Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells
Abstract
Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were upregulated while Bcl-2 was down-regulated under KR exposure. A tumor growth in mice was dramatically suppressed by KR. In contrast, human skin fibroblast CCL-116 and bovine primary fibroblast cells show resistances to KR and no significant changes in Bad, Bcl-X(L,) and cleaved PARP were observed. Our data suggest that KR selectively induces apoptosis in cancer cells through the classical mitochondria dependent apoptosis pathway.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Kinetin riboside could induce apoptosis in HeLa and mouse melanoma B16F-10 cells.
“A recent study revealed that kinetin riboside could induce apoptosis in HeLa and mouse melanoma B16F-10 cells [50].”
From The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water (2009) · cites this paper as [50]
Cites
The Bcl2 family: regulators of the cellular life-or-death switch
Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032 · see citing works
Ge, L., Yong, J. W. H., Goh, N. K., Chia, L. S., Tan, S. N., & Ong, E. S. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.09.026 · Cited by 126 · see citing works
Self-citation1955: Kinetin arrives. The 50th anniversary of a new plant hormone
Amasino, R. (2005) · Plant Physiology · doi:10.1104/pp.104.900160 · Cited by 112 · see citing works
Sharma, S. P., Kaur, P., & Rattan, S. I. S. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2729 · Cited by 70 · see citing works
Sharma, S. P., Kaur, J., & Rattan, S. I. S. (1997) · IUBMB Life · doi:10.1080/15216549700201911 · Cited by 57 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water
Yong, J. W. H., Ge, L., Ng, Y. F., & Tan, S. N. (2009) · Molecules · doi:10.3390/molecules14125144 · Cited by 753 · see citing works
“A recent study revealed that kinetin riboside could induce apoptosis in HeLa and mouse melanoma B16F-10 cells [50].”
BackgroundSelf-citationComposition, Properties and Reactions of Coconut Water
Rethinam, P., & Krishnakumar, V. (2022) · Coconut Water · doi:10.1007/978-3-031-10713-9_4 · Cited by 9 · see citing works
- Authors
- Choi, B.-H., Kim, W., Wang, Q. C., Kim, D.-C., Tan, S. N., Yong, J. W. H., Kim, K.-T., & Yoon, H. S.
- Affiliations
- Nanyang Technological University (SG)
- Pohang University of Science and Technology (KR)
- Corresponding author
- Yoon, Ho Sup
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 261
- Issue
- 1
- Pages
- 37-45
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2137810208
- Cited by
- 75
- References
- 5
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 10
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- cytokinin analogs, apoptosis, Bcl-2 family proteins, Bcl-2, Bad, caspase-3, mitochondrial membrane potential, cytochrome c release, mitochondrial apoptosis, tumor selectivity, tumor growth inhibition, melanoma, HeLa cells
- MeSH terms
- Adenosine, Animals, Cattle, Cell Line, Fibroblasts, Humans, Kinetin, Neoplasms, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Cytochromes c, Cell Line, Tumor, bcl-Associated Death Protein, Mice, Membrane Potential, Mitochondrial, Caspase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
