagli, M BIANCHIN, Martina Chiappelli, Emanuela Tumini, Luigi Bolondi · 2005 · Experimental Gerontology
Specific uptake of Aβ1-40 in rat brain occurs in astrocyte, but not in microglia
Matsunaga, Wataru, Shirokawa, Tetsuya, Isobe, Kenichi · 2003 · Neuroscience Letters
Minimal role for STAT1 in interleukin‐6 signaling and actions in the murine brain
Elisenda Sanz, Markus J. Hofer, Mercedes Unzeta, Iain Leslie Campbell · 2007 · Glia
Inflammation‐related genes and the risk of Parkinson’s disease: a multilocus approach
Jon Infante, Inés García‐Gorostiaga, Pascual Sánchez‐Juan, Coro Sánchez‐Quintana, José Luis Martín-Gurpegui, Eloy Rodríguez‐Rodríguez, Ignacio Mateo, José Berciano, Onofre Combarros · 2008 · European Journal of Neurology
Stimulation of myelin gene expression in vitro and of sciatic nerve remyelination by interleukin‐6 receptor–interleukin‐6 chimera
Shalom Haggiag, P.‐L. Zhang, Giora Slutzky · 2001 · Journal of Neuroscience Research
Induction of neuronal and myelin-related gene expression by IL-6-receptor/IL-6: A study on embryonic dorsal root ganglia cells and isolated Schwann cells
Peilin Zhang, Alon M. Levy, Levana Ben-Simchon · 2007 · Experimental Neurology
Effect of Interleukin-6 and Tumor Necrosis Factor-α on GABA Release from Mediobasal Hypothalamus and Posterior Pituitary
Andrea De Laurentiis, Daniel Alberto Pisera, Mercedes Lasaga, Marı́a del Carmen Dı́az, María Susana Theas, Beatriz Haydee Duvilanski, Adriana Seilicovich · 2000 · NeuroImmunoModulation
Possible Involvement of Catalase in the Protective Effect of Interleukin-6 Against 6-Hydroxydopamine Toxicity in PC12 Cells
Kiyofumi Yamada, Hiroyuki Umegaki, Izumi Maezawa · 1997 · Brain Research Bulletin
Screening of interleukins for survival-promoting effects on cultured mesencephalic dopaminergic neurons from embryonic rat brain
Rainer von Coelln, Klaus Unsicker, Kerstin G. KRIEGLSTEIN · 1995 · Developmental Brain Research
PC12‐E2 cells: A stable variant with altered responses to growth factor stimulation
Yvonne Y. Wu, Ralph A. Bradshaw · 1995 · Journal of Cellular Physiology
Expression of the α2-macroglobulin-encoding gene in rat brain and cultured astrocytes
Higuchi Masakazu, Takashi Ito, Yoshinori Imai · 1994 · Gene
Interaction between dopamine -hydroxylase and interleukin genes increases Alzheimer's disease risk
Ignacio Mateo · 2006 · Journal of Neurology Neurosurgery & Psychiatry
IL-6 release by LPS-stimulated peripheral blood mononuclear cells as a potential biomarker in Alzheimer's disease
Adam Ian Kaplin, Katherine A. L. Carroll, Jenn Cheng, Rameeza Allie, Constantine George Lyketsos, Peter A. Calabresi, Paul B. Rosenberg · 2008 · International Psychogeriatrics
Administration of monoclonal antibodies neutralizing the inflammatory mediators tumor necrosis factor alpha and interleukin -6 does not attenuate acute behavioral deficits following experimental traumatic brain injury in the rat
N. Marklund, Carrie A. Keck, R. Hoover, Kristie M Soltesz, Marie Millard, D. Lebold, Zachary P. Spangler, A. Banning, J. Benson, T. McIntosh · 2005 · Restorative Neurology and Neuroscience
Continuous interleukin‐6 application in vivo via macroencapsulation of interleukin‐6–expressing COS‐7 cells induces massive gliosis
J. Tilgner, Benedikt Volk, Christian Kaltschmidt · 2001 · Glia
Gene–gene interaction between interleukin-6 and interleukin-10 reduces AD risk
Jon Infante, C. Sanz, José L. Fernández-Luna · 2004 · Neurology
INTERLEUKIN-6 PROMOTER POLYMORPHISM AND LATE-ONSET ALZHEIMER's DISEASE IN THE FINNISH POPULATION
Anne Maria Koivisto, Seppo Helisalmi, Jussi Pihlajamäki et al. · 2005 · Journal of Neurogenetics
The −174/−597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis
Marı́a Fedetz, Fuencisla Matesanz, M. Pascual · 2001 · Journal of the Neurological Sciences
Enhancement of Th2 response in IL-6-deficient mice immunized with myelin oligodendrocyte glycoprotein
Yoshinobu Okuda, Saburo Sakoda, Yukihiko Saeki, Tadamitsu Kishimoto, Takehiko Yanagihara · 2000 · Journal of Neuroimmunology
IL-6 and sIL-6R concentration in the cerebrospinal fluid and serum of MS patients.
