Cited by 15Multiple Sclerosis Research StudiesPsoriasis: Treatment and PathogenesisGenetic Associations and Epidemiology

Cytokines Genes Polymorphisms and Risk of Multiple Sclerosis

Izad, Maryam, Vodjgani, Mohammed, Niknam, Mohammed Hossein, Amirzargar, Aliakbar, Heidari, Amir Behzad, Shahbeigi, Saeed, Keramatipour, Mohammad·2010·The American Journal of the Medical Sciences

Abstract

Association studies of proinflammatory and anti-inflammatory cytokines single nucleotide polymorphisms with multiple sclerosis (MS) in population with different ethnic background have shown inconsistent results. To study the possible role of tumor necrosis factor-alpha G-308A, interleukin-6 G-174C, interleukin-10 C-592A, C-819T, G-1082A, transforming growth factor (TGF)-beta (codons 10 and 25), and interferon-gamma T+874A polymorphisms in susceptibility to MS in Iranian population, DNA samples from 98 patients and 97 healthy controls were genotyped using polymerase chain reaction-sequence-specific primers. Analysis of the genotypes revealed a significant lower frequencies of tumor necrosis factor-alpha GA and TGF beta C/C G/G genotypes and higher frequency of TGF beta T/C G/C genotype in patients (P < 0.05). Our data suggest that these polymorphisms play a role in susceptibility to MS, which is possibly mediated by dysregulated production of these cytokines.

Integrity signals

Registry

Crossref · 10.1097/maj.0b013e3181cef1a1

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Preclinical studies highlight extensive influences of germline genetic modifiers of TGF-β activity on tumorigenesis, vascular integrity, and allergy.

    “preclinical studies highlight extensive influences of germline genetic modifiers of TGF-β activity on tumorigenesis, vascular integrity and allergy392,398–400.”

    From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [398]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Izad, M., Vodjgani, M., Niknam, M. H., Amirzargar, A., Heidari, A. B., Shahbeigi, S., & Keramatipour, M.
Affiliations
  • Tehran University of Medical Sciences (IR)
  • Shahid Beheshti University (IR)
Corresponding author
Izad, Maryam
Venue
The American Journal of the Medical Sciences
Publisher
Elsevier BV
Published
2010-04
Volume
339
Issue
4
Pages
327-331
ISSN
0002-9629 (ISSN-L)
OpenAlex
W2014687312
Cited by
15
References
36
Citations by year
2026: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2015: 1 · 2013: 1 · 2012: 1
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of the Medical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
multiple sclerosis, cytokine gene polymorphisms, genetic susceptibility, TNF-α, interleukin-6, IL-10, TGF-beta, interferon-gamma, Iranian population, genetic association
MeSH terms
Adult, Female, Gene Frequency, Humans, Male, Middle Aged, Multiple Sclerosis, Polymorphism, Genetic, Risk Factors, Genetic Variation, Cytokines, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review