Cytokines Genes Polymorphisms and Risk of Multiple Sclerosis
Abstract
Association studies of proinflammatory and anti-inflammatory cytokines single nucleotide polymorphisms with multiple sclerosis (MS) in population with different ethnic background have shown inconsistent results. To study the possible role of tumor necrosis factor-alpha G-308A, interleukin-6 G-174C, interleukin-10 C-592A, C-819T, G-1082A, transforming growth factor (TGF)-beta (codons 10 and 25), and interferon-gamma T+874A polymorphisms in susceptibility to MS in Iranian population, DNA samples from 98 patients and 97 healthy controls were genotyped using polymerase chain reaction-sequence-specific primers. Analysis of the genotypes revealed a significant lower frequencies of tumor necrosis factor-alpha GA and TGF beta C/C G/G genotypes and higher frequency of TGF beta T/C G/C genotype in patients (P < 0.05). Our data suggest that these polymorphisms play a role in susceptibility to MS, which is possibly mediated by dysregulated production of these cytokines.
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Preclinical studies highlight extensive influences of germline genetic modifiers of TGF-β activity on tumorigenesis, vascular integrity, and allergy.
“preclinical studies highlight extensive influences of germline genetic modifiers of TGF-β activity on tumorigenesis, vascular integrity and allergy392,398–400.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [398]
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TGFβ biology in cancer progression and immunotherapy
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- Authors
- Izad, M., Vodjgani, M., Niknam, M. H., Amirzargar, A., Heidari, A. B., Shahbeigi, S., & Keramatipour, M.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Shahid Beheshti University (IR)
- Corresponding author
- Izad, Maryam
- Venue
- The American Journal of the Medical Sciences
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 339
- Issue
- 4
- Pages
- 327-331
- ISSN
- 0002-9629 (ISSN-L)
- OpenAlex
- W2014687312
- Cited by
- 15
- References
- 36
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of the Medical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- multiple sclerosis, cytokine gene polymorphisms, genetic susceptibility, TNF-α, interleukin-6, IL-10, TGF-beta, interferon-gamma, Iranian population, genetic association
- MeSH terms
- Adult, Female, Gene Frequency, Humans, Male, Middle Aged, Multiple Sclerosis, Polymorphism, Genetic, Risk Factors, Genetic Variation, Cytokines, Genetic Predisposition to Disease
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