Plant growth hormone kinetin delays aging, prolongs the lifespan, and slows down development of the fruitfly Zaprionus paravittiger
Abstract
A cytokinin plant growth hormone kinetin (Kn) retards senescence in plants and delays ageing in human cells in culture. We have now observed that Kn also slows down ageing and prolongs the lifespan of the fruitfly Zaprionus paravittiger when these insects are fed with 25-125 ppm Kn added in their diet medium. In addition, 25 ppm Kn also slows down the larval and the pupal stages of the developing insects. However, the anti-ageing effects of Kn are not merely due to the slowing-down of development, but are mainly due to a reduction in the age-specific death rates throughout the adult lifespan.
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Kinetin has strong anti-ageing effects on human skin cells and fruitflies.
“Recently, its strong anti-ageing effects on human skin cells and fruitflies (Zaprionus paravittiger) were also reported [26,59,60].”
From The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water (2009) · cites this paper as [59]
The anti-aging bioactivity of CKs reduces age-associated deaths in adults by reducing development during larval and pupal stages.
“Therefore, the anti-aging bioactivity of CKs reduces age-associated deaths in adults by reducing development during larval and pupal stages [211].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [211]
6-furfurylaminopurine delays senescence and aging (increased lifespan) in several plants and Zaprionus paravittiger (fruit flies).
“Additionally, 6-furfurylaminopurine delays senescence and aging (increased lifespan) in several plants and Zaprionus paravittiger (fruit flies).”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [211]
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“The metabolic analysis also suggests that O. sinensis sustained a low-profile, energy-conserving standoff with the host, as the immunomodulator Albiflorin [30], plant hormone analogs (IBA, Kinetin) [4, 33], and ADP (cluster 1, green module, Fig.”
- Authors
- Sharma, S. P., Kaur, P., & Rattan, S. I. S.
- Affiliations
- Guru Nanak Dev University (IN)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1995-11
- Volume
- 216
- Issue
- 3
- Pages
- 1067-1071
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1972381197
- Cited by
- 70
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- kinetin, cytokinins, aging, lifespan extension, fruit flies, senescence, larval development, pupal development, age-specific mortality, anti-aging, dietary supplementation
- MeSH terms
- Adenine, Aging, Animals, Diptera, Female, Kinetin, Larva, Longevity, Male, Plant Growth Regulators, Plants, Pupa
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