Zbigniew Stelmasiak, Maria Kozioł-Montewka, Beata Dobosz, Konrad Rejdak · 2001 · PubMed
The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons
Yi Eve Sun, Pia März, U. Otten · 2002 · Biochemical and Biophysical Research Communications
Interleukin-6 Induces Prostaglandin E2 Synthesis in Mouse Astrocytes
Toshiyuki Chikuma, Tetsuya Yoshimoto, Masahiro Ohba, Makoto Sawada, Takeshi Kato, Tomoaki Sakamoto, Yukio Hiyama, Hiroshi Hojo · 2009 · Journal of Molecular Neuroscience
Interleukin 6 mediated differentiation and rescue of cell redox in PC 12 cells exposed to ionizing radiation
Kazuhiro Abeyama, Kazunori Kawano, Toshihiro Nakajima · 1995 · FEBS Letters
Interaction between interleukin?6 and intercellular adhesion molecule?1 genes and Alzheimer?s disease risk
Onofre Combarros, Jon Infante, Javier Llorca · 2005 · Journal of Neurology
Expression profiling and Ingenuity biological function analyses of interleukin-6- versus nerve growth factor-stimulated PC12 cells
Dieter Kunz, Gaby Walker, Marc Bedoucha, Ulrich Certa, Pia März, Beatrice Dimitriades‐Schmutz, U. Otten · 2009 · BMC Genomics
Cytokines disrupt intracellular patterns of Parkinson's disease-associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells
Roger J. Bick, Brian J. Poindexter, Marylee M. Kott, Yang an Liang, Kha Dinh, Berneet Kaur, Diane L. M. Bick, Marie–Françoise Doursout, Mya Caryn Schiess · 2008 · Brain Research
Effects of IL6 and IL1β on aFGF expression and excitotoxicity in NT2N cells
Veronika Thorns, Gerhard Franz Walter, Federico Licastro · 2002 · Journal of Neuroimmunology
Recapitulation of cell signaling events associated with astrogliosis using the brain slice preparation
Candice L. Damiani, James Patrick O'Callaghan · 2006 · Journal of Neurochemistry
Is there an immunologic basis for schizophrenia?
Brian E. Leonard · 2005 · Expert Review of Clinical Immunology
Increased Gene Expression of Interleukin-1 α and Interleukin-6 in Rat Primary Glial Cells Induced by β-Amyloid Fragment
Veronica Cortés Toro, Roya Tehranian, Maria Zetterström, Gun Eriksson, Ülo Langel, Tamás Bartfai, Kerstin Lverfeldt · 2001 · Journal of Molecular Neuroscience
Reconstitution of human immunodeficiency virus–induced neurodegeneration using isolated populations of human neurons, astrocytes, and microglia and neuroprotection mediated by insulin-like growth factors
Jianbin Wang, Dana H. Gabuzda · 2006 · Journal of NeuroVirology
Differential inflammatory activation of IL-6 (−/−) astrocytes
Laurel M. Bolin, A. Zhaung, Iwona Strycharska-Orczyk, E. Nelson, I. Huang, Michelle Malit, Q. Nguyen · 2005 · Cytokine
The effects of interleukin-6, leukemia inhibitory factor and interferon-gamma on STAT DNA binding and c-fos mRNA levels in cortical astrocytes and C6 glioma cells.
