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Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors

North, Sophie, Moenner, Michel, Bikfalvi, Andreas·2005·Cancer Letters
DOI 10.1016/j.canlet.2004.08.007
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Abstract

Angiogenesis in tumors is controlled by the so-called 'angiogenic switch' which allows the passage from low invasive and poorly vascularized tumors to highly invasive and angiogenic tumors. A number of cellular stress factors such as hypoxia, nutrient deprivation or inducers of reactive oxygen species (ROS) are important stimuli of angiogenic signalling. The HIF system plays a significant role in several of these effects and the molecular mechanisms of its regulation have recently been characterized. In addition, HIF-independent mechanisms have been described which involved number of other molecules and transcription factors such as nuclear factor-(kappa)B (NF-(kappa)B) and p53. p53 is an important intracellular mediator of the stress response and is now also recognized as a modifier of the angiogenic response. p53 may interact with the HIF system but may also have direct effects on angiogenesis regulators or interfere with translation mechanisms of angiogenesis factors.

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Authors
North, S., Moenner, M., & Bikfalvi, A.
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2005-01
Volume
218
Issue
1
Pages
1-14
ISSN
0304-3835
DOI
10.1016/j.canlet.2004.08.007
Cited by
113
References
13
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors. https://app.cochat.ai/papers/10.1016/j.canlet.2004.08.007
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North, S., Moenner, M., & Bikfalvi, A. (2005). Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors. Cancer Letters. https://doi.org/10.1016/j.canlet.2004.08.007