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MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer

Noh, Ji Heon, Chang, Young Gyoon, Kim, Min Gyu, Jung, Kwang Hwa, Kim, Jeong Kyu, Bae, Hyun Jin, Eun, Jung Woo, Shen, Qingyu, Kim, Seung-Jin, Kwon, So Hee, Park, Won Sang, Lee, Jung Young, Nam, Suk Woo·2013·Cancer Letters
DOI 10.1016/j.canlet.2013.03.003
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Abstract

Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to HDAC2 overexpression is not well understood. We performed microRNA (miRNA) profiling analysis in a subset of HCCs, and identified four down-regulated miRNAs that may target HDAC2 in HCC. Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells. This treatment repressed cancer cell growth and recapitulated HDAC2 knockdown effects on HCC cells. In conclusion, we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis.

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Research works printed but not linked: 27

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Metadata

Authors
Noh, J. H., Chang, Y. G., Kim, M. G., Jung, K. H., Kim, J. K., Bae, H. J., Eun, J. W., Shen, Q., Kim, S.-J., Kwon, S. H., Park, W. S., Lee, J. Y., & Nam, S. W.
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2013-07
Volume
335
Issue
2
Pages
455-462
ISSN
0304-3835
DOI
10.1016/j.canlet.2013.03.003
Cited by
102
References
2
Language
en
Licence
Funders
  • Ministry of Education, Science and Technology (2011-0010705, 2012M3A9D1054476)
  • Catholic University of Korea
  • National Research Foundation of Korea
  • Korea Science and Engineering Foundation

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