Shirzad Jenab, Vanya Quiñones-Jenab · 2002 · PubMed
High-resolution analysis of IL-6 minisatellite polymorphism in Sardinian multiple sclerosis: effect on course and onset of disease
Koen Vandenbroeck, Pierre Fiten, Isabelle Ronsse, An Goris, Ilaria Porru, Cristina Melis, Marcella Rolesu, An Billiau, Maria Giovanna Marrosu, Ghislain Opdenakker · 2000 · Genes and Immunity
Polymorphism 174 G/C of interleukin 6 gene in Alzheimer's disease--preliminary report.
Bogusław Paradowski, Dorota Celczyńska, Tadeusz Dobosz · 2009 · PubMed
Sex effects of Interleukin-6 deficiency on neuroinflammation in aged C57Bl/6 mice
Veronica M. Miller, David A. Lawrence, Gregory A. Coccaro, Tapan Kumar Mondal, K. Andrews, Anne Dreiem, Richard F. Seegal · 2010 · Brain Research
Interleukin-6 protects cerebellar granule neurons from NMDA-induced neurotoxicity.
Xiaochun Wang, Yihua Qiu, Yu-Ping Peng · 2007 · PubMed
Cytokines Genes Polymorphisms and Risk of Multiple Sclerosis
Izad, Maryam, Vodjgani, Mohammed, Niknam, Mohammed Hossein, Amirzargar, Aliakbar, Heidari, Amir Behzad, Shahbeigi, Saeed, Keramatipour, Mohammad · 2010 · The American Journal of the Medical Sciences
Gene–gene interaction between CARD8 and interleukin-6 reduces Alzheimer’s disease risk
Ana Fontalba, Olga Gutiérrez, Javier Llorca · 2009 · Journal of Neurology
Analysis of the Cerebral Transcriptome in Mice Subjected to Traumatic Brain Injury: Importance of IL-6
Albert Quintana, Mercedes Giralt, Amalia Molinero · 2007 · NeuroImmunoModulation
Investigation of a genetic variation of a variable number tandem repeat polymorphism of interleukin-6 gene in patients with multiple sclerosis
Stephan Schmidt, Andreas Papassotiropoulos, Stefano Sotgiu et al. · 2003 · Journal of Neurology
Interleukin-6 upregulates the expression of PMP22 in cultured rat Schwann cells via a JAK2-dependent pathway
Takaaki Ito, Kazuo Ikeda, Katsuro Tomita, Shigeru Yokoyama · 2010 · Neuroscience Letters
Brain Activation of Monocyte-Lineage Cells: Involvement of Interleukin-6
Shafer, Lisa L., McNulty, John A., Young, M. Rita I. · 2002 · Neuroimmunomodulation
Additive effects of amyloid β fragment and interleukin-1β on interleukin-6 secretion in rat primary glial cultures
Linda Holmlund, Veronica Cortés Toro, Kerstin Iverfeldt · 2002 · International Journal of Molecular Medicine
Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons
Michael Hüll, Jürgen Eistetter, Bernd L. Fiebich, Joachim Bauer · 1999 · Neuroscience Letters
Human MBP‐specific T cells regulate IL‐6 gene expression in astrocytes through cell–cell contacts and soluble factors
Marco Colombatti, Giuseppe Moretto, Marina Tommasi · 2001 · Glia
Cytokines decrease expression of interleukin‐6 signal transducer and leptin receptor in central nervous system glia
Jason J. Rose, Beverly Bealmear, Liljana Nedelkoska, Diane M. Studzinski, Robert P. Lisak, Joyce A. Benjamins · 2009 · Journal of Neuroscience Research
The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2
Eugster · 1998 · Pure Amsterdam UMC