Accelerated theta-burst transcranial magnetic stimulation of the bilateral dorsolateral prefrontal cortex in a patient with post-traumatic stress disorder and major depressive disorder: Case report
Open accessAbstract
Background: Theta-burst transcranial magnetic stimulation has demonstrated promising effectiveness as treatment for post-traumatic stress disorder (PTSD) and depression. However, the effect of accelerated theta-burst stimulation (TBS) in comorbid with PTSD and depression remains unknown. Case presentation: We report a case of a 25-year-old woman with PTSD and depression whose symptoms markedly improved after continuous TBS of the right dorsolateral prefrontal cortex (DLPFC) and intermittent TBS (iTBS) over the left DLPFC, and then with 20 min break before the 2nd iTBS session. Conclusions: Accelerated TBS over the bilateral DLPFC may improve severe PTSD and depression. Accelerated TBS may have more improvement of depression symptoms than PTSD symptoms. Further trials are warranted to investigate the effect and safety for patients with complicated PTSD and depression.
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Randomised and naturalistic studies suggest that rTMS and theta-burst stimulation may reduce PTSD symptoms.
“Randomised and naturalistic studies suggest that rtMs and theta-burst stimulation may reduce PtsD symptoms”
Emerging reports support bilateral and accelerated approaches in patients with comorbid depressive and posttraumatic presentations.
“emerging reports support bilateral and accelerated approaches in patients with comorbid depressive and posttraumatic presentations”
The present estimate (exact 95% CI upper bound 5.6%) is consistent with the broader safety profile of iTBS established in large multicentre trials including THREE-D, and with emerging bilateral accelerated reports in trauma-related populations.
“the present estimate (exact 95% ci upper bound 5.6%) is consistent with the broader safety profile of itBs established in large multicentre trials including thRee-D (Blumberger et al. 2018), and with emerging bilateral accelerated reports in trauma-related populations (chang et al. 2023;Vaithianathan et al. 2022).”
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- Authors
- Chang, C.-H., Liu, C.-Y., Chen, S.-J., & Tsai, H.-C.
- Affiliations
- China Medical University (TW)
- National Taipei University of Nursing and Health Science (TW)
- Mackay Memorial Hospital (TW)
- Tzu Chi University (TW)
- Corresponding author
- Tsai, Hsin-Chi
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2023-02-02
- Volume
- 14
- Pages
- 1061088-1061088
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC9932662
- OpenAlex
- W4319000667
- Cited by
- 5
- References
- 38
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- China Medical University Hospital (ANHRF110-24, ANHRF111-25)
- China Medical University
- Tainan Municipal An-Nan Hospital
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- transcranial magnetic stimulation, post-traumatic stress disorder, major depressive disorder, dorsolateral prefrontal cortex, intermittent theta burst stimulation, non-invasive brain stimulation
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