Cited by 105Transcranial Magnetic Stimulation StudiesElectroconvulsive Therapy StudiesTreatment of Major Depression

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Accelerated theta burst stimulation for the treatment of depression: A randomised controlled trial

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Chen, Leo, Thomas, Elizabeth H.X., Kaewpijit, Pakin, Miljevic, Aleksandra, Hughes, Rachel, Hahn, Lisa, Kato, Yuko, Gill, Shane, Clarke, Patrick, Ng, Felicity, Paterson, Tom, Giam, Andrew, Sarma, Shanthi, Hoy, Kate E., Galletly, Cherrie, Fitzgerald, Paul B.·2021·Brain Stimulation

DOI 10.1016/j.brs.2021.07.018

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Abstract

INTRODUCTION: Theta burst pattern repetitive transcranial magnetic stimulation (TBS) is increasingly applied to treat depression. TBS's brevity is well-suited to application in accelerated schedules. Sizeable trials of accelerated TBS are lacking; and optimal TBS parameters such as stimulation intensity are not established. METHODS: We conducted a three arm, single blind, randomised, controlled, multi-site trial comparing accelerated bilateral TBS applied at 80 % or 120 % of the resting motor threshold and left unilateral 10 Hz rTMS. 300 patients with treatment-resistant depression (TRD) were recruited. TBS arms applied 20 bilateral prefrontal TBS sessions over 10 days, while the rTMS arm applied 20 daily sessions of 10 Hz rTMS to the left prefrontal cortex over 4 weeks. Primary outcome was depression treatment response at week 4. RESULTS: The overall treatment response rate was 43.7 % and the remission rate was 28.2 %. There were no significant differences for response (p = 0.180) or remission (p = 0.316) across the three groups. Response rates between accelerated bilateral TBS applied at sub- and supra-threshold intensities were not significantly different (p = 0.319). Linear mixed model analysis showed a significant effect of time (p < 0.01), but not rTMS type (p = 0.680). CONCLUSION: This is the largest accelerated bilateral TBS study to date and provides evidence that it is effective and safe in treating TRD. The accelerated application of TBS was not associated with more rapid antidepressant effects. Bilateral sequential TBS did not have superior antidepressant effect to unilateral 10 Hz rTMS. There was no significant difference in antidepressant efficacy between sub- and supra-threshold accelerated bilateral TBS.

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Additional file 1 of Short-term and long-term efficacy of accelerated transcranial magnetic stimulation for depression: a systematic review and meta-analysis
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A standard coil placement for reliable transcranial magnetic stimulation of the frontoparietal depression network: the ‘F5-AF7 method‘Preprint
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Bayesian Dose-Finding for Theta Burst Stimulation Tolerability: A Randomized Study Comparing Intermittent and Continuous Protocols at Distinct Prefrontal TargetsPreprint
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Authors: Chen, L., Thomas, E. H. X., Kaewpijit, P., Miljevic, A., Hughes, R., Hahn, L., Kato, Y., Gill, S., Clarke, P., Ng, F., Paterson, T., Giam, A., Sarma, S., Hoy, K. E., Galletly, C., & Fitzgerald, P. B.
Affiliations: Epworth Hospital (AU)
Monash Alfred Psychiatry Research centre (AU)
SA Health (AU)
Central Adelaide Local Health Network (AU)
Gold Coast Hospital (AU)
Corresponding author: Chen, Leo
ORCID: Chen, Leo
Thomas, Elizabeth H.X.
Kaewpijit, Pakin
Miljevic, Aleksandra
Hughes, Rachel
Hahn, Lisa
Kato, Yuko
Gill, Shane
Clarke, Patrick
Ng, Felicity
Paterson, Tom
Giam, Andrew
Sarma, Shanthi
Hoy, Kate E.
Galletly, Cherrie
Fitzgerald, Paul B.
Venue: Brain Stimulation
Publisher: Elsevier BV
Published: 2021-09
Volume: 14
Issue: 5
Pages: 1095-1105
ISSN: 1876-4754 (ISSN-L)
1935-861X
DOI: 10.1016/j.brs.2021.07.018
OpenAlex: W3188020264
Cited by: 105
References: 94
Citations by year: 2026: 23 · 2025: 31 · 2024: 19 · 2023: 18 · 2022: 11 · 2021: 3
FWCI: 5.11
Type: journal article
Language: en
Update notices: erratum (2021-09-01)
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Brain stimulation (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: NHMRC
Topics: Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: theta burst stimulation, repetitive transcranial magnetic stimulation, treatment-resistant depression, 10 Hz rTMS, stimulation intensity, resting motor threshold, antidepressant efficacy, remission
MeSH terms: Antidepressive Agents, Depression, Humans, Single-Blind Method, Treatment Outcome, Prefrontal Cortex, Transcranial Magnetic Stimulation, Depressive Disorder, Treatment-Resistant

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Accelerated theta burst stimulation for the treatment of depression: A randomised controlled trial

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